A solid phase approach to quinolones using the DIVERSOMER® technology

Tetrahedron Letters

Volumn 37, Issue 27, 1996, Pages 4815-4818

  MacDonald, Alasdair A ^a,b   DeWitt, Sheila H ^b   Hogan, Eleonora M ^b   Ramage, Robert ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; QUINOLINE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ARTICLE; DRUG PURITY; DRUG SYNTHESIS; MASS SPECTROMETRY; TECHNIQUE;

EID: 0141856793     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00944-6     Document Type: Article

References (14)

1. 1. Pharmaceutical Manufacturers Association, "Facts at a Glance", 1993.
2. 2. Gallop, M.A.; Barren, R.W.; Dower, W.J.; Fodor, S.P. and Gordon, E.M., J. Med. Chem., 1994, 37, 1232.
3. 3. Ellman, J.A.; Bunin, B.A., J. Am. Chem. Soc., 1992, 114, 10997.
4. 4. Hobbs DeWitt, S.; Schroder, M.C.; Stankovic, C.J.; Cody, D.M.R. and Pavia, M.R., Proc. Natl. Acad. Sci. USA., 1993, 90, 6909.
5. 5. Patek, M.; Drake, B. and Lebl, M., Tetrahedron Lett., 1995, 36, 2227
6. 6. Ruhland, B.; Bhandari, A.; Gordon, E.M. and Gallop, M.A., J. Am. Chem. Soc., 1996, 118, 253
7. 7. Shen, L.L., Biochem. Pharmacol., 1989, 38, 2042.
8. 8. Caekenberghe, D.V., J. Antimicrob. Chemother., 1990, 26, 381.
9. 9. Renau, T.E.; Sanchez, J.P.; Shapiro, M.A.; Dever, J.A.; Gracheck, S.J. and Domagala. J.M., J. Med. Chem., 1995, 38, 2974.
10. 10. DeWitt, S.H.; Kiely, J.S.; Pavia, M.R.; Schroeder, M.C. and Stankovic, C.J., "Apparatus for Multiple Simultaneous Synthesis", US Patent No. 5,324,483. 1994.
11. 11. a) Grohe, K. and Heitzer, H., Liebigs Ann. Chem., 1987, 871.
12. b) Chu, D.T.W., J. Heterocyclic Chem., 1985, 22, 1022.
13. 12. Clay, R.J.; Collom, T.A.; Karrick, G.L. and Wemple, J., Synthesis, 1993, 290.
14. 13. MacDonald, A.A.; DeWitt, S.H.; Ghosh, S.; Hogan, E.M.; Kieras, L.; Czarnik, A.W. and Ramage, R., Molecular Diversity, 1996, In press.