IFN-γ induces cell growth inhibition by fas-mediated apoptosis: Requirement of STAT1 protein for up-regulation of Fas and FasL expression

Cancer Research

Volumn 58, Issue 13, 1998, Pages 2832-2837

  Xu, Xiulong ^a   Fu, Xin Yuan ^b   Plate, Janet ^a   Chong, Anita S F ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; SERINE PROTEINASE; STAT1 PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL INTERACTION; CELL STRAIN HT29; DNA DETERMINATION; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 1; CELL DIVISION; CYSTEINE ENDOPEPTIDASES; DNA FRAGMENTATION; DNA, NEOPLASM; DNA-BINDING PROTEINS; EPIDERMAL GROWTH FACTOR; FAS LIGAND PROTEIN; FIBROBLAST GROWTH FACTORS; HT29 CELLS; HUMANS; INTERFERON TYPE II; LEUKEMIA, T-CELL; MEMBRANE GLYCOPROTEINS; PLATELET-DERIVED GROWTH FACTOR; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0032125574     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Platanias, L. C. Interferons: laboratory to clinic investigations. Curr. Opinion. Oncol., 7: 560-565, 1995.
2. Shui, K. Interferon-activated signal transduction to the nucleus. Curr. Opin. Cell Biol., 6: 253-259, 1994.
3. Leaman, D. W., Leung, S., Li, X., and Stark, G. R. Regulation of STAT-dependent pathways by growth and cytokines. FASEB J., 10: 1578-1288, 1996.
4. Weller, M., Frei, K., Groscurth, P., Krammer, P. H., Yonekawa, Y., and Fontana, A. Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines. J. Clin. Invest., 94: 954-964, 1994.
5. Matsue, H., Kobayashi, H., Hosokawa, T., Akitaya, T., and Ohkawara, A. Keratinocytes constitutively express the Fas antigen that mediates apoptosis in IFN-γ-treated cultured keratinocytes. Arch. Dermatol. Res., 287: 315-320, 1995.
6. Leithauser, F., Dhein, J., Mechtersheimer, G. K., Koretz, K., Bruderlein, S., Henne, C., Schimidt, A., Debatin, K-M., Krammer, P. H., and Moller, P. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab. Invest., 69: 415-429, 1993.
7. Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S-I., Sameshima, M., Hase, A., Seto, Y., and Nagata, S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell, 66: 233-243, 1991.
8. Nagata, S. Apoptosis by death factor. Cell, 88: 355-365, 1997.
9. Sayama, K., Yonehawa, S., Watanabe, Y., and Miki, Y. Expression of Fas antigen on keratinocytes in vivo and induction of apoptosis in cultured keratinocytes. J. Invest. Dermatol., 103: 330-334, 1994.
10. Moller, P., Koretz, K., Leithauser, F., Bruderlein, S., Henne, C., Quentmeier, A., and Krammer, P. H. Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int. J. Cancer, 57: 371-377, 1994.
11. Ni, R., Tomita, Y., Matsuda, K., Ichihara, A., Ishimura, K., Ogasawara, J., and Nagata, S. Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp. Cell Res., 215: 332-337, 1994.
12. WAF1/CIP1 mediated by STAT1. Science (Washington DC), 272: 719-722, 1996.
13. Weller, M., Malipiero, U., Aguzzi, A., Reed, J. C., and Fontana, A. Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J. Clin. Invest., 95: 2633-2643, 1995.
14. Keane, M. M., Ettenberg, S. A., Lowery, G. A., Russell, E. K., and Lipkowitz, S. Fas expression and function in normal and malignant breast cell lines. Cancer Res., 56: 4791-4798, 1996.
15. Rokhlin, O. W., Bishop, G. A., Hostaer, B. S., Waldschmidt, T. J., Sidorenko, S. P., Pavloff, N., Kiefer, M. C., Umansky, S. R., Glover, R. A., and Cohen, M. B. Fas-mediated apoptosis in human prostatic cell lines. Cancer Res., 57: 1758-1768, 1997.
16. Muller, M., Strand, S., Hug, H., Heinemann, E-M., Walczak, H., Hofmann, W. J., Stremmel, W., Krammer, P. H., and Galle, P. R. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest., 99: 403-413, 1997.
17. McKendry, R., John, J., Flavell, D., Mueller, M., Kerr, I., and Stark, G. R. High-frequency mutagenesis of human cells and characterization of mutant unresponsive to both α and γ interferons. Proc. Natl. Acad. Sci. USA, 88: 11455-11459, 1991.
18. Muller, M., Laxton, C., Briscoe, J., Schinder, C., Improta, T., and Darnell, J. E. Complementation of a mutant cell line: central role of the 91-kDa polypeptide of ISCF3 in the interferon-α and γ signal transduction pathway. EMBO J., 12: 4221-4228, 1993.
19. O'Connell, J., O'Sullivan, G. C., Collins, K., and Shanahan, F. The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J. Exp. Med., 184: 1075-1082, 1996.
20. Shiraki, K., Tsuji, N., Isselbacher, K. J., and Takahashi, H. Expression of Fas ligand in liver metastases of human colonic adenocarcinomas. Proc. Natl. Acad. Sci. USA, 94: 6420-6425, 1997.
21. Abreu-Martin, M. T., Vidrich, A., Lynch, D. H., and Targan, S. R. Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-α and ligation of Fas antigen. J. Immunol., 155: 4147-4154, 1995.
22. Niehans, G. A., Brunner, T., Frizelle, S. P., Liston, J. C., Salerno, C. T., Knapp, D. J., Green, D. R., and Kratzke, R. A. Human lung carcinomas express Fas ligand. Cancer Res., 57: 1007-1012, 1997.
23. Saas, P., Walker, P. R., Hanhe, M., Quiquerez, A-L., Schnuriger, V., Perrin, G., French, L., Meir, E. G. V., Tribolet, N. D., Tschopp, J., and Dietrich, P-V. Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? J. Clin. Invest., 99: 1173-1178, 1997.
24. Strand, S., Hofmann, W. J., Hug, H., Muller, M., Otto, G., Strand, D., Mariani, S. M., Stremmel, W., Krammer, P. H., and Galle, P. R. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells: a mechanism of immune evasion? Nat. Med., 2: 1361-1366, 1996.
25. Hahne, M., Rimolde, D., Schroter, M., Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., Cerottini, J-C., and Tschopp, J. Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape. Science (Washington DC), 274: 1363-1366, 1996.
26. Hill, C. S., and Treisman, R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell, 80: 199-211, 1995.
27. Vaughan, P. S., van Wijnen, A. J., Stein, J. L., and Stein, G. Interferon regulatory factors: growth control and histone gene regulation-it's not just interferon anymore. J. Mol. Med., 75: 348-359, 1997.
28. Cheng, J., Liu, C., Koopman, W. J., and Mountz, J. D. Characterization of human Fas gene exon/intron organization and promoter region. J. Immunol., 154: 1239-1254, 1995.
29. Tanaka, N., Ichihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M., Aisawa, S., Mak, T. W., and Taniguchi, T. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell, 77: 829-839, 1994.
30. Chin, Y. E., Kitagawa, M., Kuida, K., Flavell, R. A., and Fu, X-Y. Activation of STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell. Biol., 17: 5328-5337, 1997.
31. Kumar, A., Commane, M., Flickinger, T. W., Horvath, C. M., and Stark, G. R. Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science (Washington DC), 278: 1630-1632, 1997.
32. Huang, S., Jiang, Y., Li, Z., Nishida, E., Mathias, P., Lin, S., Ulevitch, R. J., Nemerow, G. R., and Han, J. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity, 6: 739-749, 1997.
33. Goillot, E., Raingeaud, J., Ranger, A., Tepper, R. I., Davis, R. J., Harlow, E., and Sanchez, I. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc. Natl. Acad. Sci. USA, 94: 3302-3307, 1997.
34. Yang, X., Khosravi-Far, R., Chang, H. Y., and Baltimore, D. Daxx, a novel Fasbinding protein that activates JNK and apoptosis. Cell, 89: 1067-1076, 1997.
35. Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., and Taniguchi, T. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (Lond.), 376: 596-599, 1995.