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Volumn 34, Issue 6, 1999, Pages 879-886

Nitric oxide as a signaling molecule in the vascular system: An overview

Author keywords

Atherosclerosis; Cyclic GMP; Endothelium; Hypertension; Nitroglycerin; NO synthase; Platelet aggregation; Vasodilation

Indexed keywords

ACETYLSALICYLIC ACID; CYCLIC GMP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCEROL NITRATE; NEBIVOLOL; NITRATE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; SILDENAFIL;

EID: 0032707717     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199912000-00016     Document Type: Article
Times cited : (673)

References (114)
  • 1
  • 2
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
    • (1980) Nature , vol.288 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 3
    • 0019430671 scopus 로고
    • Evidence for the inhibitory role of guanosine 3′,5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators
    • Mellion BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ. Evidence for the inhibitory role of guanosine 3′,5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood 1981;57:946-55.
    • (1981) Blood , vol.57 , pp. 946-955
    • Mellion, B.T.1    Ignarro, L.J.2    Ohlstein, E.H.3    Pontecorvo, E.G.4    Hyman, A.L.5    Kadowitz, P.J.6
  • 4
    • 0020522496 scopus 로고
    • Inhibition of human platelet aggregation by S-nitrosothiols: Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation
    • Mellion BT, Ignarro LJ, Myers CB, et al. Inhibition of human platelet aggregation by S-nitrosothiols: heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation. Mol Pharmacol 1983;23:653-64.
    • (1983) Mol Pharmacol , vol.23 , pp. 653-664
    • Mellion, B.T.1    Ignarro, L.J.2    Myers, C.B.3
  • 5
    • 0018936824 scopus 로고
    • Coronary arterial relaxation and guanylale cyclase activation by cigaretle smoke, N′-nitrosonornicotine and nitric oxide
    • Gruetter CA, Barry BK, McNamara DB, Kadowitz PJ, Ignarro LJ. Coronary arterial relaxation and guanylale cyclase activation by cigaretle smoke, N′-nitrosonornicotine and nitric oxide. J Pharmacol Exp Ther 1980;214:9-15.
    • (1980) J Pharmacol Exp Ther , vol.214 , pp. 9-15
    • Gruetter, C.A.1    Barry, B.K.2    McNamara, D.B.3    Kadowitz, P.J.4    Ignarro, L.J.5
  • 6
    • 0019179169 scopus 로고
    • Activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside, and nitrosoguanidine: Inhibition by calcium, lanthanum, and other cations, enhancement by thiols
    • Gruetter DY, Gruetter CA, Barry BK, et al. Activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside, and nitrosoguanidine: inhibition by calcium, lanthanum, and other cations, enhancement by thiols. Biochem Phannacol 1980;29: 2943-50.
    • (1980) Biochem Phannacol , vol.29 , pp. 2943-2950
    • Gruetter, D.Y.1    Gruetter, C.A.2    Barry, B.K.3
  • 7
    • 0019443140 scopus 로고
    • Relationship between cyclic guanosine 3′,5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrale, nitroprusside, nitrite and nitric oxide: Effects of methylene blue and methemoglobin
    • Gruetter CA, Gruetter DY, Lyon JE, Kadowitz PJ, Ignarro LJ. Relationship between cyclic guanosine 3′,5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrale, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin. J Phannacol Exp Ther 1981; 219:181-6.
    • (1981) J Phannacol Exp Ther , vol.219 , pp. 181-186
    • Gruetter, C.A.1    Gruetter, D.Y.2    Lyon, J.E.3    Kadowitz, P.J.4    Ignarro, L.J.5
  • 8
    • 0019313372 scopus 로고
    • Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: Possible involvemenl of S-nitrosothiols
    • Ignarro LJ, Gruetter CA. Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvemenl of S-nitrosothiols. Biochim Biophys Acta 1980;631:221-31.
    • (1980) Biochim Biophys Acta , vol.631 , pp. 221-231
    • Ignarro, L.J.1    Gruetter, C.A.2
  • 9
    • 0019322058 scopus 로고
    • Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds
    • Ignarro LJ, Edwards JC, Gruetter DY, Barry BK, Gruetter CA. Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds. FEBS Lett 1980;110: 275-8.
    • (1980) FEBS Lett , vol.110 , pp. 275-278
    • Ignarro, L.J.1    Edwards, J.C.2    Gruetter, D.Y.3    Barry, B.K.4    Gruetter, C.A.5
  • 10
    • 0018871580 scopus 로고
    • Guanylate cyclase activation of nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediates
    • Ignairo LJ, Barry BK, Gruetter DY, et al. Guanylate cyclase activation of nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediates. Biochem Biophys Res Commun 1980;94:93-100.
    • (1980) Biochem Biophys Res Commun , vol.94 , pp. 93-100
    • Ignairo, L.J.1    Barry, B.K.2    Gruetter, D.Y.3
  • 11
    • 0019388174 scopus 로고
    • Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates
    • Ignarro LJ, Lippton H, Edwards JC, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981; 218:739-49.
    • (1981) J Pharmacol Exp Ther , vol.218 , pp. 739-749
    • Ignarro, L.J.1    Lippton, H.2    Edwards, J.C.3
  • 12
    • 0018388658 scopus 로고
    • Methemoglobin blockade of coronary arterial soluble guanylate cyclase activation by nitroso compounds and its reversal with dithiothreitol
    • Ohlstein EH, Barry BK, Gruetter DY, Ignarro LJ. Methemoglobin blockade of coronary arterial soluble guanylate cyclase activation by nitroso compounds and its reversal with dithiothreitol. FEBS Lett 1979;102:316-20.
    • (1979) FEBS Lett , vol.102 , pp. 316-320
    • Ohlstein, E.H.1    Barry, B.K.2    Gruetter, D.Y.3    Ignarro, L.J.4
  • 13
    • 0017365359 scopus 로고
    • Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine
    • Katsuki S, Arnold W, Mittal C, Murad F. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res 1977; 3:23-35.
    • (1977) J Cyclic Nucleotide Res , vol.3 , pp. 23-35
    • Katsuki, S.1    Arnold, W.2    Mittal, C.3    Murad, F.4
  • 14
    • 0015595425 scopus 로고
    • Mechanism of tolerance development to organic nitrates
    • Needleman P, Johnson EM. Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther 1973;184:709-15.
    • (1973) J Pharmacol Exp Ther , vol.184 , pp. 709-715
    • Needleman, P.1    Johnson, E.M.2
  • 15
    • 0015713177 scopus 로고
    • Sulfhydryl requirement for relaxation of vascular smooth muscle
    • Needleman P, Jakschik B, Johnson EM. Sulfhydryl requirement for relaxation of vascular smooth muscle. J Pharmacol Exp Ther 1973;187:324-31.
    • (1973) J Pharmacol Exp Ther , vol.187 , pp. 324-331
    • Needleman, P.1    Jakschik, B.2    Johnson, E.M.3
  • 16
    • 0019967216 scopus 로고
    • Vascular smooth muscle relaxation by nitrocompounds: Reduced relaxation and cGMP elevation in tolerant vessels and reversal of tolerance by dithiothreitol
    • Axelsson KL, Anderson RGG, Wikberg JES. Vascular smooth muscle relaxation by nitrocompounds: reduced relaxation and cGMP elevation in tolerant vessels and reversal of tolerance by dithiothreitol. Acta Pharmacol Toxicol 1982;50:350-7.
    • (1982) Acta Pharmacol Toxicol , vol.50 , pp. 350-357
    • Axelsson, K.L.1    Anderson, R.G.G.2    Wikberg, J.E.S.3
  • 17
    • 0020614041 scopus 로고
    • Tolerance toward nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover
    • Axelsson KL, Andersson RG. Tolerance toward nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover. Eur J Pharmacol 1983;88:71-9.
    • (1983) Eur J Pharmacol , vol.88 , pp. 71-79
    • Axelsson, K.L.1    Andersson, R.G.2
  • 18
    • 0021019453 scopus 로고
    • Potentiation of the cardiovascular effects of nitroglycerin by N-acetylcysteine
    • Horowitz JD, Antman EM, Lorell BH, Barry WH, Smith TW. Potentiation of the cardiovascular effects of nitroglycerin by N-acetylcysteine. Circulation 1983;68:1247-53.
    • (1983) Circulation , vol.68 , pp. 1247-1253
    • Horowitz, J.D.1    Antman, E.M.2    Lorell, B.H.3    Barry, W.H.4    Smith, T.W.5
  • 19
    • 0019990987 scopus 로고
    • Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle
    • Keith RA, Burkman AM, Sokoloski TD, Fertel RH. Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle. J Pharmacol Exp Ther 1982;221:525-31.
    • (1982) J Pharmacol Exp Ther , vol.221 , pp. 525-531
    • Keith, R.A.1    Burkman, A.M.2    Sokoloski, T.D.3    Fertel, R.H.4
  • 20
    • 0023663712 scopus 로고
    • In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries
    • May DC, Popma JJ, Black WH, et al. In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries. N Engl J Med 1987;317:805-9.
    • (1987) N Engl J Med , vol.317 , pp. 805-809
    • May, D.C.1    Popma, J.J.2    Black, W.H.3
  • 21
    • 0023240541 scopus 로고
    • Prevention and reversal of nitrate tolerance in patients with congestive heart failure
    • Packer M, Lee WH, Kessler PD, Gottlieb SS, Medina N, Yushak M. Prevention and reversal of nitrate tolerance in patients with congestive heart failure. N Engl J Med 1987;317:799-804.
    • (1987) N Engl J Med , vol.317 , pp. 799-804
    • Packer, M.1    Lee, W.H.2    Kessler, P.D.3    Gottlieb, S.S.4    Medina, N.5    Yushak, M.6
  • 22
    • 0022574514 scopus 로고
    • Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine
    • Winniford MD, Kennedy PL, Wells PJ, Hillis LD. Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine. Circulation 1986;73:138-42.
    • (1986) Circulation , vol.73 , pp. 138-142
    • Winniford, M.D.1    Kennedy, P.L.2    Wells, P.J.3    Hillis, L.D.4
  • 23
    • 0017146235 scopus 로고
    • Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines
    • DeRubertis FR, Craven PA. Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines. Science 1976;193:897-9.
    • (1976) Science , vol.193 , pp. 897-899
    • DeRubertis, F.R.1    Craven, P.A.2
  • 24
    • 0021894599 scopus 로고
    • The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation
    • Ignarro LJ, Kadowitz PJ. The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annu Rev Pharmacol Toxicol 1985;25:171-91.
    • (1985) Annu Rev Pharmacol Toxicol , vol.25 , pp. 171-191
    • Ignarro, L.J.1    Kadowitz, P.J.2
  • 26
    • 0019495457 scopus 로고
    • Purification of a soluble, sodium-nitroprusside-stimulated guanylate cyclase from bovine lung
    • Gerzer R, Hofmann F, Schultz G. Purification of a soluble, sodium-nitroprusside-stimulated guanylate cyclase from bovine lung. Eur J Biochem 1981;116:479-86.
    • (1981) Eur J Biochem , vol.116 , pp. 479-486
    • Gerzer, R.1    Hofmann, F.2    Schultz, G.3
  • 27
    • 0020494044 scopus 로고
    • The separation of the heme and apoheme forms of soluble guanylate cyclase
    • Gerzer R, Radany EW, Garbers DL. The separation of the heme and apoheme forms of soluble guanylate cyclase. Biochem Biophys Res Commun 1982;108:678-86.
    • (1982) Biochem Biophys Res Commun , vol.108 , pp. 678-686
    • Gerzer, R.1    Radany, E.W.2    Garbers, D.L.3
  • 28
    • 0006109789 scopus 로고
    • Activation of purified soluble guanylate cyclase by protoporphyrin IX
    • Ignarro LJ, Wood KS, Wolin MS. Activation of purified soluble guanylate cyclase by protoporphyrin IX. Proc Natl Acad Sci U S A 1982;79:2870-3.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 2870-2873
    • Ignarro, L.J.1    Wood, K.S.2    Wolin, M.S.3
  • 29
    • 0020485917 scopus 로고
    • Activation of purified guanylate cyclase by nitric oxide requires heme: Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung
    • Ignarro LJ, Degnan JN, Baricos WH, Kadowitz PJ, Wolin MS. Activation of purified guanylate cyclase by nitric oxide requires heme: comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung. Biochim Biophys Acta 1982;718:49-59.
    • (1982) Biochim Biophys Acta , vol.718 , pp. 49-59
    • Ignarro, L.J.1    Degnan, J.N.2    Baricos, W.H.3    Kadowitz, P.J.4    Wolin, M.S.5
  • 30
    • 0021323975 scopus 로고
    • Guanylate cyclase from bovine lung: Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes
    • Ignarro LJ, Wood KS, Ballot B, Wolin MS. Guanylate cyclase from bovine lung: evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes. J Biol Chem 1984;259:5923-31.
    • (1984) J Biol Chem , vol.259 , pp. 5923-5931
    • Ignarro, L.J.1    Wood, K.S.2    Ballot, B.3    Wolin, M.S.4
  • 31
    • 0021275463 scopus 로고
    • Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins
    • Ignarro LJ, Ballot B, Wood KS. Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J Biol Chem 1984;259:6201-7.
    • (1984) J Biol Chem , vol.259 , pp. 6201-6207
    • Ignarro, L.J.1    Ballot, B.2    Wood, K.S.3
  • 32
    • 0020198013 scopus 로고
    • Purification and properties of heme-deficient hepatic soluble guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX
    • Ohlstein EH, Wood KS, Ignarro LJ. Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX. Arch Biochem Biophys 1982;218:187-98.
    • (1982) Arch Biochem Biophys , vol.218 , pp. 187-198
    • Ohlstein, E.H.1    Wood, K.S.2    Ignarro, L.J.3
  • 33
    • 0020491331 scopus 로고
    • Guanylate cyclase from bovine lung: A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme
    • Wolin MS, Wood KS, Ignarro LJ. Guanylate cyclase from bovine lung: a kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. J Biol Chem 1982;257:13312-20.
    • (1982) J Biol Chem , vol.257 , pp. 13312-13320
    • Wolin, M.S.1    Wood, K.S.2    Ignarro, L.J.3
  • 34
    • 0021306536 scopus 로고
    • Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: A unifying concept
    • Ignarro LJ, Wood KS, Wolin MS. Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept. Adv Cyclic Nucleotide Protein Phosphorylation Res 1984;17:267-74.
    • (1984) Adv Cyclic Nucleotide Protein Phosphorylation Res , vol.17 , pp. 267-274
    • Ignarro, L.J.1    Wood, K.S.2    Wolin, M.S.3
  • 35
    • 0022593098 scopus 로고
    • Phosphodiesterase inhibitors induce endothelium dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor
    • Martin W, Furchgott RF, Villani GM, Jothianandan D. Phosphodiesterase inhibitors induce endothelium dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor. J Pharmacol Exp Ther 1986;237:539-47.
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 539-547
    • Martin, W.1    Furchgott, R.F.2    Villani, G.M.3    Jothianandan, D.4
  • 36
    • 0022481682 scopus 로고
    • Cyclic guanosine monophosphate as a mediator of vasodilation
    • Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest 1986;78:1-5.
    • (1986) J Clin Invest , vol.78 , pp. 1-5
    • Murad, F.1
  • 37
    • 0024390169 scopus 로고
    • Endothelium-derived relaxing and contracting factors
    • Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors. FASEB J 1989;3:2007-18.
    • (1989) FASEB J , vol.3 , pp. 2007-2018
    • Furchgott, R.F.1    Vanhoutte, P.M.2
  • 38
    • 0026071876 scopus 로고
    • Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells
    • Forstermann U, Pollock JS, Schmidt HH, Heller M, Murad F. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci USA 1991;88:1788-92.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1788-1792
    • Forstermann, U.1    Pollock, J.S.2    Schmidt, H.H.3    Heller, M.4    Murad, F.5
  • 40
    • 0030010784 scopus 로고    scopus 로고
    • Decomposition of S-nitrosoglutathione in the presence of copper ions and glutathione
    • Gorren AC, Schrammel A, Schmidt K, Mayer B. Decomposition of S-nitrosoglutathione in the presence of copper ions and glutathione. Arch Biochem Biophys 1996;330:219-28.
    • (1996) Arch Biochem Biophys , vol.330 , pp. 219-228
    • Gorren, A.C.1    Schrammel, A.2    Schmidt, K.3    Mayer, B.4
  • 41
    • 0029836873 scopus 로고    scopus 로고
    • S-nitrosothiols and role of metal ions in decomposition to nitric oxide
    • Williams DL. S-nitrosothiols and role of metal ions in decomposition to nitric oxide. Methods Enzymol 1996;268:299-308.
    • (1996) Methods Enzymol , vol.268 , pp. 299-308
    • Williams, D.L.1
  • 42
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84:9265-9.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 43
    • 0023518452 scopus 로고
    • Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical
    • Ignarro LJ, Byrns RE, Buga GM, Wood KS. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 1987;61:866-79.
    • (1987) Circ Res , vol.61 , pp. 866-879
    • Ignarro, L.J.1    Byrns, R.E.2    Buga, G.M.3    Wood, K.S.4
  • 44
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-6.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 45
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginine
    • Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-6.
    • (1988) Nature , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 46
    • 0022461711 scopus 로고
    • Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: Stimulation by acetylcholine, bradykinin and arachidonic acid
    • Ignarro LJ, Harbison RG, Wood KS, Kadowitz PJ. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther 1986;237:893-900.
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 893-900
    • Ignarro, L.J.1    Harbison, R.G.2    Wood, K.S.3    Kadowitz, P.J.4
  • 47
    • 0001447798 scopus 로고
    • Pharmacological and biochemical properties of endothelium-derived relaxing factor (EDRF): Evidence that EDRF is closely related to nitric oxide (NO) radical
    • Ignarro LJ, Wood KS, Byrns RE. Pharmacological and biochemical properties of endothelium-derived relaxing factor (EDRF): evidence that EDRF is closely related to nitric oxide (NO) radical [Abstract]. Circulation 1986;74:II-287.
    • (1986) Circulation , vol.74
    • Ignarro, L.J.1    Wood, K.S.2    Byrns, R.E.3
  • 48
    • 0022640297 scopus 로고
    • Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
    • Gryglewski RJ, Palmer RMJ, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986;320:454-6.
    • (1986) Nature , vol.320 , pp. 454-456
    • Gryglewski, R.J.1    Palmer, R.M.J.2    Moncada, S.3
  • 49
    • 0022456638 scopus 로고
    • Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
    • Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol 1986;250:H822-7.
    • (1986) Am J Physiol , vol.250
    • Rubanyi, G.M.1    Vanhoutte, P.M.2
  • 50
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 1990;87:1620-4.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 51
    • 0022599662 scopus 로고
    • Endothelium-dependent inhibition of platelet aggregation
    • Azuma H, Ishikawa M, Sekizaki S. Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol 1986;88:411-5.
    • (1986) Br J Pharmacol , vol.88 , pp. 411-415
    • Azuma, H.1    Ishikawa, M.2    Sekizaki, S.3
  • 52
    • 0023145898 scopus 로고
    • Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein
    • Ignarro LJ, Byrns RE, Wood KS. Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein. Circ Res 1987;60: 82-92.
    • (1987) Circ Res , vol.60 , pp. 82-92
    • Ignarro, L.J.1    Byrns, R.E.2    Wood, K.S.3
  • 53
    • 0024706628 scopus 로고
    • Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein
    • Ignarro LJ. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 1989;65:1-21.
    • (1989) Circ Res , vol.65 , pp. 1-21
    • Ignarro, L.J.1
  • 54
    • 0024552879 scopus 로고
    • Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein
    • Ignarro LJ, Gold ME, Buga GM, et al. Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein. Circ Res 1989;64:315-29.
    • (1989) Circ Res , vol.64 , pp. 315-329
    • Ignarro, L.J.1    Gold, M.E.2    Buga, G.M.3
  • 56
    • 0024475102 scopus 로고
    • G-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?
    • G-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? Biochem Biophys Res Commun 1989;160: 881-6.
    • (1989) Biochem Biophys Res Commun , vol.160 , pp. 881-886
    • Aisaka, K.1    Gross, S.S.2    Griffith, O.W.3    Levi, R.4
  • 57
    • 0001599370 scopus 로고
    • Role of endothelium-derived nitric oxide in the regulation of blood pressure
    • Rees DD, Palmer RM, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A 1989;86:3375-8.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 3375-3378
    • Rees, D.D.1    Palmer, R.M.2    Moncada, S.3
  • 59
    • 84940621549 scopus 로고
    • Flow-dependent dilation in myograph-mounted resistance artery segments
    • Bevan JA, Joyce EH. Flow-dependent dilation in myograph-mounted resistance artery segments. Blood Vessels 1988;25: 101-4.
    • (1988) Blood Vessels , vol.25 , pp. 101-104
    • Bevan, J.A.1    Joyce, E.H.2
  • 60
    • 0026032652 scopus 로고
    • Shear stress-induced release of nitric oxide from endothelial cells grown on beads
    • Buga GM, Gold ME, Fukuto JM, Ignarro LJ. Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension 1991;17:187-93.
    • (1991) Hypertension , vol.17 , pp. 187-193
    • Buga, G.M.1    Gold, M.E.2    Fukuto, J.M.3    Ignarro, L.J.4
  • 61
    • 0021360664 scopus 로고
    • Reactive dilation of large coronary arteries in conscious dogs
    • Hintze TH, Vatner SF. Reactive dilation of large coronary arteries in conscious dogs. Circ Res 1984;54:50-7.
    • (1984) Circ Res , vol.54 , pp. 50-57
    • Hintze, T.H.1    Vatner, S.F.2
  • 62
    • 0021000747 scopus 로고
    • Two dilatory mechanisms of antianginal drugs on epicardial coronary arteries in vivo: Indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation
    • Holtz J, Giesler M, Bassenge E. Two dilatory mechanisms of antianginal drugs on epicardial coronary arteries in vivo: indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation. Z Kardiol 1983;72:98-106.
    • (1983) Z Kardiol , vol.72 , pp. 98-106
    • Holtz, J.1    Giesler, M.2    Bassenge, E.3
  • 63
    • 0021719788 scopus 로고
    • Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: Effects of cyclooxygenase inhibition
    • Holtz J, Forstermann U, Pohl U, Giesler M, Bassenge E. Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition. J Cardiovasc Pharmacol 1984;6:1161-9.
    • (1984) J Cardiovasc Pharmacol , vol.6 , pp. 1161-1169
    • Holtz, J.1    Forstermann, U.2    Pohl, U.3    Giesler, M.4    Bassenge, E.5
  • 64
    • 84939685037 scopus 로고
    • Endothelium-dependent flow-induced dilation of canine femoral and saphenous arteries
    • Hull SS, Kaiser L, Jaffe MD, Sparks HV. Endothelium-dependent flow-induced dilation of canine femoral and saphenous arteries. Blood Vessels 1986;23:183-98.
    • (1986) Blood Vessels , vol.23 , pp. 183-198
    • Hull, S.S.1    Kaiser, L.2    Jaffe, M.D.3    Sparks, H.V.4
  • 65
    • 0022545202 scopus 로고
    • Methylene blue and ETYA block flow-dependent dilation in canine femoral artery
    • Kaiser L, Hull SS Jr, Sparks HV Jr. Methylene blue and ETYA block flow-dependent dilation in canine femoral artery. Am J Physiol 1986;250:H974-81.
    • (1986) Am J Physiol , vol.250
    • Kaiser, L.1    Hull Jr., S.S.2    Sparks Jr., H.V.3
  • 66
    • 0022516979 scopus 로고
    • Flow-induced release of endothelium-derived relaxing factor
    • Rubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 1986;250: H1145-9.
    • (1986) Am J Physiol , vol.250
    • Rubanyi, G.M.1    Romero, J.C.2    Vanhoutte, P.M.3
  • 67
    • 84940134338 scopus 로고
    • Effects of perfusion and endothelium on the reactivity of isolated resistance arteries
    • Tesfamariam B, Halpern W, Osol G. Effects of perfusion and endothelium on the reactivity of isolated resistance arteries. Blood Vessels 1985;22:301-5.
    • (1985) Blood Vessels , vol.22 , pp. 301-305
    • Tesfamariam, B.1    Halpern, W.2    Osol, G.3
  • 68
    • 0029914567 scopus 로고    scopus 로고
    • Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells
    • Ayajiki K, Kindermann M, Hecker M, Fleming I, Busse R. Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells. Circ Res 1996;78:750-8.
    • (1996) Circ Res , vol.78 , pp. 750-758
    • Ayajiki, K.1    Kindermann, M.2    Hecker, M.3    Fleming, I.4    Busse, R.5
  • 69
    • 0030990083 scopus 로고    scopus 로고
    • Calcium-dependent and calcium-independent activation of the endothelial NO synthase
    • Fleming I, Bauersachs J, Busse R. Calcium-dependent and calcium-independent activation of the endothelial NO synthase. J Vasc Res 1997;34:165-74.
    • (1997) J Vasc Res , vol.34 , pp. 165-174
    • Fleming, I.1    Bauersachs, J.2    Busse, R.3
  • 70
    • 0033055559 scopus 로고    scopus 로고
    • Endothelial dysfunction: From physiology to therapy
    • Mombouli JV, Vanhoutte PM. Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol 1999;31:61-74.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 61-74
    • Mombouli, J.V.1    Vanhoutte, P.M.2
  • 71
    • 0023028215 scopus 로고
    • Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
    • Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-51.
    • (1986) N Engl J Med , vol.315 , pp. 1046-1051
    • Ludmer, P.L.1    Selwyn, A.P.2    Shook, T.L.3
  • 72
    • 0024590132 scopus 로고
    • Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis
    • Shimokawa H, Vanhoutte PM. Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ Res 1989;64:900-14.
    • (1989) Circ Res , vol.64 , pp. 900-914
    • Shimokawa, H.1    Vanhoutte, P.M.2
  • 73
    • 0026062979 scopus 로고
    • Hypercholesterolaemia, atherosclerosis and release of endothelium-derived relaxing factor by aggregating platelets
    • Vanhoutte PM. Hypercholesterolaemia, atherosclerosis and release of endothelium-derived relaxing factor by aggregating platelets. Eur Heart J 1991;12(suppl):E25-32.
    • (1991) Eur Heart J , vol.12 , Issue.SUPPL.
    • Vanhoutte, P.M.1
  • 74
    • 0025993736 scopus 로고
    • Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis
    • Zeiher AM, Drexler H, Wollschlager H, Just H. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation 1991;84:1984-92.
    • (1991) Circulation , vol.84 , pp. 1984-1992
    • Zeiher, A.M.1    Drexler, H.2    Wollschlager, H.3    Just, H.4
  • 75
    • 0030723041 scopus 로고    scopus 로고
    • Endothelial dysfunction and atherosclerosis
    • Vanhoutte PM. Endothelial dysfunction and atherosclerosis. Eur Heart J 1997;18(suppl):E19-29.
    • (1997) Eur Heart J , vol.18 , Issue.SUPPL.
    • Vanhoutte, P.M.1
  • 76
    • 0028283817 scopus 로고
    • Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia
    • Egashira K, Hirooka Y, Kai H, et al. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation 1994;89:2519-24.
    • (1994) Circulation , vol.89 , pp. 2519-2524
    • Egashira, K.1    Hirooka, Y.2    Kai, H.3
  • 77
    • 0031786766 scopus 로고    scopus 로고
    • Cholesterol, cholesterol lowering, and endothelial function
    • Vogel RA, Corretti MC, Gellman J. Cholesterol, cholesterol lowering, and endothelial function. Prog Cardiovasc Dis 1998;41: 117-36.
    • (1998) Prog Cardiovasc Dis , vol.41 , pp. 117-136
    • Vogel, R.A.1    Corretti, M.C.2    Gellman, J.3
  • 78
    • 0033537633 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthase inhibitor: A novel marker of atherosclerosis
    • Miyazaki H, Matsuoka H, Cooke JP, et al. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 1999;99:1141-6.
    • (1999) Circulation , vol.99 , pp. 1141-1146
    • Miyazaki, H.1    Matsuoka, H.2    Cooke, J.P.3
  • 79
    • 0025307354 scopus 로고
    • Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans
    • Creager MA, Cooke JP, Mendelsohn ME, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990;86:228-34.
    • (1990) J Clin Invest , vol.86 , pp. 228-234
    • Creager, M.A.1    Cooke, J.P.2    Mendelsohn, M.E.3
  • 80
    • 0027242030 scopus 로고
    • Hypercholesterolemia increases endothelial superoxide anion production
    • Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;91:2546-51.
    • (1993) J Clin Invest , vol.91 , pp. 2546-2551
    • Ohara, Y.1    Peterson, T.E.2    Harrison, D.G.3
  • 81
    • 0028128943 scopus 로고
    • The oxidation hypothesis of atherosclerosis
    • Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet 1994;344:793-5.
    • (1994) Lancet , vol.344 , pp. 793-795
    • Witztum, J.L.1
  • 82
    • 0031456505 scopus 로고    scopus 로고
    • Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia: Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions
    • Napoli C, D'Armiento FP, Mancini FP, Witztum JL, Palumbo G, Palinski W. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia: intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 1997;100:2680-90.
    • (1997) J Clin Invest , vol.100 , pp. 2680-2690
    • Napoli, C.1    D'Armiento, F.P.2    Mancini, F.P.3    Witztum, J.L.4    Palumbo, G.5    Palinski, W.6
  • 83
    • 0033586684 scopus 로고    scopus 로고
    • Intracranial arteries of human fetuses are more resistant to hypercholesterolemia induced fatty streak formation than extracranial arteries
    • Napoli C, Witztum JL, de Nigris F, Palumbo G, D'Armiento FP, Palinski W. Intracranial arteries of human fetuses are more resistant to hypercholesterolemia induced fatty streak formation than extracranial arteries. Circulation 1999;99:2003-10.
    • (1999) Circulation , vol.99 , pp. 2003-2010
    • Napoli, C.1    Witztum, J.L.2    De Nigris, F.3    Palumbo, G.4    D'Armiento, F.P.5    Palinski, W.6
  • 84
    • 0029849574 scopus 로고    scopus 로고
    • Oxidized lipoproteins and nitric oxide
    • Jessup W. Oxidized lipoproteins and nitric oxide. Curr Opin Lipidol 1996;7:274-80.
    • (1996) Curr Opin Lipidol , vol.7 , pp. 274-280
    • Jessup, W.1
  • 85
    • 0030710513 scopus 로고    scopus 로고
    • Mildly oxidized low-density lipoprotein impairs responses of carotid but not basilar artery in rabbits
    • Napoli C, Paternò R, Faraci FM, Taguchi H, Postiglione A, Heistad DD. Mildly oxidized low-density lipoprotein impairs responses of carotid but not basilar artery in rabbits. Stroke 1997; 28:2266-72.
    • (1997) Stroke , vol.28 , pp. 2266-2272
    • Napoli, C.1    Paternò, R.2    Faraci, F.M.3    Taguchi, H.4    Postiglione, A.5    Heistad, D.D.6
  • 86
    • 0031623305 scopus 로고    scopus 로고
    • Nitric oxide signaling: Would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?
    • Murad F. Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone? Recent Prog Horm Res 1998;53:43-59.
    • (1998) Recent Prog Horm Res , vol.53 , pp. 43-59
    • Murad, F.1
  • 87
    • 0344073985 scopus 로고    scopus 로고
    • Atherosclerosis and the two faces of endothelial nitric oxide synthase
    • Wever RM, Luscher TF, Cosentino F, Rabelink TJ. Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation 1998;97:108-12.
    • (1998) Circulation , vol.97 , pp. 108-112
    • Wever, R.M.1    Luscher, T.F.2    Cosentino, F.3    Rabelink, T.J.4
  • 89
    • 0027436619 scopus 로고
    • Negative feedback regulation of endothelial cell function by nitric oxide
    • Buga GM, Griscavage JM, Rogers NE, Ignarro LJ. Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res 1993;73:808-12.
    • (1993) Circ Res , vol.73 , pp. 808-812
    • Buga, G.M.1    Griscavage, J.M.2    Rogers, N.E.3    Ignarro, L.J.4
  • 90
    • 33750824305 scopus 로고    scopus 로고
    • Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo
    • Cohen GA, Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G, Ignarro LJ. Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo. Am J Physiol 1996;271:H133-9.
    • (1996) Am J Physiol , vol.271
    • Cohen, G.A.1    Hobbs, A.J.2    Fitch, R.M.3    Zinner, M.J.4    Chaudhuri, G.5    Ignarro, L.J.6
  • 91
    • 0029092658 scopus 로고
    • Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis
    • Abu-Soud HM, Wang J, Rousseau DL, Fukuto JM, Ignarro LJ, Stuehr DJ. Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis. J Biol Chem 1995;270:22997-3006.
    • (1995) J Biol Chem , vol.270 , pp. 22997-23006
    • Abu-Soud, H.M.1    Wang, J.2    Rousseau, D.L.3    Fukuto, J.M.4    Ignarro, L.J.5    Stuehr, D.J.6
  • 92
    • 0025081992 scopus 로고
    • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle
    • Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990;170:843-50.
    • (1990) Biochem Biophys Res Commun , vol.170 , pp. 843-850
    • Ignarro, L.J.1    Bush, P.A.2    Buga, G.M.3    Wood, K.S.4    Fukuto, J.M.5    Rajfer, J.6
  • 93
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992;326:90-4.
    • (1992) N Engl J Med , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 95
    • 0026731333 scopus 로고
    • L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum
    • L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochem Biophys Res Commun 1992;186:308-14.
    • (1992) Biochem Biophys Res Commun , vol.186 , pp. 308-314
    • Bush, P.A.1    Gonzalez, N.E.2    Ignarro, L.J.3
  • 97
    • 0004873336 scopus 로고    scopus 로고
    • Experimental evidences of selective antagonistic action of nebivolol on α-1-adrenergic receptors
    • Cleophas TJ. Experimental evidences of selective antagonistic action of nebivolol on α-1-adrenergic receptors. J Clin Med 1998; 2:2-25.
    • (1998) J Clin Med , vol.2 , pp. 2-25
    • Cleophas, T.J.1
  • 101
    • 0031713430 scopus 로고    scopus 로고
    • Endothelial dysfunction and inhibition of converting enzyme
    • Vanhoutte PM. Endothelial dysfunction and inhibition of converting enzyme. Eur Heart J 1998;19(suppl):J7-15.
    • (1998) Eur Heart J , vol.19 , Issue.SUPPL.
    • Vanhoutte, P.M.1
  • 102
    • 0032211543 scopus 로고    scopus 로고
    • Divergent effects of ACE inhibition and calcium channel blockers blockade on NO-activity in systemic and renal circulation in essential hypertension
    • Dijkhorst-Oei LT, Beutler JJ, Stroes ES, Koomans HA, Rabelink TJ. Divergent effects of ACE inhibition and calcium channel blockers blockade on NO-activity in systemic and renal circulation in essential hypertension. Cardiovasc Res 1998;40:402-9.
    • (1998) Cardiovasc Res , vol.40 , pp. 402-409
    • Dijkhorst-Oei, L.T.1    Beutler, J.J.2    Stroes, E.S.3    Koomans, H.A.4    Rabelink, T.J.5
  • 103
    • 34548519494 scopus 로고    scopus 로고
    • Vascular protection with newer antihypertensive agents
    • Schiffrin EL. Vascular protection with newer antihypertensive agents. J Hypertens 1998;61:525-9.
    • (1998) J Hypertens , vol.61 , pp. 525-529
    • Schiffrin, E.L.1
  • 104
    • 0032410741 scopus 로고    scopus 로고
    • Role of nitric oxide in the control of renin secretion
    • Kurtz A, Wagner C. Role of nitric oxide in the control of renin secretion. Am J Physiol 1998;275:F849-62.
    • (1998) Am J Physiol , vol.275
    • Kurtz, A.1    Wagner, C.2
  • 105
    • 0028800359 scopus 로고
    • Antithrombotic effects of a nitric oxide-releasing, gastric sparing aspirin derivative
    • Wallace JL, McKnight W, Del Soldato P, Baydoun A, Cirino G. Antithrombotic effects of a nitric oxide-releasing, gastric sparing aspirin derivative. J Clin Invest 1995;96:2711-8.
    • (1995) J Clin Invest , vol.96 , pp. 2711-2718
    • Wallace, J.L.1    McKnight, W.2    Del Soldato, P.3    Baydoun, A.4    Cirino, G.5
  • 106
    • 0032907875 scopus 로고    scopus 로고
    • Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats
    • Fiorucci S, Antonelli E, Santucci L, et al. Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. Gastroenterology 1999;116:1089-106.
    • (1999) Gastroenterology , vol.116 , pp. 1089-1106
    • Fiorucci, S.1    Antonelli, E.2    Santucci, L.3
  • 107
    • 0031408178 scopus 로고    scopus 로고
    • Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: Role of neutrophils
    • Wallace JL, McKnight W, Wilson TL, Del Soldato P, Cirino G. Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils. Am J Physiol 1997;273:G1246-51.
    • (1997) Am J Physiol , vol.273
    • Wallace, J.L.1    McKnight, W.2    Wilson, T.L.3    Del Soldato, P.4    Cirino, G.5
  • 109
    • 0343060358 scopus 로고    scopus 로고
    • Roles of nitric oxide in brain hypoxiaischemia
    • Bolanos JP, Almeida A. Roles of nitric oxide in brain hypoxiaischemia. Biochim Biophys Acta 1999;1411:415-36.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 415-436
    • Bolanos, J.P.1    Almeida, A.2
  • 110
    • 0032961726 scopus 로고    scopus 로고
    • A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat
    • Coert BA, Anderson RE, Meyer FB. A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat. J Neurosurg 1999;90:332-8.
    • (1999) J Neurosurg , vol.90 , pp. 332-338
    • Coert, B.A.1    Anderson, R.E.2    Meyer, F.B.3
  • 111
    • 0032133353 scopus 로고    scopus 로고
    • Design of isoform-selective inhibitors of nitric oxide synthase
    • Babu BR, Griffith OW. Design of isoform-selective inhibitors of nitric oxide synthase. Curr Opin Chem Biol 1998;2:491-500.
    • (1998) Curr Opin Chem Biol , vol.2 , pp. 491-500
    • Babu, B.R.1    Griffith, O.W.2
  • 112
    • 0032551891 scopus 로고    scopus 로고
    • Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis
    • Martin PY, Gines P, Schrier RW. Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis. N Engl J Med 1998;339:533-41.
    • (1998) N Engl J Med , vol.339 , pp. 533-541
    • Martin, P.Y.1    Gines, P.2    Schrier, R.W.3
  • 113
    • 0031690993 scopus 로고    scopus 로고
    • Restoration of nitric oxide function in human hyperlipidaemia, congestive heart failure and liver cirrhosis
    • Chin-Dusting JP, Kaye DM. Restoration of nitric oxide function in human hyperlipidaemia, congestive heart failure and liver cirrhosis. Clin Exp Pharmacol Physiol 1998;25:645-52.
    • (1998) Clin Exp Pharmacol Physiol , vol.25 , pp. 645-652
    • Chin-Dusting, J.P.1    Kaye, D.M.2
  • 114
    • 0031950006 scopus 로고    scopus 로고
    • The therapeutic potential of nitric oxide in lung transplantation
    • Meyer KC, Love RB, Zimmerman JJ. The therapeutic potential of nitric oxide in lung transplantation. Chest 1998;113:1360-71.
    • (1998) Chest , vol.113 , pp. 1360-1371
    • Meyer, K.C.1    Love, R.B.2    Zimmerman, J.J.3


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