메뉴 건너뛰기




Volumn 43, Issue 1-2, 1998, Pages 43-68

Combinatorial chemistry for the generation of molecular diversity and the discovery of bioactive leads

Author keywords

Combinatorial chemistry; Compound collections; Compound libraries; Deconvolution; Encoding; Lead identification; Molecular diversity; Parallel synthesis; Positional scanning; Split synthesis; Tagging

Indexed keywords

LIGAND; ORGANIC COMPOUND;

EID: 0032575947     PISSN: 01697439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-7439(98)00082-3     Document Type: Article
Times cited : (30)

References (175)
  • 3
  • 5
    • 0010350016 scopus 로고    scopus 로고
    • Suppl
    • Verdine G.L. Nature. 384:1996;10-13. Suppl.
    • (1996) Nature , vol.384 , pp. 10-13
    • Verdine, G.L.1
  • 9
    • 0002994114 scopus 로고
    • Molecular similarity
    • in: H. Kubinyi (Ed.) ESCOM Leiden, NL
    • P.M. Dean, Molecular similarity, in: H. Kubinyi (Ed.), 3D QSAR in Drug Design, ESCOM Leiden, NL, 1993, pp. 150-172.
    • (1993) 3D QSAR in Drug Design , pp. 150-172
    • Dean, P.M.1
  • 10
    • 0344748837 scopus 로고    scopus 로고
    • Quantification of molecular similarity and its application to combinatorial chemistry
    • in: H. van de Water-beemd, B. Testa, G. Folkers (Eds.) Basel
    • R.A. Lewis, A.C. Good, S.D. Pickett, Quantification of molecular similarity and its application to combinatorial chemistry, in: H. van de Water-beemd, B. Testa, G. Folkers (Eds.), Computer-Assisted Lead Finding and Optimization, Helvetica Chimica Acta, Basel, 1997, pp. 137-156.
    • (1997) Computer-Assisted Lead Finding and Optimization, Helvetica Chimica Acta , pp. 137-156
    • Lewis, R.A.1    Good, A.C.2    Pickett, S.D.3
  • 19
    • 0010304362 scopus 로고    scopus 로고
    • Using pharmacophore diversity to select molecules to test from commercial catalogues
    • in: I. Chaiken, K.D. Janda (Eds.) American Chemical Society, WA
    • K. Davies, Using pharmacophore diversity to select molecules to test from commercial catalogues, in: I. Chaiken, K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry, American Chemical Society, WA, 1996, pp. 309-316.
    • (1996) Molecular Diversity and Combinatorial Chemistry , pp. 309-316
    • Davies, K.1
  • 22
    • 0010394489 scopus 로고    scopus 로고
    • Molecular dynamic simulations as a tool to investigate the three-dimensional diversity of peptide and pseudopeptide libraries
    • in: H. van de Waterbeemd, B. Testa, G. Folkers (Eds.) Basel
    • G. Grassy, A. Yasri, B. Calas, A.M. Armbruster, R. Lahana, J.L. Fauchère, Molecular dynamic simulations as a tool to investigate the three-dimensional diversity of peptide and pseudopeptide libraries, in: H. van de Waterbeemd, B. Testa, G. Folkers (Eds.), Computer-Assisted Lead Finding and Optimization, Helvetica Chimica Acta, Basel, 1997, pp. 211-221.
    • (1997) Computer-Assisted Lead Finding and Optimization, Helvetica Chimica Acta , pp. 211-221
    • Grassy, G.1    Yasri, A.2    Calas, B.3    Armbruster, A.M.4    Lahana, R.5    Fauchère, J.L.6
  • 44
    • 0001323198 scopus 로고    scopus 로고
    • Second-generation robotic synthesizer for peptide, pseudopeptide and non-peptide libraries
    • in: J.N. Little, C. O'Neil, J.R. Strimaitis (Eds.) Zymark, Hopkinton, MA, USA
    • J.A. Boutin, J.L. Fauchère, Second-generation robotic synthesizer for peptide, pseudopeptide and non-peptide libraries, in: J.N. Little, C. O'Neil, J.R. Strimaitis (Eds.), Proceedings of the International Symposium on Laboratory Automation and Robotics 1995, Zymark, Hopkinton, MA, USA, 1996, pp. 197-210.
    • (1996) Proceedings of the International Symposium on Laboratory Automation and Robotics 1995 , pp. 197-210
    • Boutin, J.A.1    Fauchère, J.L.2
  • 47
    • 84958232329 scopus 로고    scopus 로고
    • PEG grafted polystyrene tentacle polymers: physicochemical properties and application in chemical synthesis
    • in: G. Jung (Ed.) VCH, Weinheim, Germany
    • W. Rapp, PEG grafted polystyrene tentacle polymers: physicochemical properties and application in chemical synthesis, in: G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries, VCH, Weinheim, Germany, 1996, pp. 425-464.
    • (1996) Combinatorial Peptide and Nonpeptide Libraries , pp. 425-464
    • Rapp, W.1
  • 70
    • 0003052549 scopus 로고    scopus 로고
    • Solid-phase synthesis, characterization, and screening of a 43 000-compound tetrahydroisoquinoline combinatorial library
    • in: I. Chaiken, K.D. Janda (Eds.) American Chemical Society, WA
    • M.C. Griffith, C.T. Dooley, R.A. Houghten, Solid-phase synthesis, characterization, and screening of a 43 000-compound tetrahydroisoquinoline combinatorial library, in: I. Chaiken, K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry, American Chemical Society, WA, 1996, pp. 50-57.
    • (1996) Molecular Diversity and Combinatorial Chemistry , pp. 50-57
    • Griffith, M.C.1    Dooley, C.T.2    Houghten, R.A.3
  • 131
  • 175
    • 0000889026 scopus 로고    scopus 로고
    • (Guest Ed.), Symposium-in-print number 70: solution phase combinatorial chemistry.
    • D.L. Coffen (Guest Ed.), Tetrahedron 54 (1998) 3955-4150. Symposium-in-print number 70: solution phase combinatorial chemistry.
    • (1998) Tetrahedron , vol.54 , pp. 3955-4150
    • Coffen, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.