Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone

Journal of Immunology

Volumn 157, Issue 2, 1996, Pages 670-678

  Udaka, Keiko ^a,c   Wiesmüller, Karl Heinz ^b   Kienle, Stefan ^b   Jung, Günther ^b   Walden, Peter ^a,d  

^a MAX PLANCK INST FÜR BIOLOGIE   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c KYOTO UNIVERSITY   (Japan)

^d HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELL CLONE; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CLONE CELLS; CYTOTOXICITY TESTS, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; ISOANTIGENS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029902364     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. + cytolytic T cells. Nature 344:742.
2. + T cells. Science 248:1227.
3. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
4. Mach, B., V. Steimle, and W. Reith. 1994. MHC class II-deficient combined immunodeficiency: a disease of gene regulation. Immunol. Rev. 138:207.
5. + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J. Exp. Med. 177:1469.
6. + T cells in the thymus. Cell 73:1041.
7. + T cells in major histocompatibility complex class II-deficient mice. Science 253:1417.
8. Bevan, M. J. 1977. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269:417.
9. Zinkemagel, R. M., G. N. Callahan, A. Althage, S. Cooper, P. A. Klein, and J. Klein. 1978. On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? J. Exp. Med. 147:882.
10. Zinkernagel, R. M., G. N. Callahan, A. Althage, S. Cooper, J. W. Streilein, and J. Klein. 1978. The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help. J. Exp. Med. 147:897.
11. Zinkernagel, R. M., G. N. Callahan, J. Klein, and G. Dennert. 1978. Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature 271:251.
12. Janeway, C. A., H. Wigzell, and H. Binz. 1976. Two different VH gene products make up the T-cell receptors. Scand. J. Immunol. 5:993.
13. Hünig, T., and M. J. Bevan. 1981. Specificity of T-cell clones illustrates altered self hypothesis. Nature 294:460.
14. Hünig, T. R., and M. J. Bevan. 1982. Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered self hypothesis. J. Exp. Med. 155:111.
15. Bevan, M. J., and T. Hünig. 1981. T cells respond preferentially to antigens that are similar to self H-2. Proc. Natl Acad. Sci. USA 78:1843.
16. Bevan, M. J. 1977. Killer cells reactive to altered-self antigens can also be alloreactive. Proc. Natl. Acad. Sci. USA 74:2094.
17. Finberg, R., S. J. Burakoff, H. Cantor, and B. Benacerraf. 1978. Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells. Proc. Natl. Acad. Sci. USA 75:5145.
18. von Boehmer, H., H. Hengartner, M. Nabholz, W. Lernhardt, M. H. Schreier, and W. Haas. 1979. Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur. J. Immunol. 9:592.
19. Bux, E., K. Matsunaga, T. Nagatani, P. Walden, Z. A. Nagy, and J. Klein. 1985. Distribution of alloreactivity among antigen-specific class II-restricted T-cell clones and hybridomas. Immunogenetics 22:189.
20. Matis, L. A., S. B. Sorger, D. L. McElligott, P. J. Fink, and S. M. Hedrick. 1987. The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones. Cell 51:59.
21. Rötzschke, O., K. Falk, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1991. On the nature of peptides involved in T cell alloreactivity. J. Exp. Med. 174:1059.
22. + cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69:989.
23. Man, L. A., R. D. Selter, and V. H. Engelhard. 1992. Role of endogenous peptide in human alloreactive cytotoxic T cell responses. Int. Immunol 4:367.
24. Reiss, C., J. L. Greenstein, M. A. V. Crimms, L. L. Lui, A. Rao, R. T. Maziaraz, C. Murre, and S. J. Burakoff. 1986. Recognition of the α-1 and α-2 domains of H-2 molecules by allospecific cloned T cells. J. Immunol. 136:2191.
25. Aosai, F., C. Ohlen, H.-G. Ljunggren, P. Hoglund, L. Frankson, H. Ploegh, A. Townsend, K. Kärre, K., and H. Stauss. 1991. Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells. Eur. J. Immunol. 21:2767.
26. Elliott, T. J., and H. N. Eisen. 1990. Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc. Natl. Acad. Sci. USA 87:5213.
27. Kranz, D. M., D. H. Sherman, M. V. Sitkovsky, M. S. Pasternack, and H. N. Eisen. 1984. Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera. Proc. Natl. Acad. Sci. USA 81:573.
28. + T-cell clone. Proc. Natl. Acad. Sci. USA 90:11272.
29. Sha, W. C., C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russel, and D. Y. Loh. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335:271.
30. b mutations that involve peptide binding. Proc. Natl. Acad. Sci. USA 87:6186.
31. Köhler, G., K. Fischer-Lindahl, and C. Heusser. 1981. In The Immune System, C. Steinberg, and I. Lefkovitz, eds., Karger, Basel, p. 202.
32. Lemke, H., G. J. Hämmerling, and U. Hämmerling. 1979. Fine specificity analysis with monoclonal antibodies controlled by the major histocompatibility complex and by the Qa/Tla region in mice. Immunol. Rev. 47:175.
33. Ozato, K., T. H. Hansen, and D. H. Sachs. 1980. Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the product of a third polymorphic locus in the mouse MHC. J. Immunol. 125:2473.
34. Figueroa, F., W. C. Davis, and J. Klein. 1981. Ten new monoclonal antibodies detecting antigenic determinants on class I H-2 molecules. Immunogenetics 14: 177.
35. Tewarson, S., F. Figueroa, and J. Klein. 1982. Monoclonal antibodies specific for class I and class II molecules controlled by the mouse H-2 complex. Immunogenetics 16:373.
36. d. Eur. J. Biochem. 236:249.
37. Ljunggren, H.-G., and K. Kärre. 1985. Host resistance directed selectively against H-2-deficient lymphoma variants. J. Exp. Med. 162:1745.
38. Klein, J., F. Figueroa, and C. S. David. 1983. H-2 haplotypes, genes and antigens: second listing. Immunogenetics 17:553.
39. Udaka, K., K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1995. Decrypting the structure of MHC-I restricted CTL epitopes with complex peptide libraries. J. Exp. Med. 181:2097.
40. Sherman, L. A., T. A. Burke, and J. A. Biggs. 1992. Extracellular processing of peptide antigens that bind class I major histocompatibility molecules. J. Exp. Med. 175:1221.
41. Borges, E., K.-H. Wiesmüller, G. Jung, and P. Walden. 1994. Efficacy of synthetic vaccines in the induction of cytotoxic T lymphocytes: comparison of the costimulating support provided by helper T cells and lipoamino acids. J. Immunol. Methods 173:253.
42. Sha, W. C., C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russel, and D. Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73.
43. Dooley, C. T., and R. A. Houghten. 1993. The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opiod receptor ligands. Life Sci. 52:1509.
44. Falk, K., O. Rötzschke, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
45. b. J. Biol. Chem. 270:24130.
46. b. Science 257:919.
47. Wiesmüller, K.-H., M. Brich, G. Jung, K. Sparbier, and P. Walden. 1995. Peptide binding to MHC class I molecules analysed by confocal microscopy. Eur. J. Cell Biol. 66:389.
48. Gundlach, B. R., K.-H. Wiesmüller, T. Junt, S. Kienle, G. Jung, and P. Walden. 1996. Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted cytotoxic T lymphocytes. J. Immunol. 156:3645.
49. Gundlach, B. R., T. Junt, K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1996. Determination of T cell epitopes with random peptide libraries. J. Immunol. Methods. In press.
50. Dutz, J. P., T. J. Tsomides, S. Kageyama, M. H. Rasmussen, and H. N. Eisen. 1994. A cytotoxic T lymphocyte clone can recognize the same naturally occurring self peptide in association with self and non-self class I MHC protein. Mol. Immunol. 31:967.
51. Saito, H., D. M. Kranz, Y. Takagaki, A. C. Hayday, H. N. Eisen, and S. Tonegawa. 1984. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature 312:36.
52. bm3 molecule. J. Immunol. 155: 2419.
53. Matsumura, M., D. H. Fremont, P. A. Peterson, and I. A. Wilson. 1992. Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science 257:927.
54. Madden, D. R., D. N. Garboczi, and D. C. Wiley. 1993. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75:693.
55. Gavin, M. A., B. Dere, A. G. Grandea III, K. A. Hogquist, and M. J. Bevan. 1994. Major histocompatibility complex class I allele-specific peptide libraries: identification of peptides that mimic an H-Y T cell epitope. Eur. J. Immunol. 24:2124.