Estradiol 17ß-D-glucuronide is a high-affinity substrate for oatp organic anion transporter

American Journal of Physiology

Volumn 270, Issue 2 PART 2, 1996, Pages

  Kanai, Naoaki ^a   Lu, Run ^a   Bao, Y I ^a   Wolkoff, Allan W ^a   Vore, Mary ^a   Schuster, Victor L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Bile salts; Estrogens; Glucuronosyltransferase; Kidney; Liver; Organic anion transport; Steroid hormones

Indexed keywords

ADENOSINE TRIPHOSPHATE; ESTRADIOL 17 GLUCURONIDE; GLUCURONOSYLTRANSFERASE; STEROID HORMONE;

ACTIVE TRANSPORT; ANIMAL CELL; ANION TRANSPORT; ARTICLE; CELL MEMBRANE PERMEABILITY; CITRIC ACID CYCLE; ENZYME SUBSTRATE; GLUCURONIDATION; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SIGNAL NOISE RATIO; STEROID METABOLISM; SULFATION;

ANION TRANSPORT PROTEINS; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; ESTRADIOL; HELA CELLS; HORMONES; HUMANS; STEROIDS; SUBSTRATE SPECIFICITY; SULFOBROMOPHTHALEIN; TAUROCHOLIC ACID;

EID: 0029876335     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Barnes, S., J. L. Gollan, and B. H. Billings. The role of tubular reabsorption in the renal excretion of bile acids. Biochem. J. 166: 65-73, 1977.
2. Bergwerk, A., X.-Y. Shi, A. C. Ford, E. Jacquemin, R. D. Burk, S. Bai, P. M. Novikoff, B. Stieger, P. J. Meier, and A. W. Wolkoff. Immunological distribution of an organic aniona transport protein (oatp) in rat liver and kidney (Abstract). Hepatology 20: 205, 1994.
3. Brown, C. H., B. D. Saffan, C. M. Howard, and J. R. K. Preedy. The renal clearance of endogenous estrogens in late pregnancy. J. Clin. Invest. 43: 295-303, 1964.
4. Chaudhuri, G., C. Verbeugen, W. M. Pardridge, and H. L. Judd. Selective availability of protein bound estrogen and estrogen conjugates to the rat kidney. J. Endocrinol. Invest. 10: 283-290, 1987.
5. Chowdhury, J. R., P. M. Novikoff, N. R. Chowdhury, and A. B. Novikoff. Distribution of UDP-glucuronosyltransferase in rat tissue. Proc. Natl. Acad. Sci. USA 82: 2990-2994, 1985.
6. Coughtrie, M. W. H., B. Burchell, and J. R. Bend. Purification and properties of rat kidney UDP-glucuronosyltransferase. Biocliem. Pharmaml. 36: 245-251, 1987.
7. Durham, S., and M. Vore. Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver. J. Pharmacol. Exp. Then 237: 490-495, 1986.
8. Essig, A., and J. V. Taggart. Competitive inhibition of renal transport of p-aminohippurate by other mono-substituted hippurates.Am. J. Physiol. 199: 509-512, 1960.
9. Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. Eukaryotic transient expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83: 8122-8126, 1986.
10. Gower, D. B., and J. W. Honour. Steroid catabolism and urinary excretion; biliary excretion and enterohepatic circulation. In: Biochemistry of Steroid Hormones (2nd ed.), edited by H. L. J. Makin. Oxford, UK: Blackwell Scientific, 1984, p. 349-408.
11. Hobkirk, R. Steroid sulfation. Current concepts. Trends Endocrinol. Metab. 4: 69-74, 1993.
12. Hobkirk, R., R. N. Green, M. Nilsen, and B. A. Jennings. Formation of estrogen glucosiduronates by human kidney homogenates. Can. J. Biochem. 52: 9-14, 1974.
13. Hobkirk, R., and M. Nilsen. Early urinary conjugated metabolites of intravenously injected (6,7-3H)-estradiol-17ß in the human subject. J. Steroid Biochem. 5: 15-20, 1974.
14. Honjo, H., N. R. Barua, Y. Osawa, R. Y. Kirdani, and A. A. Sandberg. Studies on phenolic studies in human subjects. XX. In vivo conjugation and metabolism of estradiol-17ß in the human kidney. J. Clin. Endocrinol. Metab. 43: 1294-1300, 1976.
15. Jacquemin, E., B. Hagenbuch, B. Stieger, A. W. Wolkoff, and P. J. Meier. Expression cloning of a rat liver Na ' independent organic anion transporter. Proc. Natl. Acad. Sci. C7SA91: 133-137, 1994.
16. Kanai, N., R. Lu, Y. Bao, A. W. Wolkoff, and V. L. Schuster. Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am. J. Physiol. 270 (Renal Fluid Electrolyte Physiol. 39): F319-F325, 1996.
17. Kanai, N., R. Lu, J. Satriano, Y. Bao, A. W. Wolkoff, and V. L. Schuster. Identification and characterization of a prostaglandin transporter. Science Wash. DC 268: 866-869, 1995.
18. Kanai, N., A. W. Wolkoff, R. Lu, Y. Bao, P. Novikoff, and V. L. Schuster. Organic anion transporting polypeptide (oatp): local-ization to the S3 segment and identification of anionic steroids as substrates (Abstract). J. Am. Soc. Nephrol. 5: 311, 1994.
19. Kurisu, H., P. Nilprabhassorn, and A. W. Wolkoff. Preparation of [35S]sulfobromophthalein of high specific activity. Anal. Biochem. 179: 72-74, 1989.
20. Lu, R., N. Kanai, Y. Bao, A. W. Wolkoff, and V. L. Schuster. Regulation of renal oatp mRNA expression by testosterone. Am. J. Physiol. 270 (Renal Fluid Electrolyte Phvsiol. 39): F332F337, 1996.
21. Mackenzie, P. I., L. Rodbourne, and S. Stranks. Steroid UDP glucuronosyltransferases. J. Steroid Biochem. Mol. Biol. 43: 1099-1105, 1992.
22. Makin, H. L. J. Biochemistry of Steroid Hormones. Oxford, UK: Blackwell Scientific, 1984.
23. Mellor, J. D., and R. Hobkirk. In vitro synthesis of estrogen glucuronides and sulfates by human renal tissue. Can. J. Biochem. 53: 779-783, 1975.
24. Meyers, M., W. Slikker, G. Pascoe, and M. Vore. Characterization of cholestasis induced by estradiol-17ß-D-glucuronide in the rat. J. Pharmacol. Exp. Ther. 214: 87-93, 1980.
25. Moore, A. B., G. D. Bottoms, G. L. Coppoc, R. C. Pohland, and O. F. Roesel. Metabolism of estrogens in the gastrointestinal tract of swine. I. Instilled estradiol. J. Anim. Sci. 55: 124-134, 1982.
26. Neame, K. D., and T. G. Richards. Elementary Kinetics of Membrane Carrier Transport. New York: Wiley, 1972, p. 120.
27. Paigen, K. Mammalian ß-glucuronidase: genetics, molecular biology, and cell biology. Prog. Nucleic Acid Res. Mol. Biol. 37: 155-205, 1989.
28. Scharl, A., M. W. Beckmann, J. E. Artwohl, S. Kullander, and J. A. Holt. Rapid liver metabolism, urinary and biliary excretion, and enterohepatic circulation of 16-radioiodo-17ßestradiol. Int. J. Radiât. Oncol. Biol. Phys. 21: 1235-1240, 1991.
29. Ullrich, K. J., and G. Rumrich. Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions. Am. J. Physiol. 254 (Renal Fluid Electrolyte Physiol. 23): F453-F462, 1988.
30. UHrich, K. J., G. Rumrich, F. Papavassiliou, and K. Hierholzer. Contralateral p-aminohippurate transport in the proximal tubule of the rat kidney. VIII. Transport of corticosteroids. Pfluegers Arch. 418: 371-382, 1991.
31. Vore, M., and T. Hoffman. Carrier-mediated electrogenic transport of estradiol-17ß-glucuronide in rat liver BMV. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G546-G551, 1994.
32. Weiner, I. M., J. E. Glasser, and L. Lack. Renal excretion of bile acids: taurocholic, glycocholic, and cholic acids. Am. J. Physiol. 207: 964-970, 1964.
33. Wilson, F. A., G. Burckhardt, H. Murer, G. Rumrich, and K. J. Ullrich. Sodium-coupled taurocholate transport in the proximal convolution of the rat kidney in vivo and in vitro. J. Clin. Invest. 67: 1141-1150, 1981.
34. Wong, M. H., P. Oelkers, A. L. Craddock, and P. A. Dawson. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J. Biol. Chem. 269: 1340-1347, 1994.