Rnase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus(EMCV)- infected cells

European Journal of Biochemistry

Volumn 254, Issue 2, 1998, Pages 248-255

  Martinand, Camille ^a   Salehzada, Tamim ^a   Silhol, Michelle ^a   Lebleu, Bernard ^a   Bisbal, Catherine ^a,b  

^a CNRS   (France)

^b INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

Antisense RNA; Interferon; Ribonuclease L; Ribonuclease L inhibitor; Virus infection

Indexed keywords

ENZYME INHIBITOR; RIBONUCLEASE;

ARTICLE; ENCEPHALOMYOCARDITIS VIRUS; ENZYME INHIBITION; ENZYME REGULATION; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

ANTIBODIES; ATP-BINDING CASSETTE TRANSPORTERS; CARDIOVIRUS INFECTIONS; CHAPERONINS; DNA, ANTISENSE; DOWN-REGULATION; ENCEPHALOMYOCARDITIS VIRUS; ENDORIBONUCLEASES; ENZYME INHIBITORS; HELA CELLS; HUMANS; PROTEINS; TRANSFECTION;

ENCEPHALOMYOCARDITIS VIRUS;

EID: 0032103209     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2540248.x     Document Type: Article

References (28)

1. Hassel, B. A., Zhou, A., Sotomayor, C., Maran, A. & Silverman, R. H. (1993) A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon, EMBO J. 12, 3297-3304.
2. Sen, G. C. & Lengyel, P. (1992) The interferon system. A bird's eye view of its biochemistry, J. Biol. Chem. 267, 5017-5020.
3. Kerr, I. M. & Brown, R. E. (1978) pppA2′p5′A2′p5′A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells, Proc. Natl Acad. Sci. USA 75, 256-260.
4. Floyd-Smith, G., Slattery, E. & Lengyel, P. (1981) Interferon action: RNA cleavage pattern of a (2′-5′)oligoadenylate-dependant endonuclease, Science 212, 1030-1032.
5. Dong, B. & Silverman, R. H. (1995) 2-5A-dependent RNase molecules dimerize during activation by 2-5A, J. Biol. Chem. 270, 4133-4137.
6. Bisbal, C., Martinand, C., Silhol, M., Lebleu, B. & Salehzada, T. (1995) Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway, J. Biol. Chem. 270, 13308-13317.
7. Chebath, J., Benech, P., Revel, M. & Vigneron, M. (1987) Constitutive expression of (2′-5′) oligo A synthetase confers resistance to picornavirus infection, Nature 330, 587-588.
8. Coccia, E. M., Romeo, G., Nissim, A., Marziali, G., Albertini, R., Affabris, E., Battistini, A., Fiorucci, G., Orsatti, R. & Rossi, G. B. (1990) A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication, Virology 179, 228-233.
9. Krishnan, I. & Baglioni, C. (1980) 2′5′ oligo(A) polymerase activity in serum of mice infected with EMC virus or treated with interferon, Nature 285, 485-488.
10. Rysiecki, G., Gewert, D. R & Williams, B. R. (1989) Constitutive expression of a 2′,5′-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression, J. Interferon Res. 9, 649-657.
11. Cayley, P. J., Davies, J. A., McCullagh, K. G. & Kerr, I. M. (1984) Activation of the ppp(A2′p)nA system in interferon-treated, herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2′p)nA-dependent RNase, Eur. J. Biochem. 143, 165-174.
12. Paez, E. & Esteban, M. (1984) Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system, Virology 134, 12-28.
13. Bisbal, C., Silhol, M., Lemaitre, M., Bayard, B., Salehzada, T., Lebleu, B., Perree, T. D. & Blackburn, M. G. (1987) 5′-modified agonist and antagonist (2′-5′)(A)n analogues: synthesis and biological activity, Biochemistry 26, 5172-5178.
14. Defilippi, P., Huez, G., Verhaegen, L. M., De, C. E., Imai, J., Torrenee, P. & Content, J. (1986) Antiviral activity of a chemically stabilized 2-5A analog upon microinjection into HeLa cells, FEBS Lett. 198, 326-332.
15. Cayley, P. J., Knight, M. & Kerr, I. M. (1982) Virus-mediated inhibition of the ppp(A2′p)nA system and its prevention by interferon, Biochem. Biophys. Res. Commun. 104, 376-382.
16. Silverman, R. H., Cayley, P. J., Knight, M., Gilbert, C. S. & Kerr, I. M. (1982) Control of the ppp(a2′p)nA system in HeLa cells. Effects of interferon and virus infection, Eur. J. Biochem. 124, 131-138.
17. Silverman, R. H. (1994) Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action, J. Interferon Res. 14, 101-104.
18. Watling, D., Serafinowska, H. T., Reese, C. B. & Kerr, I. M. (1985) Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication, EMBO J. 4, 431-436.
19. Salehzada, T., Silhol, M., Steff, A. M., Lebleu, B. & Bisbal, C. (1993) 2′,5′-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits, J. Biol. Chem. 268, 7733-7740.
20. Zhou, A., Hassel, B. A. & Silverman, R. H. (1993) Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action, Cell 72, 753-765.
21. Towbin, H., Staehelin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, Proc. Natl Acad. Sci. USA 76, 4350-4354.
22. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular cloning: a laboratory manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
23. Knight, M., Cayley, P. J., Silverman, R. H., Wreschner, D. H., Gilbert, C. S., Brown, R. E. & Kerr, I. M. (1980) Radioimmune, radiobinding and HPLC analysis of 2-5A and related oligonucleotides from intact cells, Nature 288, 189-192.
24. Wreschner, D. H., Silverman, R. H., James, T. C., Gilbert, C. S. & Kerr, I. M. (1982) Affinity labelling and characterization of the ppp(A2′p)nA-dependent endoribonuclease from different mammalian sources, Eur. J. Biochem. 124, 261-268.
25. Bayard, B., Bisbal, C. & Lebleu, B. (1986) Activation of ribonuclease L by (2′-5′)(A)4-poly(L-lysine) conjugates in intact cells, Biochemistry 25, 3730-3736.
26. Bisbal, C., Salehzada, T., Lebleu, B. & Bayard, B. (1989) Characterization of two murine (2′-5′)(A)n-dependent endonucleases of different molecular mass, Eur. J. Biochem. 179, 595-602.
27. Katze, M. G. (1992) The war against the interferon-induced dsRNA-activated protein kinase: can viruses win? J. Interferon Res. 12, 241-248.
28. Lee, T. G., Tang, N., Thompson, S., Miller, J. & Katze, M. G. (1994) The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins, Mol. Cell. Biol. 14, 2331-2342.