Network theory of aging

Experimental Gerontology

Volumn 32, Issue 4-5, 1997, Pages 395-399

  Kirkwood, T B L ^b   Kowald, A ^a,b  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Aging; Antioxidants; Free radicals; Mitochondria; Network theory

Indexed keywords

ANTIOXIDANT; FREE RADICAL;

AGING; CELL AGING; CONFERENCE PAPER; HUMAN; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; THEORY;

AGING; ANIMALS; ANTIOXIDANTS; COMPUTER SIMULATION; EVOLUTION; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEINS;

LETHRINIDAE;

EID: 0030814276     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(96)00171-4     Document Type: Conference Paper

References (21)

1. BURNET, F.M. Intrinsic Mutagenesis: A Genetic Approach to Ageing, J. Wiley & Sons, New York, 1974.
2. CURTIS, H.J. Biological Mechanisms of Aging, C.C. Thomas, Springfield, IL, 1966.
3. HARMAN, D. A theory based on free radical and radiation chemistry. J. Gerontol, 11, 298-300, 1956.
4. HARMAN, D. The aging process. Proc. Natl. Acad. Sci. USA 78, 7124-7128, 1981.
5. HOLLIDAY, R. and KIRKWOOD, T.B.L. Predictions of the somatic mutation and mortalization theories of cellular ageing are contrary to experimental observations. J. Theor. Biol. 93, 627-642, 1981.
6. KIRKWOOD, T.B.L. Evolution of ageing. Nature 270, 301-304, 1977.
7. KIRKWOOD, T.B.L. Evolution of repair: Survival versus reproduction. In: Physiological Ecology: An Evolutionary Approach to Resource Use, Townsend, C.R. and Calow, P. (Editors), pp. 165-189, Blackwell Scientific Publications, Oxford, 1981.
8. KIRKWOOD, T.B.L. DNA, mutations and aging. Mutat. Res. 219, 1-7, 1989.
9. KIRKWOOD, T.B.L. and HOLLIDAY, R. The evolution of ageing and longevity. Proc. R. Soc. Lond., Ser. B 205, 531-546, 1979.
10. KIRKWOOD, T.B.L. and FRANCESCHI, C. Is aging as complex as it would appear? Ann. NY Acad. Sci. 663, 412-417, 1992.
11. KOWALD, A. and KIRKWOOD, T.B.L. Mitochondrial mutations, cellular instability and ageing: Modeling the population dynamics of mitochondria. Mutat. Res. 295, 93-103, 1993.
12. KOWALD, A. and KIRKWOOD, T.B.L. Towards a network theory of ageing: A model combining the free radical theory and the protein error theory. J. Theor. Biol. 168, 75-94, 1994.
13. KOWALD, A. and KIRKWOOD, T.B.L. A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat. Res. 316, 209-236, 1996.
14. LINNANE, A.W., MARZUKI, S., OZAWA, T., and TANAKA, M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet i, 642-645, 1989.
15. ORGEL, L.E. The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc. Natl. Acad. Sci. USA 49, 517-521, 1963.
16. RICHTER, C. Do mitochondrial fragments promote cancer and aging? FEBS Lett. 241, 1-5, 1988.
17. ROSENBERGER, R.F. Senescence and the accumulation of altered proteins. Mutat. Res. 256, 255-262, 1991.
18. SOHAL, R.S. and ORR, W.C. Is oxidative stress a causal factor in aging? In: Molecular Aspects of Aging, Esser, K. and Martin, G.M. (Editors), pp. 109-127, J. Wiley & Sons, Chichester, 1995.
19. SZILARD, L. On the nature of the aging process. Proc. Natl. Acad. Sci. USA 45, 35-45, 1959.
20. VIJG, J. DNA sequence changes in aging: how frequent, how important? Aging 2, 227-229, 1990.
21. WALLACE, D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256, 628-632, 1992.