The nitric oxide hypothesis of brain aging

Experimental Gerontology

Volumn 32, Issue 4-5, 1997, Pages 431-440

  Mccann, S M ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

aminobutyric acid; Cyclooxygenase; Cytokines; Dopamine; Glutamic acid; Hypothalamic releasing and inhibiting hormones; Neurodegenerative diseases; Nitric oxide synthase; Norepinephrine; Soluble guanylate cyclase

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; FOLLITROPIN RELEASING FACTOR; GLUTAMIC ACID; GONADORELIN; GROWTH HORMONE RELEASING FACTOR; GUANYLATE CYCLASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE;

AGING; BRAIN DEGENERATION; CELL AGING; CONFERENCE PAPER; ENZYME ACTIVITY; HUMAN; HYPOPHYSIS; HYPOTHALAMUS; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SENESCENCE;

AGING; ANIMALS; BRAIN; HUMANS; MODELS, NEUROLOGICAL; NITRIC OXIDE;

BACTERIA (MICROORGANISMS); RODENTIA;

EID: 0030846399     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(96)00154-4     Document Type: Conference Paper

References (25)

1. AGUILA, M.C. Growth hormone-releasing factor increases somatostatin release and mRNA levels in the rat periventricular nucleus via nitric oxide by activation of guanylate cyclase. Proc. Nati. Acad. Sci. USA 91, 782-786, 1994.
2. BANKS, W.A., KASTIN, A.J., and BROADWELL, R.D. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 2, 241, 1995.
3. BREDT, D.S., HWANG, P.M., and SNYDER, S.H. Localization of nitric oxide synthase I indicating a neural role for nitric oxide. Nature 347, 768-770, 1990.
4. CANTEROS, G., RETTORI, V., FRANCHI, A., GENARO, A., CEBRAL, E., FALETTI, A., GIMENO, M., and McCANN, S.M. Ethanol inhibits lutenizing hormone-releasing hormone (LHRH) secretion by blocking the response of LHRH neuronal terminals to nitric oxide. Proc. Natl. Acad. Sci. USA 92, 3416-3420, 1995.
5. DUVILANSKI, B.H., ZAMBRUNO, C., SEILICOVICH, A., PISERA, D., LASAGA, M., DEL, C., DIAZ, M., BELOVA, N., RETTORI, V., and McCANN, S.M. Role of nitric oxide in control of prolactin release by the adenohypophysis. Proc. Natl. Acad. Sci. USA 92, 170-174, 1995.
6. GRIFFIN, S. Neuroimmunology symposium. Am. Assoc. Immunol. Mtg., New Orleans, June 1996.
7. KAMAT, A., YU, W.H., RETTORI, V., and McCANN, S.M. Glutamic acid stimulated lutenizing-hormone releasing hormone release is mediated by alpha adrenergic stimulation of nitric oxide release. Brain Res. Bull. 37, 233-235, 1995.
8. KARANTH, S., LYSON, K., and McCANN, S.M. Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami. Proc. Natl. Acad. Sci. USA 90, 3383-3387, 1993.
9. KNOLL, J. Sexual performance and longevity. Proc. 3rd International Symposium on Neurobiology of Aging, Bregenz, Austria, July 21-25, 1996.
10. MANI, S.K., ALLEN, J.M.C., RETTORI, V., O'MALLEY, B.W., CLARK, J.H., and McCANN. Nitric oxide mediates sexual behavior in female rats by stimulating LHRH release. Proc. Natl. Acad. Sci. USA 91, 6468-6472, 1994.
11. McCANN, S.M. and RETTORI, V. The role of nitric oxide in reproduction. Proc. Soc. Exp. Biol. Med. 211, 7-15, 1996.
12. McDONALD, L.J. and MURAD, F. Nitric oxide and cyclic GMP signaling. Proc. Soc. Exp. Biol. Med. 211, 1-6, 1996.
13. PIERPAOLI, W. The melatonin hypothesis of aging. Proc. 3rd International Symposium on the Neurobiology and Neuroendcrinology of Aging, Bregenz, Austria, July 21-25, 1996.
14. PRZEDBORSKI, S., JACKSON-LEWIS, V., YOKOYAMA, R., SHIBATA T., DAWSON, V.L., and DAWSON, T.M. Role of neuronal NO in 1-methyl-4-phynyl-1,2,3,4-tetrahydopyridine (MPTP)-induced dopaminergic toxicity. Proc. Natl. Acad. Sci. USA 93, 4565-4571, 1996.
15. RETTORI, V., BELOVA, N., DEES, W.L, NYBERG, C.L., GIMENO, M., and McCANN, S.M. Role of nitric oxide in the control of lutenizing hormone-releasing hormone release in vivo and in vitro. Proc. Natl. Acad. Sci. USA 90, 10130-10134, 1993.
16. RETTORI, V., BELOVA, N., GIMENO, M., and McCANN, S.M. Inhibition of nitric oxide synthase in the hypothalamus blocks the increase in plasma prolactin induced by intraventricular injection of interleukin-1α in the rat. Neuroimmunomodulation 1, 116-120, 1994a.
17. RETTORI, V., BELOVA, N., YU., W.H., GIMENO, M., and McCANN, S.M. Role of nitric oxide in control of growth hormone release in the rat. Neuroimmunomodulation 1, 195-200, 1994b.
18. RETTORI, V., CANTEROS, G., FALETTI, R., REYNOSO, M., and McCANN, S.M. Oxytocin stimulates the release of LHRH via NO. Program of the 10th International Congress of Endocrinology, San Francisco, CA, June 1996, Abstract P2-511.
19. RETTORI, V., DEES, W.L., HINEY, J.K., LYSON, K., and McCANN, S.M. An interleukin-la-like neuronal system in the preoptic-hypothalamic region and its induction by bacterial lipopolysaccharide in concentrations which alter pituitary hormone release. Neuroimmunomodulation 1, 251-258, 1994c.
20. SCHULTZ, BRAAK, H., and BRAAK, E. A sex difference in neurodegeneration of the human hypothalamus. Proc. 3rd International Symposium on Neurobiology of Aging, Bregenz, Austria, 1997.
21. SEILICOVICH, A., DUVILANSKI, B.H., PISERA, D., THIES, S., GIMENO, M., RETTORI, V., and McCANN, S.M. Nitric oxide inhibits hypothalamic lutenizing hormone-releasing hormone release by releasing γ-aminobutyric acid. Proc. Natl. Acad. Sci. USA 92, 3421-3424, 1995a.
22. SEILICOVICH, A., LASAGA, M., BEFUMO, M., DUVILANSKI, B.H., DEL C. DIAS, M., RETTORI, V., and McCANN, S.M. Nitric oxide inhibits the release of norepinephrine and dopamine from the medial basal hypothalamus of the rat. Proc. Natl. Acad. Sci. USA 92, 11299-11302, 1995b.
23. SEWERYNEK, E., MELCHIORI, D., REITER, R.J., CHUANG, J.I., ORTIZ, G.G., GUERRO, J.M., PABLOS, M.L., and LEWINSKI A. Oxidative damage induced by brain ischemia-reperfusion is protected by melatonin. Program of the 10th International Congress of Endocrinology, San Francisco, Abstract Pq2-501, June 1996.
24. WONG, M.L., RETTORI, V., AL-SHEKHELEE, A., BONGIORNO, P.B., CANTEROS, G., MCCANN, S.M., GOLD, P.W., and LICINIO J. Inducible nitric oxide synthase gene expression in the brain during systemic inflammation. Nat. Med. 2, 581-584, 1996.
25. XIAO-JIANG, L., SHARP, A.H., SHI-HUA, L., DAWSON, T.M., SNYDER, S.H., and ROSS, C.A. Huntingtin-associated protein (HAP1): Discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proc. Natl. Acad. Sci. USA 93, 4839-4844, 1996.