Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport(TM) (RMP-7)

Brain Research

Volumn 801, Issue 1-2, 1998, Pages 259-266

  Emerich, Dwaine F ^a   Snodgrass, Pamela ^a   Pink, Melissa ^a   Bloom, Floyd ^b   Bartus, Raymond T ^a,c  

^a ALKERMES INC   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Analgesia; Blood brain barrier; Bradykinin agonist; Drug delivery; Opiates; Psychopharmacology

Indexed keywords

LOBRADIMIL; LOPERAMIDE; NALOXONE; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG PENETRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; BRADYKININ; CENTRAL NERVOUS SYSTEM; DRUG SYNERGISM; HEAT; INJECTIONS, INTRAVENOUS; LOPERAMIDE; MALE; PAIN MEASUREMENT; RATS; RATS, INBRED F344; TIME FACTORS;

EID: 0032504604     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00571-X     Document Type: Article

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