Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage

Brain Research

Volumn 716, Issue 1-2, 1996, Pages 118-122

  Barker, Jane E ^a   Heales, Simon J R ^a,b   Cassidy, Adrian ^a   Bolaños, Juan P ^c   Land, John M ^a,b   Clark, John B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b National Hospital   (United Kingdom)

^c UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

glutathione reductase; neurodegeneration; oxidative stress; peroxynitrite

Indexed keywords

GLUTATHIONE; GLUTATHIONE REDUCTASE; PEROXYNITRITE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

EID: 0029970099     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00003-0     Document Type: Article

References (23)

1. Beckman, J.S., Beckman, T.W., Chen, J., Marshal, P.A. and Freeman, B.A., Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide, Proc. Natl. Acad. Sci. USA, 87 (1990) 1620-1624.
2. Bolaños, J.P., Heales, S.J.R., Land, J.M. and Clark, J.B., Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurones and astrocytes in primary culture, J. Neurochem., 64 (1995) 1965-1972.
3. Boveris, A. and Chance, B., The mitochondrial generation of hydrogen peroxide, Biochem. J., 134 (1973) 707-716.
4. DiMonte, D.A., Chan, P. and Sandy, M.S., Glutathione in Parkinson's disease: A link between oxidative stress and mitochondrial damage?, Ann. Neurol., 32 (1992) S111-115.
5. Fearnley, J.M. and Lees, A.J., Aging and Parkinson's disease: substantia nigra regional selectivity, Brain, 114 (1991) 2283-2301.
6. Heales, S.J.R., Davies, S.E.C., Bates, T.E. and Clark, J.B., Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration, Neurochem. Res., 20 (1995) 31-38.
7. Hughes, M.N. and Nicklin, H.G., The chemistry of pernitrites. Part I. Kinetics of decomposition of pernitrous acid. J. Chem. Soc. Abstr., (1968) 450-452.
8. Jain, A., Mårtensson, J., Stole, E., Auld, P.A.M. and Meister, A., Glutathione deficiency leads to mitochondrial damage in brain, Proc. Natl. Acad. Sci. USA, 88 (1991) 1913-1917.
9. Jenner, P., Dexter, D.T., Sian, J., Schapira, A.H.V. and Marsden, C.D., Oxidative stress as a cause of nigral cell death in Parkinson's Disease and incidental Lewy body disease, Ann. Neurol., 32 (1992) S82-87.
10. Koprowski, H., Zheng, Y.M., Heber-Katz, E., Fraser, N., Rorke, L., Fu, Z., Hanlon, C. and Dietzschold, B., In vivo expression of inducible nitric oxide synthase in experimentally induced neurological diseases, Proc. Natl. Acad. Sci. USA, 90 (1993) 3024-3027.
11. Lipton, S.A., Choi, Y.-B., Pan, Z.-H., Lei, S.Z., Chen, H.-S.V., Sucher, N.J., Loscalzo, J., Singel, D.J. and Stamler, J.S., A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds, Nature, 364 (1993) 626-632.
12. Loplane, D., Attal, N., Sauron, B., Debilly, A. and Dubois, B., Lesions of basal ganglia due to disulfiram neurotoxicity, J. Neurol. Neurosurg. Psych., 55 (1992) 925-929.
13. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J., Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
14. Meister, A., A selective modification of glutathione metabolism, Science, 220 (1983) 472-477.
15. Nagendra, S.N., Shetty, K.T., Rao, K.M. and Rao, B.S.S.R., Effect of disulfiram administration on rat-brain glutathione metabolism, Alcohol, 11 (1994) 7-10.
16. Ochi, T., Inhibition of the activity of glutathione-peroxidase by tertiary-butylhydroperoxide in cultured chinese-hamster cells and the role of cellular glutathione in the recovery of activity, Toxicology, 71 (1992) 119-127.
17. Radi, R., Beckman, J.S., Bush, K.M. and Freeman., B.A., Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide, J. Biol. Chem., 266 (1991) 4244-4250.
18. Radi, R., Rodriguez, M., Castro, L. and Tellerei, R., Inhibition of mitochondrial electron transport by peroxynitrite, Arch. Biochem. Biophys., 308 (1994) 89-95.
19. Reiderer, P., Sofic, E., Rausch, W.-D., Schimdt, B., Reynolds, G.P., Jellinger, K. and Youdim, M.B.H., Transition metals, ferritin, glutathione and ascorbic acid in parkinsonian brains, J. Neurochem. 52 (1989) 525-520.
20. Schapira, A.H.V., Cooper, J.M., Dexter, D., Clark, J.B., Jenner, P. and Marsden, C.D., Mitochondrial complex I deficiency in Parkinson's disease, J. Neurochem., 54 (1990) 823-827.
21. Schulz, G.E., Schirmer, R.H., Sachsenheimer, W. and Pai, E.F., The structure of the flavoenzyme glutathione reductase, Nature, 273 (1978) 120-124.
22. Sian, J., Dexter, D.T., Lees, A.J., Daniel, S., Jenner, P. and Marsden, C.D., Glutathione-related enzymes in brain in Parkinson's disease, Ann. Neurol., 36 (1994) 356-361.
23. Zhang, Y., Marcillat, O., Giulivi, C., Ernster, L. and Davies, K.J.A., The oxidative inactivation of mitochondrial electron transport components and ATPase, J. Biol. Chem., 265 (1990) 16330-16336.