Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: Implications for neuronal/astrocytic trafficking and neurodegeneration?

Developmental Neuroscience

Volumn 18, Issue 5-6, 1996, Pages 391-396

  Barker, J E ^a   Bolanos, J P ^b   Land, J M ^a,c   Clark, J B ^a   Heales, S J R ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Glutathione; Mitochondria; Neurodegeneration; Neuronal astrocytic trafficking; Peroxynitrite

Indexed keywords

GLUTATHIONE; LACTATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ASTROCYTE; CELL DEATH; CONFERENCE PAPER; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NERVE DEGENERATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ASTROCYTES; GLUTATHIONE; MITOCHONDRIA; NERVE DEGENERATION; NEURONS; NITRATES; RATS; RATS, WISTAR;

EID: 0029962693     PISSN: 03785866     EISSN: 14219859     Source Type: Journal    
DOI: 10.1159/000111432     Document Type: Article

References (31)

1. Bredt DS, Snyder SH: Nitric oxide mediates glutamate linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 1989.86:9030-9033.
2. Knowles RG, Moncada S: Nitric oxide synthases in mammals. BiochemJ 1994:298:249-258.
3. Lipton SA, Choi Y-B, Pan Z-H, Lei SZ, Chen IIl-SV, Suchcr NJ, Loscalzo J. Singel DJ. Slam-ler JS: A redox based mechanism fortheneuro-protective and neurodestructive effects of nitric oxide and related nitroso compounds. Nature 1993:364:626-632.
4. Bolanos JP, Peuchen S, Heales SJR, Land JM, Clark JB: Nitric oxide mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem 1994:63:910-916.
5. Bolarios JP, Heales SJR, Land JM, Clark JB: Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurones and astrocytes in primary culture. J Neurochem 1995;64:1965-1972.
6. Beckman JS. Beckman TW, Chen J. Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and super-oxide. Proc Natl Acad Sci USA 1990:87: 1620-1624.
7. Zhang Y, Marcillat OO, Giulivi C, Emstcr L, Davies KJA: The oxidative inactivation of mitochondrial electron transport chain components and ATPasc. J Biol Chem 1990:265: 16330-16336.
8. Bowling AC. Beal MF: Biocnergctic and oxidative stress in neurodegenerative diseases. Life Sci 1995:56:1151-1171.
9. Schapira AHV, Cooper JM, Dexter D. Clark JB, Jcnncr P. Marsden CD: Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem 1990:54:823-827.
10. Mutisya EM, Bowling AC, Beal MF: Cortical cytochrome oxidase is reduced in Alzheimer's disease.! Neurochem 1994;63:2179-2184.
11. Johnson AW, Land JM, Thompson EJ. Bolanos JP. Clark JB. Heales SJR: Evidence for increased nitric oxide production in multiple sclerosis. J Neurol Neurosurg Psychiatr 1995: 58:107.
12. Aoki E, Semba R. Mikoshiba K. Kashiwamata S: Predominant localisation in glial cells of free L-arginine: Immunocytochemical evidence. Brain Res 1991;547:190-192.
13. Murphy S. Simmons ML. Agullo L. Garcia A. Feinstien DL, Galea E, Reis DJ. Minc-Golomb D. Schwatz JP: Synthesis of nitric oxide in CNS glial cells. Trends Neurosci 1993:16: 323-328.
14. Koprowski H, Zheng YM. Hcber-Katz E, Fraser N. Rorke L, Fu ZF, Hanlon C, Dietz-schold B; In vivo expression of inducible nitric oxide synthase in experimentally induced neurological diseases. Proc Natl Acad Sci USA 1993:90:3024-3027.
15. Bo L, Dawson TM, Wesselingh S. Mork S, Choi S. Kong P. Hanley D. Trapp BD: Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 1994:36:778-776.
16. Brown GC. Bolanos JP. Hcalcs SJR, Clark JB: Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration. Ncurosci Lett 1995:193:201-204.
17. Makar TK. Nedcrgaard M. Preuss A. Gelbard AS. Perumal AS, Cooper AJL: Vitamin E. Ascorbate, glutathione, glutathione disulfide and enzymes of glutathione metabolism in cultures of chick astrocytes and neurones: Evidence that astrocytes play an important antioxidant role in antioxidalive processes in the brain. J Neurochenr 1994:62:45-53.
18. Meister A: New aspects of glutathione biochemistry and transport: Selective alteration of glutathione metabolism. Fed Proc 1984:43: 3031-3041.
19. Ragan CI. Wilson MT. Darley-Usmar VM. Lowe PN: Sub-I'ractionation of mitochondria and isolation of the proteins of oxidative phosphorylation; In Darley-Usmar VM. Rickwood D. Wilson MT (cds): Mitochondria, a Practical Approach. London. ILR Press. 1987. pp 79-112.
20. King TE: Preparation of succinate cytochrome c reductase and the cytochrome b-c' panicle and reconstitution of succinate cytochrome c reductase. Methods Enzymol 1967:10:216-225.
21. Wharton DC, Tzagoloff A: Cytochrome oxidase from beef heart mitochondria. Methods Enzymol 1967;10:245-250.
22. Shepherd JA. Garland PB: Citrate synthase from rat liver. Methods Enzymol 1969:13: 11-19.
23. Vassult A: L-Lactate dehydrogenase. UV method with pyruvate and NADU; In Bcrg-nteyer J. Grassl M (eds); Methods of Enzymatic Analysis. Weinheim. Verlag Chenrie. 1983. pp 118-126.
24. Riedercr P. Sofic E. Rausch W-D. Schmidt B. Reynolds GP. Jellinger K, Youdim MBH: Transition metals, ferritin, glutathione and ascorbic acid in parkinsonian brains. J Neu-rochetn 1989:52:515-520.
25. Lowry OH. Rosebrough NJ. Farr AL. Randall KJ: Protein measurement with the Folin phenol reagent. J Biol Client 1951:193:265-275.
26. Radi R. Rodriguez M. Castro L, Telleri R: Inhibition of mitochondrial electron transport by peroxynilrite. Arch Biochem Biophys 1994: 308:89-95.
27. Soussi B, Idstrom J-P. Schersten T, Bylund-Fellinus A-C: Cytochrome c oxidase activity and cardiolipin alterations in response to skeletal muscle ischaemia and reperfusion. Acta Physiol Scand 1990:138:107-114.
28. Phoenix J, Edwards RHT. Jackson MJ: Inhibition of Ca;> induced cytosolic enzyme efflux from skeletal muscle by vitamin E and related compounds. Biochem J 1989:257:207-213.
29. Heales SJR. Bolahos JP, Land JM, Clark JB: Trolox protects mitochondrial complex IV from nitric oxide mediated damage in astrocytes. Brain Res 1994:668:243-245.
30. Sagara J-I, Miura K. Bannai S: Maintenance of neuronal glutathione by glial cells. J Neuro-chem 1993:61:1672-1676.
31. Jenner P. Dexter DT. Sian J. Schapira AHV. Mardsen CD: Oxidative stress is a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. Ann Neurol 1992;32:S82-87.