Mechanisms of transcriptional synergism of eukaryotic genes: The interferon-β paradigm

Hypertension

Volumn 27, Issue 4, 1996, Pages 1025-1029

  Thanos, Dimitris ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

genes, eukaryotic; interferon beta; transcription, genetic

Indexed keywords

BETA INTERFERON; HIGH MOBILITY GROUP PROTEIN; TRANSCRIPTION FACTOR;

CONFERENCE PAPER; DNA BINDING; EUKARYOTE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

EID: 0029924080     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.27.4.1025     Document Type: Conference Paper

References (25)

1. Weintraub H. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell. 1993;75:1241-1244.
2. Thanos D, Maniatis T. NF-κB: a lesson in family values. Cell. 1995;80:529-532.
3. Hill CS, Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell. 1995;80:199-211.
4. Tjian R, Maniatis T. Transcriptional activation: a complex puzzle with few easy pieces. Cell. 1994;77:5-8.
5. Isaacs A, Lindenmann J. Virus interference. I: the interferon. Proc R Soc Land Biol Sci. 1957;147:258-267.
6. Vilcek J. Interferons. In: Handbook of Experimental Pharmacology. Berlin, FRG: Springer-Verlag: 1990;95/II:1-37.
7. Sen GC, Lengyel P. The interferon system. J Biol Chem. 1992;267: 5017-5020.
8. Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;264:1415-1421.
9. Maniatis T, Whittemore LA, Du W, Fan C-M, Keller A, Palombella VJ, Thanos T. Positive and negative control of human interferon-β gene expression. In: McKnight SL, Yamamoto KR, eds. Transcriptional Regulation. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1992:1193-1220.
10. Thanos D, Du W, Maniatis T. The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex. In: Cold Spring Harbor Symposia on Quantitative Biology. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1993;58:73-81.
11. Fujita T, Miyamoto M, Kimura Y, Hammer J, Taniguchi T. Involvement of a cis element that binds an H2TF/NF-κB-like factors in the virus induced interferon-β gene expression. Nucleic Acids Res. 1989;17:3335-3346.
12. Lenardo MJ, Fan C-M, Maniatis T, Baltimore D. The involvement of NF-κB in β-interferon gene expression reveals its role as a widely inducible mediator of signal transaction. Cell. 1989;57:287-294.
13. Hiscott J, Alper D, Cohen L, LeBlanc J-F, Sportza L, Wong A, Xanthoudakis S. Induction of human Interferon gene expression is associated with a nuclear factor that interacts with the NF-κB site of the human immunodeficiency virus enhancer. J Virol. 1989;63: 2557-2566.
14. Thanos D, Maniatis T. The high mobility group protein HMG I(Y) is required for NF-κB dependent virus induction of the human interferon-β gene. Cell. 1992;71:777-789.
15. Thanos D, Maniatis T. Identification of the rel family members required for virus induction of the human beta Interferon gene. Mol Cell Biol. 1995;15:152-164.
16. Goodbourn S, Maniatis T. Overlapping positive and negative regulatory domains of the human β-interferon gene. Proc Natl Acad Sci USA. 1988;85:1447-1451.
17. Du W, Maniatis T. An ATF/CREB binding site is required for virus induction of the human IFNβ gene. Proc Natl Acad Sci USA. 1992;89:2150-2154.
18. Du W, Thanos D, Maniatis T. Mechanisms of transcriptional synergism between distinct virus inducible enhancer elements. Cell. 1993;74:887-898.
19. Fujita T, Sakakibara J, Sudo Y, Miyamoto M, Kimura Y, Taniguchi T. Evidence for a nuclear factor(s). IRF-1, mediating induction and silencing properties to human IFNβ regulatory elements. EMBO J. 1988;7:3397-3406.
20. Miyamoto M, Fujita T, Kimura Y, Maruyama H, Harada H, Sudo Y, Miyata T, Taniguchi T. Regulated expression of a gene encoding a nuclear factor. IRF-1, that specifically binds to IFNβ gene regulatory element. Cell. 1988;54:903-913.
21. Fujita T, Kimura Y, Miyamoto M, Barsoumian EL, Taniguchi T. Induction of endogenous IFNα and IFNβ genes by a regulatory transcription factor IRF-1. Nature. 1989;337:270-273.
22. Reis LFL, Harada H, Wolchok JD, Taniguchi T, Vilcek J. Critical role of a common transcription factor, IRF-1, in the regulation of IFNβ and IFN inducible genes. EMBO J. 1992;11:185-193.
23. Matsuyama T, Kimura T, Kitagawa M, Pfeffer K, Kawakami T, Watanabe N, Kundig T, Amakawa R, Kishihara K, Wakeham A, Poter J, Furlonger C, Narendran A, Suzuki H, Ohashi PS, Paige T, Taniguchi T, Mak T. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 1993;75:83-94.
24. Thanos D, Maniatis T, Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome. Cell. 1995;83:1091-1100.
25. Falvo J, Thanos D, Maniatis T. Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell. 1995;83:1101-1111.