Reoviruses and the interferon system

Current Topics in Microbiology and Immunology

Volumn 233 II, Issue , 1998, Pages 125-145

  Samuel, C E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON;

ANTIVIRAL ACTIVITY; CELLULAR IMMUNITY; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REOVIRUS; REVIEW; VIRUS INFECTION;

ANIMALS; HUMANS; INTERFERONS; ORTHOREOVIRUS; REOVIRIDAE INFECTIONS; VIRUS REPLICATION;

ANIMALIA; ORTHOREOVIRUS; REOVIRUS SP.;

EID: 0031815068     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-72095-6_7     Document Type: Article

References (130)

1. Atta MS, Irving WI, Powell RJ, Todd I (1995) Enhanced expression of MHC class I molecules on cultured human thyroid follicular cells infected with reovirus through induction of type 1 interferons. Clin Exp Immunol 101:121-126
2. Atwater JA, Samuel CE (1982) Interferon inhibits the synthesis of viral proteins and induces P1 phosphorylation in both adenylate cyclase-deficient and cAMP-dependent protein kinase deficient variants of mouse lymphoma cells. Virology 123:206-211
3. Atwater JA, Munemitsu SM, Samuel CE (1986) Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain S4 mRNA which encodes the major capsid surface polypeptide σ3. Biochem Biophys Res Commun 136:183-192
4. Atwater JA, Munemitsu SM, Samuel CE (1987) Efficiency of expression of cDNAs of the reovirus S1 and S4 genes in transfected animal cells differs at the level of translation. Virology 159:350-357
5. Baglioni C, De Benedetti A, Williams GJ (1984) Cleavage of nascent reovirus mRNA by localized activation of the 2′-5′-oligoadenylate-dependent endoribonuclease. J Virol 52:865-871
6. Barber GN, Edelhoff S, Katze MG, Disteche CM (1993) Chromosomal assignment of the interferon-inducible double-stranded RNA-dependent protein kinase (PRKR) to human chromosome 2p21-p22 and mouse chromosome 17E2. Genomics 16:765-767
7. Bass BL, Weintraub H (1988) An unwinding activity that covalently modified its double-stranded RNA substrate. Cell 55:1089-1098
8. Beattie E, Tartaglia J, Paoletti E (1991) Vaccinia virus-encoded eIF-2α homologue abrogates the antiviral effect of interferon. Virology 183:419-122
9. Beattie E, Denzler KL, Tartaglia J, Perkus ME, Paoletti E, Jacobs BL (1995) Reversal of the interferon-sensitive phenotype of a vaccina virus lacking E3L by expression of the reovirus S4 gene. J Virol 69:499-505
10. Benkirane M, Neuveut C, Chun RF, Smith SM, Samuel CE, Gatignol A, Jeang KT (1997) Oncogenic potential of TAR RNA-binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR. EMBO J 16:611-624
11. Berry MJ, Knutson GS, Lasky SR, Munemitsu SM, Samuel CE (1985) Mechanism of interferon action. Purification and substrate specificities of the double-stranded RNA-dependent protein kinase from untreated and interferon-treated mouse fibroblasts. J Biol Chem 260:11240-11247
12. Bischoff JR, Samuel CE (1989) Activation of the P1/eIF-2a protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA. Virology 172:106-115
13. Blatt LM, Davis JM, Klein SB, Taylor MW (1996) The biologic activity and molecular characterization of a novel synthetic interferon-alpha species, consensus interferon. J Interferon Cytokine Res 16: 489-499
14. Campbell IL, Harrison LC (1989) Viruses and cytokines: evidence for multiple roles in pancreatic beta cell destruction in type 1 insulin-dependent diabetes mellitus. J Cell Biochem 40:57-66
15. Cattaneo R (1994) Biased (A > I) hypermutation of animal RNA virus genomes. Curr Opin Genet Dev 4:895-900
16. Chang HW, Jacobs BL (1993) Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA. Virology 194:537-547
17. Chang HW, Watson JC, Jacobs BL (1992) The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci USA 89:4825-4829
18. Chebath J, Benech P, Revel M, Vigneron M (1987) Constitutive expression of 2′5′ oligo A synthetase confers resistance to picornavirus infection. Nature 330:587-588
19. Clemens MJ (1996) Protein kinases that phosphorylate eIF-2 and eIF-2B, and their role in eukaryotic cell translational control. In: Hershey JWB, Mathews MB, Sonenberg N (eds) Translational control. Cold Spring Harbor Press, Cold Spring Harbor, NY, pp 139-172
20. Coccia EM, Romeo G, Nissim A, Marziali G, Albertini R, Affabris E, Ballistini A, Fiorucci G, Orsatti R, Rossi GB, Chebath J (1990) A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Virology 179:228-233
21. Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N (1995) Double-stranded RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proc Natl Acad Sci USA 92:9445-9449
22. Daher KA, Samuel CE (1982) Mechanism of interferon action. Differential effect of interferon on the synthesis of simian virus 40 and reovirus polypeptides in monkey kidney cells. Virology 117:379-390
23. Darnell JE Jr, Kerr IM, Stark GM (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421
24. Davies MV, Furtado M, Hershey JWB, Thimmappaya B, Kaufman RJ (1989) Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. Proc Natl Acad Sci USA 86:9163-9167
25. DeBenedetti A, Williams GJ, Comeau L, Baglioni C (1985a) Inhibition of viral mRNA translation in interferon-treated L cells infected with reovirus. J Virol 55:588-593
26. DeBenedetti A, Williams GJ, Baglioni C (1985b) Inhibition of binding to initiation complexes of nascent reovirus mRNA by double-stranded RNA-dependent protein kinase. J Virol 54:408-413
27. DeMaeyer E, DeMaeyer-Guignard J (1988) Interferons and other regulatory cytokines. Wiley, New York
28. Desrosiers RC, Lengyel P (1979) Impairment of reovirus mRNA "cap" methylation in interferon-treated mouse L929 cells. Biochim Biphys Acta 562:471-480
29. Diaz MO, Bohlander S, Allen G (1993) Nomenclature of the human interferon genes. J Interferon Res 13:61-62
30. Ellis MN, Eidson CS, Brown J, Kleven SH (1983) Studies on interferon induction and interferon sensitivity of avian reoviruses. Avian Dis 27:927-936
31. Feduchi E, Esteban M, Carrasco L (1988) Reovirus type 3 synthesizes proteins in interferon-treated HeLa cells without reversing the antiviral state. Virology 164:420-426
32. Fields BN, Greene MI (1982) Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment. Nature 300:19-32
33. Galster RL, Lengyel P (1976) Formation and characteristics of reovirus subviral particles in interferon-treated mouse L cells. Nucleic Acid Res 3:581-598
34. Gaillard RK, Joklik WK (1985) The relative translation efficiency of reovirus messenger RNAs. Virology 147:336-348
35. Gale M, Tan SL, Wambach M, Katze MG (1996) Interaction of the interferon-induced PKR protein kinase with inhibitory proteins p58 and vaccinia virus K3L is mediated by unique domains: implication for kinase regulation. Mol Cell Biol 16:4172-4181
36. George CX, Samuel CE (1988) Mechanism of interferon action. Expression of reovirus S3 gene in transfected COS cells and subsequent inhibition at the level of protein synthesis by type I but not by type II interferon. Virology 166:573-582
37. Giantini M, Shatkin AJ (1989) Stimulation of chloramphenicol acetyltransferase mRNA translation by reovirus capsid polypeptide σ3 in cotransfected COS cells. J Virol 63:2415-2421
38. Gupta SL, Graziadi WD, Weideli H, Sopori M, Lengyel P (1974) Selective inhibition of viral protein accumulation in interferon-treated cells: nondiscriminate inhibition of the translation of added viral and cellular messenger RNAs in their extracts. Virology 57:49-63
39. Gupta SL, Holmes SL, Mehra LL (1982) Interferon action against reovirus: activation of interferon-induced protein kinase in mouse L929 cells upon reovirus infection. Virology 120:495-499
40. Henderson DR, Joklik WK (1978) The mechanism of interferon induction by UV-irradiated reovirus. Virology 91:389-406
41. Henry GL, McCormack SJ, Thomis DC, Samuel CE (1994) Translational control and the RNA-dependent protein kinase PKR: antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus s1 mRNA. J Biol Regul Homeost Agents 8:15-24
42. Hershey JWB (1991) Translational control in mammalian cells. Annu Rev Biochem 60:715-755
43. Hiscott J, Nguyen M, Lin RT (1995) Molecular mechanisms of interferon beta gene induction. Semin Virol 6:161-173
44. Huismans H, Joklik WK (1976) Reovirus-coded polypeptides in infected cells: isolation of two native monomeric polypeptides with affinity for single-stranded and double-stranded RNA respectively. Virology 70:411-424
45. Icely PL, Gross P, Bergeron JJM, Devault A, Afar DEH, Bell JC (1991) TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem 266: 16073-16077
46. Imani F, Jacobs BL (1988) Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein. Proc Natl Acad Sci USA 85:7887-7891
47. Isaacs A, Lindenmann J (1957) Virus interference. I. The interferon. Proc R Soc Lond B 147:258-267
48. Jacobs BL, Ferguson RE (1991) The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon. J Virol 65:5102-5104
49. Jacobs BL, Langland JO (1996) When two strands are better than one: the mediators of modulators of cellular responses to double-stranded RNA. Virology 219:339-349
50. Joklik WK (1983) The reoviridae. Plenum, New York
51. Kaempfer R, Israeli R, Rosen H, Knoller S, Zilberstein A, Schmidt A, Revel M (1979) Reversal of the interferon-induced block of protein synthesis by purified preparation of eukaryotic initiation factor 2. Virology 99:170-173
52. Kedl R, Schmechel S, Schiff L (1995) Comparative sequence analysis of the reovirus S4 genes from 13 serotype 1 and serotype 3 field isolates. J Virol 69:552-559
53. Kingsman SM, Smith MD, Samuel CE (1980) Mechanism of interferon action. Simian virus 40-specific early polypeptides synthesized in untreated and interferon-treated monkey kidney cells. Proc Natl Acad Sci USA 77:2419-2423
54. Kitajewski J, Schneider RJ, Safer B, Munemitsu SM, Samuel CE, Thimmappaya B, Shenk T (1986) Adenovirus VAI RNA antagonizes the antiviral state of interferon by preventing activation of the interferon-induced eIF-2a kinase. Cell 45:195-200
55. Kuhen KL, Samuel CE (1997) Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5′-flanking region of the human and mouse Pkr genes. Virology 227:119-130
56. Kuhen KL, Shen X, Carlisle ER, Richardson AL, Weier HUG, Tanak H, Samuel CE (1996a) Structural organization of the human gene PKR encoding an interferon-inducible RNA-dependent protein kinase and differences from its mouse homolog. Genomics 36:197-201
57. Kuhen KL, Shen X, Samuel CE (1996b) Mechanism of interferon action. Sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones. Gene 178:191-193
58. Lai M-HT, Joklik WK (1973) The induction of interferon by temperature-sensitive mutants of reovirus, UV-irradiated reovirus, and subviral reovirus particles. Virology 51:191-204
59. Lee PWK, Hayes EC, Joklik WK (1981) Characterization of anti-reovirus immunoglobulins secreted by cloned hybridoma cell lines. Virology 108:134-146
60. Lengyel P, Desrosiers R, Broeze R, Slattery E, Taira H, Dougherty J, Samanta H, Pichon J, Farrell P, Ratner L, Sen G (1980) In microbiology 1980. American Society of Microbiology, Washington DC, pp 219-226
61. Levin KH, Samuel CE (1980) Biosynthesis of reovirus-specified polypeptides. Purification and characterization of the small-sized class mRNAs of reovirus type 3: coding assignments and translational efficiencies. Virology 106:1-13
62. Lewis JA (1988) Induction of an antiviral state by interferon in the absence of elevated levels of 2,5-oligo(A) synthetase and eIF-2 kinase. Virology 162:118-127
63. Liu Y, Samuel CE (1996) Mechanism of interferon action. Functionally distinct dsRNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase. J Virol 70:1961-1968
64. Liu Y, George CX, Patterson JB, Samuel CE (1997) Functionally distinct dsRNA-binding domains associated with alternative splice-site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase. J Biol Chem 272:4419-1428
65. Lloyd RM, Shatkin AJ (1992) Translational stimulation by reovirus polypeptide σ3: substitution for VAI RNA and inhibition of phosphorylation of the α subunit of eukaryotic initiation factor eIF-2. J Virol 66:6878-6884
66. Long WF, Burke DC (1971) Interferon production by double-stranded RNA: a comparison of interferon induction by reovirus RNA to that by a synthetic double-stranded polynucleotide. J Gen Virol 12: 1-11
67. Major AS, Cuff CF (1996) Effects of the route of infection on immunoglobulin G subclasses and specificity of the reovirus-specific humoral immune response. J Virol 70:5968-5974
68. Mathews MB, Shenk T (1991) Adenovirus virus-associated RNA and translational control. J Virol 65:5657-5662
69. McCormack SJ, Samuel CE (1995) Mechanism of interferon action. RNA-binding activity of full-length and R-domain forms of the RNA-dependent protein kinase PKR - determination of KD values for VAI and TAR RNAs. Virology 206:511-519
70. McCormack SJ, Thomis DC, Samuel CE (1992) Mechanism of Interferon action. Identification of a RNA-binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2α protein kinase. Virology 188:47-56
71. Meurs E, Chong K, Galabru J, Thomas NSB, Kerr IM, Williams BRG, Hovanessian AG (1990) Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62:379-390
72. Miller JE, Samuel CE (1992) Proteolytic cleavage of the reovirus sigma 3 protein results in enhanced double-stranded RNA-binding activity: identification of a repeated basic amino acid motif within the C-terminal binding region. J Virol 66:5347-5356
73. Miyamoto NG, Samuel CE (1980) Mechanism of interferon action. Interferon-mediated inhibition of reovirus mRNA translation in the absence of detectable mRNA degradation but in the presence of protein phosphorylation. Virology 107:461-475
74. Miyamoto NG, Jacobs BL, Samuel CE (1983) Mechanism of interferon action. Effect of double-stranded RNA and the 5′-O-monophosphate form of 2′,5′-oligoadenylate on the inhibition of reovirus mRNA translation in vitro. J Biol Chem 258:15232-15237
75. Munemitsu SM, Samuel CE (1988) Biosynthesis of reovirus-specified polypeptides: effect of point mutation of the sequences flanking the 5′-proximal AUG initiation codons of the reovirus s1 and s4 genes on the efficiency of mRNA translation. Virology 163:643-646
76. Munoz A, Carrasco L (1984) Action of human lymphoblastoid interferon on HeLa cells infected with RNA-containing animal viruses. J Gen Virol 65:377-390
77. Nagano Y, Kojima Y (1958) Inhibition de l'infection vaccinale par le virus homologue. CR Seances Soc Bio Filiales 152:1627-1630
78. Neufeld DS, Platzer M, Davies TF (1989) Reovirus induction of MHC class II antigen in rat thyroid cells. Endocrinology 124:543-545
79. Nilsen TW, Maroney PA, Baglioni C (1982a) Inhibition of protein synthesis in reovirus-infected HeLa cells with elevated levels of interferon-induced protein kinase activity. J Biol Chem 257:14593-14596
80. Nilsen TW, Maroney PA, Baglioni C (1982b) Synthesis of (2′-5′)oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus. J Virol 42:1039-1045
81. Nilsen TW, Maroney PA, Baglioni C (1983) Maintenance of protein synthesis in spite of mRNA breakdown in interferon-treated HeLa cells infected with reovirus. Mol Cell Biol 3:64-69
82. Ortega LG, McCotter MD, Henry GL, McCormack SJ, Thomis DC, Samuel CE (1996) Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells. Virology 215:31-39
83. Pathak VK, Schindler D, Hershey JWB (1988) Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. Mol Cell Biol 8:993-995
84. Patterson JB, Samuel CE (1995) Expression and regulation by interferon of a double-stranded RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Mol Cell Biol 15:5376-5388
85. Patterson JB, Thomis DC, Hans SL, Samuel CE (1995) Mechanism of interferon action. Double-stranded RNA-specific adenosine deaminase from human cells is inducible by alpha and gamma interferons. Virology 210:508-511
86. Pestka S, Langer JA, Zoon KC, Samuel CE (1987) Interferons and their actions. Annu Rev Biochem 56:727-777
87. Roner MR, Gaillard RK, Joklik WK (1989) Control of reovirus mRNA translation efficiency by the regions upstream of initiation codons. Virology 168:292-301
88. Rubin BY, Gupta SL (1980) Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents. Proc Natl Acad Sci USA 77:5928-5932
89. Samuel CE (1979) Mechanism of interferon action. Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated protein kinase possessing site-specificity similar to hemin-regulated rabbit reticulocyte kinase. Proc Natl Acad Sci USA 76:600-604
90. Samuel CE (1986) Relationship between the interferon-induced antiviral state and protein P1/eIF-2α phosphorylation in mouse fibroblasts treated with natural and recombinant viral and immune interferon. In: The biology of the interferon system 1985. Elsevier, Amsterdam, pp 101-110
91. Samuel CE (1991) Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1-11
92. Samuel CE (1993) The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans. J Biol Chem 268:7603-7606
93. Samuel CE, Brody MS (1990) Biosynthesis of reovirus-spccified polypeptides: 2-aminopurine increases the efficiency of translation of reovirus si mRNA but not s4 mRNA in transfected cells. Virology 176:106-113
94. Samuel CE, Farris DA (1977) Mechanism of interferon action. Species specificity of interferon and of the interferon-mediated inhibitor of translation from mouse, human and monkey cells. Virology 77: 556-565
95. Samuel CE, Joklik WK (1974) A protein synthesizing system from interferon treated cells that discriminates between cellular and viral messenger RNAs. Virology 74:403-413
96. Samuel CE, Knutson GS (1981) Mechanism of interferon action: cloned human leukocyte interferons induce protein kinase and inhibit vesicular stomatitis virus but not reovirus replication in human amnion cells. Virology 114:302-306
97. Samuel CE, Knutson GS (1982a) Mechanism of interferon action. Kinetics of induction of the antiviral state and protein phosphorylation in mouse fibroblasts treated with natural and cloned interferons. J Biol Chem 257:11791-11795
98. Samuel CE, Knutson GS (1982b) Mechanism of interferon action. Kinetics of decay of the antiviral state and protein phosphorylation in mouse fibroblasts treated with natural and cloned interferons. J Biol Chem 257:11796-11801
99. Samuel CE, Knutson GS (1983) Mechanism of interferon action: human leukocyte and immune interferons regulate the expression of different genes and induce different antiviral states in human amnion U cells. Virology 130:474-184
100. Samuel CE, Farris DA, Eppstein DA (1977) Mechanism of interferon action. Kinetics of interferon action in mouse L929 cells: translation inhibition, protein phosphorylation, and messenger RNA methylation and degradation. Virology 83:56-71
101. Samuel CE, Kingsman SM, Melamed RW, Farris D, Smith MD, Miyamoto NG, Lasky SR, Knutson GS (1980) Mechanism of interferon mediated inhibition of protein synthesis. Ann NY Acad Sci 350: 475-485
102. Samuel CE, Knutson GS, Masters PS (1982) Ability of cloned human type-alpha interferons to induce protein phosphorylation and inhibit virus replication is specified by the host cell rather than the interferon subspecies. J Interferon Res 2:563-574
103. Samuel CE, Duncan R, Knutson GS, Hershey JW (1984) Mechanism of interferon action. Increased phosphorylation of protein synthesis initiation factor eIF-2 alpha in interferon-treated, reovirus-infected mouse L929 fibroblasts in vitro and in vivo. J Biol Chem 259:13451-13457
104. Samuel CE, Knutson GS, Berry MJ, Atwater JA, Lasky SR (1986) Purification of double-stranded RNA-dependent protein kinase from mouse fibroblasts. Methods Enzymol 119:499-516
105. Schiff LA, Nibert ML, Co MS, Brown EG, Fields BN (1988) Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein σ3. Mol Cell Biol 8:273-283
106. Schindler C, Darnell JE Jr (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621-651
107. Schmechel S, Chute M, Skinner P, Anderson R, Schiff L (1997) Preferential translation of reovirus mRNA by a sigma3-dependent mechanism. Virology 232:62-73
108. Schneider RJ, Safer B, Munemitsu SM, Samuel CE, Shenk T (1985) Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 α subunit subsequent to infection. Proc Natl Acad Sci USA 82:4321-4325
109. Sen GC, Ransohoff RM (1992) Interferon-induced antiviral actions and their regulation. Adv Virus Res 42:57-102
110. Sharpe AH, Fields BN (1983) Pathogenesis of reovirus infection. In: Joklik WK (ed) The reoviridae. Plenum, New York, pp 229-285
111. Seliger LS, Giantini M, Shatkin AJ (1992) Translational effects and sequence comparisons of the three serotypes of the reovirus S4 gene. Virology 187:202-210
112. Sherry B, Baty CJ, Blum MA (1996) Reovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes. J Virol 70:6709-6715
113. Smith RE, Zweerink HJ, Joklik WK (1969) Polypeptide components of virions, top component, and cores of reovirus type 3. Virology 39:791-798
114. Staeheli P (1990) Interferon-induced proteins and the antiviral state. Adv Virus Res 38:147-200
115. Stewart WE (1979) The interferon system. Springer, Berlin Heidelberg New York
116. Tanaka H, Samuel CE (1994) Mechanism of interferon action. Structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase. Proc Natl Acad Sci USA 91:7995-7999
117. Tanaka H, Samuel CE (1995) Sequence of the murine interferon-inducible RNA-dependent protein kinase PKR deduced from genomic clones. Gene 153:283-284
118. Thomis DC, Samuel CE (1995) Characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible RNA-dependent protein kinase. J Virol 69:5195-5198
119. Thomis DC, Doohan JP, Samuel CE (1992) Mechanism of interferon action: cDNA structure, expression and regulation of the interferon-induced, RNA-dependent P1/eIF-2a protein kinase from human cells. Virology 188:33-46
120. Tillotson L, Shatkin AJ (1992) Reovirus polypeptide σ3 and N-terminal myristoylation of polypeptide μ1 are required for site-specific cleavage to μ1C in transfected cells. J Virol 66:2180-2186
121. Townsend A, Bodmer H (1989) Antigen recognition by class I restricted T lymphocytes. Annu Rev Immunol 7:601-624
122. Vilcek J, Sen GC (1996) Interferons and other cytokines. In: Fields BN, Knipe DM, Howley PM (eds) Fundamental virology. Lippincott-Raven, Philadelphia, pp 341-365
123. Wiebe ME, Joklik WK (1975) The mechanism of inhibition of reovirus replication by interferon. Virology 66:229-240
124. Williams BRG, Silverman RH (1985) The 2-5A system: molecular and clinical aspects of the interferon-regulated pathway. Prog Clin Biol Res 202:1-478
125. Winship TR, Marcus PI (1980) Interferon induction by viruses. VI. Reovirus: virion genome dsRNA as the interferon inducer in aged chick embryo cells. J Interferon Res 1:155-167
126. Yang YL, Reis LFL, Pavlovic J, Aguzzi A, Schafer R, Kumar A, Williams BRG, Aguet M, Weissmann C (1995) Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 14:6095-6106
127. Yue Z, Shatkin AJ (1997) Double-stranded RNA-dependent protein kinase (PKR) is regulated by reovirus structural proteins. Virology 234:364-371
128. Yewdell JW, Bennink JR (1990) The binary logic of antigen processing and presentation to T cells. Cell 62:203-206
129. Young HA (1996) Regulation of interferon-γ gene expression. J Interferon Cytokine Res 16:563-568
130. Zhou A, Hassel BA, Silverman RH (1993) Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell 72:753-765