NO Synthase and NO-Dependent Signal Pathways in Brain Aging and Neurodegenerative Disorders: The Role of Oxidant/Antioxidant Balance

Neurochemical Research

Volumn 25, Issue 9-10, 2000, Pages 1315-1341

  Calabrese, Vittorio ^a   Bates, Timothy Edward ^b   Giuffrida Stella, Anna Maria ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; CO; Heat shock proteins; Neurodegeneartive disorders; NO synthase; Oxidative stress; Signal transduction

Indexed keywords

ANTIOXIDANT; HEAT SHOCK PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT;

AGING; ANIMAL; BRAIN; DEGENERATIVE DISEASE; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN; HEAT-SHOCK PROTEINS; HUMANS; NEURODEGENERATIVE DISEASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDANTS; SIGNAL TRANSDUCTION;

EID: 0034304391     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1007604414773     Document Type: Article

References (245)

1. Halliwell, B. 1992. Reactive oxygen species and the central nervous system. J. Neurochem. 59:1609-1623.
2. Halliwell, B. 1999 Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Radie. Res. 31:261-272.
3. Knight, A. J. 1997. Reactive oxygen species and the neurodegenerative disorders. Ann. Clin. Lab. Sci. 27:11-25.
4. Davey, G. P., Peuchen, S., and Clark, J. B. 1998. Energy thresholds in brain mitochondria. J. Biol. Chem. 273:12753-12757.
5. Storz, G. and Tartaglia, L. A. 1992. OxyR: a regulator of antioxidant genes. J. Nutr. 122:627-639.
6. Tong, L., Toliver-Kinsky, T., Taglialatela, G., Werrbach- Perez, K., Wood, T., and Perez-Polo, R. 1998. Signal transduction in neuronal death. J. Neurochem. 71:447-459.
7. Wang, J. K., Kiyokawa, E., Verdin, E., and Trono, D. 2000. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc. Natl. Acad. Sci. USA 97:394-399.
8. Morimoto, R. I. and Santoro, M. G. 1998. Stress-inducible response and heat shock proteins: new pharmacologic targets for cytoprotection. Nature Biotechnol. 16:833-838.
9. Santoro, M. G. 2000. Heat shock and the control of the stress response. Biochem. Pharmacol. 59:55-63.
10. Motterlini, R., Foresti, R., Bassi, R., Calabrese, V., Clark, J. E., and Green, C. J. 2000. Endothelial Heme oxygenase-1 induction by hypoxia: modulation by inducible nitric oxide synthase (iNOS) and S-nitrosothiols. J. Biol. Chem. 275:13613-13620.
11. Baek, S. H., Kim, J. Y., Choi, J. H., Park, E. M., Han, M. Y., Kim, C. H., Ahn, Y. S., and Park, Y. M. 2000. Reduced glutathione oxidation ratio and 8 ohdG accumulation by mild ischemic pretreatment. Brain. Res. 856:28-36.
12. Calabrese, V., Copani, A., Testa, D., Ravagna, A., Spadaro, F., Tendi, E., Nicoletti, V. G., and Giuffrida Stella, A. M. 2000 Nitric oxide synthase induction in astroglial cell cultures: Effect on heat shock protein 70 synthesis and oxidant/antioxidant balance. J. Neurosci. Res. 60:613-622.
13. Calabrese, V., Testa, D., Ravagna, A., Bates, T. E., and Giuffrida Stella, A. M. 2000. HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochem. Biophys. Res. Comm. 269: 397-400.
14. Giuffrida Stella, A. M. 1991. Macromolecular changes in the aging brain. Pages 317-328, in: Timiras, P. S. et al., (eds), Plasticity and Regeneration of the nervous system, Plenum Press, New York.
15. Giuffrida Stella, A. M. and Lajtha, A. 1987. Macromolecular turnover in brain during aging. Gerontology 33:136-48.
16. Kirkwood, T. B. and Kowald, A. 1997. Network theory of aging. Exp. Gerontol. 32:395-399.
17. Sohal, R. S. 1997. Role of mitochondria and oxidative stress in the aging process. Pages 91-107, in: Flint Beal, M., Howell, N., Bodis-Wollner, I. (eds), Mitochondria and Free Radicals in Neurodegenerative diseases, Wiley-Liss, New York.
18. Benzi, G., Pastoris, O., Marzatico, F., Villa, R. F., Dagani, F., and Curti, D. 1992. The mitochondrial electron transfer alteration as a factor involved in the brain aging. Neurobiol. Aging 13: 361-368.
19. Sohal, R. S., Sohal, B. H., and Orr, W. C., Mitochondria superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies. Free Rad. Biol. Med. 19:499-504.
20. Davies, K. J. 1999. The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life 48:41-47.
21. Han, J., Cheng F., Yang, Z., and Dryhurst G. 1999. Inhibitors of mitochondrial respiration, iron (II) and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. J. Neurochem. 73:1683-1695.
22. Gabbita, S. P., Lovell, M. A., and Markesbery, W. R. 1998. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J. Neurochem. 71:2034-2040.
23. Li, W. P., Chan, W. Y., Lai, H. W., and Yew, D. T. 1997. Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients. J. Mol. Neurosci. 8:75-82.
24. Hirano, T., Yamaguchi, R., Asami, S., Iwamoto, N., and Kasai, H. 1996. 8-hydroxyguanine levels in nuclear DNA and its repair activity in rat organs associated with age. J. Gerontol. A. Biol. Sci. Med. Sci. 51:B303-7.
25. Tan, B. H., Bencsath, F. A., and Gaubatz, J. W. 1990. Steady- state levels of 7-methylguanine increase in nuclear DNA of postmitotic mouse tissues during aging. Mutat. Res. 237: 229-238.
26. Gaubatz, J. W. and Tan, B. H. 1993. Age-related studies on the removal of 7-methylguanine from DNA of mouse kidney tissue following N-methyl-N-nitrosourea treatment. Mutat. Res. 295:81-91.
27. Gaubatz, J. W. and Tan, B. H. 1994. Aging affects the levels of DNA damage in postmitotic cells. Ann. N. Y. Acad. Sci. 719:97-107.
28. Mandavilli, B. S. and Rao, K. S. 1996. Accumulation of DNA damage in aging neurons occurs through a mechanism other than apoptosis. J. Neurochem. 67:1559-1565.
29. Demple, B. and Harrison, L. 1994. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63: 915-948.
30. Fujiwara, Y. 1996. The mechanisms of aging and perspective for elimination of deleterious effects. Nippon. Ronen. Igakkai. Zasshi. 33:499-502.
31. Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., and Beal, M. F. 1993. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34:609-616.
32. Beckman, K. B. and Ames, B. N. 1999. Endogenous oxidative damage of mtDNA. Mutat. Res. 424:51-58.
33. Radman, M., Matic, I., Halliday, J. A., and Taddei, F. 1995. Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 347:97-103.
34. Mecocci, P., Beal, M. F., Cecchetti, R., Polidori, M. C., Cherubini, A., Chionne, F., Avellini, L., Romano, G., and Senin, U. 1997. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol. Chem. Neuropathol. 31:53-64.
35. Bohr, V. A. and Dianov, G. L. 1999. Oxidative DNA damage processing in nuclear and mitochondrial DNA. Biochimie 81: 155-160.
36. Beckman, K. B. and Ames, B. N. 1998. Mitochondrial aging: open questions. Ann. N. Y. Acad. Sci. 854:118-127.
37. Schapira, A. H. 1998. Mitochondrial dysfunction in neurodegenerative disorders. Biochim. Biophys. Acta 1366:225-233.
38. Stadtman, E. R., Starke-Reed, P. E., Oliver, C. N., Carney, J. M., and Floyd, R. A. 1992. Protein modification in aging. EXS 62:64-72.
39. Tian, L., Cai, Q., and Wei, H. 1998. Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging. Free Radic. Biol. Med. 24: 1477-1484.
40. Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Landum. R. W., Cheng, M. S., Wu, J. F., and Floyd, R. A. 1991. Reversal of age- related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha- phenylnitrone. Proc. Natl. Acad. Sci. USA 88: 3633-3636.
41. Squier, T. C. and Bigelow, D. J. 2000 Protein oxidation and age-dependent alterations in calcium homeostasis. Front. Biosci. 5:504-526.
42. Verkhratsky, A. and Toescu E. 1998. Calcium and neuronal ageing. TINS 21:2-7.
43. Ojaimi, J., Masters, C. L., McLean, C., Opeskin, K., McKelvie, P., and Byrne, E. 1999. Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease. Ann. Neurol. 46:656-660.
44. Barja, G. 1999. Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity. J. Bioenerg. Biomembr. 31:347-366.
45. Ruggiero, F. M., Cafagna, F., Petruzzella, V., Gadaleta, M. N., and Quagliariello, E. 1992. Lipid composition in synaptic and nonsynaptic mitochondria from rat brains and effect of aging. J. Neurochem. 59:487-491.
46. Giuffrida Stella, A. M. and Lajtha, A. 1983. Perspectives for neural regeneration with changes in macromolecular metabolism. Birth Defects: Original Article Series 19, vol.4, Pages 23-32, in: Haber, B., Perez-Polo, R., Hashim, G. A., Giuffrida Stella, A. M., Nervous system regeneration, Alan Liss, New York.
47. Itoh K., Weis, S., Mehraein, P., and Muller-Hocker, J. 1996. Cytochrome c oxidase defects of the human substantia nigra in normal aging. Neurobiol. Aging 17:843-848.
48. Calabrese, V., Distefano, A., Ricciardi, R., Calderone, A., and Rizza, V. 1992. Long term ethanol abuse enhances age dependent modulation of redox state in central and peripheral organs of rat: protection by L-carnitine. Neurosci. Lett. 43:18-21.
49. Villa, R. F., Turpeenoja, L., Benzi, G., and Giuffrida Stella, A. M. 1988. Action of L-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum. Neurochem. Res. 13:909-916.
50. Gorini, A., D'Angelo, A., and Villa, R. F. 1998. Energy metabolism of synaptosomal subpopulations from different neuronal systems of rat hippocampus: effect of L-acetylcarnitine administration in vivo. Neurochem. Res. 23:1485-1491.
51. Laganiere, S., and Yu, B. P. 1993. Modulation of membrane phospholipid fatty acid composition by age and food restriction. Gerontology 39:7-18.
52. Sohal, R. S., Ku, H. H., Agarwal, S., Forster, M. J., and Lal, H. 1994. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Dev. 74:121-133.
53. Gabbita, S. P., Butterfield, D. A., Hensley, K., Shaw, W., and Carney, J. M. 1997. Aging and caloric restriction affect mitochondrial respiration and lipid membrane status: an electron paramagnetic resonance investigation. Free Radic. Biol. Med. 23:191-201.
54. Mhatre, M. C. and Ticku, M. K. 1998. Caloric restriction retards the aging associated changes in gamma-aminobutyric acidA receptor gene expression in rat cerebellum. Brain Res. Mo.1 Brain Res. 54:270-275.
55. Joseph, J. A., Denisova, N., Fisher, D., Shukitt-Hale, B., Bickford, P., Prior, R., and Cao, G. 1998. Membrane and receptor modifications of oxidative stress vulnerability in aging. Nutritional considerations. Ann. NY Acad. Sci. 854:268-276.
56. Kass, G. E. and Orrenius, S. 1999. Calcium Signaling and Cytotoxicity. Environ. Health Perspect. 107:25-35.
57. Albers, D. S., Augood, S. J., Park, L. C., Browne, S. E., Martin, D. M., Adanson, J., Hutton, M., Standaert, D. G., Vonsattel, J. P., Gibson, G. E., and Beal, M. F. 2000 Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. J. Neurochem. 74:878-881.
58. Dawson, R., Jr., Beal, M. F., Bondy, S. C., Di Monte, D. A., and Isom, G. E. 1995. Excitotoxins, aging, and environmental neurotoxins: implications for understanding human neurodegenerative diseases. Toxicol. Appl. Pharmacol. 134:1-17.
59. Dawson, T. M., Zhang, J., Dawson, V. L., and Snyder, S. H. 1994. Nitric oxide: cellular regulation and neuronal injury. Prog. Brain. Res. 103:365-369.
60. Dyrks, T., Dyrks, E., Masters, C. L., and Beyreuther, K. 1993. FEBS Lett. 324:231-236.
61. Smith, C. D., Carney, J. M., Tatsumo, T., Stadtman, E. R., Floyd, R. A., and Markesbery, W. R. 1992. Protein oxidation in aging brain. Ann. NY Acad. Sci. 663:110-119.
62. Smith, M. A., Perry, G., Richey, P. L., Sayre, L. M., Anderson, V. E., Beal, M. F., and Kowall, N. 1996. Oxidative damage in Alzheimer's. Nature 382:120-121.
63. Smith, M. A. and Perry, G. 1996. Alzheimer disease: protein- protein interaction and oxidative stress. Bol. Estud. Med. Biol. 44:5-10.
64. Forster, M. J., Dubey, A., Dawson, K. M., Stutts, W. A., Lal, H., and Sohal, R. S. 1996. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc. Natl. Acad. Sci. USA 93: 4765-4769.
65. Floyd, R. A. and Carney, J. M. 1992. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32:22-27.
66. Halliwell and Gutteridge (1989) in Free Radicals in Biology and Medicine, pp 80, Clarendon Press, Oxford.
67. Fernandezcheca, J. C., Kaplowitz, N., Garciaruiz, C., Colell, A., Miranda, M., Mari, M., Ardite, E., and Morales, A. 1997. Gsh transport in mitochondria: defense against tnf-induced oxidative stress and alcohol-induced defect. Am. J. Physiol.-Gastrointestinal & Liver Physiol. 36:G7-G17.
68. Kristiián, T., Gertsch, J., Bates, T. E., and Siesjö., B. K. 2000. Characteristics of the calcium-triggered mitochondrial permeability transition in non-synaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. J. Neurochem. 74: 1999-2009.
69. Chang, M. L., Klaidman, L. K., and Adams, J. D.,Jr. 1997. The effects of oxidative stress on in vivo brain GSH turnover in young and mature mice. Mol. Chem. Neuropathol. 30:187-197.
70. Lipton, S. A., Rayudu, P. V., Choi, Y. B., Sucher, N. J., and Chen, H. S. 1998. Redox modulation of the NMDA receptor by NO-related species. Prog. Brain Res. 118:73-82.
71. Floyd, R. A. 1999. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc. Soc. Exp. Biol. Med. 222: 236-245.
72. Iwata Ichikawa, E., Kondo, Y., Miyazaki, I., Asanuma, M., and Ogawa, N. 1999. Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis. J. Neurochem. 72:2334-2344.
73. Muller, W. E., Romero, F. J., Perovic, S., Pergande, G., and Pialoglou, P. 1997. Protection of flupirtine on beta-amyloid- induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion. J. Neurochem. 68: 2371-2377.
74. Favilli, F., Iantomasi, T., Marraccini, P., Stio, M., Lunghi, B., Treves, C., and Vincenzini, M. T. 1994. Relationship between age and GSH metabolism in synaptosomes of rat cerebral cortex. Neurobiol. Aging 15:429-433.
75. Cooper, A. J. and Kristal, B. S. (1997). Multiple roles og glutathione in the central nervous system. Biol. Chem. 378: 793-802.
76. Ignarro, L. J., Cirino, G., Casini, A., and Napoli, C. 1999. Nitric oxide as a signaling molecule in the vascular system: an overview. J. Cardiovasc. Pharmacol. 34:879-886.
77. Yang, G., Chen, G., Ebner, T. J., and Iadecola, C. 1999. Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats. Am. J. Physiol. 277: R1760-70.
78. Knowles, R. G. and Moncada, S. 1994. Nitric oxide synthases in mammals. Biochem. J. 298:249-258.
79. Bredt, D. S. 1999. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic. Res. 31: 577-596.
80. Pollock, J. S., Klinghofer, V., Forstermann, U., and Murad, F. 1992. Endothelial nitric oxide synthase is myristylated. FEBS Lett. 309:402-404.
81. Dawson, V.L. and Dawson, T. M. 1995. Physiological and toxicological actions of nitric oxide in the central nervous system. Adv. Pharmacol. 34:323-342.
82. Sharma, H. S., Nyberg, F., Westman, J., Aim, P., Gordh, T., and Lindholm, D. 1998. Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. An immunohistochemical study in the rat. Amino. Acids. 14:121-129.
83. Mori, M., Gotoh, T., Nagasaki, A., Takiguchi, M., and Sonoki, T. 1998. Regulation of the urea cycle enzyme genes in nitric oxide synthesis. J. Inherit. Metab. Dis. 21:59-57.
84. Radi, R. 1998. Peroxynitrite reactions and diffusion in biology. Chem. Res. Toxicol. 11:720-721.
85. Wiseman, H. and Halliwell, B. 1996. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J. 313:17-29.
86. Thomas, S. R., Davies, M. J., and Stocker, R. 1998. Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite. Chem. Res. Toxicol. 11:484-494.
87. Koppal, T., Drake, J., Yatin, S., Jordan, B., Varadarajan, S., Bettenhausen, L., and Butterfield, D. A. 1999. Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease. J. Neurochem. 72:310-317.
88. Douki, T. and Cadet, J. 1996. Peroxynitrite mediated oxidation of purine bases of nucleosides and isolated DNA. Free Radic. Res. 24:369-380.
89. Jourd'heuil, D., Hallen, K., Feelisch, M., and Grisham, M. B. 2000. Dynamic state of S-nitrosothiols in human plasma and whole blood. Free Radic. Biol. Med. 28:409-417.
90. Broillet, M. C. 1999. S-nitrosylation of proteins. Cell Mol. Life Sci. 55:1036-1042.
91. Lipton, S. A., Rayudu, P. V., Choi, Y. B., Sucher, N. J., and Chen, H. S. 1998. Redox modulation of the NMDA receptor by NO-related species. Prog. Brain Res. 118:73-82.
92. Zhang, J. and Snyder, S. H. 1992. Nitric oxide stimulates auto- ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Proc. Natl. Acad. Sci. USA 89:9382-9385.
93. Mohr, S., Hallak, H., de Boitte, A., Lapetina, E. G., and Brune, B. 1999. Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J. Biol. Chem. 274:9427-9430.
94. Heales, S. J., Davies, S. E., Bates, T. E., and Clark, J. B. 1995. Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochem. Res. 20:31-38.
95. Nicoletti, V., Caruso, A., Tendi, E., Privitera, A., Console, A., Calabrese, V., Spadaro, F., Ravagna, A., Copani, A., and Giuffrida Stella, A. M. 1998. Effect of nitric oxide synthase induction on the expression of mitochondrial respiratory chain subunits in mixed cortical and astroglial cell cultures. Biochimie 80: 871-881.
96. Ignarro, L. J. 1989. Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins. Semin. Hematol. 26:63-76.
97. Gorbunov, N. V., Yalowich, J. C., Gaddam, A., Thampatty, P., Ritov, V. B., Kisin, E. R., Elsayed, N. M., and Kagan, V. E. 1997. Nitric oxide prevents oxidative damage produced by tertbutyl hydroperoxide in erythroleukemia cells via nitrosylation of heme and non-heme iron. Electron paramagnetic resonance evidence. J. Biol. Chem. 272:12328-12341.
98. Lipton, S. A., Choi, Y. B., Sucher, N. J., Pan, Z. H., and Stamler, J. S. 1996. Redox state, NMDA receptors and NO-related species [comment]. Trends. Pharmacol. Sci. 17:186-187.
99. Lipton, S. A. and Stamler, J. S. 1994. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology 33:1229-1233.
100. Gunasekar, P. G., Kanthasamy, A. G., Borowitz, J. L., and Isom, G. E. 1995. NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death. J. Neurochem. 65:2016-2021.
101. Beal, M. F. 1995. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38:357-366.
102. Papa, S. 1996. Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications. Biochim. Biophys. Acta 1276:87-105.
103. Papa, S. and Skulachev, V. P. 1997. Reactive oxygen species, mitochondria, apoptosis and aging. Mol Cell. Biochem. 174: 305-319.
104. Papa, S., Scacco, S., Schliebs, M., Trappe, J., and Seibel, P. 1996. Mitochondrial diseases and aging. Mol. Aspects Med. 17: 513-563.
105. Lenaz, G. 1998. Role of mitochondria in oxidative stress and ageing. Biochim. Biophys. Acta 1336:53-67.
106. Bolanos, J. P., Almeida, A., Stewart, V., Peuchen, S., Land, J. M., Clark, J. B., and Heales, S. J. 1997. Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J. Neurochem. 68: 2227-2240.
107. Cleeter, M. W., Cooper, J. M., Darley Usmar, V. M., Moncada, S., and Schapira, A. H. 1994. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345:50-54.
108. Bolanos, J. P., Heales, S. J., Land, J. M., and Clark, J. B. 1995. Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J. Neurochem. 64:1965-1972.
109. Barker, J. E., Bolanos, J. P., Land, J. M., Clark, J. B., and Heales, S. J. 1996. Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal/astrocytic trafficking and neurodegeneration. Dev. Neurosci. 18:391-396.
110. Heales, S. J., Bolanos, J. P., Land, J. M., and Clark, J. B. 1994. Trolox protects mitochondrial complex IV from nitric oxidemediated damage in astrocytes. Brain Res. 668:243-245.
111. Barker, J. E., Heales, S. J., Cassidy, A., Bolanos, J. P., Land, J. M., and Clark, J. B. 1996. Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage. Brain Res. 716:118-122.
112. Canevari, L., Clark, J. B., and Bates, T. E. 1999. beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett. 457:131-134.
113. Yamada, K., Noda, Y., Komori, Y., Sugihara, H., Hasegawa, T., and Nabeshima, T. 1996. Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats. Neurosci. Res. 24:393-402.
114. Uttenthal, L. O., Alonso, D., Fernandez, A. P., Campbell, R. O., Moro, M. A., Leza, J. C., Lizasoain, I., Esteban, F. J., Barroso, J. B., Valderrama, R., Pedrosa, J. A., Peinado, M. A., Serrano, J., Richart, A., Bentura, M. L., Santacana, M., Martinez- Murillo, R., and Rodrigo, J. 1998. Neuronal and inducible nitric oxide synthase and nitrotyrosine immunoreactivities in the cerebral cortex of the aging rat. Microsc. Res. Tech. 43:75-88.
115. Vernet, D., Bonavera, J. J., Swerdloff, R. S., Gonzalez-Cadavid, N. F., and Wang, C. 1998. Spontaneous expression of inducible nitric oxide synthase in the hypothalamus and other brain regions of aging rats. Endocrinology 139:3254-3261.
116. Inada, K., Yokoi, I., Kabuto, H., Namba, Y., and Ogawa, N. 1997 The effects of chronic administration of nimodipine on age- related changes in nitric oxide and its synthase in senescence-accelerated mouse brain. Biochem. Mol, Biol. Int. 41:753-765.
117. Cannon, J. G. 1995. Cytokines in aging and muscle homeostasis. J. Gerontol. A. Biol. Sci. Med. Sci. 50:120-123.
118. Spangelo, B. L., Judd, A.M., Call, G. B., Zumwalt, J., and Gorospe, W. C. 1995. Role of the cytokines in the hypothalamic-pituitary-adrenal and gonadal axes. Neuroimmunomod. 2: 299-312.
119. McCann, S. M. 1997. The nitric oxide hypothesis of brain aging. Exp. Gerontol. 32:431-440.
120. McCann, S. M., Licinio, J., Wong, M. L., Yu, W. H., Karanth, S., and Rettorri, V. 1998. The nitric oxide hypothesis of aging. Exp. Gerontol. 33:813-826.
121. Schapira, A. H., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., and Marsden, C. D. 1990. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54:823-827.
122. Chagnon, P., Betard, C., Robitaille, Y., Cholette, A., and Gauvreau, D. 1995. Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases. NeuroReport. 6:711-715.
123. Schapira, A. H. 1998. Mitochondrial dysfunction in neurodegenerative disorders. Biochim. Biophys. Acta 1366:225-233.
124. Markesbery, W. R. 1997. Oxidative stress hypothesis in Alzheimer's disease. Free Radie. Biol. Med. 23:134-147.
125. Boka, G., Anglade, P., Wallach, D., Javoy Agid, F., Agid, Y., and Hirsch, E. C. 1994. Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. Neurosci. Lett. 172:151-154.
126. Mrak, R. E., Sheng, J. G., and Griffin, W. S. 1995. Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum. Pathol. 26:816-823.
127. Chao, C. C., Hu, S., and Peterson, P. K. 1995. Glia, cytokines, and neurotoxicity. Crit. Rev. Neurobiol. 9:189-205.
128. Hunot, S., Boissiere, F., Faucheux, B., Brugg, B., Mouatt Prigent, A., Agid, Y., and Hirsch, E. C. 1996. Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 72:355-363.
129. Jenner, P. and Olanow, C. W. 1998. Understanding cell death in Parkinson's disease. Ann. Neurol. 44:872-84.
130. Przedborski, S., Jackson Lewis, V., Yokoyama, R., Shibata, T., Dawson, V. L., and Dawson, T. M. 1996. Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc. Natl. Acad. Sci. USA 93:4565-4571.
131. Sheng, J. G., Mrak, R. E., and Griffin, W. S. 1994. S100 beta protein expression in Alzheimer disease: potential role in the pathogenesis of neuritic plaques. J. Neurosci. Res. 39: 398-404.
132. Hu, J., Castets, F., Guevara, J. L., and Van Eldik, L. J. 1996. S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes. J. Biol. Chem. 271:2543-2547.
133. Hogg, N., Darley Usmar, V. M., Wilson, M. T., and Moncada, S. 1992. Production of hydroxyl radicals from the simultaneous generation of Superoxide and nitric oxide. Biochem. J. 281:419-424.
134. Sergent, O., Griffon, B., Morel, I., Chevanne, M., Dubos, M. P., Cillard, P., and Cillard, J. 1997. Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocyte culture. Hepatology 25:122-127.
135. Puntarulo, S. and Cederbaum, A. I. 1997. Inhibition of ferritin- stimulated microsomal production of reactive oxygen intermediates by nitric oxide. Arch. Biochem. Biophys. 340:19-26.
136. Lipton, S. A., Choi, Y. B., Sucher, N. J., Pan, Z. H., and Stamler, J. S. 1996. Redox state, NMDA receptors and NO-related species [comment]. Trends. Pharmacol. Sci. 17:186-187.
137. Rossig, L., Fichtlscherer, B., Breitschopf, K., Haendeler, J., Zeiher, A. M., Mulsch, A., and Dimmeler, S. 1999. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J. Biol. Chem. 274:6823-6826.
138. Farinelli, S. E., Park, D. S., and Greene, L. A. 1996. Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism. J. Neurosci. 16:2325-2334.
139. Park, S. K., Lin, H. L., and Murphy, S. 1997. Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-kappaB binding to DNA. Biochem. J. 322:609-613.
140. Mohr, S., Hallak, H., de Boitte, A., Lapetina, E. G., and Brune, B. 1999. Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J. Biol. Chem. 274:9427-9430.
141. Ishitani, R., Tanaka, M., Sunaga, K., Katsube, N., and Chuang, D. M. 1998. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis. Mol. Pharmacol. 53:701-707.
142. Rosenberg, P. A., Li, Y., Ali, S., Altiok, N., Back, S. A., and Volpe, J. J. 1999. Intracellular redox state determines whether nitric oxide is toxic or protective to rat oligodendrocytes in culture. J. Neurochem. 73:476-484.
143. Gold, R., Zielasek, J., Kiefer, R., Toyka, K. V., and Hartung, H. P. 1996. Secretion of nitrite by Schwann cells and its effect on T-cell activation in vitro. Cell Immunol. 168:69-77.
144. Mattson, M., Culmsee, C., Zaifang, Yu., and Camandola, S. 2000. Roles of nuclear factor kB in neuronal survival and plasticity. 74:443-456.
145. Taylor, B. S., de Vera, M. E., Ganster, R. W., Wang, Q., Shapiro, R. A., Morris, S. M., Billiar, T. R., and Geller, D. A. 1998. Multiple NFkB enhancer elements regulate cytokine induction of the human of the human inducible nitric oxide synthase gene. J. Biol. Chem. 273:15148-15156.
146. Mirza, A., Liu, S. L., Frizell, E., Zhu, J., Maddukuri, S., Martinez, J., Davies, P., Schwarting, R., Norton, P., and Zern, M. A. 1997. A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB. Am. J. Physiol. 272:281-288.
147. Zong, W. X., Edelstein, L. C., Chen, C., Bash, J., and Gelinas, C. 1999. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes. Dev. 13:382-387.
148. Mattson, M. P., Goodman, Y., Luo, H., Fu, W., and Furukawa, K. 1997. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 49:681-697.
149. Walton, M., Connor, B., Lawlor, P., Young, D., Sirimanne, E., Gluckman, P., Cole, G., and Dragunow, M. 1999. Neuronal death and survival in two models of hypoxic-ischemic brain damage. Brain Res. Brain Res. Rev. 29:137-168.
150. Matsuoka, K., Kitamura, Y., Okazaki, M., Terai, K., and Taniguchi, T. 1999. Kainic acid-induced activation of nuclear factor-kB in rat hippocampus. Exp. Brain Res. 124:215-222.
151. Yang, R., Mu, X., and Hayes, R. L. 1995. Increased cortical nuclear factor-kB DNA binding activity after traumatic brain injury in rats. Neurosci. Lett. 197:101-104.
152. Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., and Kaltschmidt, C. 1997. Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 94:2642-2647.
153. Migheli, A., Piva, R., Atzori, C., Troost, D., and Schiffer, D. 1997. c-Jun, JNK/SAPK kinases and transcription factor NF- kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 56:1314-1322.
154. Bruce-Keller, A. J., Geddes, J. W., Knapp, P. E., McFall, R. W., Keller, J. N., Holtsberg, F. W., Parthasarathy, S., Steiner, S. M., and Mattson, M. P. 1999. Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD. J. Neuroimmunol. 93:53-71.
155. Wernyj, R. P., Mattson, M. P., and Christakos, S. 1999. Expression of calbindin-D28k in C6 glial cells stabilizes intracellular calcium levels and protects against apoptosis induced by calcium ionophore and amyloid beta-peptide. Brain Res. Mol. Brain. Res. 64:69-79.
156. Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., and Baldwin, A. S. 1998. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and C-IAP2 to suppress caspase-8 activation. Science 281:1680-1683.
157. Qin, Z. H., Wang, Y., Nakai, M., and Chase, T. N. 1998. Nuclear factor-kappa B contributes to excitotoxin-induced apoptosis in rat striatum. Mol. Pharmacol. 53:33-42.
158. Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., and Green, D. R. (1998) DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappaB and AP-1. Mol. Cell 4:543-551.
159. Abraham, N. G., Jiang, S., Yang, L., Zand, B. A., Laniado- Schwartzman, M., Marji, J., Drummond, G. S., and Kappas, A. 2000. Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity. J. Pharmacol. Exp. Ther. 293:494-500.
160. Yenay, M. A., Giffard, R., Sapolsky, R. M., and Steinberg, G. K. 1999. The neuroprotective potential of heat shock protein (HSP70). Mol. Med. Tod. 51:525-531.
161. Yenari, M. A., Fink, S. L., Sun, G. H., Chang, L. K., Patel, M. K., Kunis, D. M., Onley, D., Ho, D. Y., Sapolsky, R. M., and Steinberg, G. K. 1998. Gene therapy with HSP72 is neuroprotective in rat model s of stroke and epilepsy. Ann. Neurol. 44:584-591.
162. Hata, R., Gass, P., Mies, G., Wiessner, C., and Hossmann, K. A. 1998. Attenuated c-fos mRNA induction after middle cerebral artery occlusion in CREB knockout mice does not modulate focal ischemic injury. J. Cereb. Blood. Flow. Metab. 18:1325-1335.
163. Nishimura, R. N. and Dwyer, B. E. 1995. Pharmacological induction of heat shock protein 68 synthesis in cultured rat astrocytes. J. Biol. Chem. 270:29967-29970.
164. Fink, S. L., Chang, L. K., Ho, D. Y., and Sapolsky, R. M. 1997. Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock. J. Neurochem. 68:961-969.
165. Huot, J., Houle, F., Marceau, F., and Landry, J. 1997. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ. Res. 80:383-392.
166. Takayama, S., Bimston, D. N., Matsuzawa, S., Freeman, B. C., Aime-Sempe, C., Xie, Z., Morimoto, R. I., and Reed, J. C. 1997. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 16:4887-4896.
167. Laney, J. D. and Hochstrasser, M. 1999. Substrate targeting in the ubiquitin system. Cell 97:427-430.
168. Mairesse, N., Bernaert, D., Del Bino, G., Herman, S., Mosselmans, R., Robaye, B., and Galand, P. 1998. Expression of HSP27 results in increased sensitivity to tumor necrosis factor, etoposide, and H2O2 in an oxidative stress-resistant cell line. J. Cell Physiol. 177:606-617.
169. Turner, C. P., Panter, S. S., and Sharp, F. R. 1999. Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood. Brain Res. Mol. Brain Res. 65:87-102.
170. Sharp, F. R., Massa, S., and Swanson R. A. 1999. Heat shock protein protection. TINS 22:97-99.
171. Maines, M. D. 1997. The heme oxygenase system; a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37:517-554.
172. Morano, K. A. and Thiele, D. J. 1999. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals. Gene Expr. 7:271-282.
173. Panahian, N., Yoshiura, M., and Maines, M. D. 1999. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J. Neurochem. 72:1187-1203.
174. Schipper, H. M., Cissè, S., and Stopa, E. G. 1995. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Ann. Neurol. 37:758-768.
175. Schipper, H. M., Liberman, A., and Stopa, E. G. 1998. Neural Heme oxygenase-1 expression in idiopathic Parkinson's disease. Exp. Neurol. 150:60-68.
176. Turner, C. P., Bergeron, M., Matz, P., Zegna, A., Noble, L. J., Panter, S. S., and Sharp, F. R. 1998. Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin. J. Cereb. Blood. Flow Metab. 18:257-273.
177. Nath, K. A., Haggard, J. J., Croatt, A. J., Grande, J. P., Poss, K. D., and Alam, J. 2000. The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am. J. Pathol. 156:1527-1535.
178. Ewing, J. F. and Maines, M. D. 1991. Rapid induction of heme oxygenase 1 mRNA and protein by hyperhermia in rat brain: heme oxygenase 2 is not a heat shock protein. Proc. Natl. Acad. Sci. USA 88:5364-5368.
179. Piantadosi, C. A., Zhang, J., Levin, E. D., Folz, R. J., and Schmechel, D. E. 1997. Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat. Exp. Neurol. 147:103-114.
180. Dawson, T. M., Dawson, V. L., and Snyder, S. H. 1994. Molecular mechanisms of nitric oxide actions in the brain. Ann. NY Acad. Sci. 738:76-85.
181. Graser, T., vedernikov, Y. P., and Li, D. S. 1990. Study on the mechanism of carbon monoxide induced endothelium-independent relaxation in porcine coronary artery and vein. Biomed. Biochim. Acta 49:293-296.
182. Glaum, S. R. and Miller, R. J. 1993. Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii. Mol. Pharmacol. 43:965-969.
183. Takeda, A., Perry, G., Abraham, N. G., Dwyer, B. E., Kutty, R. K., Laitinen, J. T., Petersen, R. B., and Smith, M. A. 2000. Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau. J. Biol. Chem. 275:5395-5399.
184. White, L. A. and Marletta, M. A. 1992. Nitric oxide synthase is a cytochrome P-450 hemoprotein. Biochemistry 31:6627-6631.
185. Sharma, H. S., Westman, J., and Nyberg, F. 1998. Pathophysiology of brain edema and cell changes following hypertermic brain injury. Pages 351-412, in: Sharma, H. S., Westman, J. (eds) Brain function in hot environment (Vol. 115) Progress in brain research, Elsevier, Amsterdam.
186. Foresti, R. and Motterlini R. 1999. The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis. Free Rad. Res. 31:459-475.
187. Turcanu, V., Dhouib, M., and Poindron, P. 1998. Nitric oxide synthase inhibition by haeme oxigenase decreases macrophage nitric oxide-dependent cytotoxicity: a negative feedback mechanism for the regulation of nitric oxide production. Res. Immunol. 149:741-744.
188. Rosen, D. R., Siddique, T., and Patterson, D. 1993. Mutations in Cu/Zn SOD gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59-62.
189. Brwon, R. H. 1994. Clinical implications of basic research: a transgenic-mouse model of amyothrophic lateral sclerosis. N. Engl. J. Med. 331:1091-1092.
190. Beckman, J. S., Carlson, M., Smith, C. D., and Koppenol, W. H. 1993. ALS, SOD and peroxynitrite. Nature 364:584.
191. Menschik, E. D. and Finkel, L. H. 1999 Cholinergic neuro- modulation and Alzheimer's disease: from single cells to network simulations. Prog. Brain Res. 121:19-45.
192. Christen, Y. 2000. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 71:6218-6298.
193. Munch, G., Schinzel, R., Loske, C., Wong, A., Durany, N., Li, J. J., Vlassara, H., Smith, M. A., Perry, G., and Riederer, P. 1998. Alzheimer's disease. Synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J. Neural Transm. 105:439-461.
194. Bartzokis, G., Sultzer, D., Cummings, J., Holt, L. E., Hance, D. B., Henderson, V. W., and Mintz, J. 2000. In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging. Arch. Gen. Psychiatry 57:47-53.
195. Sayre, L. M., Perry, G., Harris, P. L., Liu, Y., Schubert, K. A., and Smith, M. A. 2000. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J. Neurochem. 74:270-279.
196. El Khoury, J., Hickman, S. E., Thomas, C. A., Loike, J. D., and Silverstein, S. C. 198. Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease. Neurobiol. Aging 19:881-4.
197. Markesbery, W. R. 1997. Oxidative stress hypothesis in Alzheimer's disease. Free Rad. Biol. Med. 23:134-147.
198. Butterfield, D. A. and Stadtman, E. R. 1997. Protein oxidation processes in aging brain, Adv. Cell Aging Gerontol. 2:161-191.
199. Butterfield, D. A., Koppal, T., Subramaniam, R., and Yatin, S. 1999. Vitamin E as an antioxidant/free radical scavenger against amyloid β-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: Insights into Alzheimer's disease. Rev. Neurosci. 10:141-149.
200. Koppal, T., Subramaniam, R., Drake, J., Prasad, R. P., Dhillon, H., and Butterfield, D. A. 1998 Vitamin E protects against Alzheimer's amyloid peptide (25-35)-induced changes in neocortical synaptosomal membrane lipid structure and composition. Brain Res. 786:270-273.
201. Yatin, S. M., Kink, C. D., and Butterfield, D. A. 1999 In-vitro and in-vivo oxidative stress associated with Alzheimer's amyloid β-peptide (1-42). Neurobiol. of Aging 20:325-330.
202. Butterfield, D. A. 1999. On methionine and Alzheimer's amyloid, β-peptide (1-42)-induced oxidative stress. Neurobiol. of Aging 20:339-342.
203. Harris, M. E., Hensley, K., Butterfield, D. A., Leedle, R. E., and Carney, J. M. 1995. Direct evidence of oxidative injury by the Alzheimer's amyloid β-peptide in cultured hippocampal neurons. Exp. Neurol. 131:193-202.
204. Butterfield, D. A. 1997 β-Amyloid-associated free radical oxidative stress and neurotoxicity: Implications for Alzheimer's disease. Chem. Res. Toxicol. 10:495-506.
205. Jen, L. S., Hart, A. J., Jen, A., Relvas, J. B., and Gentleman, S. M. 1998 Alzheimer's peptide kills cells of retina in vivo. Nature. 392:140-141.
206. Gwebu, E. T., Williams, J., Mathis, D., Warden, J. A., Selassie, M., Richardson, S., and Gwebu, N. T. 1997 Cytotoxicity of β-amyloid peptide 25-35 on vascular smooth muscle cells and attenuation by vitamin E. In Vitro Cell Dev. Biol. Anim. 33:672-673.
207. Thomas, T., Thomas, G., McLendon, C., Sutton, T., and Mullan, M. 1996 β-amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168-171.
208. Zaman, Z., Roche, S., Fielden, P., Niriella, D. C., and Cayley, A. C. 1992. Plasma concentrations of vitamin A and E and carotenoids in Alzheimer's disease. Age Ageing 21:91-94.
209. Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., Schneider, L. S., and Thai, L. J. 1997. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study, N. Engl. J. Med. 336:1216-1222.
210. Peyser, C. E., Folstein, M., Chase, G. A., Starkstein, S., Brandt, J., Cockrell, J. R., Bylsma, F., Coyle, J. T., McHugh, P. R., and Folstein, S. E. 1995. Trial of d-α-tocopherol in Huntington's disease. Amer. J. Psychiatry 152:1771-1775.
211. Reider, C. R. and Paulson, G. W. 1997 Lou Gehrig and amyotrophic lateral sclerosis. Is vitamin E to be revisited? Arch. Neurol. 54:527-528.
212. Ilic, T. V., Jovanovic, M., Jovicic, A., and Tomovic, M. 1999. Oxidative stress indicators are elevated in de novo Parkinson's disease patients. Funct. Neurol. 14:141-147.
213. Dexter, D. T., Holley, A. E., Flitter, W. D., Slater, T. F., Wells, F. R., Daniel, S. E., Lees, A. J., Jenner, P., and Marsden, C. D. 1994. Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov. Disord 9:92-97.
214. Spencer, J. P., Jenner, P., Daniel, S. E., Lees, A. J., Marsden, D. C., and Halliwell, B. 1998. Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species. J. Neurochem. 71:2112-2122.
215. Dexter, D. T., Carayon, A., Javoy-Agid, F., Agid, Y., Wells, F. R., Daniel, S., Lees, A. J., Jenner, P., and Marsden, C. D. 1991. Alterations in the levels of iron ferritin and other trace metals in Parkinson's diseases affecting the basal ganglia. Brain 114: 1953-1975.
216. Gerlach, M., Ben-Shachar, D., Rieder, P., and Youdim, M. B. H. 1994. Altered brain metabolism of iron as cause of neurodegenerative disease. 63:793-807.
217. Li H., Dryhurst, G. 1997. Irreversible inhibition of mitochondrial complex I by 2-aminoethyl-3,4-dyhydro-5-hydroxy-2-benzothiazine-3-carboxylic acid (DHBT): a putative nigral endotoxin of relevance to Parkinson's disease. J. Neurochem. 69:1530-1541.
218. Spencer, J., Jenner, A., Aruoma, O., Evans, P., Jenner, P., Lees, A., Marsden, D., and Halliwell, B. 1994. Intense oxidative DNA damage promoted by L-DOPA and its metabolites. Implication for neurodegenerative diseases. FEBS Lett. 353:246-250.
219. Perry, T. L., Godin, D. V., and Hansen, S. 1982. Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci. Lett. 33:305-310.
220. Sian, J., Dexter, D. T., and Lees, A. J. 1994. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting the basal ganglia. Ann. Neurol. 36: 348-355.
221. Hunot, S., Brugg, B., Richard, D., Michel, P. P., Muriel, M. P., Ruberg, M., Faucheux, B. A., Agid, Y., and Hirsch, E. C. 1997. Nuclear Translocation of NF-kB is increased in dopaminergic neurons of patients with Parkinson's disease. Proc. Natl. Acad. Sci. USA 94:7531-7536.
222. France-Lanord, V., Brugg, B., Michel, P. P., Agid, Y., and Ruberg, M. 1997. Mitochondrial free radical signal in ceramide- dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease. J. Neurochem. 69:1612-1621.
223. Schapira, A. H. V., Cooper, J. M., and Dexter, D. 1990. Mitochondrial complex I deficiency in Parkinson disease. J. Neurochem. 54:823-827.
224. Beal, M. F. 1998 Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis Ann. Neurol. 44:8110-4.
225. Risch, N. and Merikangas, K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-1517.
226. Storch, M. K., Piddlesden, S., Haltia, M., livanainen, M., Morgan, P., and Lassmann, H. 1998. Multiple sclerosis: in situ evidence for antibody- and complement-mediated demyelination. Ann. Neurol. 43:465-471.
227. Lindsey, J. W., Kerman, R. H., and Wolinsky, J. S. 1997. T cell- T cell activation in multiple sclerosis, Mult. Scler. 3:238-242.
228. van Noort, J. M., van Sechel, A. C., van Stipdonk M. J., and Bajramovic, J. J. 1998 The small heat shock protein alpha B- crystallin as key autoantigen in multiple sclerosis. Prog. Brain Res. 117:435-452.
229. van Noort, J. M. 1996 Multiple sclerosis: an altered immune response or an altered stress response? J. Mol. Med. 74:285-296.
230. Toshniwal, P. K. and Zarling, E. J. 1992. Evidence for increased lipid peroxidation in multiple sclerosis. Neurochem. Res. 17: 205-207.
231. Bo, L., Dawson, T. M., Wesselingh, S., Mork, S., Choi, S., Kong, P. A., Hanley D., and Trapp, B. D. 1994. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains, Ann. Neurol. 36:778-786.
232. Hooper, D. C., Bagasra, O., Marini, J. C., Zborek, A., Ohnishi, S. T., Kean, R., Champion, J. M., Sarker, A. B., Bobroski, L., Farber, J. L., Akaike, T., Maeda, H., and Koprowski, H. 1997. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis, Proc. Natl. Acad. Sci. USA 94: 2528-2533.
233. Evans, P. H. 1993. Free radical in brain metabolism and pathology. Br. Med. Bull. 49:577-587.
234. De Voldr, A., Bol, A., Michel, C., Cogneau, M., Evrard, P., Lyon, G., and Goffinet, A. M. 1988. Brain glucose utilization in childhood Huntington's disease studied with positron emission tomography (PET). Brain Dev. 10:47-50.
235. Sokoloff, L. 1986. Cerebral circulation, energy metabolism, and protein synthesis: general characteristics and principles of measurement. Pages 1-71, in Phelps, M. E., Mazziotta, J. C., Schelbert, H. R. (eds), Positron Emission Tomography and Autoradiography: Principles and applications for the brain and heart. Raven press, New York.
236. Jenkins, B., Koroshetz, W., Beal, M. F., and Rosen, B. 1993. Evidence for an energy metabolism defect in Huntington's disease using localized proton spectroscopy. Neurol. 43:2689-2695.
237. Nicoli, F., Vion-Dury, J., Maloteaux, J. M., Delwaide, C., Confort-Gouny, S., Sciaky, M., and Cozzone, P. J. 1993. CSF and serum metabolic profile of patients with Huntington' s chorea: a study by high resolution proton NMR spectroscopy and HPLC. Neurosci. Lett. 154:47-51.
238. Browne, S. E. 1997. Mitochondrial dysfunction and oxidative damage in Huntington's disease, in Flint Beal, M., Howell, N., Bodis-Wollner, I. (eds), Mitochondria and Free Radicals in Neurodegenerative diseases, Wiley-Liss, New York.
239. Morgan Hughes, J. A., Sweeney, M. G., Cooper, J. M., Hammans, S. R., Brockington, M., Schapira, A. H., Harding, A. E., and Clark, J. B. 1995. Mitochondrial DNA (mtDNA) diseases: correlation of genotype to phenotype. Biochim. Biophys. Acta 1271:135-140.
240. Wallace, D. C. 1999. Mitochondrial diseases in man and mouse. Science 283:1482-1488.
241. Xu, Q., Hu, Y., Kleindienst, M., and Wick, G. 1997. Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1. J. Clin. Invest. 100:1089-1097.
242. Calabrese, V., Renis, M., Calderone, A., Russo, A., Reale, S., Barcellona, M. L., and Rizza, V. 1998. Stress proteins and SH-groups in oxidant-induced cell injury after chronic ethanol administration in rat. Free Radical Biol. Med. 24: 1159-1167.
243. Polla, B. S., Kantengwa, S., Francois, D., Salvioli, S., Franceschi, C., Marsac, C., and Cossarizza, A. 1996. Mitochondria are selective target for the protective effects of heat shock against oxidative injury. Proc. Natl. Acad. Sci. USA 93: 6458-6463.
244. Santoro, M. G. and Roberts, S. M. Serch for novel cytoprotective and antiviral prostanoids. 1999. Drug News Perspect 12: 395-400.
245. Stephanou, A., Isenberg, D. A., Nakajima, K., and Latchman, D. S. 1999. Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters. J. Biol. Chem. 274:1723-1728.