Multiple sclerosis: In situ evidence for antibody- and complement- mediated demyelination

Annals of Neurology

Volumn 43, Issue 4, 1998, Pages 465-471

  Storch, Maria K ^a   Piddlesden, Sara ^b   Haltia, Matti ^c   Iivanainen, Matti ^c   Morgan, Paul ^b   Lassmann, Hans ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; COMPLEMENT; MYELIN;

ADULT; ARTICLE; CASE REPORT; DEMYELINATION; FEMALE; HUMAN; IMMUNOGLOBULIN DEPOSITION; MACROPHAGE; MULTIPLE SCLEROSIS; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION;

BIOLOGICAL MARKERS; BRAIN; COMPLEMENT INACTIVATOR PROTEINS; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; FATAL OUTCOME; FEMALE; HUMANS; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MACROPHAGES; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELIN SHEATH; OLIGODENDROGLIA; SPINAL CORD;

EID: 0031748566     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410430409     Document Type: Article

References (31)

1. Babinski J. Recherches sur l'anatomie pathologique de la sclerose en plaque et étude comparative des diverses variétés de la scleroses de la moelle. Arch Physiol (Paris) 1885;5-6:186-207
2. Prineas JW, Graham JS. Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann Neurol 1981;10:149-158
3. Prineas JW. The neuropathology of multiple sclerosis. In: Koetsier JC, ed. Handbook of clinical neurology. Vol 47. Demyelinating diseases. New York: Elsevier Science, 1985:337-395
4. Selmaj KW. Brosnan CF, Raine CS. Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65 + oligodendrocytes in multiple sclerosis. Proc Natl Acad Sci USA 1991;88:6425-6456
5. Marburg O. Die sogenannte "akute Multiple Sklerose." Jahrb Psychiatrie 1906;27:211-312
6. Selmaj KW, Raine CS. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 1988;23: 339-346
7. Rodriguez M, Prayoonwiwat N, Howe C, et al. Proteolipid protein gene expression in demyelination and remyelination of the central nervous system: a model for multiple sclerosis. J Neuropathol Exp Neurol 1994;53:136-143
8. Compston DA, Morgan BP, Campell AK, et al. Immunocytochemical localization of the terminal complement complex in multiple sclerosis. Neuropathol Appl Neurobiol 1989; 15:307-316
9. Woyciechowska JL, Brzosko WJ. Immunofluorescence study of brain plaques from two patients with multiple sclerosis. Neurology 1977;27:620-622
10. Lumsden CE. The immunogenesis of the multiple sclerosis plaque. Brain Res 1971;28:365-390
11. Gay D, Esiri M. Blood-brain-barrier damage in acute multiple sclerosis plaques. Brain 1991;114:557-572
12. Wu E, Brosnan CF, Raine CS. SP-40/40 immunoreactivity in inflammatory CNS lesions displaying astrocyte/oligodendrocyte interactions. J Neuropathol Exp Neurol 1993;52:129-134
13. Sobel RA, Chen M, Maeda A, et al. Vitronectin and integrin vitronectin receptor localization in multiple sclerosis lesions. J Neuropathol Exp Neurol 1995;54:202-213
14. Vass K, Lassmann H, Wekerle H, et al. The distribution of Ia antigen in the lesions of rat acute experimental allergic enceph-alomyelitis. Acta Neuropathol (Berlin) 1986;70:149-160
15. Vass K, Berger ML, Nowak TS Jr, et al. Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat. Neurosci Lett 1989;100:259-264
16. Breitschopf H, Suchanek G, Gould RM, et al. In situ hybridization with digoxigenin-labelled probes: sensitive and reliable detection method applied to myelinating rat brain. Acta Neuropathol (Berlin) 1992;84:581-587
17. Gold R, Schmied M, Rothe G, et al. Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections. J Histochem Cytochem 1993;41:1023-1030
18. Bhardwaj RS, Zotz C, Zwadlo-Klarwasser G, et al. The calcium-binding proteins MRP8 and MRP14 form a membrane-associated heterodimer in a subset of monocytes/macrophages present in acute but absent in chronic inflammatory lesions. Eur J Immunol 1992;22:1891-1897
19. Zwadlo G, Schlegel R, Sorg C. A monoclonal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues. J Immunol 1986;137:512-518
20. Ozawa K, Suchanek G, Breitschopf H, et al. Patterns of oligodendroglia pathology in multiple sclerosis. Brain 1994;117: 1311-1322
21. Scolding NJ, Morgan BP, Houston A, et al. Normal rat serum cytotoxicity against syngeneic oligodendrocytes: complement activation and attack in the absence of antimyelin antibodies. J Neurol Sci 1989;89:289-300
22. Zajicek J, Wing M, Skepper J, et al. Human oligodendrocytes are not sensitive to complement: a study of CD59 expression in the human central nervous system. Lab Invest 1995;73:128-138
23. Piddlesden SJ, Lassmann H, Zimprich F, et al. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am J Pathol 1993;143:555-564
24. Matthieu J-M, Amiguet P. Myelin/oligodendrocyte glycoprotein expression during development in normal and myelindeficient mice. Dev Neurosci 1990;12:293-302
25. Brunner C, Lassmann H, Waehneldt TV, et al. Differential ultrastructural localization of myelin basic protein, myelin/ oligodendroglial glycoprotein, and 2′, 3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats. J Neurochem 1989;52:296-304
26. Sun J, Link H, Olsson T, et al. T and B cell responses to myelin oligodendroglia glycoprotein in multiple sclerosis. J Immunol 1991;146:1490-1495
27. Lucchinetti CF, Brueck W, Rodriguez M, et al. Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol 1996;6:259-274
28. Grundke-Iqbal I, Bornstein MB. Multiple sclerosis: serum gamma globulin and demyelination in culture. Neurology 1980;30:749-754
29. Brück W, Porada P, Poser S, et al. Monocyte/macrophage differentiation in early multiple sclerosis lesios. Ann Neurol 1995; 38:788-796
30. Radzun HJ, Hansmann ML, Heidebrecht HJ, et al. Detection of a monocyte/macrophage differentiation antigen in routinely processed paraffin-embedded tissues by monoclonal antibody Ki-M1P. Lab Invest 1991;65:306-315
31. Zwadlo G, Bruecker EB, von Bassewitz DB, et al. A monoclonal antibody to a differentiation antigen present on mature human macrophages and absent from monocytes. J Immunol 1985;134:1487-1492