-
1
-
-
0013058862
-
System and method of automatically generating chemical compounds with desired properties
-
United States Patent 5,463,564 Agrafiotis D.A. Bone R.F. Salemme F.R. Soll R.M. System and method of automatically generating chemical compounds with desired properties 1995 Oct. 31, 1995
-
(1995)
-
-
Agrafiotis, D.A.1
Bone, R.F.2
Salemme, F.R.3
Soll, R.M.4
-
2
-
-
0029623184
-
Computational methods to predict binding free energy in ligand receptor complexes
-
Ajay Murcko M.A. Computational methods to predict binding free energy in ligand receptor complexes J. Med. Chem. 38 1995 4953 4967
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4953-4967
-
-
Ajay1
Murcko, M.A.2
-
3
-
-
0028821490
-
Solid-phase synthesis and C-terminal amidation of peptides using a photolabile o-nitrobenzhydrylaminopolystyrene support
-
Ajayaghosh A. Pillal V.N.R. Solid-phase synthesis and C -terminal amidation of peptides using a photolabile o -nitrobenzhydrylaminopolystyrene support Tetrahedron Lett. 36 1995 777 780
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 777-780
-
-
Ajayaghosh, A.1
Pillal, V.N.R.2
-
4
-
-
85114535132
-
Discovery and optimization of a specific, orally available, active site inhibitor of, Factor Xa discovered using synthetic combinatorial chemistry
-
Al-Obeidi F.A.D. Wildgoose P. Stringer S.K. Safar P. Safarova A. Abdul-Latif F.A. Thorpe D.S. Seligmann B.E. Sepetov K.F. Strop P. Ostrem J.A. Discovery and optimization of a specific, orally available, active site inhibitor of, Factor Xa discovered using synthetic combinatorial chemistry J. Invest. Med. 43 Suppl. 2 1995 232A
-
(1995)
J. Invest. Med.
, vol.43
, Issue.Suppl. 2
, pp. 232A
-
-
Al-Obeidi, F.A.D.1
Wildgoose, P.2
Stringer, S.K.3
Safar, P.4
Safarova, A.5
Abdul-Latif, F.A.6
Thorpe, D.S.7
Seligmann, B.E.8
Sepetov, K.F.9
Strop, P.10
Ostrem, J.A.11
-
6
-
-
85114533792
-
SYBYL line notation: Full Markush, combinatorial and query specification in a single language
-
Ash J. SYBYL line notation: Full Markush, combinatorial and query specification in a single language Fourth Int. Conf. Chemical Structures, Abstr. No. 49 Noordwijkerhout, June 2–5, 1996 1996
-
(1996)
-
-
Ash, J.1
-
7
-
-
37049106853
-
Peptide synthesis. Part 2. Procedure for solid-phase synthesis using N-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptide
-
Atherton E. Logan C.J. Sheppard R.C. Peptide synthesis. Part 2. Procedure for solid-phase synthesis using N -fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptide J. Chem Soc. Perkin Trans. 1 1981 538 546
-
(1981)
J. Chem Soc. Perkin Trans.
, vol.1
, pp. 538-546
-
-
Atherton, E.1
Logan, C.J.2
Sheppard, R.C.3
-
9
-
-
0027199771
-
Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries
-
Barbas C.F. III Rosenblum J.S. Lerner R.A. Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries Proc. Natl Acad. Sci. USA 90 1993 6385 6389
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 6385-6389
-
-
Barbas, C.F.1
Rosenblum, J.S.2
Lerner, R.A.3
-
11
-
-
33751392117
-
Clustering of chemical structures on the basis of two-dimensional similarity measures
-
Barnard J.M. Downs G.M. Clustering of chemical structures on the basis of two-dimensional similarity measures J. Chem. Inf. Comput. Sci. 32 1992 644 649
-
(1992)
J. Chem. Inf. Comput. Sci.
, vol.32
, pp. 644-649
-
-
Barnard, J.M.1
Downs, G.M.2
-
13
-
-
0029126779
-
Inhibitors of human heart chymase based on a peptide library
-
Bastos M. Maeji N.J. Abeles R.H. Inhibitors of human heart chymase based on a peptide library Proc. Natl Acad Sci. USA 92 1995 6738 6742
-
(1995)
Proc. Natl Acad Sci. USA
, vol.92
, pp. 6738-6742
-
-
Bastos, M.1
Maeji, N.J.2
Abeles, R.H.3
-
14
-
-
0027104788
-
Polymer-supported synthesis of 2,5-disubstituted tetrahydrofurans
-
Beebe X. Schore N.E. Kurth M.J. Polymer-supported synthesis of 2,5-disubstituted tetrahydrofurans J. Am. Chem. Soc. 114 1992 10061 10062
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10061-10062
-
-
Beebe, X.1
Schore, N.E.2
Kurth, M.J.3
-
15
-
-
0028064952
-
Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids
-
Blondelle S.E. Takahashi E. Weber P.A. Houghten R.A. Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids Antimicrob. Agents Chemother. 38 1994 2280 2286
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2280-2286
-
-
Blondelle, S.E.1
Takahashi, E.2
Weber, P.A.3
Houghten, R.A.4
-
16
-
-
0030049034
-
Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries
-
Blondelle S.E. Takahashi E. Houghten R.A. Perez-Paya E. Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries Biochem. J. 313 1996 141 147
-
(1996)
Biochem. J.
, vol.313
, pp. 141-147
-
-
Blondelle, S.E.1
Takahashi, E.2
Houghten, R.A.3
Perez-Paya, E.4
-
17
-
-
0030028551
-
Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries
-
Blondelle S. Houghten R.A. Perez-Paya E. Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries J. Biol. Chem. 271 1996 4093 4099
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4093-4099
-
-
Blondelle, S.1
Houghten, R.A.2
Perez-Paya, E.3
-
18
-
-
0026575221
-
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
-
Bock L.C. Griffin L.C. Latham J.A. Vermaas E.H. Toole J.J. Selection of single-stranded DNA molecules that bind and inhibit human thrombin Nature 355 1992 564 566
-
(1992)
Nature
, vol.355
, pp. 564-566
-
-
Bock, L.C.1
Griffin, L.C.2
Latham, J.A.3
Vermaas, E.H.4
Toole, J.J.5
-
19
-
-
15844384484
-
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists
-
Boden P. Eden J.M. Hodgson J. Horwell D.C. Hughes J. McKnight A.T. Lewthwaite R.A. Pritchard M.C. Raphy J. Meecham K. Ratcliffe G.S. Suman-Chauhan N. Woodruff G.N. Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists J. Med. Chem. 39 1996 1664 1675
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1664-1675
-
-
Boden, P.1
Eden, J.M.2
Hodgson, J.3
Horwell, D.C.4
Hughes, J.5
McKnight, A.T.6
Lewthwaite, R.A.7
Pritchard, M.C.8
Raphy, J.9
Meecham, K.10
Ratcliffe, G.S.11
Suman-Chauhan, N.12
Woodruff, G.N.13
-
20
-
-
0029987185
-
Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries
-
Boger D.L. Tarby C.M. Myers P.L. Caporale L.H. Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries J. Am. Chem. Soc. 118 1996 2109 2110
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2109-2110
-
-
Boger, D.L.1
Tarby, C.M.2
Myers, P.L.3
Caporale, L.H.4
-
21
-
-
0029978630
-
Solid phase synthesis of azabicyclo[4.3.0]nonen-8-one amino acid derivatives via intramolecular Pauson-Khand cyclization
-
Bolton G.L. Solid phase synthesis of azabicyclo[4.3.0]nonen-8-one amino acid derivatives via intramolecular Pauson-Khand cyclization Tetrahedron Lett. 37 1996 3433 3436
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 3433-3436
-
-
Bolton, G.L.1
-
22
-
-
0025354607
-
High efficiency liquid phase. Synthesis of oligonucleotides on a soluble polymer
-
Bonora G.M. Scremin C.L. Colonna F.P. Garbesi A. High efficiency liquid phase. Synthesis of oligonucleotides on a soluble polymer Nucl. Acids Res. 18 1990 3155 3159
-
(1990)
Nucl. Acids Res.
, vol.18
, pp. 3155-3159
-
-
Bonora, G.M.1
Scremin, C.L.2
Colonna, F.P.3
Garbesi, A.4
-
23
-
-
0001759581
-
Synthetic receptor for internal residues of a peptide chain. Highly selective binding of (L)X-(L)Pro-(L)X tripeptides
-
Borchardt A. Still W.C. Synthetic receptor for internal residues of a peptide chain. Highly selective binding of (L)X-(L)Pro-(L)X tripeptides J. Am. Chem. Soc. 116 1994 7467 7468
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 7467-7468
-
-
Borchardt, A.1
Still, W.C.2
-
24
-
-
0040251963
-
Combinatorial peptide synthesis: Statistical evaluation of peptide distribution
-
Boutin J.A. Fauchère A.L. Combinatorial peptide synthesis: Statistical evaluation of peptide distribution TIPS 17 1996 8 12
-
(1996)
TIPS
, vol.17
, pp. 8-12
-
-
Boutin, J.A.1
Fauchère, A.L.2
-
25
-
-
0030056289
-
Combinatorial peptide libraries: Robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques
-
Boutin J.A. Henning P. Lambert P.H. Bertin S. Petit L. Mahieu J.P. Serkiz P. Volland J.P. Fauchère J.-L. Combinatorial peptide libraries: Robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques Anal. Biochem. 234 1996 126 141
-
(1996)
Anal. Biochem.
, vol.234
, pp. 126-141
-
-
Boutin, J.A.1
Henning, P.2
Lambert, P.H.3
Bertin, S.4
Petit, L.5
Mahieu, J.P.6
Serkiz, P.7
Volland, J.P.8
Fauchère, J.-L.9
-
26
-
-
0028100318
-
Peptidosteroidal receptors for opioid peptides. Sequence-selective binding using a synthetic receptor library
-
Boyce R. Li G. Nestler P. Suenaga T. Still W.C. Peptidosteroidal receptors for opioid peptides. Sequence-selective binding using a synthetic receptor library J. Am. Chem. Soc. 116 1994 7955 7956
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 7955-7956
-
-
Boyce, R.1
Li, G.2
Nestler, P.3
Suenaga, T.4
Still, W.C.5
-
27
-
-
0025106227
-
The simultaneous multiple production of solution phase peptides: assessment of the Geysen method of simultaneous peptide synthesis
-
Bray A.M. Maeji N.J. Geysen H.M. The simultaneous multiple production of solution phase peptides: assessment of the Geysen method of simultaneous peptide synthesis Tetrahedron Lett. 31 1990 5811 5814
-
(1990)
Tetrahedron Lett.
, vol.31
, pp. 5811-5814
-
-
Bray, A.M.1
Maeji, N.J.2
Geysen, H.M.3
-
28
-
-
0001736786
-
Simultaneous multiple synthesis of peptide amides by the multipin method. Application of vapor-phase ammonolysis
-
Bray A.M. Jhingran A.G. Valerio R.M. Maeji N.J. Simultaneous multiple synthesis of peptide amides by the multipin method. Application of vapor-phase ammonolysis J. Org. Chem. 59 1994 2197 2203
-
(1994)
J. Org. Chem.
, vol.59
, pp. 2197-2203
-
-
Bray, A.M.1
Jhingran, A.G.2
Valerio, R.M.3
Maeji, N.J.4
-
29
-
-
85047670016
-
Rapid optimization of organic reactions on solid phase using the multipin approach: synthesis of 4-aminoproline analogues, by reductive amination
-
Bray A.M. Chiefari D.S. Valerio R.M. Maeji N.J. Rapid optimization of organic reactions on solid phase using the multipin approach: synthesis of 4-aminoproline analogues, by reductive amination Tetrahedron Lett. 36 1995 5081 5084
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 5081-5084
-
-
Bray, A.M.1
Chiefari, D.S.2
Valerio, R.M.3
Maeji, N.J.4
-
30
-
-
0029361783
-
A single-bead decode strategy using electrospray ionization mass spectrometry and a new photolabile linker: 3-Amino-3-(2-nitrophenyl)propionic acid
-
Brown B.B. Wagner D.S. Geysen H.M. A single-bead decode strategy using electrospray ionization mass spectrometry and a new photolabile linker: 3-Amino-3-(2-nitrophenyl)propionic acid Molec. Diversity 1 1995 4 12
-
(1995)
Molec. Diversity
, vol.1
, pp. 4-12
-
-
Brown, B.B.1
Wagner, D.S.2
Geysen, H.M.3
-
31
-
-
0026669435
-
Engineered iron oxide adhesion mutants of the Escherichia coli phage lambda receptor
-
Brown S. Engineered iron oxide adhesion mutants of the Escherichia coli phage lambda receptor Proc. Natl Acad Sci. USA 89 1992 8651 8655
-
(1992)
Proc. Natl Acad Sci. USA
, vol.89
, pp. 8651-8655
-
-
Brown, S.1
-
32
-
-
0029200741
-
Bio-affinity characterization mass spectrometry
-
Bruce J.E. Anderson G.A. Chen R. Cheng X. Gale D.C. Hofstadler S.A. Schwartz B.L. Smith R.D. Bio-affinity characterization mass spectrometry Rapid Comm. Mass Spectrom. 9 1995 644 650
-
(1995)
Rapid Comm. Mass Spectrom.
, vol.9
, pp. 644-650
-
-
Bruce, J.E.1
Anderson, G.A.2
Chen, R.3
Cheng, X.4
Gale, D.C.5
Hofstadler, S.A.6
Schwartz, B.L.7
Smith, R.D.8
-
33
-
-
9044227620
-
Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries
-
Brummel C.L. Vickerman J.C. Carr S.A. Hemling M.E. Roberts G.D. Johnson W. Weinstock J. Gaitanopouos D. Benkovic S.J. Winograd N. Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries Anal. Chem. 68 1996 237 242
-
(1996)
Anal. Chem.
, vol.68
, pp. 237-242
-
-
Brummel, C.L.1
Vickerman, J.C.2
Carr, S.A.3
Hemling, M.E.4
Roberts, G.D.5
Johnson, W.6
Weinstock, J.7
Gaitanopouos, D.8
Benkovic, S.J.9
Winograd, N.10
-
34
-
-
0027068161
-
A general and expedient method for the synthesis of 1,4-benzodiazepine derivatives
-
Bunin B.A. Ellman J.A. A general and expedient method for the synthesis of 1,4-benzodiazepine derivatives J. Am. Chem. Soc. 114 1992 10997 10998
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10997-10998
-
-
Bunin, B.A.1
Ellman, J.A.2
-
35
-
-
0029036168
-
A paradigm for drug discovery employing encoded combinatorial libraries
-
Burbaum J.J. Ohlmeyer M.H.J. Reader J.C. Henderson I. Dillard L.W. Li G. Randle T.L. Sigal N.H. Chelsky D. Baldwin J.J. A paradigm for drug discovery employing encoded combinatorial libraries Proc. Natl. Acad. Sci. USA 92 1995 6027 6031
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 6027-6031
-
-
Burbaum, J.J.1
Ohlmeyer, M.H.J.2
Reader, J.C.3
Henderson, I.4
Dillard, L.W.5
Li, G.6
Randle, T.L.7
Sigal, N.H.8
Chelsky, D.9
Baldwin, J.J.10
-
36
-
-
0024715264
-
Molecular identification numbers for substructure searches
-
Burden F.R. Molecular identification numbers for substructure searches J. Chem. Inf. Comp. Sci. 29 1989 225 227
-
(1989)
J. Chem. Inf. Comp. Sci.
, vol.29
, pp. 225-227
-
-
Burden, F.R.1
-
38
-
-
85050324014
-
Searching techniques for, databases of three-dimensional structures
-
Bures M.G. Martin Y.C. Willett P. Searching techniques for, databases of three-dimensional structures Topics Stereochem. 21 1994 467 511
-
(1994)
Topics Stereochem.
, vol.21
, pp. 467-511
-
-
Bures, M.G.1
Martin, Y.C.2
Willett, P.3
-
39
-
-
0028807548
-
Synthetic ionophores. Encoded combinatorial libraries of cyclen-based receptors for Cu2+ and Co2+
-
2+ J. Org. Chem. 60 1995 7382 7383
-
(1995)
J. Org. Chem.
, vol.60
, pp. 7382-7383
-
-
Burger, M.T.1
Still, W.C.2
-
40
-
-
0028135116
-
Combinatorial technologies involving reiterative division/coupling/recombination: Statistical considerations
-
Burgess K. Liaw A.I. Wang N. Combinatorial technologies involving reiterative division/coupling/recombination: Statistical considerations J. Med. Chem. 37 1984 2985 2987
-
(1984)
J. Med. Chem.
, vol.37
, pp. 2985-2987
-
-
Burgess, K.1
Liaw, A.I.2
Wang, N.3
-
41
-
-
0000517240
-
Solid-phase synthesis of non-natural biopolymers with repetitive urea subunits
-
Burgess K. Linthicum D.S. Shin H.W. Solid-phase synthesis of non-natural biopolymers with repetitive urea subunits Angew. Chem., Int. Ed. Engl. 34 1995 907 909
-
(1995)
Angew. Chem., Int. Ed. Engl.
, vol.34
, pp. 907-909
-
-
Burgess, K.1
Linthicum, D.S.2
Shin, H.W.3
-
42
-
-
33845379303
-
Atom pairs as molecular features in structure-activity studies: Definitions and applications
-
Carhart R.E. Smith D.H. Ventkatataraghavan R. Atom pairs as molecular features in structure-activity studies: Definitions and applications J. Chem. Inf. Comput. Sci. 25 1985 64 73
-
(1985)
J. Chem. Inf. Comput. Sci.
, vol.25
, pp. 64-73
-
-
Carhart, R.E.1
Smith, D.H.2
Ventkatataraghavan, R.3
-
43
-
-
3743084024
-
Analogous organic synthesis of small-compound libraries: validation of combinatorial chemistry in small-molecule synthesis
-
Chen C. Ahlberg Randall L.A. Miller R.B. Jones A.D. Kurth M.J. Analogous organic synthesis of small-compound libraries: validation of combinatorial chemistry in small-molecule synthesis J. Am. Chem. Soc. 116 1994 2661 2662
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 2661-2662
-
-
Chen, C.1
Ahlberg Randall, L.A.2
Miller, R.B.3
Jones, A.D.4
Kurth, M.J.5
-
44
-
-
0027892193
-
Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase
-
Chen J.K. Lane W.S. Brauer A.W. Tanaka A. Schreiber S.L. Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase J. Am. Chem. Soc. 115 1993 12591 12592
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 12591-12592
-
-
Chen, J.K.1
Lane, W.S.2
Brauer, A.W.3
Tanaka, A.4
Schreiber, S.L.5
-
45
-
-
0013249477
-
Protodetachable arylsilane polymer linkages for use in solid phase organic synthesis
-
Chenera B. Finkelstein J.A. Veber D.F. Protodetachable arylsilane polymer linkages for use in solid phase organic synthesis J. Am. Chem. Soc. 117 1995 11999 12000
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11999-12000
-
-
Chenera, B.1
Finkelstein, J.A.2
Veber, D.F.3
-
46
-
-
0027889510
-
An unnatural biopolymer
-
Cho C.Y. Moran E.J. Cherry S.Z. Stephens J.C. Fodor S. Adams A. Sundaram A. Jacobs J.W. Schultz P.G. An unnatural biopolymer Science 261 1993 1303 1305
-
(1993)
Science
, vol.261
, pp. 1303-1305
-
-
Cho, C.Y.1
Moran, E.J.2
Cherry, S.Z.3
Stephens, J.C.4
Fodor, S.5
Adams, A.6
Sundaram, A.7
Jacobs, J.W.8
Schultz, P.G.9
-
47
-
-
0029011168
-
NPIT: A new reagent for quantitatively monitoring reactions of amines in combinatorial synthesis
-
Chu S.S. Reich S.H. NPIT: A new reagent for quantitatively monitoring reactions of amines in combinatorial synthesis Bioorg. Med. Chem. Lett. 5 1995 1053 1058
-
(1995)
Bioorg. Med. Chem. Lett.
, vol.5
, pp. 1053-1058
-
-
Chu, S.S.1
Reich, S.H.2
-
48
-
-
0029074226
-
Free solution identification of candidate peptides from combinatorial libraries by affinity capillary electrophoresis/mass spectrometry
-
Chu Y.H. Kirby D.P. Karger B.L. Free solution identification of candidate peptides from combinatorial libraries by affinity capillary electrophoresis/mass spectrometry J. Am. Chem. Soc. 117 1995 5419 5420
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 5419-5420
-
-
Chu, Y.H.1
Kirby, D.P.2
Karger, B.L.3
-
49
-
-
0029876415
-
Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2
-
Colas P. Cohen B. Jessen T. Grishina I. McCoy J. Brent R. Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2 Nature 380 1996 548 550
-
(1996)
Nature
, vol.380
, pp. 548-550
-
-
Colas, P.1
Cohen, B.2
Jessen, T.3
Grishina, I.4
McCoy, J.5
Brent, R.6
-
51
-
-
85114552197
-
Validated molecular diversity in library design
-
Cramer R.D. Validated molecular diversity in library design Fourth Int. Conf. on Chemical Structures, Abst. No. 50 Noordwijkerhout, June 2–5, 1996 1996
-
(1996)
-
-
Cramer, R.D.1
-
52
-
-
0026546880
-
Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor
-
Cull M.G. Miller J.F. Schatz P.J. Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor Proc. Natl Acad. Sci. USA 89 1992 1865 1869
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 1865-1869
-
-
Cull, M.G.1
Miller, J.F.2
Schatz, P.J.3
-
54
-
-
0005757079
-
Combinatorial chemistry library design using pharmacophore diversity
-
July 1995 Davies K. Briant C. Combinatorial chemistry library design using pharmacophore diversity Network Science 1995 http://www.awod.com
-
(1995)
Network Science
-
-
Davies, K.1
Briant, C.2
-
55
-
-
84894675217
-
An information management architecture for combinatorial chemistry
-
July 1995 Davies K. White C. An information management architecture for combinatorial chemistry Network Science 1995 http://www.awod.com
-
(1995)
Network Science
-
-
Davies, K.1
White, C.2
-
56
-
-
0028784356
-
Drug leads from combinatorial phosphodiester libraries
-
Davis P.W. Vickers T.A. Wilson-Lingardo L. Wyatt J.R. Guinosso C.J. Sanghvi Y.S. DeBaets E.A. Acevedo O.L. Cook P.D. Ecker D.J. Drug leads from combinatorial phosphodiester libraries J. Med. Chem. 38 1995 4363 4366
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4363-4366
-
-
Davis, P.W.1
Vickers, T.A.2
Wilson-Lingardo, L.3
Wyatt, J.R.4
Guinosso, C.J.5
Sanghvi, Y.S.6
DeBaets, E.A.7
Acevedo, O.L.8
Cook, P.D.9
Ecker, D.J.10
-
59
-
-
0025004285
-
Random peptide libraries: a source of specific protein binding molecules
-
Devlin J.J. Panganiban L.C. Devlin P.E. Random peptide libraries: a source of specific protein binding molecules Science 249 1990 404 406
-
(1990)
Science
, vol.249
, pp. 404-406
-
-
Devlin, J.J.1
Panganiban, L.C.2
Devlin, P.E.3
-
60
-
-
0027372945
-
Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries
-
Dooley C.T. Chung N.N. Schiller P.W. Houghten R.A. Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries Proc. Natl Acad. Sci. USA 90 1993 10811 10815
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 10811-10815
-
-
Dooley, C.T.1
Chung, N.N.2
Schiller, P.W.3
Houghten, R.A.4
-
64
-
-
85114546552
-
Techniques for generating descriptive fingerprints in combinatorial libraries
-
Downs G.M. Barnard J.M. Techniques for generating descriptive fingerprints in combinatorial libraries Fourth Int. Conf. on Chemical Structures, Abstract No. 13 Noordwijkerhout, June 2–5, 1996 1996
-
(1996)
-
-
Downs, G.M.1
Barnard, J.M.2
-
65
-
-
0030034999
-
Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization/cleavage step
-
Dressman B.A. Spangle L.A. Kaldor S.W. Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization/cleavage step Tetrahedron Lett. 37 1996 937 940
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 937-940
-
-
Dressman, B.A.1
Spangle, L.A.2
Kaldor, S.W.3
-
66
-
-
0027454521
-
Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries
-
Eichler J. Houghten R.A. Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries Biochemistry 32 1993 11035 11041
-
(1993)
Biochemistry
, vol.32
, pp. 11035-11041
-
-
Eichler, J.1
Houghten, R.A.2
-
67
-
-
0028535335
-
Cyclic peptide template combinatorial libraries: Synthesis and identification of chymotrypsin inhibitors
-
Eichler J. Lucka A.W. Houghten R.A. Cyclic peptide template combinatorial libraries: Synthesis and identification of chymotrypsin inhibitors Peptide Res. 7 1994 300 307
-
(1994)
Peptide Res.
, vol.7
, pp. 300-307
-
-
Eichler, J.1
Lucka, A.W.2
Houghten, R.A.3
-
68
-
-
0028229903
-
Sorting single molecules: application to diagnostics and evolutionary biotechnology
-
Eigen M. Rigler R. Sorting single molecules: application to diagnostics and evolutionary biotechnology Proc. Natl Acad. Sci. USA 91 1994 5740 5747
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 5740-5747
-
-
Eigen, M.1
Rigler, R.2
-
69
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington A.D. Szostak J.W. In vitro selection of RNA molecules that bind specific ligands Nature 346 1990 818 822
-
(1990)
Nature
, vol.346
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
70
-
-
2842561522
-
Design, synthesis, and evaluation of small-molecule libraries
-
Ellman J.A. Design, synthesis, and evaluation of small-molecule libraries Acc. Chem. Res. 29 1996 132 143
-
(1996)
Acc. Chem. Res.
, vol.29
, pp. 132-143
-
-
Ellman, J.A.1
-
71
-
-
33847797467
-
Bromination and lithiation: two important steps in the functionalization of polystyren resins
-
Farall M.J. Frechet J.M.J. Bromination and lithiation: two important steps in the functionalization of polystyren resins J. Org. Chem. 41 1976 3877 3882
-
(1976)
J. Org. Chem.
, vol.41
, pp. 3877-3882
-
-
Farall, M.J.1
Frechet, J.M.J.2
-
72
-
-
0342666470
-
Discovery and optimization of pseudopeptide leads towards peptidomimetic drugs
-
Fauchère J.-L. Discovery and optimization of pseudopeptide leads towards peptidomimetic drugs Lett. Pept. Sci. 2 1995 115 120
-
(1995)
Lett. Pept. Sci.
, vol.2
, pp. 115-120
-
-
Fauchère, J.-L.1
-
73
-
-
21844524973
-
The challenge of preparing and testing combinatorial compound libraries in the fast lane, at the front end of drug development
-
Felder E.R. The challenge of preparing and testing combinatorial compound libraries in the fast lane, at the front end of drug development Chimia 48 1994 531 541
-
(1994)
Chimia
, vol.48
, pp. 531-541
-
-
Felder, E.R.1
-
74
-
-
0030072692
-
A new combination of protecting groups and links for encoded synthetic libraries suited for consecutive tests on the solid phase and in solution
-
Felder E.R. Heizmann G. Matthews I.T. Rink H. Spieser E. A new combination of protecting groups and links for encoded synthetic libraries suited for consecutive tests on the solid phase and in solution Molec. Diversity 1 1995 109 112
-
(1995)
Molec. Diversity
, vol.1
, pp. 109-112
-
-
Felder, E.R.1
Heizmann, G.2
Matthews, I.T.3
Rink, H.4
Spieser, E.5
-
76
-
-
0026108692
-
Light-directed, spatially addressable parallel chemical synthesis
-
Fodor S.P.A. Read J.L. Pirrung M.C. Stryer L. Lu A.T. Solas D. Light-directed, spatially addressable parallel chemical synthesis Science 251 1991 767 773
-
(1991)
Science
, vol.251
, pp. 767-773
-
-
Fodor, S.P.A.1
Read, J.L.2
Pirrung, M.C.3
Stryer, L.4
Lu, A.T.5
Solas, D.6
-
77
-
-
0028216366
-
A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera
-
Folgori A. Tafi R. Meola A. Felici F. Galfre G. Cortese R. Monaci P. Nicosia A. A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera EMBO J. 13 1994 2236 2243
-
(1994)
EMBO J.
, vol.13
, pp. 2236-2243
-
-
Folgori, A.1
Tafi, R.2
Meola, A.3
Felici, F.4
Galfre, G.5
Cortese, R.6
Monaci, P.7
Nicosia, A.8
-
78
-
-
33751156294
-
Solid-phase synthesis of biaryls via the Stille reaction
-
Forman F.W. Sucholeiki I. Solid-phase synthesis of biaryls via the Stille reaction J. Org. Chem. 60 1995 523 528
-
(1995)
J. Org. Chem.
, vol.60
, pp. 523-528
-
-
Forman, F.W.1
Sucholeiki, I.2
-
79
-
-
0029040208
-
Deconvolution of combinatorial libraries for drug discovery: A model system
-
Freier S.M. Konings D.A.M. Wyatt J.R. Ecker D.J. Deconvolution of combinatorial libraries for drug discovery: A model system J. Med. Chem. 38 1995 344 352
-
(1995)
J. Med. Chem.
, vol.38
, pp. 344-352
-
-
Freier, S.M.1
Konings, D.A.M.2
Wyatt, J.R.3
Ecker, D.J.4
-
80
-
-
0028088788
-
Biaryl synthesis via Suzuki coupling on a solid support
-
Frenette R. Friesen R.W. Biaryl synthesis via Suzuki coupling on a solid support Tetrahedron Lett. 35 1994 9177 9180
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 9177-9180
-
-
Frenette, R.1
Friesen, R.W.2
-
82
-
-
85114534706
-
-
Furka, A. (1982). Study on possibilities of systematic searching for pharmaceutically useful peptides. Written and notarized document, Dr Judik Bókai, State Notary Public, Budapest, Hungary, pp. 1–11.
-
-
-
-
83
-
-
0028037524
-
Sub-library composition of peptide libraries: potential application in screening
-
Furka A. Sub-library composition of peptide libraries: potential application in screening Drug Dev. Res. 33 1994 90 97
-
(1994)
Drug Dev. Res.
, vol.33
, pp. 90-97
-
-
Furka, A.1
-
84
-
-
85114536283
-
Composition of biooligomer libraries: Potential application in screening
-
Furka A. Sebestyen F. Composition of biooligomer libraries: Potential application in screening Maia H.L.S. Peptides 1994—Proc. 23rd Eur. Pept. Symp 1995 Escom Leiden 498 499
-
(1995)
, pp. 498-499
-
-
Furka, A.1
Sebestyen, F.2
-
86
-
-
0010330428
-
More peptides by less labor
-
Furka A. Sebestyen F. Asgedom M. Dibo G. More peptides by less labor Abstr. 10th Int. Symp. Med. Chem. Budapest Abstr. P-168 1988 288
-
(1988)
, pp. 288
-
-
Furka, A.1
Sebestyen, F.2
Asgedom, M.3
Dibo, G.4
-
87
-
-
0028243847
-
Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries
-
Gallop M.A. Barrett R.W. Dower W.J. Fodor S.P.A. Gordon E.M. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries J. Med. Chem. 37 1994 1233 1251
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1233-1251
-
-
Gallop, M.A.1
Barrett, R.W.2
Dower, W.J.3
Fodor, S.P.A.4
Gordon, E.M.5
-
88
-
-
0000951677
-
Use of peptide synthesis probe viral antigens for epitopes to a resolution of a single amino acid
-
Geysen H.M. Meloen R.H. Barteling S.J. Use of peptide synthesis probe viral antigens for epitopes to a resolution of a single amino acid Proc. Natl Acad. Sci, USA 81 1984 3998 4002
-
(1984)
Proc. Natl Acad. Sci, USA
, vol.81
, pp. 3998-4002
-
-
Geysen, H.M.1
Meloen, R.H.2
Barteling, S.J.3
-
89
-
-
0022646579
-
A priori delineation of a peptide which mimics a discontinuous antigenic determinant
-
Geysen H.M. Rodda S.J. Mason T.J. A priori delineation of a peptide which mimics a discontinuous antigenic determinant Mol. Immunol. 23 1986 709 715
-
(1986)
Mol. Immunol.
, vol.23
, pp. 709-715
-
-
Geysen, H.M.1
Rodda, S.J.2
Mason, T.J.3
-
90
-
-
85114535478
-
CICLOPS—the Ciba chemical library optimization system
-
Gobbi A. Poppinger D. Rohde B. CICLOPS—the Ciba chemical library optimization system Fourth Int. Conf. on Chemical Structures, Abstract No. 10 Noordwijkerhout, June 2–5, 1996 1996
-
(1996)
-
-
Gobbi, A.1
Poppinger, D.2
Rohde, B.3
-
91
-
-
0029132234
-
Beyond peptide and nucleic acid combinatorial libraries—Applying unions of multicomponent reactions towards the generation of carbohydrate combinatorial libraries
-
Goebel M. Ugi I. Beyond peptide and nucleic acid combinatorial libraries—Applying unions of multicomponent reactions towards the generation of carbohydrate combinatorial libraries Tetrahedron Lett. 36 1995 6043 6046
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 6043-6046
-
-
Goebel, M.1
Ugi, I.2
-
92
-
-
0029142607
-
Solid-phase synthesis of highly substituted peptoid 1(2H)-isoquinolinones
-
Goff D.A. Zuckermann R.N. Solid-phase synthesis of highly substituted peptoid 1(2H)-isoquinolinones J. Org. Chem. 60 1995 5748 5749
-
(1995)
J. Org. Chem.
, vol.60
, pp. 5748-5749
-
-
Goff, D.A.1
Zuckermann, R.N.2
-
93
-
-
0028784074
-
A combinatorial approach to artificial receptor design
-
Goodman M.S. Jubian V. Hamilton A.D. A combinatorial approach to artificial receptor design J. Am. Chem. Soc. 117 1995 11610 11611
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11610-11611
-
-
Goodman, M.S.1
Jubian, V.2
Hamilton, A.D.3
-
94
-
-
0028277928
-
High-affinity urokinase receptor antagonists identified with bacteriophage peptide display
-
Goodson R.J. Doyle M.V. Kaufman S.E. Rosenberg S. High-affinity urokinase receptor antagonists identified with bacteriophage peptide display Proc. Natl Acad. Sci. USA 91 1994 7129 7133
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 7129-7133
-
-
Goodson, R.J.1
Doyle, M.V.2
Kaufman, S.E.3
Rosenberg, S.4
-
95
-
-
0030038838
-
Approaches to combinatorial synthesis of heterocycles: A solid-phase synthesis of 1,4-dihydropyridines
-
Gordeev M.F. Patel D.V. Gordon E.M. Approaches to combinatorial synthesis of heterocycles: A solid-phase synthesis of 1,4-dihydropyridines J. Org. Chem. 61 1996 924 928
-
(1996)
J. Org. Chem.
, vol.61
, pp. 924-928
-
-
Gordeev, M.F.1
Patel, D.V.2
Gordon, E.M.3
-
96
-
-
0028833961
-
Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library
-
Gordon D.W. Steele J. Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library Bioorg. Med. Chem. Lett. 5 1995 47 50
-
(1995)
Bioorg. Med. Chem. Lett.
, vol.5
, pp. 47-50
-
-
Gordon, D.W.1
Steele, J.2
-
97
-
-
0028318863
-
Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions
-
Gordon E.M. Barrett R.W. Dower W.J. Fodor S.P.A. Gallop M.A. Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions J. Med. Chem. 37 1994 1385 1401
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1385-1401
-
-
Gordon, E.M.1
Barrett, R.W.2
Dower, W.J.3
Fodor, S.P.A.4
Gallop, M.A.5
-
98
-
-
37049140414
-
Peptide synthesis by the soluble-polymer technique
-
Green B. Garson L.R. Peptide synthesis by the soluble-polymer technique J. Chem. Soc. C 1969 401 405
-
(1969)
J. Chem. Soc.
, Issue.C
, pp. 401-405
-
-
Green, B.1
Garson, L.R.2
-
99
-
-
0030113947
-
Use of FT-IR internal reflection spectroscopy in combinatorial chemistry
-
Gremlich H.-U. Berets S.L. Use of FT-IR internal reflection spectroscopy in combinatorial chemistry Appl. Spectroscopy 50 4 1996 532 536
-
(1996)
Appl. Spectroscopy
, vol.50
, Issue.4
, pp. 532-536
-
-
Gremlich, H.-U.1
Berets, S.L.2
-
100
-
-
0030137005
-
Information retrieval and genomics—An introduction
-
Guidi J.N. Fox E.A. Information retrieval and genomics—An introduction Computers Biol. Med. 26 1996 179 182
-
(1996)
Computers Biol. Med.
, vol.26
, pp. 179-182
-
-
Guidi, J.N.1
Fox, E.A.2
-
101
-
-
0000805679
-
The molecular connectivity chi indexes and kappa shape indexes in structure-property modeling
-
Hall L.H. Kier L.B. The molecular connectivity chi indexes and kappa shape indexes in structure-property modeling Lipkowitz K.B. Boyd D.B. Reviews in Computational Chemistry 1991 VCH Publishers Inc. New York 367 422
-
(1991)
, pp. 367-422
-
-
Hall, L.H.1
Kier, L.B.2
-
102
-
-
0029944026
-
Solid phase synthesis of proline analogs via a three component 1,3-dipolar cycloaddition
-
Hamper B.C. Dukesherer D.R. South M.S. Solid phase synthesis of proline analogs via a three component 1,3-dipolar cycloaddition Tetrahedron Lett. 37 1996 3671 3674
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 3671-3674
-
-
Hamper, B.C.1
Dukesherer, D.R.2
South, M.S.3
-
104
-
-
0029988589
-
Azatides: solution and liquid phase syntheses of a new peptidomimetic
-
Han H. Janda K.D. Azatides: solution and liquid phase syntheses of a new peptidomimetic J. Am. Chem. Soc. 118 1996 2539 2544
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2539-2544
-
-
Han, H.1
Janda, K.D.2
-
106
-
-
0029865824
-
Silicon directed ipso-sobstitution of polymer bound arylsilanes: preparation of biaryls via the Suzuki cross-coupling reaction
-
Han Y. Walker S.D. Young R.N. Silicon directed ipso-sobstitution of polymer bound arylsilanes: preparation of biaryls via the Suzuki cross-coupling reaction Tetrahedron Lett. 37 1996 2703 2706
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 2703-2706
-
-
Han, Y.1
Walker, S.D.2
Young, R.N.3
-
107
-
-
0029868515
-
Selection of RNA-binding peptides in vivo
-
Harada K. Martin S.S. Frankel A.D. Selection of RNA-binding peptides in vivo Nature 380 1996 175 179
-
(1996)
Nature
, vol.380
, pp. 175-179
-
-
Harada, K.1
Martin, S.S.2
Frankel, A.D.3
-
108
-
-
0028911496
-
A solid phase Cbz chloride equivalent—a new matrix specific linker
-
Hauske J.R. Dorff P. A solid phase Cbz chloride equivalent—a new matrix specific linker Tetrahedron Lett. 36 10 1995 1589 1592
-
(1995)
Tetrahedron Lett.
, vol.36
, Issue.10
, pp. 1589-1592
-
-
Hauske, J.R.1
Dorff, P.2
-
109
-
-
0028148638
-
Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries
-
Hébert N. Davis P.W. De Baets E.L. Acevedo O.L. Synthesis of N -substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries Tetrahedron Lett. 35 51 1994 9509 9512
-
(1994)
Tetrahedron Lett.
, vol.35
, Issue.51
, pp. 9509-9512
-
-
Hébert, N.1
Davis, P.W.2
De Baets, E.L.3
Acevedo, O.L.4
-
110
-
-
0025811052
-
Minimum analogue peptide sets (MAPS) for quantitative structure-activity relationships
-
Hellberg S. Erikson L. Jonsson J. Lindgren F. Fjöström M. Skegerberg B. Wold S. Andrews P. Minimum analogue peptide sets (MAPS) for quantitative structure-activity relationships Int. J. Pept. Protein Res. 37 1991 414 424
-
(1991)
Int. J. Pept. Protein Res.
, vol.37
, pp. 414-424
-
-
Hellberg, S.1
Erikson, L.2
Jonsson, J.3
Lindgren, F.4
Fjöström, M.5
Skegerberg, B.6
Wold, S.7
Andrews, P.8
-
111
-
-
0029930278
-
Solid-phase organic reactions: a review of the recent literature
-
Hermkens P.H.H. Ottenheijm H.C.J. Rees D. Solid-phase organic reactions: a review of the recent literature Tetrahedron 52 1996 4527 4554
-
(1996)
Tetrahedron
, vol.52
, pp. 4527-4554
-
-
Hermkens, P.H.H.1
Ottenheijm, H.C.J.2
Rees, D.3
-
113
-
-
0027202613
-
Diversomers: An approach to nonpeptide, nonoligomeric chemical diversity
-
Hobbs De Witt S. Kiely J.S. Stankovic C.J. Schroeder M.C. Reynolds Cody D.M. Pavia M.R. Diversomers: An approach to nonpeptide, nonoligomeric chemical diversity Proc. Natl Acad. Sci. USA 90 1993 6909 6913
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 6909-6913
-
-
Hobbs De Witt, S.1
Kiely, J.S.2
Stankovic, C.J.3
Schroeder, M.C.4
Reynolds Cody, D.M.5
Pavia, M.R.6
-
114
-
-
0029610459
-
A fast algorithm for selecting sets of dissimilar molecules from large chemical databases
-
Holliday J.D. Ranade S.S. Willett P. A fast algorithm for selecting sets of dissimilar molecules from large chemical databases Quant. Struct.-Act. Relat. 14 1995 501 506
-
(1995)
Quant. Struct.-Act. Relat.
, vol.14
, pp. 501-506
-
-
Holliday, J.D.1
Ranade, S.S.2
Willett, P.3
-
115
-
-
0001216513
-
Reagents for combinatorial organic synthesis: Development of a new o-nitrobenzyl photolabile linker for solid phase synthesis
-
Holmes C.P. Jones D.J. Reagents for combinatorial organic synthesis: Development of a new o -nitrobenzyl photolabile linker for solid phase synthesis J. Org. Chem. 60 1995 2318 2319
-
(1995)
J. Org. Chem.
, vol.60
, pp. 2318-2319
-
-
Holmes, C.P.1
Jones, D.J.2
-
116
-
-
0000058677
-
Strategies for combinatorial organic synthesis: solution and polymer-supported synthesis of 4-thiazolidinones and 4-metathiazanones from amino acids
-
Holmes C.P. Chinn J.P. Look G.C. Gordon E.M. Gallop M.A. Strategies for combinatorial organic synthesis: solution and polymer-supported synthesis of 4-thiazolidinones and 4-metathiazanones from amino acids J. Org. Chem. 60 1995 7328 7333
-
(1995)
J. Org. Chem.
, vol.60
, pp. 7328-7333
-
-
Holmes, C.P.1
Chinn, J.P.2
Look, G.C.3
Gordon, E.M.4
Gallop, M.A.5
-
118
-
-
0000478940
-
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids
-
Houghten R.A. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids Proc. Natl Acad. Sci. USA 82 1985 5131 5135
-
(1985)
Proc. Natl Acad. Sci. USA
, vol.82
, pp. 5131-5135
-
-
Houghten, R.A.1
-
119
-
-
0027756721
-
The broad utility of soluble peptide libraries for drug discovery
-
Houghten R.A. The broad utility of soluble peptide libraries for drug discovery Gene 137 1993 7 11
-
(1993)
Gene
, vol.137
, pp. 7-11
-
-
Houghten, R.A.1
-
120
-
-
0026419319
-
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
-
Houghten R.A. Pinilla C. Blondelle S.E. Appel J.R. Dooley T. Cuervo J.H. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery Nature 354 1991 84 86
-
(1991)
Nature
, vol.354
, pp. 84-86
-
-
Houghten, R.A.1
Pinilla, C.2
Blondelle, S.E.3
Appel, J.R.4
Dooley, T.5
Cuervo, J.H.6
-
121
-
-
0028956786
-
A strategy for urea linked diamine libraries
-
Hutchins S.M. Chapman K.T. A strategy for urea linked diamine libraries Tetrahedron Lett 36 1995 2583 2586
-
(1995)
Tetrahedron Lett
, vol.36
, pp. 2583-2586
-
-
Hutchins, S.M.1
Chapman, K.T.2
-
122
-
-
0029986009
-
Peptide Nucleic Acids (PNA): synthesis, properties and potential applications
-
Hyrup B. Nielsen P.E. Peptide Nucleic Acids (PNA): synthesis, properties and potential applications Bioorg. Med. Chemistry 4 1996 5 23
-
(1996)
Bioorg. Med. Chemistry
, vol.4
, pp. 5-23
-
-
Hyrup, B.1
Nielsen, P.E.2
-
124
-
-
85114547991
-
A database system for combinatorial synthesis experiments
-
July 1995 James C.A. Weininger D. A database system for combinatorial synthesis experiments Network Science 1995 http://www.awod.com
-
(1995)
Network Science
-
-
James, C.A.1
Weininger, D.2
-
126
-
-
0028850172
-
Solid phase synthesis of alkenes using the Horner-Wadworth-Emmons reaction and monitoring by gel phase 31P NMR
-
31P NMR Tetrahedron Lett. 36 1995 9253 9256
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 9253-9256
-
-
Johnson, C.R.1
Zhang, B.2
-
127
-
-
0003832686
-
Combinatorial peptide and nonpeptide libraries: a handbook
-
Jung G. Combinatorial peptide and nonpeptide libraries: a handbook 1996 VCH Verlagsgesellschaft Weinheim
-
(1996)
-
-
Jung, G.1
-
128
-
-
33751143402
-
Multiple peptide synthesis methods and their applications
-
Jung G. Beck-Sickinger A.G. Multiple peptide synthesis methods and their applications Angew. Chem., Int. Ed. Engl. 31 1992 367 486
-
(1992)
Angew. Chem., Int. Ed. Engl.
, vol.31
, pp. 367-486
-
-
Jung, G.1
Beck-Sickinger, A.G.2
-
129
-
-
85114526529
-
Identification of specific receptor peptoid ligands in combinatorial mixtures by affinity selection and mass spectrometry
-
Kaur S. Huebner V. Tang D. McGuire L. Drummond R. Csetjey J. Identification of specific receptor peptoid ligands in combinatorial mixtures by affinity selection and mass spectrometry Abstracts of 43rd ASMS Conference on Mass Spectrometry and Allied Topics 1995 300
-
(1995)
, pp. 300
-
-
Kaur, S.1
Huebner, V.2
Tang, D.3
McGuire, L.4
Drummond, R.5
Csetjey, J.6
-
130
-
-
0029240364
-
Predicting ligand binding to proteins by affinity fingerprinting
-
Kauvar L.M. Higgins D.L. Villar H.O. Sportsman J.R. Engqvist-Goldstein A. Bukar R. Bauer K.E. Dilley H. Rocke D.M. Predicting ligand binding to proteins by affinity fingerprinting Chem. Biol. 2 1995 107 118
-
(1995)
Chem. Biol.
, vol.2
, pp. 107-118
-
-
Kauvar, L.M.1
Higgins, D.L.2
Villar, H.O.3
Sportsman, J.R.4
Engqvist-Goldstein, A.5
Bukar, R.6
Bauer, K.E.7
Dilley, H.8
Rocke, D.M.9
-
132
-
-
0029963887
-
Postcondensation modifications of Ugi four-component condensation produts—1-Isocyanocyclohexene as a convertible isocyanide—Mechanisms of conversion, synthesis of diverse structures, and demonstration of resin capture
-
Keating T.A. Armstrong R.W. Postcondensation modifications of Ugi four-component condensation produts—1-Isocyanocyclohexene as a convertible isocyanide—Mechanisms of conversion, synthesis of diverse structures, and demonstration of resin capture J. Am. Chem. Soc. 118 1996 2574 2583
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2574-2583
-
-
Keating, T.A.1
Armstrong, R.W.2
-
133
-
-
0000772738
-
Encoded combinatorial peptide libraries containing non-natural amino acids
-
Kerr J.M. Banville S.C. Zuckerman R.N. Encoded combinatorial peptide libraries containing non-natural amino acids J. Am. Chem. Soc. 115 1993 2529 2531
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 2529-2531
-
-
Kerr, J.M.1
Banville, S.C.2
Zuckerman, R.N.3
-
134
-
-
0029127055
-
Kemp's triacid scaffolding for synthesis of combinatorial nonpeptide uncoded libraries
-
Kocis P. Issakova O. Sepetov N.F. Lebl M. Kemp's triacid scaffolding for synthesis of combinatorial nonpeptide uncoded libraries Tetrahedron Lett. 36 1995 6623 6626
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 6623-6626
-
-
Kocis, P.1
Issakova, O.2
Sepetov, N.F.3
Lebl, M.4
-
135
-
-
0029897237
-
Deconvolution of combinatorial libraries for drug discovery: theoretical comparison of pooling strategies
-
Konings D.A.M. Wyatt J.R. Ecker D.J. Freier S.M. Deconvolution of combinatorial libraries for drug discovery: theoretical comparison of pooling strategies J. Med. Chem. 39 1996 2710 2719
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2710-2719
-
-
Konings, D.A.M.1
Wyatt, J.R.2
Ecker, D.J.3
Freier, S.M.4
-
136
-
-
0030132582
-
Synthetic library techniques: Subjective (biased and generic) thoughts and views
-
Krchnak V. Lebl M. Synthetic library techniques: Subjective (biased and generic) thoughts and views Molec. Diversity 1 1995 193 216
-
(1995)
Molec. Diversity
, vol.1
, pp. 193-216
-
-
Krchnak, V.1
Lebl, M.2
-
137
-
-
0029090312
-
Polymer-supported Mitsunobu ether formation and its use in combinatorial chemistry
-
Krchnak V. Flegelova Z. Weichsel A.S. Lebl M. Polymer-supported Mitsunobu ether formation and its use in combinatorial chemistry Tetrahedron Lett. 36 1995 6193 6196
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 6193-6196
-
-
Krchnak, V.1
Flegelova, Z.2
Weichsel, A.S.3
Lebl, M.4
-
138
-
-
0028151071
-
Library-based lead compound discovery: antioxidants by an analogous synthesis deconvolutive assay strategy
-
Kurth M.J. Ahlberg Randall L.A. Chen C. Melander C. Miller R. Library-based lead compound discovery: antioxidants by an analogous synthesis deconvolutive assay strategy J. Org. Chem. 59 1994 5862 5864
-
(1994)
J. Org. Chem.
, vol.59
, pp. 5862-5864
-
-
Kurth, M.J.1
Ahlberg Randall, L.A.2
Chen, C.3
Melander, C.4
Miller, R.5
-
139
-
-
85114550114
-
An evaluation of the performance of dissimilarity selection
-
Lajiness M. An evaluation of the performance of dissimilarity selection Silipo C. Vittoria A. QSAR: Rational approaches to the design of bioactive compounds 1991 Elsevier Amsterdam 173 198
-
(1991)
, pp. 173-198
-
-
Lajiness, M.1
-
140
-
-
0024572818
-
Implementing drug screening programs using molecular similarity methods
-
Lajiness M. Johnson M.A. Maggiora G.M. Implementing drug screening programs using molecular similarity methods Fauchère J.L. QSAR: Quantitative Structure-Activity Relationships in Drug Design 1989 Alan Liss Inc New York 173 176
-
(1989)
, pp. 173-176
-
-
Lajiness, M.1
Johnson, M.A.2
Maggiora, G.M.3
-
143
-
-
84955066834
-
Solid phase synthesis of bicyclo[2.2.2]octane derivatives via tandem Michael addition reactions and subsequent reductive amination
-
Ley S.V. Mynett D.M. Koot W.-J. Solid phase synthesis of bicyclo[2.2.2]octane derivatives via tandem Michael addition reactions and subsequent reductive amination Synlett 1995 1017 1020
-
(1995)
Synlett
, pp. 1017-1020
-
-
Ley, S.V.1
Mynett, D.M.2
Koot, W.-J.3
-
144
-
-
0027413883
-
Strategies for indirect computer-aided drug design
-
Loew G.H. Villar H.O. Alkorta I. Strategies for indirect computer-aided drug design Pharmaceut. Res. 10 1993 475 486
-
(1993)
Pharmaceut. Res.
, vol.10
, pp. 475-486
-
-
Loew, G.H.1
Villar, H.O.2
Alkorta, I.3
-
147
-
-
85114550630
-
-
Maggiora G.M. Johnson M.A. Concepts and Applications of Molecular Similarity 1990 Wiley New York
-
(1990)
-
-
Maggiora, G.M.1
Johnson, M.A.2
-
148
-
-
0000271610
-
β-Adrenergic receptors
-
Chapt. 12.2 Main B.G. β-Adrenergic receptors Hansch C. Sammes P.G. Taylor J.B. Emmet J.C. Comprehensive Medicinal Chemistry Vol. 3 1990 Pergamon Press Oxford 195
-
(1990)
, pp. 195
-
-
Main, B.G.1
-
149
-
-
0029175021
-
Identification of Technetium-99m binding peptides using combinatorial cellulose-bound peptide libraries
-
Malin R. Steinbrecher R. Jannsen J. Semmler W. Noll B Johannsen B. Frömmel C. Höhne W. Schneider-Mergener J. Identification of Technetium-99m binding peptides using combinatorial cellulose-bound peptide libraries J. Am. Chem. Soc. 117 1995 11821 11822
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11821-11822
-
-
Malin, R.1
Steinbrecher, R.2
Jannsen, J.3
Semmler, W.4
Noll, B5
Johannsen, B.6
Frömmel, C.7
Höhne, W.8
Schneider-Mergener, J.9
-
150
-
-
85114536133
-
-
Martens H. Naes T. Multivariate Calibration 1989 Wiley New York
-
(1989)
-
-
Martens, H.1
Naes, T.2
-
152
-
-
0001094338
-
Quantifying diversity
-
Martin Y.C. Brown R.D. Bures M.G. Quantifying diversity Gordon E.M. Kerwin J.F. Jr Combinational Chemistry and Molecular Diversity in Discovery 1997 Wiley New York
-
(1997)
-
-
Martin, Y.C.1
Brown, R.D.2
Bures, M.G.3
-
153
-
-
0030061466
-
Solid support synthesis of highly functionalized pyrazoles and isoxazoles; scaffolds for molecular diversity
-
Marzinzik A.L. Felder E.R. Solid support synthesis of highly functionalized pyrazoles and isoxazoles; scaffolds for molecular diversity Tetrahedron Lett. 37 1996 1003 1006
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 1003-1006
-
-
Marzinzik, A.L.1
Felder, E.R.2
-
155
-
-
0028592703
-
An in vitro polysome display system for identifying ligands from very large peptide libraries
-
Mattheakis L.C. Bhatt R.R. Dower W.J. An in vitro polysome display system for identifying ligands from very large peptide libraries Proc. Natl Acad. Sci. USA 91 1994 9022 9026
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 9022-9026
-
-
Mattheakis, L.C.1
Bhatt, R.R.2
Dower, W.J.3
-
156
-
-
0000596050
-
Phosphatase catalysis developed via combinatorial organic chemistry
-
Menger F.M. Eliseev A.V. Migulin V.A. Phosphatase catalysis developed via combinatorial organic chemistry J. Org. Chem. 60 1995 6666 6667
-
(1995)
J. Org. Chem.
, vol.60
, pp. 6666-6667
-
-
Menger, F.M.1
Eliseev, A.V.2
Migulin, V.A.3
-
157
-
-
0028917153
-
Derivation of vaccines from mimotopes: Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage
-
Meola A. Delmastro P. Monaci P. Luzzago A. Nicosia A. Felici F. Cortese R. Galfre G. Derivation of vaccines from mimotopes: Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage J. Immunol. 154 1995 3162 3172
-
(1995)
J. Immunol.
, vol.154
, pp. 3162-3172
-
-
Meola, A.1
Delmastro, P.2
Monaci, P.3
Luzzago, A.4
Nicosia, A.5
Felici, F.6
Cortese, R.7
Galfre, G.8
-
158
-
-
0028002025
-
Electrospray mass spectrometry and tandem mass spectrometry of synthetic multicomponent peptide mixtures: Determination of composition and purity
-
Metzger J.W. Kempter C. Wiesmüller K.H. Jung G. Electrospray mass spectrometry and tandem mass spectrometry of synthetic multicomponent peptide mixtures: Determination of composition and purity Anal. Biochem. 219 1994 261 277
-
(1994)
Anal. Biochem.
, vol.219
, pp. 261-277
-
-
Metzger, J.W.1
Kempter, C.2
Wiesmüller, K.H.3
Jung, G.4
-
161
-
-
0029059507
-
Comparison of proteolytic susceptibilities of homologous l-aminoacid, d-aminoacid, and N-substituted glycine peptide and peptoid oligomers
-
Miller S.M. Simon R.J. Ng S. Zuckermann R.N. Kerr J.M. Moos W.H. Comparison of proteolytic susceptibilities of homologous l -aminoacid, d -aminoacid, and N -substituted glycine peptide and peptoid oligomers Drug Dev. Res. 35 1995 20 32
-
(1995)
Drug Dev. Res.
, vol.35
, pp. 20-32
-
-
Miller, S.M.1
Simon, R.J.2
Ng, S.3
Zuckermann, R.N.4
Kerr, J.M.5
Moos, W.H.6
-
163
-
-
0029940759
-
Solid phase synthesis of pyrroles derived from a four component condensation
-
Mjalli A.M.M. Sarshar S. Baiga T.J. Solid phase synthesis of pyrroles derived from a four component condensation Tetrahedron Lett 37 1996 2943 2946
-
(1996)
Tetrahedron Lett
, vol.37
, pp. 2943-2946
-
-
Mjalli, A.M.M.1
Sarshar, S.2
Baiga, T.J.3
-
165
-
-
85114523155
-
Combinatorial Chemistry: A Strategy for the Future
-
Molecular Design Ltd Combinatorial Chemistry: A Strategy for the Future Network Science July 1995 http://www.awod.com
-
(1995)
Network Science
-
-
Molecular Design Ltd1
-
167
-
-
0028293066
-
Designing peptide mimetics
-
Moore G.J. Designing peptide mimetics TIPS 15 1994 124
-
(1994)
TIPS
, vol.15
, pp. 124
-
-
Moore, G.J.1
-
168
-
-
0028815228
-
Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase PTB1B
-
Moran E.J. Sarshar S. Cargill J.E. Shahbaz M.M. Lio A. Mjalli A.M.M. Armstrong R.W. Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase PTB1B J. Am. Chem. Soc. 117 1995 10787 10788
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 10787-10788
-
-
Moran, E.J.1
Sarshar, S.2
Cargill, J.E.3
Shahbaz, M.M.4
Lio, A.5
Mjalli, A.M.M.6
Armstrong, R.W.7
-
169
-
-
85114541111
-
Use of similarity analysis to reduce large molecular libraries (in-house, combinatorial or commercial) to smaller sets of representative molecules
-
Moreau G. Use of similarity analysis to reduce large molecular libraries (in-house, combinatorial or commercial) to smaller sets of representative molecules Conf. Proc. Synthetic Chemical Libraries in Drug Discovery London, October 30–31, 1995 1995
-
(1995)
-
-
Moreau, G.1
-
170
-
-
0001057103
-
The autocorrelation of a topological structure: A new molecular descriptor
-
Moreau G. Broto P. The autocorrelation of a topological structure: A new molecular descriptor Nouv. J. Chim. 4 1980 359 360
-
(1980)
Nouv. J. Chim.
, vol.4
, pp. 359-360
-
-
Moreau, G.1
Broto, P.2
-
171
-
-
0029991217
-
A novel linker strategy for solid-phase synthesis
-
Morphy J.R. Rankovic Z. Rees D.C. A novel linker strategy for solid-phase synthesis Tetrahedron Lett. 37 1996 3209 3212
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 3209-3212
-
-
Morphy, J.R.1
Rankovic, Z.2
Rees, D.C.3
-
172
-
-
0029042575
-
Combinatorial organic synthesis of highly functionalized pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library
-
Murphy M.M. Schullek J.R. Gordon E.M. Gallop M.A. Combinatorial organic synthesis of highly functionalized pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library J. Am. Chem. Soc. 117 1995 7029 7030
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 7029-7030
-
-
Murphy, M.M.1
Schullek, J.R.2
Gordon, E.M.3
Gallop, M.A.4
-
173
-
-
0027942568
-
A comprehensive human linkage map with centimorgan density
-
Murray J.C. Buetow K.H. Weber J.L. Ludwigsen S. Scherpbier-Heddema T. Manion F. Quillen J. Sheffield V.C. Sunden S. Duyk G.M. Weissenbach J. Gyapay G. Dib C. Morrissette J. Lathrop G.M. Vignal A. White R. Matsunami N. Gerken S. Melis R. Albertsen H. Plaetke R. Odelberg S. Ward D. Dausset J. Cohen D. Cann H. A comprehensive human linkage map with centimorgan density Science 265 1994 2049 2054
-
(1994)
Science
, vol.265
, pp. 2049-2054
-
-
Murray, J.C.1
Buetow, K.H.2
Weber, J.L.3
Ludwigsen, S.4
Scherpbier-Heddema, T.5
Manion, F.6
Quillen, J.7
Sheffield, V.C.8
Sunden, S.9
Duyk, G.M.10
Weissenbach, J.11
Gyapay, G.12
Dib, C.13
Morrissette, J.14
Lathrop, G.M.15
Vignal, A.16
White, R.17
Matsunami, N.18
Gerken, S.19
Melis, R.20
Albertsen, H.21
Plaetke, R.22
Odelberg, S.23
Ward, D.24
Dausset, J.25
Cohen, D.26
Cann, H.27
more..
-
174
-
-
0027375520
-
Generation and screening of an oligonucleotide-encoded synthetic peptide library
-
Needels M.C. Jones D.G. Tate E.H. Heinkel G.L. Kochersperger L.M. Dower W.J. Barrett R.W. Gallop M.A. Generation and screening of an oligonucleotide-encoded synthetic peptide library Proc. Natl Acad. Sci. USA 90 1993 10700 10704
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 10700-10704
-
-
Needels, M.C.1
Jones, D.G.2
Tate, E.H.3
Heinkel, G.L.4
Kochersperger, L.M.5
Dower, W.J.6
Barrett, R.W.7
Gallop, M.A.8
-
175
-
-
33751157590
-
A general method for molecular tagging of encoded combinatorial chemistry libraries
-
Nestler H.P. Bartlett P.A. Still W.C. A general method for molecular tagging of encoded combinatorial chemistry libraries J. Org. Chem. 59 1994 4723 4724
-
(1994)
J. Org. Chem.
, vol.59
, pp. 4723-4724
-
-
Nestler, H.P.1
Bartlett, P.A.2
Still, W.C.3
-
177
-
-
0029873825
-
Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags
-
Ni Z.J. Maclean D. Holmes C.P. Murphy M.M. Ruhland B. Jacobs J.W. Gordon E.M. Gallop M.A. Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags J. Med. Chem. 39 1996 1601 1608
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1601-1608
-
-
Ni, Z.J.1
Maclean, D.2
Holmes, C.P.3
Murphy, M.M.4
Ruhland, B.5
Jacobs, J.W.6
Gordon, E.M.7
Gallop, M.A.8
-
179
-
-
84989568285
-
Synthetic methods for the implementation of encoded combinatorial chemistry
-
Nielsen J. Brenner S. Janda K.D. Synthetic methods for the implementation of encoded combinatorial chemistry J. Am. Chem. Soc. 115 1993 9812 9813
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 9812-9813
-
-
Nielsen, J.1
Brenner, S.2
Janda, K.D.3
-
180
-
-
0027597947
-
Peptide-encoding for structure determination of non-sequenceable polymers within libraries synthesized and tested on solid-phase supports
-
Nikolaiev V. Stierandova A. Krchnak V. Seligmann B. Lam K.S. Salmon S.E. Lebl M. Peptide-encoding for structure determination of non-sequenceable polymers within libraries synthesized and tested on solid-phase supports Peptide Res. 6 1993 161 170
-
(1993)
Peptide Res.
, vol.6
, pp. 161-170
-
-
Nikolaiev, V.1
Stierandova, A.2
Krchnak, V.3
Seligmann, B.4
Lam, K.S.5
Salmon, S.E.6
Lebl, M.7
-
181
-
-
15844389533
-
Calcium-dependent oligonucleotide antagonists specific for l-selectin
-
O'Connell D. Koenig A. Jennings S. Hicke B. Han H.L. Fritzwater T. Chang Y.F. Varki N. Parma D. Varki A. Calcium-dependent oligonucleotide antagonists specific for l -selectin Proc. Natl Acad. Sci. USA 93 1996 5883 5887
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 5883-5887
-
-
O'Connell, D.1
Koenig, A.2
Jennings, S.3
Hicke, B.4
Han, H.L.5
Fritzwater, T.6
Chang, Y.F.7
Varki, N.8
Parma, D.9
Varki, A.10
-
182
-
-
0027362628
-
Complex synthetic chemical libraries indexed with molecular tags
-
Ohlmeyer M.H. Swanson R.N. Dillard L.W. Reader J.C. Asouline G. Kobayashi R. Wigler M. Still W.C. Complex synthetic chemical libraries indexed with molecular tags Proc. Natl Acad. Sci. USA 90 1993 10922 10926
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 10922-10926
-
-
Ohlmeyer, M.H.1
Swanson, R.N.2
Dillard, L.W.3
Reader, J.C.4
Asouline, G.5
Kobayashi, R.6
Wigler, M.7
Still, W.C.8
-
183
-
-
0028173391
-
Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity
-
Ostresh J.M. Husar G.M. Blondelle S.E. Dörner B. Weber P.A. Houghten R.A. Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity Proc. Natl Acad. Sci. USA 91 1994 11138 11142
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 11138-11142
-
-
Ostresh, J.M.1
Husar, G.M.2
Blondelle, S.E.3
Dörner, B.4
Weber, P.A.5
Houghten, R.A.6
-
184
-
-
0029932458
-
Organ targeting in vivo using phage display peptide libraries
-
Pasqualini R. Ruoslahti E. Organ targeting in vivo using phage display peptide libraries Nature 380 1996 364 366
-
(1996)
Nature
, vol.380
, pp. 364-366
-
-
Pasqualini, R.1
Ruoslahti, E.2
-
185
-
-
0025900609
-
Safety-catch anchoring linkage for synthesis of peptide amides by Boc/Fmoc strategy
-
Patek M. Lebl M. Safety-catch anchoring linkage for synthesis of peptide amides by Boc/Fmoc strategy Tetrahedron Lett. 32 1991 3891 3894
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 3891-3894
-
-
Patek, M.1
Lebl, M.2
-
186
-
-
0028901827
-
Solid phase synthesis of ‘small’ organic molecules based on a thiazolidine scaffold
-
Patek M. Drake B. Lebl M. Solid phase synthesis of ‘small’ organic molecules based on a thiazolidine scaffold Tetrahedron Lett. 36 1995 2227 2230
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 2227-2230
-
-
Patek, M.1
Drake, B.2
Lebl, M.3
-
187
-
-
0003230848
-
Novel software tools for addressing chemical diversity
-
June 1996 Pearlman R.S. Novel software tools for addressing chemical diversity Network Science 1996 http://www.awod.com
-
(1996)
Network Science
-
-
Pearlman, R.S.1
-
188
-
-
0028021332
-
Post-modification of peptoid side chains: (3+2) cycloaddition of nitrile oxides with alkenes and alkynes on the solid-phase
-
Pei Y. Moos W.H. Post-modification of peptoid side chains: (3+2) cycloaddition of nitrile oxides with alkenes and alkynes on the solid-phase Tetrahedron Lett. 35 1994 5825 5828
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 5825-5828
-
-
Pei, Y.1
Moos, W.H.2
-
190
-
-
0027052983
-
Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries
-
Pinilla C. Appel J.R. Blanc P. Houghten R.A. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries Bio Techniques 13 1992 901 905
-
(1992)
Bio Techniques
, vol.13
, pp. 901-905
-
-
Pinilla, C.1
Appel, J.R.2
Blanc, P.3
Houghten, R.A.4
-
191
-
-
0028794072
-
Preparation and screening against acetylcholinesterase of a non-peptide indexed combinatorial library
-
Pirrung M.C. Chen J. Preparation and screening against acetylcholinesterase of a non-peptide indexed combinatorial library J. Am. Chem. Soc. 117 1995 1240 1245
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 1240-1245
-
-
Pirrung, M.C.1
Chen, J.2
-
192
-
-
33751156625
-
A silicon-based linker for traceless solid-phase synthesis
-
Plunkett M.J. Ellman J.A. A silicon-based linker for traceless solid-phase synthesis J. Org. Chem. 60 1995 6006 6007
-
(1995)
J. Org. Chem.
, vol.60
, pp. 6006-6007
-
-
Plunkett, M.J.1
Ellman, J.A.2
-
193
-
-
0028928237
-
Solid-phase synthesis of structurally diverse 1,4-benzodiazepine derivatives using the Stille coupling reaction
-
Plunkett M.J. Ellman J.A. Solid-phase synthesis of structurally diverse 1,4-benzodiazepine derivatives using the Stille coupling reaction J. Am. Chem. Soc. 117 1995 3306 3307
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 3306-3307
-
-
Plunkett, M.J.1
Ellman, J.A.2
-
194
-
-
0029557124
-
Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemistry library
-
Puras-Lutzke R.A. Eppens N.A. Weber P.A. Houghten R.A. Plasterk R.H.A. Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemistry library Proc. Natl Acad. Sci. USA 92 1995 11456 11460
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 11456-11460
-
-
Puras-Lutzke, R.A.1
Eppens, N.A.2
Weber, P.A.3
Houghten, R.A.4
Plasterk, R.H.A.5
-
195
-
-
0028949169
-
Combinatorial diffusion assay used to identify topically active melanocyte-stimulating hormone receptor antagonists
-
Quillan J.M. Jayawickreme C.K. Lerner M.R. Combinatorial diffusion assay used to identify topically active melanocyte-stimulating hormone receptor antagonists Proc. Natl Acad. Sci. USA 92 1995 2894 2898
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 2894-2898
-
-
Quillan, J.M.1
Jayawickreme, C.K.2
Lerner, M.R.3
-
196
-
-
0029996782
-
A new method for the solid phase synthesis of oligosaccharides
-
Rademann J. Schmidt R.R. A new method for the solid phase synthesis of oligosaccharides Tetrahedron Lett. 37 1996 3989 3990
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 3989-3990
-
-
Rademann, J.1
Schmidt, R.R.2
-
198
-
-
0016856718
-
Preparation of a new o-nitrobenzyl resin for solid-phase synthesis of tert.-butyloxycarbonyl protected peptide acids
-
Rich D.H. Gurwara S.K. Preparation of a new o -nitrobenzyl resin for solid-phase synthesis of tert.-butyloxycarbonyl protected peptide acids J. Am. Chem. Soc. 97 1975 1575 1578
-
(1975)
J. Am. Chem. Soc.
, vol.97
, pp. 1575-1578
-
-
Rich, D.H.1
Gurwara, S.K.2
-
199
-
-
0028302419
-
A surprising observation about Mitsunobu reactions in solid phase synthesis
-
Richter L.S. Gadek T.R. A surprising observation about Mitsunobu reactions in solid phase synthesis Tetrahedron Lett 35 1994 4705 4706
-
(1994)
Tetrahedron Lett
, vol.35
, pp. 4705-4706
-
-
Richter, L.S.1
Gadek, T.R.2
-
200
-
-
0029067206
-
Synthesis of peptide nucleic acids (PNA) by submonomer solid-phase synthesis
-
Richter L.S. Zuckermann R.N. Synthesis of peptide nucleic acids (PNA) by submonomer solid-phase synthesis Bioorg. Med. Chem. Lett. 5 1995 1159 1162
-
(1995)
Bioorg. Med. Chem. Lett.
, vol.5
, pp. 1159-1162
-
-
Richter, L.S.1
Zuckermann, R.N.2
-
201
-
-
0029091561
-
Fluorescence correlation, single molecule detection and large number screening. Applications in biotechnology
-
Rigler R. Fluorescence correlation, single molecule detection and large number screening. Applications in biotechnology J. Biotechnol. 41 1995 177 186
-
(1995)
J. Biotechnol.
, vol.41
, pp. 177-186
-
-
Rigler, R.1
-
202
-
-
45949123116
-
Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin
-
Rink H. Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin Tetrahedron Lett. 28 1987 3787 3790
-
(1987)
Tetrahedron Lett.
, vol.28
, pp. 3787-3790
-
-
Rink, H.1
-
203
-
-
0030052554
-
Biological insights through genomics—Mouse to man
-
Rubin E.M. Barsh G.S. Biological insights through genomics—Mouse to man J. Clin. Invest. 97 1996 275 280
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 275-280
-
-
Rubin, E.M.1
Barsh, G.S.2
-
204
-
-
0030064961
-
Solid-supported combinatorial synthesis of structurally diverse β-lactams
-
Ruhland B. Bhandari A. Gordon E.M. Gallop M.A. Solid-supported combinatorial synthesis of structurally diverse β-lactams J. Am. Chem. Soc. 118 1996 253 254
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 253-254
-
-
Ruhland, B.1
Bhandari, A.2
Gordon, E.M.3
Gallop, M.A.4
-
205
-
-
85114536674
-
Novel uses of graph eigenvalues: applications to database mining and combinatorial chemistry
-
Rusinko A. Webster Andrews E. Brown F.K. Cummins D.J. Farmen M.W. Manius J.A. Young S.S. Novel uses of graph eigenvalues: applications to database mining and combinatorial chemistry Fourth Int. Conf. Chemical Structures, Abstr. No. 6 Noordwijkerhout, June 2–5, 1996 1996
-
(1996)
-
-
Rusinko, A.1
Webster Andrews, E.2
Brown, F.K.3
Cummins, D.J.4
Farmen, M.W.5
Manius, J.A.6
Young, S.S.7
-
206
-
-
33751136693
-
Assessing similarity and diversity of combinatorial libraries by spatial autocorrelation functions and neural networks
-
Sadowski S.K. Wagener M. Gasteiger J. Assessing similarity and diversity of combinatorial libraries by spatial autocorrelation functions and neural networks Angew. Chem., Int. Ed. 34 1995 2674 2677
-
(1995)
Angew. Chem., Int. Ed.
, vol.34
, pp. 2674-2677
-
-
Sadowski, S.K.1
Wagener, M.2
Gasteiger, J.3
-
207
-
-
85030305839
-
Amino acid-like subunits based on iminodiacatic acid and their application in linear and DkP libraries
-
Proc. 23 EPS Safar P. Stierandova A. Lebl M. Amino acid-like subunits based on iminodiacatic acid and their application in linear and DkP libraries H.L.S. Maia Peptides 94 1995 ESCOM Leiden 471 472
-
(1995)
, pp. 471-472
-
-
Safar, P.1
Stierandova, A.2
Lebl, M.3
-
208
-
-
0027142990
-
Discovery of biologically active peptides in random libraries. Solution phase testing after staged orthogonal release from resin beads
-
Salmon S.E. Lam K.S. Lebl M. Kandola A. Khattri P.S. Wade S. Patek M. Kocis P. Krchnak V. Thorpe D. Felder S. Discovery of biologically active peptides in random libraries. Solution phase testing after staged orthogonal release from resin beads Proc. Natl Acad. Sci. USA 90 1993 11708 11712
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 11708-11712
-
-
Salmon, S.E.1
Lam, K.S.2
Lebl, M.3
Kandola, A.4
Khattri, P.S.5
Wade, S.6
Patek, M.7
Kocis, P.8
Krchnak, V.9
Thorpe, D.10
Felder, S.11
-
209
-
-
0029871215
-
An NMR method to identify nondestructively chemical compounds bound to a single solid-phase-synthesis bead for combinatorial chemistry applications
-
Sarkar S.K. Garigipati R.S. Adams J.L. Keifer P.A. An NMR method to identify nondestructively chemical compounds bound to a single solid-phase-synthesis bead for combinatorial chemistry applications J. Am. Chem. Soc. 118 1996 2305 2306
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2305-2306
-
-
Sarkar, S.K.1
Garigipati, R.S.2
Adams, J.L.3
Keifer, P.A.4
-
211
-
-
84986412103
-
The CAMET and CASET links for the synthesis of protected oligopeptides and oligonucleotides on solid and soluble supports
-
Schwyzer R. Felder E.R. Failli P. The CAMET and CASET links for the synthesis of protected oligopeptides and oligonucleotides on solid and soluble supports Helv. Chim. Acta 67 1984 1316 1327
-
(1984)
Helv. Chim. Acta
, vol.67
, pp. 1316-1327
-
-
Schwyzer, R.1
Felder, E.R.2
Failli, P.3
-
212
-
-
0025112794
-
Searching for peptide ligands with an epitope library
-
Scott J.K. Smith G.P. Searching for peptide ligands with an epitope library Science 249 1990 386 390
-
(1990)
Science
, vol.249
, pp. 386-390
-
-
Scott, J.K.1
Smith, G.P.2
-
213
-
-
0029171218
-
Binary synthesis of multicomponent peptide mixtures by the portioning-mixing technique
-
Sebestyen F. Szalatnyai T. Durgo J.A. Furka A. Binary synthesis of multicomponent peptide mixtures by the portioning-mixing technique J. Pept. Sci. 1 1995 26 30
-
(1995)
J. Pept. Sci.
, vol.1
, pp. 26-30
-
-
Sebestyen, F.1
Szalatnyai, T.2
Durgo, J.A.3
Furka, A.4
-
215
-
-
37049101668
-
A new protecting group combination for solid phase synthesis of protected peptides
-
Sheppard R.C. Williams B.J. A new protecting group combination for solid phase synthesis of protected peptides J. Chem. Soc. Chem. Commun. 1982 587 589
-
(1982)
J. Chem. Soc. Chem. Commun.
, pp. 587-589
-
-
Sheppard, R.C.1
Williams, B.J.2
-
216
-
-
0029271228
-
Using a genetic algorithm to suggest combinatorial libraries
-
Sheridan R.P. Kearsley S.K. Using a genetic algorithm to suggest combinatorial libraries J. Chem. Inf. Comput. Sci. 35 1995 310 320
-
(1995)
J. Chem. Inf. Comput. Sci.
, vol.35
, pp. 310-320
-
-
Sheridan, R.P.1
Kearsley, S.K.2
-
218
-
-
0028431114
-
CHUCKLES: A method for representing and searching peptide and peptoid sequences on both monomer and atomic levels
-
Siani M.A. Weininger D. James Blaney J.M. CHUCKLES: A method for representing and searching peptide and peptoid sequences on both monomer and atomic levels J. Chem. Inf. Comput. Sci. 34 1994 599
-
(1994)
J. Chem. Inf. Comput. Sci.
, vol.34
, pp. 599
-
-
Siani, M.A.1
Weininger, D.2
James3
Blaney, J.M.4
-
220
-
-
0026726041
-
Peptoids: a modular approach to drug discovery
-
Simon R.J. Kania R.S. Zuckermann R.N. Huebner V.D. Jewell D.A. Banville S. Ng S. Wang L. Rosenberg S. Marlowe C.K. Spellmeyer D.C. Tan R. Frankel A.D. Santi D.V. Cohen F.E. Bartlett P.A. Peptoids: a modular approach to drug discovery Proc. Natl Acad Sci. USA 89 1992 9367 9371
-
(1992)
Proc. Natl Acad Sci. USA
, vol.89
, pp. 9367-9371
-
-
Simon, R.J.1
Kania, R.S.2
Zuckermann, R.N.3
Huebner, V.D.4
Jewell, D.A.5
Banville, S.6
Ng, S.7
Wang, L.8
Rosenberg, S.9
Marlowe, C.K.10
Spellmeyer, D.C.11
Tan, R.12
Frankel, A.D.13
Santi, D.V.14
Cohen, F.E.15
Bartlett, P.A.16
-
221
-
-
0029878670
-
Application of genetic algorithms to combinatorial synthesis: A computational approach to lead identification and lead optimization
-
Singh J. Ator M.A. Jaeger E.P. Allen M.P. Whipple D.A. Soloweij J.E. Chowdhary S. Treasurywala A.M. Application of genetic algorithms to combinatorial synthesis: A computational approach to lead identification and lead optimization J. Am. Chem. Soc. 118 1995 1669 1676
-
(1995)
J. Am. Chem. Soc.
, vol.118
, pp. 1669-1676
-
-
Singh, J.1
Ator, M.A.2
Jaeger, E.P.3
Allen, M.P.4
Whipple, D.A.5
Soloweij, J.E.6
Chowdhary, S.7
Treasurywala, A.M.8
-
222
-
-
85114542704
-
Managing the combinatorial explosion
-
Smith D.H. Managing the combinatorial explosion Fourth Int. Conf. Chemical Structures, Abstr. No. 11 Noordwijkerhout, June 2–5, 1996 1996
-
(1996)
-
-
Smith, D.H.1
-
223
-
-
0021818675
-
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface
-
Smith G.P. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface Science 228 1985 1315 1317
-
(1985)
Science
, vol.228
, pp. 1315-1317
-
-
Smith, G.P.1
-
224
-
-
0027984955
-
Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries
-
Sparks A.B. Quilliam L.A. Thorn J.M. Der C.J. Kay B.K. Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries J. Biol. Chem. 269 1994 23853 23856
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23853-23856
-
-
Sparks, A.B.1
Quilliam, L.A.2
Thorn, J.M.3
Der, C.J.4
Kay, B.K.5
-
225
-
-
85114547387
-
Computational approaches to chemical libraries
-
Spellmeyer D.C. Blaney J.M. Martin E. Computational approaches to chemical libraries Charifson P. Computer-assisted Molecular Modeling in Molecular Pharmacology 1997 Marcel Dekker New York
-
(1997)
-
-
Spellmeyer, D.C.1
Blaney, J.M.2
Martin, E.3
-
226
-
-
0011316542
-
Permeability screen for synthetic peptide combinatorial libraries using caco-2 cell monolayers and LC-MS-MS
-
Stevenson C.L. Augustijns P.F. Hendren R.W. Permeability screen for synthetic peptide combinatorial libraries using caco-2 cell monolayers and LC-MS-MS Pharm. Res. 12 1995 94
-
(1995)
Pharm. Res.
, vol.12
, pp. 94
-
-
Stevenson, C.L.1
Augustijns, P.F.2
Hendren, R.W.3
-
227
-
-
0030063277
-
Use of a convertible isocyanide for generation of Ugi reaction derivatives on solid support: synthesis of α-acylaminoesters and pyrroles
-
Strocker A.M. Keating T.A. Tempest P.A. Armstrong R.W. Use of a convertible isocyanide for generation of Ugi reaction derivatives on solid support: synthesis of α-acylaminoesters and pyrroles Tetrahedron Lett. 37 1996 1149 1152
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 1149-1152
-
-
Strocker, A.M.1
Keating, T.A.2
Tempest, P.A.3
Armstrong, R.W.4
-
230
-
-
0029233859
-
Simulation analysis of experimental design strategies for screening random compounds as potential new drugs and agrochemicals
-
Taylor R. Simulation analysis of experimental design strategies for screening random compounds as potential new drugs and agrochemicals J. Chem. Inf. Comp. Sci. 35 1995 59 67
-
(1995)
J. Chem. Inf. Comp. Sci.
, vol.35
, pp. 59-67
-
-
Taylor, R.1
-
232
-
-
0029005353
-
The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317
-
Terrett N.K. Bojanic D. Brown D. Bungay P.J. Gardner M. Gordon D.W. Mayers C.J. Steele J. The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317 Bioorg. Med. Chem. Lett. 5 1995 917 922
-
(1995)
Bioorg. Med. Chem. Lett.
, vol.5
, pp. 917-922
-
-
Terrett, N.K.1
Bojanic, D.2
Brown, D.3
Bungay, P.J.4
Gardner, M.5
Gordon, D.W.6
Mayers, C.J.7
Steele, J.8
-
233
-
-
0029065615
-
Combinatorial synthesis—The design of compound libraries and their application to drug discovery
-
Terrett N.K. Gardner M. Gordon D.W. Kobylecki R.J. Steele J. Combinatorial synthesis—The design of compound libraries and their application to drug discovery Tetrahedron 51 1995 8135 8173
-
(1995)
Tetrahedron
, vol.51
, pp. 8135-8173
-
-
Terrett, N.K.1
Gardner, M.2
Gordon, D.W.3
Kobylecki, R.J.4
Steele, J.5
-
234
-
-
0027940148
-
Straightforward and general method for coupling alcohols to solid supports
-
Thompson L.A. Ellman J.A. Straightforward and general method for coupling alcohols to solid supports Tetrahedron Lett. 35 1994 9333 9336
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 9333-9336
-
-
Thompson, L.A.1
Ellman, J.A.2
-
235
-
-
7044263277
-
Synthesis and applications of small molecule libraries
-
Thompson L.A. Ellman J.A. Synthesis and applications of small molecule libraries Chem. Rev. 96 1996 555 600
-
(1996)
Chem. Rev.
, vol.96
, pp. 555-600
-
-
Thompson, L.A.1
Ellman, J.A.2
-
236
-
-
85114546924
-
-
Tripos Inc. Legion and Selector Software 1995 Tripos Inc St Louis, MO
-
(1995)
-
-
Tripos Inc.1
-
237
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to Bacteriophage T4 DNA Polymerase
-
Tuerk C. Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to Bacteriophage T4 DNA Polymerase Science 249 1990 505 510
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
238
-
-
85114538927
-
Comparison of compound-selection techniques
-
Turner D.B. Tyrrell S.M. Willett P. Comparison of compound-selection techniques Fourth Int. Conf. Chemical Structures, Abstr. No. 28 Noordwijkerhout, June 2–5, 1996 1996
-
(1996)
-
-
Turner, D.B.1
Tyrrell, S.M.2
Willett, P.3
-
239
-
-
0028757621
-
Multicomponent reactions in organic chemistry
-
Ugi I. Dömling A. Hörl W. Multicomponent reactions in organic chemistry Endeavour 18 1994 115 122
-
(1994)
Endeavour
, vol.18
, pp. 115-122
-
-
Ugi, I.1
Dömling, A.2
Hörl, W.3
-
241
-
-
85033843231
-
3D Database searching in drug discovery
-
September 1995 Van Drie J.H. 3D Database searching in drug discovery Network Science 1995 http://www.awod.com
-
(1995)
Network Science
-
-
Van Drie, J.H.1
-
242
-
-
0029092629
-
Synthetic chemical diversity: solid phase synthesis of libraries of c2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores
-
Wang G.T. Li S. Wideburg N. Krafft G.A. Kempf D.J. Synthetic chemical diversity: solid phase synthesis of libraries of c2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores J. Med. Chem. 38 1995 2995 3002
-
(1995)
J. Med. Chem.
, vol.38
, pp. 2995-3002
-
-
Wang, G.T.1
Li, S.2
Wideburg, N.3
Krafft, G.A.4
Kempf, D.J.5
-
243
-
-
0015931593
-
p-Alkoxybenzyl alcohol resin and p-alkoxybenzyloxycarbonylhydrazide for solid phase synthesis of protected peptide fragments
-
Wang S.S. p -Alkoxybenzyl alcohol resin and p -alkoxybenzyloxycarbonylhydrazide for solid phase synthesis of protected peptide fragments J. Am. Chem. Soc. 95 1973 1328 1333
-
(1973)
J. Am. Chem. Soc.
, vol.95
, pp. 1328-1333
-
-
Wang, S.S.1
-
244
-
-
33749842822
-
Optimization of the biological activity of combinatorial compound libraries by a genetic algorithm
-
Weber L. Wallbaum S. Broger C. Gubernator K. Optimization of the biological activity of combinatorial compound libraries by a genetic algorithm Angew. Chem. Int. Ed. 34 1995 2280 2282
-
(1995)
Angew. Chem. Int. Ed.
, vol.34
, pp. 2280-2282
-
-
Weber, L.1
Wallbaum, S.2
Broger, C.3
Gubernator, K.4
-
245
-
-
0009074770
-
Statistical design of experiments in industrial practice
-
Weihs C. Berres M. Grize Y.L. Statistical design of experiments in industrial practice Surv. Math. Ind. 5 1995 49 73
-
(1995)
Surv. Math. Ind.
, vol.5
, pp. 49-73
-
-
Weihs, C.1
Berres, M.2
Grize, Y.L.3
-
246
-
-
85114549406
-
-
Willett P. 3D Chemical Structure Handling 1991 Wiley Int. New York
-
(1991)
-
-
Willett, P.1
-
247
-
-
8944242226
-
Deconvolution of combinatorial libraries for drug discovery: Experimental comparison of pooling strategies
-
Wilson-Lingardo L. Davis P.W. Ecker D.J. Hebert N. Acevedo O. Sprankle K. Brennan T. Schwarcz L. Freier S.M. Wyatt J.R. Deconvolution of combinatorial libraries for drug discovery: Experimental comparison of pooling strategies J. Med. Chem. 39 1996 2720 2726
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2720-2726
-
-
Wilson-Lingardo, L.1
Davis, P.W.2
Ecker, D.J.3
Hebert, N.4
Acevedo, O.5
Sprankle, K.6
Brennan, T.7
Schwarcz, L.8
Freier, S.M.9
Wyatt, J.R.10
-
248
-
-
0028001658
-
Bacteriophage display: Peptide libraries and drug discovery
-
Winter J. Bacteriophage display: Peptide libraries and drug discovery Drug Dev. Res. 33 1994 71 89
-
(1994)
Drug Dev. Res.
, vol.33
, pp. 71-89
-
-
Winter, J.1
-
249
-
-
0028827034
-
A solid phase protocol of the Biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry
-
Wipf P. Cunningham A. A solid phase protocol of the Biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry Tetrahedron Lett. 36 1995 7819 7822
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 7819-7822
-
-
Wipf, P.1
Cunningham, A.2
-
250
-
-
0027983025
-
Combinatorially selected guanosine-quartet structure is a potent inhibitor of Human Immunodeficiency Virus envelope-mediated cell fusion
-
Wyatt J.R. Vickers T.A. Roberson J.L. Buckheit R.W. Klimkait T. Debaets E. Davis P.W. Rayner B. Imbach J.L. Ecker D.J. Combinatorially selected guanosine-quartet structure is a potent inhibitor of Human Immunodeficiency Virus envelope-mediated cell fusion Proc. Natl. Acad. Sci. USA 91 1994 1356 1360
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1356-1360
-
-
Wyatt, J.R.1
Vickers, T.A.2
Roberson, J.L.3
Buckheit, R.W.4
Klimkait, T.5
Debaets, E.6
Davis, P.W.7
Rayner, B.8
Imbach, J.L.9
Ecker, D.J.10
-
252
-
-
0000508254
-
Glycosylation on the Merrifield resin using anomeric sulfoxides
-
Yan L. Taylor C.M. Goodnow R. Kahne D. Glycosylation on the Merrifield resin using anomeric sulfoxides J. Am. Chem. Soc. 116 1994 6953 6954
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 6953-6954
-
-
Yan, L.1
Taylor, C.M.2
Goodnow, R.3
Kahne, D.4
-
253
-
-
0028924171
-
Protein-peptide interactions analyzed with the yeast two-hybrid system
-
Yang M. Wu Z. Fields S. Protein-peptide interactions analyzed with the yeast two-hybrid system Nucl. Acids Res. 23 1995 1152 1156
-
(1995)
Nucl. Acids Res.
, vol.23
, pp. 1152-1156
-
-
Yang, M.1
Wu, Z.2
Fields, S.3
-
254
-
-
0006155679
-
Random versus rational. Which is better for general compound screening?
-
August 1996 Young S.S. Farmen M. Rusinko A. Random versus rational. Which is better for general compound screening? Network Science 1996 http://www.awod.com
-
(1996)
Network Science
-
-
Young, S.S.1
Farmen, M.2
Rusinko, A.3
-
256
-
-
85114546995
-
Data management for combinatorial chemistry
-
November 1995 Zaborowski M. Hobbs DeWitt S. Data management for combinatorial chemistry Network Science 1995 http://www.awod.com
-
(1995)
Network Science
-
-
Zaborowski, M.1
Hobbs DeWitt, S.2
-
257
-
-
0030059786
-
Synthesis of tetrasubstituted imidazoles via α-(N-acyl-N-alkylamino)-β-ketoamides on Wang resin
-
Zhang C Moran E.J. Woiwode T.F. Short K.M. Mjalli A.M.M. Synthesis of tetrasubstituted imidazoles via α-( N -acyl- N -alkylamino)-β-ketoamides on Wang resin Tetrahedron Lett. 37 1996 751 754
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 751-754
-
-
Zhang, C1
Moran, E.J.2
Woiwode, T.F.3
Short, K.M.4
Mjalli, A.M.M.5
-
258
-
-
0030050672
-
Two new criteria for choosing sample sizes in combinatorial chemistry
-
Zhao P.L. Nachbar J.A. Bolognese J.A. Chapman K. Two new criteria for choosing sample sizes in combinatorial chemistry J. Med. Chem. 39 1996 350 352
-
(1996)
J. Med. Chem.
, vol.39
, pp. 350-352
-
-
Zhao, P.L.1
Nachbar, J.A.2
Bolognese, J.A.3
Chapman, K.4
-
260
-
-
0000908874
-
Efficient method for the preparation of peptoids (Oligo(N-substituted glycines)) by submonomer solid-phase synthesis
-
Zuckermann R.N. Kerr J.M. Kent S.B.H. Moos W.H. Efficient method for the preparation of peptoids (Oligo( N -substituted glycines)) by submonomer solid-phase synthesis J. Am. Chem. Soc. 114 1992 10646 10647
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10646-10647
-
-
Zuckermann, R.N.1
Kerr, J.M.2
Kent, S.B.H.3
Moos, W.H.4
-
261
-
-
0027934780
-
Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted) glycine peptoid library
-
Zuckermann R.N. Martin E.J. Spellmeyer D.C. Stauber G.B. Shoemaker K.R. Kerr J.M. Figliozzi G.M. Goff D.A. Siani M.A. Simon R.J. Banville S.C. Brown E.G. Wang L. Richter L.S. Moos W.H. Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N -(substituted) glycine peptoid library J. Med. Chem. 37 1994 2678 2685
-
(1994)
J. Med. Chem.
, vol.37
, pp. 2678-2685
-
-
Zuckermann, R.N.1
Martin, E.J.2
Spellmeyer, D.C.3
Stauber, G.B.4
Shoemaker, K.R.5
Kerr, J.M.6
Figliozzi, G.M.7
Goff, D.A.8
Siani, M.A.9
Simon, R.J.10
Banville, S.C.11
Brown, E.G.12
Wang, L.13
Richter, L.S.14
Moos, W.H.15
|