Transport of the antiviral nucleoside analogs 3'-azido-3'- deoxythymidine and 2',3'-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes

Molecular Pharmacology

Volumn 50, Issue 2, 1996, Pages 388-393

  Yao, Sylvia Y M ^a,c   Cass, Carol E ^a   Young, James D ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ALBERTA ENVIRONMENT AND PARKS   (Canada)

^c Croucher Foundation   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; URIDINE; ZALCITABINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE TRANSPORT; DRUG ABSORPTION; DRUG PROTEIN BINDING; DRUG UPTAKE; GENETIC RECOMBINATION; INTESTINE ABSORPTION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTESTINAL ABSORPTION; MEMBRANE PROTEINS; NUCLEOSIDE TRANSPORT PROTEINS; PROBENECID; RATS; RECOMBINANT PROTEINS; URIDINE; XENOPUS LAEVIS; ZALCITABINE; ZIDOVUDINE;

EID: 0029812857     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Cass, C. E. Nucleoside transport, in Drug Transport in Antimicrobial and Anticancer Chemotherapy (N. H. Georgopapadakou, ed.). Marcel Dekker, New York, 403-451 (1995).
2. +-independent, facilitated transport of formycin B in mouse spleen lymphocytes. Biochim. Biophys. Acta 1022:93-102 (1990). .
3. Crawford, C. R., C. Y. C. Ng, D. Noel, and J. A. Belt. Nucleoside transport in L1210 murine leukemia cells. J. Biol. Chem. 265:9732-9736 (1990).
4. Dagnino, L., L. J. Bennett, and A. R. P. Paterson. Substrate specificity, kinetics, and stoichiometry of sodium-dependent adenosine transport in L1210/AM mouse leukemia cells. J. Biol. Chem. 266:6312-6317 (1991).
5. 1 mutant deficient in facilitated nucleoside transport. J. Cell. Biochem. 46:54-59 (1991).
6. +-dependent, concentrative nucleoside transport in rat macrophages: specificity for natural nucleosides and nucleoside analogs, including dideoxynucleosides, and comparison of nucleoside transport in rat, mouse and human macrophages. Biochem. Pharmacol. 42:247-252 (1991).
7. Roden, M., A. R. P. Paterson, and K. Turnheim. Sodium-dependent nucleoside transport in rabbit intestinal epithelium. Gastroenterology 100: 1553-1562 (1991).
8. Williams, T. C., and S. M. Jarvis. Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles. Biochem. J. 274:27-33 (1991).
9. +-dependent nucleoside transport in human myeloid leukemia cell lines and freshly isolated myeloblasts. Proc. Amer. Assoc. Cancer Res. 33:20 (1992).
10. Che, M., T. Nishida, Z. Gatmaitan, and I. M. Arias. A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane. J. Biol. Chem. 267:9684-9688 (1992).
11. + dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis: demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second novel system N3 having board specificity for purine and pyrimidine nucleosides. J. Biol. Chem. 268:20613-20619 (1993).
12. Wu, X., M. M. Gutierrez, and K. M. Giacomini. Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. Biochim. Biophys. Acta 1191:190-196 (1994).
13. Brett, C. M., C. B. Washington, R. J. Ott, M. M. Gutierrez, and K. M. Giacomini. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharm. Res. 10:423-426 (1993).
14. Clumeck, N. Current use of anti-HIV drugs in AIDS. J. Antimicrobiol. Chemother. 32 (Suppl. A):133-138 (1993).
15. Klecker, R. W., Jr., J. M. Collins, R. Yarchoan, R. Thomas, J. F. Jenkins, and S. Broder. Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clin. Pharmacol. Ther. 41:407-412 (1987).
16. Yarchoan, R., H. Mitsuya, C. E. Myers, and S. Broder. Clinical pharmacology of 3′-azido-2′,3′-dideoxythymidine (zidovudine) and related dideoxynucleosides. N. Engl. J. Med. 321:726-738 (1989).
17. Melvin, G. C., S. R. Ellison, C. M. Monk, and T. R. Bates. Existence of a flip-flop kinetic model for zidovudine (AZT) after oral administration. Res. Commun. Chem. Pathol. Pharmacol. 70:193-204 (1990).
18. Park, G. B., and A. K. Mitra. Mechanism and site dependency of intestinal mucosal transport and metabolism of thymidine analogs. Pharmaceut. Res. 9:326-331 (1992).
19. Good, S. S., C. S. Koble, R. Crouch, R. L. Johnson, J. L. Rideout, and P. De Miranda. Isolation and characterisation of an ether glucuronide of zidovudine, a major metabolite in monkeys and humans. Drug Metab. Dispos. 18:321-326 (1990).
20. Furman, P. A., J. A. Fyfe, M. H. St. Clair, K. Weinhold, J. L. Rideout, G. A. Freeman, S. N. Lehrman, D. P. Bolognesi, S. Broder, H. Mitsuya, and D. W. Barry. Phosphorylation of 3′-azido-3′deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA 83:8333-8337 (1986).
21. Barry, M., M. Wild, G. Veal, D. Back, A. Breckenridge, R. Fox, N. Beeching, F. Nye, P. Carey, and D. Timmins. Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers. AIDS 8:F1-F5 (1994).
22. Cheng, Y. C., G. E. Dutschman, K. F. Bastow, M. G. Sarngadharan, and R. Y. C. Ting. Human immunodeficiency virus reverse transcriptase: general properties and its interactions with nucleoside triphosphate analogs. J. Biol. Chem. 262:2187-2189 (1987).
23. Fischl, M. A., D. D. Richman, M. H. Grieco, M. S. Gottlieb, P. A. Volberding, R. T. Schooley, G. G. Jackson, D. T. Durack, D. King, and the AZT Collaborative Working Group. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N. Engl. J. Med. 317:185-191 (1987).
24. Fischl, M. A., D. D. Richman, D. M. Causey, M. H. Grieco, Y. Bryson, D. Mildwan, O. L. Laskin, J. E. Groopmam, P. A. Volarking, R. T. Achooley, and the AZT Collaborative Working Group. Prolonged zidovudine therapy in patients with AIDS and advanced AIDS-related complex. JAMA 262: 2405-2410 (1989).
25. Langtry, H. D., and D. M. Campoli-Richards. Zidovudine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 37:408-450 (1989).
26. Zimmerman, T. P., W. B. Mahony, and K. L. Prus. 3′-Azido-3′-deoxythymidine, an unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by non-facilitated diffusion. J. Biol. Chem. 262:5748-5754 (1987).
27. Chan, T. C. K., G. D. Boon, L. Shaffer, and R. Redmond. Antiviral nucleoside toxicity in canine bone marrow progenitor cells and its relationship to drug permeation. Eur. J. Haematol. 49:71-76 (1992).
28. Chan, T. C. K., L. Shapper, R. Redmond, and K. L. Pennington. Permeation and metabolism of anti-HIV and endogenous nucleosides in human immune effector cells. Biochem. Pharmacol. 46:273-278 (1993).
29. Ullman, B., T. Coons, S. Rockwell, and K. McCartan. Genetic analysis of 2′,3′-dideoxycytidine incorporation into cultured human T lymphoblasts. J. Biol. Chem. 263:12391-12396 (1988).
30. Plagemann, P. G. W., and C. Woffendin. Dideoxycytidine permeation and salvage by mouse leukemia cells and human erythrocytes. Biochem. Pharmacol. 38:3469-3475 (1989).
31. Domin, B. A., W. B. Mahony, and T. P. Zimmerman. Membrane permeation mechanisms of 2′,3′-dideoxynucleosides. Biochem. Pharmacol. 46: 725-729 (1993).
32. Huang, Q. Q., S. Y. M. Yao, M. W. L. Ritzel, A. R. P. Paterson, C. E. Cass, and J. D. Young. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J. Biol. Chem. 269:17757-17760 (1994).
33. Craig, J. E., Y. Zhang, and M. P. Gallagher. Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS186. Mol. Microbiol. 11:1159-1168 (1994).
34. +/nucleoside cotransporter: a member of the SGLT family. J. Biol. Chem. 267:3557-3560 (1992).
35. Pajor, A. M. Molecular cloning and expression of SNST1, a renal sodium/ nucleoside cotransporter. Drug Dev. Res. 31:305 (1994).
36. +-nucleoside cotransporter. J. Biol. Chem. 270:13596-13599 (1995).
37. + dependent transport system of rabbit small intestine: studies with mRNA-injected Xenopus laevis oocytes. Biol. Pharm. Bull. 16:493-496 (1993).
38. Wong, S. L., K. Van Belle, and R. J. Sawchuk. Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/ cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis. J. Pharmacol. Exp. Ther. 264:899-909 (1993).
39. Gati, W. P., H. K. Misra, E. E. Knaus, and L. I. Wiebe. Structural modifications at the 2′- and 3′-positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter. Biochem. Pharmacol. 33:3325-3331 (1984).
40. Patel, B. A., C. K. Chu, and F. D. Boudinot. Pharmacokinetics and saturable renal tubular secretion of zidovudine in rats. J. Pharm. Sci. 78:530-534 (1988).