메뉴 건너뛰기




Volumn 89, Issue 4, 1997, Pages 1308-1318

CD2 regulates the positive selection and function of antigen-specific CD4-CD8+ T cells

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; T LYMPHOCYTE RECEPTOR;

EID: 0031059288     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.4.1308     Document Type: Article
Times cited : (72)

References (62)
  • 2
    • 0023257127 scopus 로고
    • The murine homologue of the T lymphocyte CD2 antigen: Molecular cloning, chromosome assignment and cell surface expression
    • Sewell WA, Brown MH, Owen MJ, Fink PJ, Kozak CA, Crumpton MJ: The murine homologue of the T lymphocyte CD2 antigen: Molecular cloning, chromosome assignment and cell surface expression. Eur J Immunol 17:1015, 1987
    • (1987) Eur J Immunol , vol.17 , pp. 1015
    • Sewell, W.A.1    Brown, M.H.2    Owen, M.J.3    Fink, P.J.4    Kozak, C.A.5    Crumpton, M.J.6
  • 3
    • 0025748806 scopus 로고
    • Signal transduction by the CD2 antigen in T cells and natural killer cells: Requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIa (CD16)
    • Spruyt LL, Glennie MJ, Beyers AD, Williams AF: Signal transduction by the CD2 antigen in T cells and natural killer cells: Requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIA (CD16). J Exp Med 174:1407, 1991
    • (1991) J Exp Med , vol.174 , pp. 1407
    • Spruyt, L.L.1    Glennie, M.J.2    Beyers, A.D.3    Williams, A.F.4
  • 4
    • 0024840872 scopus 로고
    • Subsets of thymopoietic rat thymocytes defined by expression of the CD2 antigen and the MRC OX-22 determinant of the leuckocyte-common antigen CD45
    • Law DA, Spruyt LL, Paterson DJ, Williams AF: Subsets of thymopoietic rat thymocytes defined by expression of the CD2 antigen and the MRC OX-22 determinant of the leuckocyte-common antigen CD45. Eur J Immunol 19:2289, 1989
    • (1989) Eur J Immunol , vol.19 , pp. 2289
    • Law, D.A.1    Spruyt, L.L.2    Paterson, D.J.3    Williams, A.F.4
  • 6
    • 0023173670 scopus 로고
    • Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion
    • Dustin ML, Sanders ME, Shaw S, Springer TA: Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. J Exp Med 165:677, 1987
    • (1987) J Exp Med , vol.165 , pp. 677
    • Dustin, M.L.1    Sanders, M.E.2    Shaw, S.3    Springer, T.A.4
  • 8
    • 0026704425 scopus 로고
    • Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59
    • Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE: Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science 256:1805, 1992
    • (1992) Science , vol.256 , pp. 1805
    • Hahn, W.C.1    Menu, E.2    Bothwell, A.L.3    Sims, P.J.4    Bierer, B.E.5
  • 9
    • 0027405371 scopus 로고
    • A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: Divergence of CD2 ligands during the evolution of humans and mice
    • Arulanandam AR, Moingeon P, Concino MF, Recny MA, Kato K, Yagita H, Koyasu S, Reinherz EL: A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: Divergence of CD2 ligands during the evolution of humans and mice. J Exp Med 177:1439, 1993
    • (1993) J Exp Med , vol.177 , pp. 1439
    • Arulanandam, A.R.1    Moingeon, P.2    Concino, M.F.3    Recny, M.A.4    Kato, K.5    Yagita, H.6    Koyasu, S.7    Reinherz, E.L.8
  • 11
    • 0025293056 scopus 로고
    • Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3
    • Wong YW, Williams AF, Kingsmore SF, Seldin MF: Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. J Exp Med 171:2115, 1990
    • (1990) J Exp Med , vol.171 , pp. 2115
    • Wong, Y.W.1    Williams, A.F.2    Kingsmore, S.F.3    Seldin, M.F.4
  • 12
    • 0024544377 scopus 로고
    • Distribution and ontogeny of CD2 expression by murine T cells
    • Duplay P, Lancki D, Allison JP: Distribution and ontogeny of CD2 expression by murine T cells. J Immunol 142:2998, 1989
    • (1989) J Immunol , vol.142 , pp. 2998
    • Duplay, P.1    Lancki, D.2    Allison, J.P.3
  • 14
    • 0028174201 scopus 로고
    • -/- mice in the absence of TCR beta chain expression
    • -/- mice in the absence of TCR beta chain expression. Int Immunol 6:995, 1994
    • (1994) Int Immunol , vol.6 , pp. 995
    • Shinkai, Y.1    Alt, F.W.2
  • 16
    • 0023626468 scopus 로고
    • Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation
    • Denning SM, Tuck DT, Vollger LW, Springer TA, Singer KH, Haynes BF: Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation. J Immunol 139:2573, 1987
    • (1987) J Immunol , vol.139 , pp. 2573
    • Denning, S.M.1    Tuck, D.T.2    Vollger, L.W.3    Springer, T.A.4    Singer, K.H.5    Haynes, B.F.6
  • 17
    • 0023134395 scopus 로고
    • Thymocyte binding to human epithelial cells is inhibited by monoclonal antibodies to CD2 and LFA-3 antigens
    • Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH: Thymocyte binding to human epithelial cells is inhibited by monoclonal antibodies to CD2 and LFA-3 antigens. J Immunol 138:358, 1987
    • (1987) J Immunol , vol.138 , pp. 358
    • Vollger, L.W.1    Tuck, D.T.2    Springer, T.A.3    Haynes, B.F.4    Singer, K.H.5
  • 18
    • 0025093310 scopus 로고
    • Cellular expression of lymphocyte function associated antigens and the intercellular adhesion molecule-1 in normal tissue
    • Smith ME, Thomas JA: Cellular expression of lymphocyte function associated antigens and the intercellular adhesion molecule-1 in normal tissue. J Clin Pathol 43:893, 1990
    • (1990) J Clin Pathol , vol.43 , pp. 893
    • Smith, M.E.1    Thomas, J.A.2
  • 19
    • 0026463650 scopus 로고
    • Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells
    • Bell GM, Bolen J, Imboden JB: Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells. Mol Cell Biol 12:5548, 1992
    • (1992) Mol Cell Biol , vol.12 , pp. 5548
    • Bell, G.M.1    Bolen, J.2    Imboden, J.B.3
  • 20
    • 0029671265 scopus 로고    scopus 로고
    • The SH3 domain of p561ck binds to proline-rich sequences in the cytoplasmic domain of CD2
    • Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB: The SH3 domain of p561ck binds to proline-rich sequences in the cytoplasmic domain of CD2. J Exp Med 183:169, 1996
    • (1996) J Exp Med , vol.183 , pp. 169
    • Bell, G.M.1    Fargnoli, J.2    Bolen, J.B.3    Kish, L.4    Imboden, J.B.5
  • 21
    • 0026598252 scopus 로고
    • Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5
    • Beyers AD, Spruyt LL, Williams AF: Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc Natl Acad Sci USA 89:2945, 1992
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2945
    • Beyers, A.D.1    Spruyt, L.L.2    Williams, A.F.3
  • 22
    • 0027218372 scopus 로고
    • Physical association of the cytoplasmic domain of CD2 with the tyrosine kinase p56lck and p59fyn
    • Carmo AM, Mason DW, Beyers AD: Physical association of the cytoplasmic domain of CD2 with the tyrosine kinase p56lck and p59fyn. Eur J Immunol 23:2196, 1993
    • (1993) Eur J Immunol , vol.23 , pp. 2196
    • Carmo, A.M.1    Mason, D.W.2    Beyers, A.D.3
  • 23
    • 0028123627 scopus 로고
    • Identification of a signaling complex involving CD2, zeta chain and p59fyn in T lymphocytes
    • Gassman M, Amrein KE, Flint NA, Schraven B, Burn P: Identification of a signaling complex involving CD2, zeta chain and p59fyn in T lymphocytes. Eur J Immunol 24:139, 1994
    • (1994) Eur J Immunol , vol.24 , pp. 139
    • Gassman, M.1    Amrein, K.E.2    Flint, N.A.3    Schraven, B.4    Burn, P.5
  • 24
    • 0000820364 scopus 로고
    • Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure
    • Seed B, Aruffo A: Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc Natl Acad Sci USA 84:3365, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3365
    • Seed, B.1    Aruffo, A.2
  • 26
    • 0024314938 scopus 로고
    • The CD2 antigen associates with the T-cell antigen complex on the surface of human T lymphocytes
    • Brown MH, Cantrell DA, Brattsand G, Crumpton MJ, Gullberg M: The CD2 antigen associates with the T-cell antigen complex on the surface of human T lymphocytes. Nature 339:551, 1989
    • (1989) Nature , vol.339 , pp. 551
    • Brown, M.H.1    Cantrell, D.A.2    Brattsand, G.3    Crumpton, M.J.4    Gullberg, M.5
  • 27
    • 0024992623 scopus 로고
    • Human T cell clones with GAMMAdelta and alphabeta receptors are differentially stimulated by monoclonal antibodies to CD2
    • Pawelec G, Schaudt K, Rehbein A, Olive D, Buhring H-J: Human T cell clones with GAMMAdelta and alphabeta receptors are differentially stimulated by monoclonal antibodies to CD2. Cell Immunol 129:385, 1990
    • (1990) Cell Immunol , vol.129 , pp. 385
    • Pawelec, G.1    Schaudt, K.2    Rehbein, A.3    Olive, D.4    Buhring, H.-J.5
  • 28
    • 0025969455 scopus 로고
    • Selective activation of gammadelta+ T cell clones by single anti-CD2 antibodies
    • Wesselborg S, Janssen O, Pechhold K, Kabelitz D: Selective activation of gammadelta+ T cell clones by single anti-CD2 antibodies. J Exp Med 173:297, 1991
    • (1991) J Exp Med , vol.173 , pp. 297
    • Wesselborg, S.1    Janssen, O.2    Pechhold, K.3    Kabelitz, D.4
  • 32
    • 0028069390 scopus 로고
    • Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival
    • Qin L, Chavin KD, Lin J, Yagita H, Bromberg JS: Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J Exp Med 179:341, 1994
    • (1994) J Exp Med , vol.179 , pp. 341
    • Qin, L.1    Chavin, K.D.2    Lin, J.3    Yagita, H.4    Bromberg, J.S.5
  • 33
  • 34
    • 0029126574 scopus 로고
    • CD2 regulates responsiveness of activated T cells to interleukin 12
    • Gollob JA, Li J, Reinherz EL, Ritz J: CD2 regulates responsiveness of activated T cells to interleukin 12. J Exp Med 182:721, 1995
    • (1995) J Exp Med , vol.182 , pp. 721
    • Gollob, J.A.1    Li, J.2    Reinherz, E.L.3    Ritz, J.4
  • 36
    • 0026478567 scopus 로고
    • Development and function of T cells in mice with a disrupted CD2 gene
    • Killeen N, Stuart SG, Littman DR: Development and function of T cells in mice with a disrupted CD2 gene. EMBO J 11:4329, 1992
    • (1992) EMBO J , vol.11 , pp. 4329
    • Killeen, N.1    Stuart, S.G.2    Littman, D.R.3
  • 37
    • 0027376261 scopus 로고
    • CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus
    • Evans CF, Rail GF, Killeen N, Littman D, Oldstone MB: CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus. J Immunol 151:6259, 1993
    • (1993) J Immunol , vol.151 , pp. 6259
    • Evans, C.F.1    Rail, G.F.2    Killeen, N.3    Littman, D.4    Oldstone, M.B.5
  • 38
    • 0023813094 scopus 로고
    • Thymic major histocompatibility antigens and the αβ T cell receptor determine the CD4/CD8 phenotype of T cells
    • Teh H-S, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, von Boehmer H: Thymic major histocompatibility antigens and the αβ T cell receptor determine the CD4/CD8 phenotype of T cells. Nature (London) 335:229, 1988
    • (1988) Nature (London) , vol.335 , pp. 229
    • Teh, H.-S.1    Kisielow, P.2    Scott, B.3    Kishi, H.4    Uematsu, Y.5    Bluthmann, H.6    Von Boehmer, H.7
  • 39
  • 40
    • 0028332738 scopus 로고
    • Lymphocyte populations and immune responses in CD5-deficient mice
    • Tarakhovsky A, Muller W, Rajewsky K: Lymphocyte populations and immune responses in CD5-deficient mice. Eur J Immunol 24:1678, 1994
    • (1994) Eur J Immunol , vol.24 , pp. 1678
    • Tarakhovsky, A.1    Muller, W.2    Rajewsky, K.3
  • 41
    • 0025313515 scopus 로고
    • Normal development of mice deficient in β2-microglobulin, MHC class I proteins, and CD8+ T cells
    • Koller B, Marrack P, Kappler JW, Smithies O: Normal development of mice deficient in β2-microglobulin, MHC class I proteins, and CD8+ T cells. Science 248:1227, 1990
    • (1990) Science , vol.248 , pp. 1227
    • Koller, B.1    Marrack, P.2    Kappler, J.W.3    Smithies, O.4
  • 42
    • 0021814334 scopus 로고
    • Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor
    • Staerz UD, Rammensee HG, Benedetto JD, Bevan MJ: Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J Immunol 134:3994, 1985
    • (1985) J Immunol , vol.134 , pp. 3994
    • Staerz, U.D.1    Rammensee, H.G.2    Benedetto, J.D.3    Bevan, M.J.4
  • 43
    • 0005582090 scopus 로고
    • Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera
    • Kranz DM, Sherman DH, Sitkovsky MV, Pasternack MS, Eisen HN: Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera. Proc Natl Acad Sci USA 81:573, 1984
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 573
    • Kranz, D.M.1    Sherman, D.H.2    Sitkovsky, M.V.3    Pasternack, M.S.4    Eisen, H.N.5
  • 44
    • 0025524074 scopus 로고
    • Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice
    • Teh H-S, Kishi H, Scott B, Borgulya P, von Boehmer H, Kisielow P: Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice. Dev Immunol 1:1, 1990
    • (1990) Dev Immunol , vol.1 , pp. 1
    • Teh, H.-S.1    Kishi, H.2    Scott, B.3    Borgulya, P.4    Von Boehmer, H.5    Kisielow, P.6
  • 45
    • 0018082103 scopus 로고
    • Monoclonal xenogeneic antibodies to murine cell surface antigens: Identification of novel leukocyte differentiation antigens
    • Springer T, Galfrie G, Secher DS, Milstein C: Monoclonal xenogeneic antibodies to murine cell surface antigens: Identification of novel leukocyte differentiation antigens. Eur J Immunol 8:539, 1978
    • (1978) Eur J Immunol , vol.8 , pp. 539
    • Springer, T.1    Galfrie, G.2    Secher, D.S.3    Milstein, C.4
  • 46
    • 0023872192 scopus 로고
    • Establishment of cell lines which constitutively secrete large quantities of interleukin 2, 3, 4, or 5 using modified cDNA expression vectors
    • Karasuyama H, Melchers F: Establishment of cell lines which constitutively secrete large quantities of interleukin 2, 3, 4, or 5 using modified cDNA expression vectors. Eur J Immunol 19:97, 1988
    • (1988) Eur J Immunol , vol.19 , pp. 97
    • Karasuyama, H.1    Melchers, F.2
  • 48
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell clone. III. Further differences in Iymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monoclonal bioassays, and monoclonal anitbodies
    • Chernowski HM, Schumacher JH, Brown KD, Mosmann TR: Two types of mouse helper T cell clone. III. Further differences in Iymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monoclonal bioassays, and monoclonal anitbodies. J Exp Med 166:1229, 1987
    • (1987) J Exp Med , vol.166 , pp. 1229
    • Chernowski, H.M.1    Schumacher, J.H.2    Brown, K.D.3    Mosmann, T.R.4
  • 49
    • 0023683669 scopus 로고
    • Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
    • Kisielow P, Teh H-S, Bluthman H, von Boehmer H: Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730, 1988
    • (1988) Nature , vol.335 , pp. 730
    • Kisielow, P.1    Teh, H.-S.2    Bluthman, H.3    Von Boehmer, H.4
  • 50
    • 0026632418 scopus 로고
    • A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein
    • Udaka K, Tsomides TJ, Eisen HN: A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69:989, 1992
    • (1992) Cell , vol.69 , pp. 989
    • Udaka, K.1    Tsomides, T.J.2    Eisen, H.N.3
  • 51
    • 0027362645 scopus 로고
    • A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone
    • Udaka K, Tsomides TJ, Walden P, Fukusen N, Eisen HN: A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc Natl Acad Sci USA 90:11272, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11272
    • Udaka, K.1    Tsomides, T.J.2    Walden, P.3    Fukusen, N.4    Eisen, H.N.5
  • 53
    • 0028410566 scopus 로고
    • Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes
    • Sykulev Y, Brunmark A, Jackson M, Cohen RJ, Peterson PA, Eisen HN: Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity 1:15, 1994
    • (1994) Immunity , vol.1 , pp. 15
    • Sykulev, Y.1    Brunmark, A.2    Jackson, M.3    Cohen, R.J.4    Peterson, P.A.5    Eisen, H.N.6
  • 54
    • 0026607073 scopus 로고
    • CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice
    • Lee NA, Loh DY, Lacy E: CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice. J Exp Med 175:1013, 1992
    • (1992) J Exp Med , vol.175 , pp. 1013
    • Lee, N.A.1    Loh, D.Y.2    Lacy, E.3
  • 56
    • 0028930772 scopus 로고
    • Distinct differentiative stages of CD4+CD8+ thymocyte development defined by lack of coreceptor binding in positive selection
    • Dutz JP, Ong CJ, Marth JD, Teh H-S: Distinct differentiative stages of CD4+CD8+ thymocyte development defined by lack of coreceptor binding in positive selection. J Immunol 154:2588, 1995
    • (1995) J Immunol , vol.154 , pp. 2588
    • Dutz, J.P.1    Ong, C.J.2    Marth, J.D.3    Teh, H.-S.4
  • 57
    • 0026078307 scopus 로고
    • Development of the CD4 and CD8 lineage of T cells: Instruction versus selection
    • Borgulya P, Kishi H, Muller U, Kirberg J, Gray C, von Boehmer H: Development of the CD4 and CD8 lineage of T cells: Instruction versus selection. EMBO J 10:913, 1991
    • (1991) EMBO J , vol.10 , pp. 913
    • Borgulya, P.1    Kishi, H.2    Muller, U.3    Kirberg, J.4    Gray, C.5    Von Boehmer, H.6
  • 58
    • 0026707755 scopus 로고
    • Phenotypic changes accompanying positive selection of CD4+ CD8+ thymocytes
    • Swat W, Dessing M, Baron A, Kisielow P, von Boehmer H: Phenotypic changes accompanying positive selection of CD4+ CD8+ thymocytes. Eur J Immunol 22:2367, 1992
    • (1992) Eur J Immunol , vol.22 , pp. 2367
    • Swat, W.1    Dessing, M.2    Baron, A.3    Kisielow, P.4    Von Boehmer, H.5
  • 60
    • 0023900635 scopus 로고
    • Tolerance in T cell receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
    • Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von Boehmer H: Tolerance in T cell receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333:742, 1988
    • (1988) Nature , vol.333 , pp. 742
    • Kisielow, P.1    Bluthmann, H.2    Staerz, U.D.3    Steinmetz, M.4    Von Boehmer, H.5
  • 61
    • 0023933596 scopus 로고
    • Antigen as a positive and negative regulator of proliferation in cytotoxic lymphocytes. A model for the differential regulation of proliferation and lytic activity
    • Russell JH, Manning DE, McCulley DE, Meleedy-Rey P: Antigen as a positive and negative regulator of proliferation in cytotoxic lymphocytes. A model for the differential regulation of proliferation and lytic activity. J Immunol 140:1796, 1988
    • (1988) J Immunol , vol.140 , pp. 1796
    • Russell, J.H.1    Manning, D.E.2    McCulley, D.E.3    Meleedy-Rey, P.4
  • 62
    • 0026682592 scopus 로고
    • Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but for in vivo protection
    • Speiser DE, Kyburz D, Stubi U, Hengartner H, Zinkernagel RM: Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but for in vivo protection. J Immunol 149:972, 1992
    • (1992) J Immunol , vol.149 , pp. 972
    • Speiser, D.E.1    Kyburz, D.2    Stubi, U.3    Hengartner, H.4    Zinkernagel, R.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.