Improvement of L-DOPA absorption by dipeptidyl derivation, utilizing peptide transporter PepT1

Journal of Pharmaceutical Sciences

Volumn 87, Issue 12, 1998, Pages 1542-1546

  Tamai, I ^a   Nakanishi, T ^a   Nakahara, H ^a   Sai, Y ^a   Ganapathy, V ^a   Leibach, F H ^a   Tsuji, A ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE; DOPAMINE; LEVODOPA;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; DRUG ABSORPTION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; XENOPUS LAEVIS;

EID: 0031773397     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980186o     Document Type: Article

References (34)

1. D.N. Wade P.T. Mearrick J.L. Morris Active transport of L-DOPA in the intestine Nature 242 1973 463 465
2. K. Sasahara T. Nitani T. Habara T. Morioka E. Nakajima Dosage form design for improvement of bioavailability of levodopa II: Bioavailability of marked levodopa preparations in dogs and parkinsonian patients J. Pharm. Sci. 69 1980 261 265
3. K. Nishimura K. Sasahara M. Arai T. Nitani Y. Ikegami T. Morioka E. Nakajima Dosage form design for improvement of bioavailability of levodopa II: Fornulation of effervescent enteric-coated tablets J. Pharm. Sci. 73 1984 942 946
4. U.R. Gundert R. Hildebrandt A. Stiehl E. Weber G. Zurcher M.D. Prada Intestinal absorption of Levodopa in man Eur. J. Clin. Pharmacol. 25 1983 69 72
5. B.G. Munck Physiology of the Gastrointestinal Tract Johnson L.R. 1985 Raven Press New York 1097
6. D.M. Matthews I.L. Craft D.M. Geddes I.J. Wise C.W. Hyde Absorption of glycine and glycine peptides from the small intestine of the rat Clin. Sci. 35 1968 415 424
7. D.M. Matthews M.T. Lis B. Cheng R.F. Crampton Observations on the intestinal absorption of some oligopep-tides of methionine and glycine in the rat Clin. Sci. 37 1969 751 764
8. D. Burston J.M. Addison D.M. Matthews Uptake of dipeptides containing basic and acidic amino acids by rat small intestine in vitro Clin. Sci. 43 1972 823 837
9. Y.J. Fei Y. Kanai S. Nussberger V. Ganapathy F.H. Leibach M.F. Romero S.K. Singh W.F. Boron M.A. Hediger Expression cloning of a mammalian proton-coupled oligopeptide transporter Nature 368 1994 563 566
10. R. Liang Y.J. Fei P.D. Prasad S. Ramamoorthy H. Han T.L. Yang-Feng M.A. Hediger V. Ganapathy F.H. Leiback Human intestinal H+/peptide cotransporter J. Biol. Chem. 270 1995 6436 6456
11. K. Miyamoto T. Shiraga K. Morita H. Yamamoto H. Haga Y. Taketani I. Tamai Y. Sai A. Tsuji E. Takeda. Sequence, tissue distribution and developmental change in rat intestinal oligopeptide transporter Biochim. Biophys. Acta 1305 1996 34 38
12. H. Saito M. Okuda T. Terada S. Sasaki K. Inui Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney J. Pharmcol. Exp. Ther. 275 1995 1631 1637
13. I. Tamai T. Nakanishi K. Hayashi T. Terao Y. Sai T. Shiraga K. Miyamoto E. Takeda H. Higashida A. Tsuji The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of β - lactam antibiotics in the rat small intestine J. Pharm. Pharmacol. 49 1997 796 801
14. H. Saito K. Inui. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2 Am. J. Physiol. 265 1993 G289 G294
15. M. Hu G.L. Amidon Passive and carrier-mediated intestinal absorption components of captopril J. Pharm. Sci. 77 1988 1007 1011
16. E. Nakashima A. Tsuji H. Mizuho T. Yamana Kinetics and mechanism of in vitro uptake of amino-beta-lactam antibiotics by rat small intestine and relation to the intact-peptide transport system Biochem. Pharmacol. 33 1984 3345 3352
17. A. Tsuji Tamai. I. Carrier-mediated intestinal transport of drugs Pharm. Res. 13 1996 963 977
18. I. Tamai N. Tomizawa T. Takeuchi K. Nakayama H. Higashida A. Tsuji Functional expression of transporter for β -lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines J. Pharmacol. Exp. Ther. 273 1995 26 31
19. J.P.F. Bai G.L.S. Amidon Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery Pharm. Res. 9 1992 969 978
20. A. Tsuji I. Tamai M. Nakanishi G.L. Amidon Mechanism of absorption of the dipeptide R-methyldopa-phe in intestinal brush-border membrane vesicles Pharm. Res. 7 1990 308 309
21. H.P. Wang H.H. Lu J.S. Lee C.Y. Cheng J.R. Mah C.Y. Ku W. Hsu C.F. Yen C.J. Lin H.S. Kuo Intestinal absorption studies on peptide mimetic R-methyldopa prodrug J. Pharm. Pharmacol. 48 1996 270 276
22. J. Fogh J.M. Fogh T. Orfeo One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice J. Natl. Cancer Inst. 59 1977 221 226
23. P. Artursson J. Karlsson Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells Biochem. Biophys. Res. Commun. 175 1991 880 885
24. A. Tsuji H. Takanaga I. Tamai T. Terasaki Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism Pharm. Res. 11 1994 30 37
25. O.H. Lowry N.J. Rosebrough A.L. Farr R.J. Randall. Protein measurement with the folin phenol reagent J. Biol. Chem. 93 1951 265 275
26. M.D. Hellier C.D. Holdsworth I. Mccoll D. Perrett. Dipeptide absorption in man Gut 13 1972 965 969
27. D.B.A. Silk D. Perrett J.P.W. Webb M.L. Clark Absorption of two tripeptides by the human small intestine: A study using a perfusion technique Clin. Sci. Mol. Med. 46 1974 393 402
28. M.T. Lis R.F. Crampton D.M. Matthews Rates of absorption of a dipeptide and the equivalent free amino acid in various mammalian species Biochim. Biophys. Acta 206 1972 592 594
29. M. Hu R.T. Borchardt Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine Biochim. Biophys. Acta 1135 1992 233 244
30. U.R. Gundert R. Hildebrandt A. Stiehl E. Weber G. Zurcher M.D. Prada Intestinal absorption of Levodopa in man Eur. J. Pharmacol. 25 1983 69 72
31. A.M. Asatoor A. Chadha M.D. Milne D.I. Prosser. Intestinal absorption of stereoisomers of dipeptides in the rat Clin. Sci. Mol. Med. 42 1973 199 212
32. Y. Sai I. Tamai H. Sumikawa K. Hayashi T. Nakanishi O. Amano M. Numata S. Iseki A. Tsuji Immunolo-calization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β -lactam antibiotics FEBS Lett. 382 1996 25 29
33. H. Ogihara H. Saito B.C. Shin T. Terada S. Takenoshita Y. Nagamachi K. Inui K. Takata Immuno-localization of H+/peptide cotransporter in rat digestive tract Biochem. Biophys. Res. Commun. 220 1996 848 852
34. J. Dyer R.B. Beechey J.P. Gorvel R.T. Smith R. Wootton S.P.S. Shirazi-Beechey Glycyl-L-proline transport in rabbit enterocyte basolateral-membrane vesicles Biochem. J. 269 1990 565 571