T cell antigen receptor signal transduction pathways

Annual Review of Immunology

Volumn 14, Issue , 1996, Pages 259-274

  Cantrell, Doreen ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

calcium; Grb2; MAP kinases; p21(ras); protein kinaseC; T cell antigen receptor

Indexed keywords

CYTOKINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; CALCIUM TRANSPORT; CLONAL ANERGY; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOREGULATION; LIPID METABOLISM; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE;

HUMANS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 0029874657     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.14.1.259     Document Type: Review

References (15)

1. Weiss A. 1993. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell 73:209-12
2. Weiss A, Littman DR. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263-74
3. Cambier J. 1995. Conserved Signaling Motifs in Antigen and Fc Receptors. Seminars in Immunology, Vol. 7. New York: Academic Press
4. Reth M. 1989. Antigen receptor tail clue. Nature 338:383-84
5. Flaswinkel H, Reth AM. 1994. Dual role of the tyrosine activation motif of the Ig-α protein during signal transduction via the B cell antigen receptor. EMBO J. 13:83-89
6. Burkhardt AL, Costa T, Misulovin Z, Stealy B, Bolen JB, Nussenzweig MC. 1994. Igeα and Igβ are functionally homologous to the signaling proteins of the T cell receptor. Mol. Cell. Biol. 14:1095-103
7. Samelson LE, Klausner RD. 1992. Tyrosine kinases and tyrosine-based activation motifs. J. Biol. Chem. 267:24913-16
8. Gauen LKT, Zhu YX, Letoumeur F, Hu Q, Bolen JB, Matis LA, Klausner RD, Shaw AS. 1994. Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol. Cell Biol. 14:3729-41
9. Iwashima M, Irving BA, van Oers NSC, Chan AC, Weiss A. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136-39
10. Weil R, Cloutier JF, Fournel M, Veillette A. 1995. Regulation of ZAP70 by Src family tyrosine kinases in an antigen specific T cell line. J Biol. Chem. 270:2791-99
11. Isakov N, Wange RL, B urgess WH, Watts JD, Aebersold R, Samelson LE. 1995. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind tyrosine based activation motifs with varying affinity. J. Exp. Med. 181:375-80
12. Osman N, Ley SC, Crumpton MJ. 1992. Evidence for an association between the T cell receptor/CD3 complex and the CD5 antigen in human T lymphocytes. Eur. J. Immunol. 22:2995-3000
13. Egerton M, Burgess WH, Chen D, Druker BJ, Bretscher A, Samelson LE. 1992. Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells. J Immunol. 149:1847-52
14. Egerton M, Ashe OR, Chen D, Druker BJ, Burgess WH, Samelson LE. 1992. VCP. the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. EMBO J. 11:3533-10
15. Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. 1992. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356:71-74