Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 575-581

  Akhteruzzaman, Sharif ^a   Kato, Yukio ^a   Hisaka, Akihiro ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BQ 518; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO THIANYLGLYCYLLEUCYL); CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN RECEPTOR ANTAGONIST; PERHYDRO 1 AZEPINYLCARBONYLLEUCYL DEXTRO TRYPTOPHYL DEXTRO TRYPTOPHAN; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; DRUG PROTEIN BINDING; DRUG UPTAKE; HYPERBILIRUBINEMIA; INTRAHEPATIC BILE DUCT; MALE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANION TRANSPORT PROTEINS; AZEPINES; BILE CANALICULI; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; DRUG INTERACTIONS; ETHERS; HYDROCARBONS, FLUORINATED; HYPERBILIRUBINEMIA; KINETICS; LIVER; MALE; MEMBRANES; OLIGOPEPTIDES; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; TRITIUM;

EID: 0033028288     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bertrams A and Ziegler K (1991) New substrates of multispecific bile acid transporter in liver cells: Interference of some linear renin inhibiting peptides with transport protein(s) for bile acids. Biochim Biophys Acta 1073:213-220.
2. Bohme M, Buchler M, Muller M and Keppler D (1993) Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane. FEBS Lett 333:193-196.
3. Cathapermal SM, Foegh ML, Rau CS and Ramwell PW (1991) Disposition and tissue distribution of angiopeptin in the rat. Drug Metab Dispos 19:735-739.
4. Chan L, Chittanandan A, Shapiro JI, Shanley PF and Schreir R (1994) Effect of endothelin-receptor antagonist on ischemic acute renal failure. Am J Physiol 266:F135-F138.
5. Chu X, Kate Y, Niinuma K, Sudo K, Hakusui H and Sugiyama Y (1997a) Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J Pharmacol Exp Ther 281:304-314.
6. Chu X, Kato Y and Sugiyama Y (1997b) Multiplicity of biliary excretion mechanisms for irinotecan CPT-11 and its metabolites in rate. Cancer Res 57:1934-1938.
7. Doherty AM (1992) Endothelin: A new challenge. J Med Chem 35:1493-1508.
8. Greenfield JC, Cook KJ and O'Leary IA (1989) Disposition, metabolism and excretion of U-71038, a novel renin inhibitor peptide in the rat. Drug Metab Dispos 17:518-525.
9. Gupta E, Safa AR, Wang X and Ratain MJ (1996) Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A. Cancer Res 56:1309-1314.
10. A) antagonist isolated from Streptomyces misakiensis. Biochem Biophys Res Commun 178:132-137.
11. Ishikawa T (1992) The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 17:463-468.
12. Kato Y, Akhteruzzaman S, Hisaka A and Sugiyama Y (1999) Hepatobiliary transport governs overall elimination of peptidic endothelia antagonists in rats. J Pharmacol Exp Ther 288:568-574.
13. Kobayashi K, Sogamo Y, Hara H and Hayashi K (1990) Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J Biol Chem 265:7737-7741.
14. Kojiri K, Ihara M, Nakajima S, Kawamura K, Funaishi K, Yano M and Suda H (1991) Endothelin binding inhibitors BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation, and characterization. J Antibiot 44:1342-1347.
15. Lemaire M, Azria M, Dannecker R, Marbach P, Schweitzer A and Maurer G (1989) Disposition of sandostatin, a new synthetic somatostatin analogue, in rats. Drug Metab Dispos 17:699-703.
16. Mino N, Kobayashi M, Nakajima H, Amano K, Ishikawa K, Watanabe K, Nihsikibe M, Yano M and Ikemoto F (1992) Protective effect of a selective endothelin receptor antagonist BQ-123 in ischemic acute renal failure in rats. Eur J Pharmacol 221:77-83.
17. Müller M and Jansen PL (1997) Molecular aspects of hepatobiliary transport. Am J Physiol 272:G1285-G1303.
18. Nakamura T, Hisaka A, Sawasaki Y, Suzuki Y, Ishikawa K, Yano M and Sugiyama Y (1996) Carrier mediated active transport of BQ-123, a peptidic endothelin antagonist into rat hepatocytes. J Pharmacol Exp Ther 278:564-572.
19. Niinuma K, Takenaka O, Horie T, Kobayashi K, Kato Y, Suzuki H and Sugiyama Y (1997) Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicuiar membrane: Comparative study of S-(24-dinitrophenyl)-glutathione and 6-hydroxy-57-dimethyl-2-methylamino-4-(3-pvridylmethyl) benzothiazole glucuronide. J Pharmacol Exp Ther 282:866-872.
20. - stimulated hydrolysis of adenosine triphosphate. Eur J Biochem 1:334-343.
21. Shin H, Kato Y, Shitara Y, Yamada T, Nakamura T, Hisaka A and Sugiyama Y (1996) The endothelin receptor is a major determinant for the nonlinear tissue distribution of the endothelin antagonist BQ-123. J Pharmacol Exp Ther 278:607-613.
22. Shin H, Kato Y, Yamada T, Niinuma K, Hisaka A and Sugiyama Y (1997) Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123. Am J Physiol 272:G979-G986.
23. Takahashi H, Kim RB, Perry PR and Wilkinson GR (1997) Characterization of the hepatic canalicular membrane transport of a model oligopeptide: Ditekiren. J Pharmacol Exp Ther 281:297-303.
24. Terasaki T, Mizukuchi H, Itoho C, Tamai I, Lemaire M and Tsuji A (1995) Hepatic uptake of octreotide, a long-acting somatostatin analogue, via a bile acid transport system. Pharm Res 12:11-16.
25. Yachi K, Sugiyama Y, Sawada Y, Iga T, Ikeda Y, Toda G and Hanano M (1989) Characterization of rose bengal binding to sinusoidal and canalicular membrane from rat liver. Biochim Biophys Acta 978:1-7.
26. Yamada T, Niinuma K, Lemaire M, Terasaki T and Sugiyama Y (1996) Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide. J Pharmacol Exp Ther 279:1357-1364.
27. Yamaoka K, Tanigawara Y, Nakagawa T and Uno T (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobio-Dyn 4:879-885.
28. Yamazaki M, Suzuki H and Sugiyama Y (1996) Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm Res 13:497-513.
29. Yanagisawa M and Masaki T (1989) Molecular biology and biochemistry of the endothelins. TiPS 10:374-378.
30. Ziegler K, Frimmer M, Kessler H and Haupt A (1988) Azidobenzodiamido-008, a new photosensitive substrate for the 'multispecific bile acid transporter' of hepatocytes: Evidence for a common transport system for bile acids and cyclosomatostatins in basolateral membranes. Biochim Biophys Acta 945:263-272.
31. Ziegler K, Kolac C and Ising W (1994) ATP-dependent transport of the linear renin-inhibiting peptide EMD-51921 by canalicular plasma membrane vesicles of rat liver: evidence of drug-stimulatable ATP-hydrolysis. Biochim Biophys Acta 1196:209-217.
32. Ziegler K, Lins W and Frimmer M (1991) Hepatocellular uptake of cyclosomatostatins: Evidence for a carrier system related to the multispecific bile acid transporter. Biochim Biophys Acta 1061:287-296.