Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T cells

Journal of Immunology

Volumn 160, Issue 1, 1998, Pages 24-27

  Kaga, Shuji ^a   Ragg, Scott ^a   Rogers, Kem A ^b   Ochi, Atsuo ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ANTIBODY; CD28 ANTIGEN; CD86 ANTIGEN; F ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL CONTACT; CHO CELL; CONTROLLED STUDY; FLUORESCENCE; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ACTINS; ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD86; CELL ADHESION; CHO CELLS; CRICETINAE; GTP-BINDING PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICROFILAMENTS; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TALIN;

EID: 0031929654     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Linsley, P. S., and J. A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
2. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
3. Fraser, J. D., D. Straus, and A. Weiss. 1993. Signal transduction events leading to T-cell lymphokine gene expression. Immunol. Today 14:35.
4. Rudd, C. E. 1996. Upstream-Downstream: CD28 coaignalling pathways and T cell function. Immunity 4:527.
5. Pai, S-Y., V. Calvo, M. Wood, and B. E. Bierer. 1994. Cross-linking CD28 leads to activation of 70-kDa S6 kinase. Eur. J. Immunol. 24:2364.
6. August, A., S. Gibson, Y. Kawakami, T. Kawakami, G. B. Mills, and B. Dupont. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat T-cell line. Proc. Natl. Acad. Sci. USA 91:9347.
7. Raab, M., Y. C. Cai, S. C. Bunnell, S. D. Heyeck, L. J. Berg, and C. E. Rudd. 1995. pS6Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. Proc. Natl. Acad. Sci. USA 92:8891.
8. Boucher, L.-M., K. Wiegmann, A. Fütterer, K. Pfeffer, T. Machleidt, S. Shütze, T. W. Mak, and M. Krönke. 1995. CD28 signals through acidic sphingomyelinase. J. Exp. Med. 181:2059.
9. Chan, G., and A. Ochi. 1995. Sphingomyelin-ceramide turnover in CD28 costimulatory signaling. Eur. J. Immunol. 25:1999.
10. Hall, A. 1994. Small GTP-binding proteins and the regulation of the actin cytoskelton. Annu. Rev. Cell Biol. 10:31.
11. Ridley, A. J. 1994. Membrane ruffling and signal transduction. Bioessays 16:321.
12. Ridley, A. J., H. F. Paterson, C. L. Johnston, D. Diekman, and A. Hall. 1992. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70:401.
13. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389.
14. Nobes, C. D., and A. Hall. 1995. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53.
15. Kozma, R., S. Ahmed, A. Best, and L. Lim. 1995. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15:1942.
16. Vojtek, A. B., and J. A. Cooper. 1995. Rho family members: Activators of MAP kinase cascades. Cell 82:527.
17. Stowers, L., D. Yelon, L. J. Berg, and J. Chant. 1995. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 92:5027.
18. Downey, G. P., C. K. Chan, P. Lea, A. Takai, and S. Grinstein. 1992. Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C. J. Cell Biol. 116:696-706.
19. Cano, M. L., L. Cassimeris, M. Joyce, and S. H. Zigmond. 1992. Characterization of tetramethylrhodaminyl-phalloidin binding to cellular F-actin. Cell Motil. Cytoskel. 21:147.
20. Stossel, T. P. 1993. On the crawling of animal cells. Science 260:1086.
21. Bar-Sagi D., D. Rotin, A. Batzer, V. Mandiyan, and J. Schlessinger. 1993. SH3 domains direct cellular localization of signaling molecules. Cell 74:83.
22. Phatak, P. D., C. H. Packman, and M. A. Lichtman. 1988. Protein kinase C modulates actin conformation in human T lymphocytes. J. Immunol. 141:2929.
23. DeBenedette, M. A., N. R. Chu, K. E. Pollok, J. Hurtado, W. F. Wade, B. S. Kwon, and T. H. Watts. 1995. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. J. Exp. Med. 181:985.
24. Quinn, M., T. Evans, L. Priscu, A. Jesaitis, and G. M. Bokoch. 1993. Translocation of Rac correlates with NADPH oxidase activation: evidence for equimolar translocation of oxidase components. J. Biol. Chem. 268:20983.
25. Takaishi, K., T. Sasaki, T. Kameyama, S. Tsukita, S. Tsukita, and Y. Takai. 1995. Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene 11:39.
26. Bokoch, G. M., and U. G. Knaus. 1994. The role of small GTP-binding proteins in leukocyte function. Curr. Opin. Immunol. 6:98.
27. Kupfer, A., and S. J. Singer. 1989. Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol. 7:309.
28. Manser, E., T. Leung, H. Salihuddin, Z.-S. Zhao, and L. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40.
29. Knaus, U. G., S. Morris, H.-J. Dong, J. Chernoff, and G. M. Bokoch. 1995. Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science 269:221.
30. Watanabe, G., Y. Saito, P. Madaule, T. Ishizaki, K. Fujisawa, N. Morii, H. Mukai, Y. Ono, A. Kakizuka, and S. Narumiya. 1996. Protein kinase N (PKN) and PKN-related protein Rhophilin as targets of small GTPase Rho. Science 271:645.
31. Amano, M., H. Mukai, Y. Ono, K. Chihara, T. Matsui, Y. Hamajima, K. Okawa, A. Iwamatsu, and K. Kaibuchi. 1996. Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science 271:648.
32. Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137.
33. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147.
34. Bagorodia, S., B. Dérijard, R. J. Davis, and R. A. Cerione. 1995. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270:27995.
35. Zhang, S., J. Han, M. A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch, and G. M. Bokoch. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270:23934.
36. 1. Science 269:1270.
37. Hill, C. S., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199.
38. June, C. H., J. A. Ledbetter, M. M. Gillespie, T. Lindsten, and C. B. Thompson. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7:4472.
39. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
40. Lamarche, N.. N. Tapon, L. Stowers, P. D. Burbelo, P. Aspenstrom, T. Bridges, J. Chant, and A. Hall. 1996. Rac and CDC42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87:519.