메뉴 건너뛰기




Volumn 15, Issue 4, 1998, Pages 203-211

Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine

Author keywords

Adenosine; Human intestine; Na+ cotransport; Nucleoside transport; Uridine; Xenopus oocyte

Indexed keywords

ADENOSINE; CARRIER PROTEIN; COMPLEMENTARY DNA; DEOXYADENOSINE; DNA; MESSENGER RNA; PURINE NUCLEOSIDE; RECOMBINANT PROTEIN; SODIUM ION; URIDINE;

EID: 0032467105     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.3109/09687689709044322     Document Type: Article
Times cited : (181)

References (56)
  • 1
    • 0030447261 scopus 로고    scopus 로고
    • Demonstration of the existance of mRNAs encoding N1/cif and N2/cif sodium/nucleoside cotransporters in rat brain
    • Anderson, C. M., Xiong, W., Young, J. D., Cass, C. E. and Parkinson, F. E., 1996, Demonstration of the existance of mRNAs encoding N1/cif and N2/cif sodium/nucleoside cotransporters in rat brain. Molecular Brain Research, 42, 358-361.
    • (1996) Molecular Brain Research , vol.42 , pp. 358-361
    • Anderson, C.M.1    Xiong, W.2    Young, J.D.3    Cass, C.E.4    Parkinson, F.E.5
  • 3
    • 0002256990 scopus 로고
    • +-dependent nucleoside transport in human myeloid leukemia cell lines and freshly isolated myeloblasts
    • +-dependent nucleoside transport in human myeloid leukemia cell lines and freshly isolated myeloblasts. Cancer Research, 33, 20.
    • (1993) Cancer Research , vol.33 , pp. 20
    • Belt, J.A.1    Harper, E.2    Byl, J.3
  • 4
    • 0029100025 scopus 로고
    • Cloning and mapping of a human gene (TX2) sharing a highly conserved protein motif with the Drosophila omb gene
    • Campbell, C., Goodrich, K., Casey, G. and Beatty, B., 1995, Cloning and mapping of a human gene (TX2) sharing a highly conserved protein motif with the Drosophila omb gene. Genomics, 28, 255-260.
    • (1995) Genomics , vol.28 , pp. 255-260
    • Campbell, C.1    Goodrich, K.2    Casey, G.3    Beatty, B.4
  • 8
    • 0026767460 scopus 로고
    • A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane
    • Che, M., Nishida, T., Gatmaitan, Z. and Arias, I. M., 1992, A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane. Journal of Biological Chemistry, 267, 9684-9688.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 9684-9688
    • Che, M.1    Nishida, T.2    Gatmaitan, Z.3    Arias, I.M.4
  • 10
    • 0028272006 scopus 로고
    • Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS186
    • Craig, J. E., Zhang, Y. and Gallagher, M. P., 1994, Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS186. Molecular Microbiology, 11, 1159-1168.
    • (1994) Molecular Microbiology , vol.11 , pp. 1159-1168
    • Craig, J.E.1    Zhang, Y.2    Gallagher, M.P.3
  • 12
    • 0032570584 scopus 로고    scopus 로고
    • Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line
    • Crawford, C. R., Patel, D. H., Naeve, C. and Belt, J. A., 1998, Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. Journal of Biological Chemistry, 273, 5288-5293.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 5288-5293
    • Crawford, C.R.1    Patel, D.H.2    Naeve, C.3    Belt, J.A.4
  • 13
    • 0025039168 scopus 로고
    • Sodium-dependent and equilibrative nucleoside transport systems in L1210 mouse leukemia cells: Effect of inhibitors of equilibrative systems on the content and retention of nucleosides
    • Dagnino, L. and Paterson, A. R. P., 1990, Sodium-dependent and equilibrative nucleoside transport systems in L1210 mouse leukemia cells: effect of inhibitors of equilibrative systems on the content and retention of nucleosides. Cancer Research, 50, 6549-6553.
    • (1990) Cancer Research , vol.50 , pp. 6549-6553
    • Dagnino, L.1    Paterson, A.R.P.2
  • 14
    • 0025859186 scopus 로고
    • Substrate specificity, kinetics, and stoichiometry of sodium-dependent adenosine transport in L1210/AM mouse leukemia cells
    • Dagnino, L., Bennett, L. L. and Paterson, A. R. P., 1991, Substrate specificity, kinetics, and stoichiometry of sodium-dependent adenosine transport in L1210/AM mouse leukemia cells. Journal of Biological Chemistry, 266, 6312-6317.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 6312-6317
    • Dagnino, L.1    Bennett, L.L.2    Paterson, A.R.P.3
  • 15
    • 0023189640 scopus 로고
    • Concentrative uridine transport by murine splenocytes: Kinetics, substrate specificity, and sodium dependency
    • Darnowski, J. W., Holdridge, C. and Handschumacker, R. E., 1987, Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency. Cancer Research, 47, 2614-2619.
    • (1987) Cancer Research , vol.47 , pp. 2614-2619
    • Darnowski, J.W.1    Holdridge, C.2    Handschumacker, R.E.3
  • 17
    • 0031575924 scopus 로고    scopus 로고
    • Expression of sodium-dependent purine nucleoside carrier (SPNT) mRNA correlates with nucleoside transport activity in rat liver
    • Felipe, A., Ferrer-Martinez, A., Casado, F. J. and Pastor-Anglada, M., 1997, Expression of sodium-dependent purine nucleoside carrier (SPNT) mRNA correlates with nucleoside transport activity in rat liver. Biochemical and Biophysical Research Communications, 233, 572-575.
    • (1997) Biochemical and Biophysical Research Communications , vol.233 , pp. 572-575
    • Felipe, A.1    Ferrer-Martinez, A.2    Casado, F.J.3    Pastor-Anglada, M.4
  • 19
    • 0025300097 scopus 로고
    • Further characterization of adenosine transport in renal brush border membranes
    • Franco, R., Centelles, J. J. and Kinne, R. K. H., 1990, Further characterization of adenosine transport in renal brush border membranes. Biochimica et Biophysica Acta, 1024, 241-248.
    • (1990) Biochimica et Biophysica Acta , vol.1024 , pp. 241-248
    • Franco, R.1    Centelles, J.J.2    Kinne, R.K.H.3
  • 21
    • 0031439882 scopus 로고    scopus 로고
    • Molecular cloning and characterisation of an NBMPR-insensitive (ei) equilibrative nucleoside transporter from human placenta
    • Griffith, M., Yao, S. Y. M., Cass, C. E., Young, J. D. and Baldwin, S. A., 1997b, Molecular cloning and characterisation of an NBMPR-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochemical Journal, 328, 739-743.
    • (1997) Biochemical Journal , vol.328 , pp. 739-743
    • Griffith, M.1    Yao, S.Y.M.2    Cass, C.E.3    Young, J.D.4    Baldwin, S.A.5
  • 22
    • 0020577769 scopus 로고
    • Isolation and characterisation of full-length cDNA clones for human α-, β- and γ-actin mRNAs: Skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed
    • Gunning, P., Ponte, P., Okayama, H., Engel, J., Blau, H. and Kedes, L., 1983, Isolation and characterisation of full-length cDNA clones for human α-, β- and γ-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Molecular and Cellular Biology, 3, 787-795.
    • (1983) Molecular and Cellular Biology , vol.3 , pp. 787-795
    • Gunning, P.1    Ponte, P.2    Okayama, H.3    Engel, J.4    Blau, H.5    Kedes, L.6
  • 23
    • 0027299916 scopus 로고
    • +-nucleoside transport in brush border membranes vesicles from human kidney
    • +-nucleoside transport in brush border membranes vesicles from human kidney. Biochimica et Biophysica Acta, 1149, 202-208.
    • (1993) Biochimica et Biophysica Acta , vol.1149 , pp. 202-208
    • Gutierrez, M.M.1    Giacomini, K.M.2
  • 24
    • 0028126585 scopus 로고
    • Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes
    • Gutierrez, M. M. and Giacomini, K. M., 1994, Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes. Biochemical Pharmacology, 48, 2251-2253.
    • (1994) Biochemical Pharmacology , vol.48 , pp. 2251-2253
    • Gutierrez, M.M.1    Giacomini, K.M.2
  • 25
    • 0000661498 scopus 로고
    • J. F. Holland, E. Frei, R. C. Bast, D. W. Kufe, D. L. Morton and R. R. Weichselbaum, eds (Philadelphia: Lea & Febiger)
    • Handschumacher, R. E. and Cheng, C. Y., 1993, In Cancer Medicine, J. F. Holland, E. Frei, R. C. Bast, D. W. Kufe, D. L. Morton and R. R. Weichselbaum, eds (Philadelphia: Lea & Febiger), pp. 712-732.
    • (1993) Cancer Medicine , pp. 712-732
    • Handschumacher, R.E.1    Cheng, C.Y.2
  • 26
    • 0027305423 scopus 로고
    • Functional expression of Na-dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis. Demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second novel system N3 having board specificity for purine and pyrimidine nucleosides
    • Huang, Q.-Q., Harvey, C. M., Paterson, A. R. P., Cass, C. E. and Young, J. D., 1993, Functional expression of Na-dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis. Demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second novel system N3 having board specificity for purine and pyrimidine nucleosides. Journal of Biological Chemistry, 268, 20613-20619.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 20613-20619
    • Huang, Q.-Q.1    Harvey, C.M.2    Paterson, A.R.P.3    Cass, C.E.4    Young, J.D.5
  • 27
  • 30
    • 0024494386 scopus 로고
    • Characterization of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesicles
    • Jarvis, S. M., 1989, Characterization of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesicles. Biochimica et Biophysica Acta, 979, 132-138.
    • (1989) Biochimica et Biophysica Acta , vol.979 , pp. 132-138
    • Jarvis, S.M.1
  • 33
    • 84939680976 scopus 로고
    • Evidence for separate carriers for purine and pyrimidine nucleosides in the renal brush border membrane
    • Le Hir, M., 1990, Evidence for separate carriers for purine and pyrimidine nucleosides in the renal brush border membrane. Renal Physiology and Biochemistry, 13, 154-161.
    • (1990) Renal Physiology and Biochemistry , vol.13 , pp. 154-161
    • Le Hir, M.1
  • 34
    • 0021201229 scopus 로고
    • Sodium-gradient-energized concentrative transport of adenosine in renal brush border vesicles
    • Le Hir, M. and Dubach, U. C., 1984, Sodium-gradient-energized concentrative transport of adenosine in renal brush border vesicles. Pflugers Archiv, 401, 58-63.
    • (1984) Pflugers Archiv , vol.401 , pp. 58-63
    • Le Hir, M.1    Dubach, U.C.2
  • 39
    • 0030824757 scopus 로고    scopus 로고
    • Sodium-dependent nucleoside transport in the human intestinal brush-border membrane
    • Patil, S. D. and Unadkat, J. D., 1997, Sodium-dependent nucleoside transport in the human intestinal brush-border membrane. American Journal of Physiology, 35, G1314-G1320.
    • (1997) American Journal of Physiology , vol.35
    • Patil, S.D.1    Unadkat, J.D.2
  • 41
    • 0025878633 scopus 로고
    • +-dependent, concentrative nucleoside transport in rat marcophages. Specificity for natural nucleosides and nucleoside analogs, including dideoxynucleosides, and comparison of nucleoside transport in rat, mouse and human macrophages
    • +-dependent, concentrative nucleoside transport in rat marcophages. Specificity for natural nucleosides and nucleoside analogs, including dideoxynucleosides, and comparison of nucleoside transport in rat, mouse and human macrophages. Biochemical Pharmacology, 42, 247-252.
    • (1991) Biochemical Pharmacology , vol.42 , pp. 247-252
    • Plagemann, P.G.W.1
  • 43
    • 0025118705 scopus 로고
    • +-dependent, active nucleoside transport in rat and mouse peritoneal macrophages, a mouse macrophage cell line and normal rat kidney cells
    • +-dependent, active nucleoside transport in rat and mouse peritoneal macrophages, a mouse macrophage cell line and normal rat kidney cells. Biochimica et Biophysica Acta, 1028, 289-298.
    • (1990) Biochimica et Biophysica Acta , vol.1028 , pp. 289-298
    • Plagemann, P.G.W.1    Aran, J.M.2
  • 46
    • 0025761776 scopus 로고
    • Sodium-dependent nucleoside transport in rabbit intestinal epithelium
    • Roden, M., Paterson, A. R. P. and Turnheim, K., 1991, Sodium-dependent nucleoside transport in rabbit intestinal epithelium. Gastroenterology, 100, 1553-1562.
    • (1991) Gastroenterology , vol.100 , pp. 1553-1562
    • Roden, M.1    Paterson, A.R.P.2    Turnheim, K.3
  • 50
    • 0025981264 scopus 로고
    • Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles
    • Williams, T. C. and Jarvis, S. M., 1991, Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles. Biochemical Journal, 274, 27-33.
    • (1991) Biochemical Journal , vol.274 , pp. 27-33
    • Williams, T.C.1    Jarvis, S.M.2
  • 51
    • 0024430047 scopus 로고
    • Characterization of sodium-dependent and sodium-independent nucleoside transport systems in rabbit brush-border and basolateral plasma-membrane vesicles from renal outer cortex
    • Williams, T. C., Doherty, A. J., Griffith, D. A. and Jarvis, S. M., 1989, Characterization of sodium-dependent and sodium-independent nucleoside transport systems in rabbit brush-border and basolateral plasma-membrane vesicles from renal outer cortex. Biochemical Journal, 264, 223-231.
    • (1989) Biochemical Journal , vol.264 , pp. 223-231
    • Williams, T.C.1    Doherty, A.J.2    Griffith, D.A.3    Jarvis, S.M.4
  • 52
    • 0028293655 scopus 로고
    • Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit
    • Wu, X., Gutierrez, M. M. and Giacomini, K. M., 1994, Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. Biochimica et Biophysica Acta, 1191, 190-196.
    • (1994) Biochimica et Biophysica Acta , vol.1191 , pp. 190-196
    • Wu, X.1    Gutierrez, M.M.2    Giacomini, K.M.3
  • 53
    • 0029812857 scopus 로고    scopus 로고
    • Transport of the antiviral nucleoside analogs 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine (ddC) by a recombinant nucleoside transporter (rCNT1) expressed in Xenopus oocytes
    • Yao, S. Y. M., Cass, C. E. and Young, J. D., 1996b, Transport of the antiviral nucleoside analogs 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine (ddC) by a recombinant nucleoside transporter (rCNT1) expressed in Xenopus oocytes. Molecular Pharmacology, 50, 388-393.
    • (1996) Molecular Pharmacology , vol.50 , pp. 388-393
    • Yao, S.Y.M.1    Cass, C.E.2    Young, J.D.3
  • 54
    • 0030707865 scopus 로고    scopus 로고
    • Molecular cloning and functional characterisation of NBMPR-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues
    • Yao, S. Y. M., Ng, A. M. L., Muzyka, W. R., Griffiths, M., Cass, C. E., Baldwin, S. A. and Young, J. D., 1997, Molecular cloning and functional characterisation of NBMPR-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues. Journal of Biological Chemistry, 271, 28423-28430.
    • (1997) Journal of Biological Chemistry , vol.271 , pp. 28423-28430
    • Yao, S.Y.M.1    Ng, A.M.L.2    Muzyka, W.R.3    Griffiths, M.4    Cass, C.E.5    Baldwin, S.A.6    Young, J.D.7
  • 55
    • 0030465008 scopus 로고    scopus 로고
    • Transport of adenosine by recombinant N1/cif and N2/cit sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus oocytes
    • Yao, S. Y. M., Ng, A. M. L., Ritzel, M. W. L., Cass, C. E. and Young, J. D., 1996a, Transport of adenosine by recombinant N1/cif and N2/cit sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus oocytes. Molecular Pharmacology, 50, 1529-1536.
    • (1996) Molecular Pharmacology , vol.50 , pp. 1529-1536
    • Yao, S.Y.M.1    Ng, A.M.L.2    Ritzel, M.W.L.3    Cass, C.E.4    Young, J.D.5
  • 56
    • 0020502155 scopus 로고
    • Nucleoside transport in animal cells
    • Young, J. D. and Jarvis, S. M., 1983, Nucleoside transport in animal cells. Bioscience Reports, 3, 309-322.
    • (1983) Bioscience Reports , vol.3 , pp. 309-322
    • Young, J.D.1    Jarvis, S.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.