Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling

EMBO Journal

Volumn 18, Issue 9, 1999, Pages 2480-2488

  Takaoka, Akinori ^a   Tanaka, Nobuyuki ^a   Mitani, Yukiko ^a   Miyazaki, Tadaaki ^a   Fujii, Hodaka ^a   Sato, Mitsuharu ^a   Kovarik, Pavel ^b   Decker, Thomas ^b   Schlessinger, Joseph ^c   Taniguchi, Tadatsugu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Vienna Biocenter   (Austria)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Interferon ; Jak Stat; MAPK; Pyk2; Signal transduction

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SERINE; STAT1 PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMORPHISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMALS; ANTIVIRAL AGENTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FOCAL ADHESION KINASE 2; IMMUNITY, NATURAL; INTERFERON TYPE II; INTERFERON-ALPHA; JANUS KINASE 2; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; SERINE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYROSINE; VIRUSES;

ANIMALIA; JANUS;

EID: 0033522422     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.9.2480     Document Type: Article

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