A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function

EMBO Journal

Volumn 15, Issue 17, 1996, Pages 4759-4766

  Mohr, Ian ^a,b   Gluzman, Yakov ^a  

^a WYETH RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

GADD 34; Herpesvirus; PKR; Translational control

Indexed keywords

INITIATION FACTOR; PROTEIN KINASE; VIRUS MESSENGER RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HERPES SIMPLEX VIRUS 1; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; TRANSLATION REGULATION; VIRUS GENE; VIRUS MUTANT; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 0029841340     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00853.x     Document Type: Article

References (46)

1. Beattie, E., Tartaglia, J. and Paoletti, E. (1991) Vaccinia virus encoded eIF-2 alpha homolog abrogates the antiviral effect of Interferon. Virology, 183, 419-422.
2. Bhat, R. and Thimmappaya, B. (1983) Two small RNAs encoded by Epstein-Barr virus can be functionally substituted for the virus-associated RNAs in the lytic growth of adenovirus 5. Proc. Natl Acad. Sci. USA, 80, 4789-4793.
3. Bischoff, J.R. and Samuel, C.E. (1989) Activation of the human P1/IF2 protein kinase by individual reovirus s-class mRNAs: sl mRNA is a potent activator relative to s4 mRNA. Virology, 172, 106-115.
4. Black, T.L., Barber, G.N. and Katze, M.G. (1993) Degradation of the interferon-induced 68,000 Mr protein kinase by poliovirus requires RNA. J. Virol., 67, 791-800.
5. Bolovan, C.A., Sawtell, N.M. and Thompson, R.L. (1994) ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. J. Virol., 68, 48-55.
6. Brown, S.M. and Harland, J. (1987) Three mutants of herpes simplex virus type 2: one lacking the genes US10, US11, and US12 and two in which Rs has been extended by 6 kb to 0.91 map units with loss of Us sequences between 0.94 and the Us/TRs junction. J. Gen Virol., 68, 1-18.
7. Chang, H.W., Watson, J.C. and Jacobs, B.L. (1992) The E3L gene of vaccinia virus encodes an inhibitor of the interferon induced, dsRNA dependent protein kinase. Proc. Natl Acad. Sci. USA, 89, 4825-4829.
8. Chou, J. and Roizman, B. (1992) The γ34.5 gene of Herpes Simplex Virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells. Proc. Natl Acad. Sci. USA, 89, 3266-3270.
9. Chou, J. and Roizman, B. (1994) Herpes simplex virus 1 γ34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage. Proc. Natl Acad. Sci. USA, 91, 5247-5251.
10. Chou, J., Kern, E.R., Whitley, R.J. and Roizman, B. (1990) Mapping of Herpes Simplex virus 1 neurovirulence to γ34.5, a gene nonessential for growth in cell culture. Science, 252, 1262-1266.
11. - mutants of herpes simplex virus 1. Proc. Natl Acad. Sci. USA, 92, 10516-10520.
12. Davies, M.V., Chang, H.W., Jacobs, B.L. and Kaufman, R.J. (1993) The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA dependent protein kinase by different mechanisms. J. Virol., 67, 1688-1692.
13. Donze, O., Jagus, R., Koromilas, A.E., Hershey, J.W.B. and Sonenberg, N. (1995) Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J., 14, 3828-3834.
14. Fomace, AJ., Jr (1992) Mammalian genes induced by radiation: activation of genes associated with growth control. Annu. Rev. Genet., 26, 507-526.
15. Gunnery, S., Green, S.R. and Mathews, M.B. (1992) Tat-responsive region RNA of human immunodeficiency virus type 1 stimulates protein synthesis in vivo and in vitro: relationship between structure and function. Proc. Natl Acad. Sci. USA, 89, 11557-11561.
16. He, B., Chou, J., Liebermann, D.A., Hoffman, B. and Roizman, B. (1996) The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the y34.5 gene of Herpes Simplex to preclude the premature shutoff of total protein synthesis in infected human cells. J. Virol., 70, 84-90.
17. Hill, A., Jugovic, P., York, I., Russ, G., Bennick, J., Yewdell, J., Ploegh, H. and Johnson, D. (1995) Herpes simplex virus turns off the TAP to evade host immunity. Nature, 375, 411-415.
18. Hoffman, B. and Liebermann, D.A. (1994) Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive and negative modulators. Oncogene, 9, 1807-1812.
19. Johnson, P.A., MacLean, C., Marsden, H.S., Dalziel, R.G. and Everett, R.D. (1986) The product of gene Usl1 of Herpes Simplex Virus Type 1 is expressed as a true late gene. J. Gen. Virol., 67, 871-883.
20. Katze, M.G. (1995) Regulation of the interferon-induced PKR: can viruses cope? Trends Microbiol., 3, 75-78.
21. Kitajewski, J., Schneider, R.J., Safer, B., Munemitsu, S., Samuel, C.E., Thimmappaya, B. and Shenk, T. (1986) Adenovirus VAI RNA antagonizes the antiviral action of interferon-induced eIF2α kinase. Cell, 45, 195-200.
22. Koromilas, A.E., Roy, S., Barber, G.N., Katze, M.G. and Sonenberg, N. (1992) Malignant transformation by a mutant of the IFN-inducible dsRNA dependent protein kinase. Science, 257, 1685-1689.
23. Lee, T.G., Tomila, J., Hovanessian, A.G. and Katze, M.G. (1990) Purification and partial characterization of a cellular inhibitor of the interferon induced protein kinase of Mr 68,000 from influenza virus infected cells. Proc. Natl Acad. Sci. USA, 87, 6208-6212.
24. Lengyel, P. (1993) Tumor-suppressor genes: news about the interferon connection. Proc. Natl Acad. Sci. USA, 90, 5893-5895.
25. Lloyd, R.M. and Shatkin, A.J. (1992) Translational stimulation by reovirus polypeptide s3: substitution for VAI RNA and inhibition of phosphorylation of the α subunit of eukaryotic initiation factor 2. J. Virol., 66, 6878-6884.
26. Longnecker, R. and Roizman, B. (1986) Generation of an inverting herpes simplex virus 1 mutant lacking the L-S junction a sequences, an origin of DNA synthesis, and several genes including those specifying glycoprotein E and the a47 gene. J. Virol., 58, 583-591.
27. MacLean, A.R., Ul-Fareed, M., Robertson, L., Harland, J. and Brown, S.M. (1991) Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence. J. Gen. Virol., 72, 631.
28. Maitra, R.K., McMillan, N.A., Desai, S., McSwiggen, J., Hovanessian, A.G., Sen, G., Williams, B.R. and Silverman, R.H. (1994) HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology, 204, 823-827.
29. Maran, A. and Mathews, M.B. (1988) Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VARNAI. Virology, 164, 106-113.
30. Mathews, M.B. and Shenk, T. (1991) Adenovirus virus-associated RNA and translational control. J. Virol., 65, 5657-5662.
31. McGeoch, D.J. and Barnett, B.C. (1991) Neurovirulence factor. Nature, 353, 609.
32. Meurs, E.F., Galabru, J., Barber, G.N., Katze, M.G. and Hovanessian, A.G. (1993) Tumor suppression function of the interferon induced double-stranded RNA-activated protein kinase. Proc. Natl Acad. Sci. USA, 90, 232-236.
33. Nishiyama, Y., Kurachi, R., Daikoku, T. and Umene, K. (1993) The US9, 10, 11, 12 genes of Herpes Simplex Type 1 are of no importance for its neurovirulence and latency in mice. Virology, 194, 419-423.
34. i. Cell, 44, 391-400.
35. O'Malley, R.P., Duncan, R.F., Hershey, J.W.B. and Mathews, M.B. (1989) Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus infected cells. Virology, 168, 112-118.
36. Park, H. et al. (1994) TAR RNA binding protein is an inhibitor of the interferon-induced protein kinase PKR. Proc. Natl Acad. Sci. USA, 91, 4713-4717.
37. Petryshyn, R., Chen, J. and London, I. (1988) Detection of activated double-stranded RNA dependent protein kinase in 3T3-F442A cells. Proc. Natl Acad. Sci. USA, 85, 1427-1431.
38. Roizman, B.R. and Sears, A.E. (1993) Herpes Simplex Viruses and their replication. In Roizman, B., Whitley, R.J. and Lopez, C. (eds). The Human Herpesviruses. Raven Press, New York, pp. 11-68.
39. Roller, R.J. and Roizman, B. (1990) The herpes simplex virus Usl1 open reading frame encodes a sequence-specific RNA binding protein. J. Virol., 64, 3463-3470.
40. Roller, R.J. and Roizman, B. (1991) The herpes simplex virus 1 RNA binding protein Usl1 negatively regulates the accumulation of a truncated viral mRNA. J. Virol., 65, 5873-5879.
41. Roller, R.J. and Roizman, B. (1992) The herpes simplex virus RNA binding protein Usl1 is a virion component and associates with ribosomal 60S subunits. J. Virol., 66, 3624-3632.
42. Sharp, T.V., Schwemmle, M., Jeffrey, I., Laing, K., Mellor, H., Proud, C.G., Hilse, K. and Clemens, M.J. (1993) Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA. Nucleic Acids Res., 21, 4483-4490.
43. Sussman, M.D., Lu, Z., Kutish, G., Alfonso, C.L., Roberts, P. and Rock, D.L. (1992) Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence associated gene of herpes simplex virus. J. Virol., 66, 5586-5589.
44. Umene, K. (1986) Conversion of a fraction of the unique sequence to part of the inverted repeats in the S component of the herpes simplex type 1 genome. J. Gen. Virol., 67, 1035-1048.
45. Williams, B.R.G. (1995) The role of the dsRNA-activated kinase, PKR, in signal transduction. Semin. Virol., 6, 191-202.
46. Zhan, Q. et al. (1994) The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol. Cell. Biol., 14, 2361.