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Volumn 75, Issue 6, 1997, Pages 683-689

Peptide and nonpeptide lead discovery using robotically synthesized soluble libraries

Author keywords

Automation; Combinatorial synthesis; Lead discovery; Peptide libraries; Robotic synthesis

Indexed keywords

PEPTIDE;

EID: 0030711492     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y97-076     Document Type: Conference Paper
Times cited : (10)

References (37)
  • 1
    • 0002186442 scopus 로고
    • The fluorenylmethoxycarbonyl amino protecting group
    • Edited by S. Udenfriend and J. Meienhofer. Academic Press, New York
    • Atherton, E., and Sheppard, R.C. 1987. The fluorenylmethoxycarbonyl amino protecting group. In The peptides, analysis, synthesis, biology. Vol. 9. Edited by S. Udenfriend and J. Meienhofer. Academic Press, New York. pp. 1-38.
    • (1987) The Peptides, Analysis, Synthesis, Biology , vol.9 , pp. 1-38
    • Atherton, E.1    Sheppard, R.C.2
  • 3
    • 0030021761 scopus 로고    scopus 로고
    • Novel antimicrobial compounds identified using synthetic combinatorial library technology
    • Blondelle, S.E., and Houghten, R.A. 1996. Novel antimicrobial compounds identified using synthetic combinatorial library technology. Trends Biotechol. 2: 60-65.
    • (1996) Trends Biotechol. , vol.2 , pp. 60-65
    • Blondelle, S.E.1    Houghten, R.A.2
  • 4
    • 0001323198 scopus 로고    scopus 로고
    • Second-generation robotic synthesizer for peptide, pseudopeptide and non-peptide libraries
    • Edited by J.N. Little, C. O'Neil, and J.R. Strimaitis. Zymark Corp., Hopkinton, Mass.
    • Boutin, J.A., and Fauchère, J.L. 1996a. Second-generation robotic synthesizer for peptide, pseudopeptide and non-peptide libraries. In Proceedings of the International Symposium on Laboratory Automation and Robotics 1995. Edited by J.N. Little, C. O'Neil, and J.R. Strimaitis. Zymark Corp., Hopkinton, Mass. pp. 197-210.
    • (1996) Proceedings of the International Symposium on Laboratory Automation and Robotics 1995 , pp. 197-210
    • Boutin, J.A.1    Fauchère, J.L.2
  • 5
    • 0040251963 scopus 로고    scopus 로고
    • Combinatorial peptide synthesis: Statistical evaluation of peptide distribution
    • Boutin, J.A., and Fauchère, A.L. 1996b. Combinatorial peptide synthesis: statistical evaluation of peptide distribution. Trends Pharmacol. Sci. 17:8-12.
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 8-12
    • Boutin, J.A.1    Fauchère, A.L.2
  • 6
    • 0030056289 scopus 로고    scopus 로고
    • Combinatorial peptide libraries: Robotic synthesis and analysis by NMR, MS, tandem MS and high-performance capillary electrophoresis techniques
    • Boutin, J.A., Hennig, P., Lambert, P.H., Bertin, S., Petit, L., Mahieu, J.P., Serkiz, B., Volland, J.P., and Fauchère, J.L. 1996. Combinatorial peptide libraries: robotic synthesis and analysis by NMR, MS, tandem MS and high-performance capillary electrophoresis techniques. Anal. Biochem. 234: 126-141.
    • (1996) Anal. Biochem. , vol.234 , pp. 126-141
    • Boutin, J.A.1    Hennig, P.2    Lambert, P.H.3    Bertin, S.4    Petit, L.5    Mahieu, J.P.6    Serkiz, B.7    Volland, J.P.8    Fauchère, J.L.9
  • 7
    • 0342645323 scopus 로고    scopus 로고
    • Use of structure - Activity data to compare structure-based clustering methods and descriptors for use in compound selection
    • Brown, R.D., and Martin, Y.C. 1996. Use of structure - activity data to compare structure-based clustering methods and descriptors for use in compound selection. J. Chem. Inf. Comput. Sci. 36: 572-584.
    • (1996) J. Chem. Inf. Comput. Sci. , vol.36 , pp. 572-584
    • Brown, R.D.1    Martin, Y.C.2
  • 9
    • 0027450097 scopus 로고
    • The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands
    • Dooley, C.T., and Houghten, R.A. 1993. The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands. Life Sci. 52: 1509-1517.
    • (1993) Life Sci. , vol.52 , pp. 1509-1517
    • Dooley, C.T.1    Houghten, R.A.2
  • 11
    • 0028149989 scopus 로고
    • Recursive deconvolution of combinatorial chemical libraries
    • Erb, E., Janda, K.D., and Brenner, S. 1994. Recursive deconvolution of combinatorial chemical libraries. Proc. Natl. Acad. Sci. U.S.A. 91: 11 422-11 426.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 11422-11426
    • Erb, E.1    Janda, K.D.2    Brenner, S.3
  • 12
    • 0000865027 scopus 로고
    • Solid-phase peptide synthesis
    • Edited by H. Neurath, R.L. Hill, and C.L. Boeder. 3rd ed. Academic Press, New York
    • Erickson, B.W., and Merrifield, R.B. 1976. Solid-phase peptide synthesis. In The proteins. Edited by H. Neurath, R.L. Hill, and C.L. Boeder. 3rd ed. Vol. II. Academic Press, New York. pp. 257-527.
    • (1976) The Proteins , vol.2 , pp. 257-527
    • Erickson, B.W.1    Merrifield, R.B.2
  • 13
    • 0002961632 scopus 로고
    • Elements for the rational design of peptide drugs
    • Fauchère, J.L. 1986. Elements for the rational design of peptide drugs. Adv. Drug Res. 15: 29-69.
    • (1986) Adv. Drug Res. , vol.15 , pp. 29-69
    • Fauchère, J.L.1
  • 14
    • 4243495494 scopus 로고
    • Optimization of peptide leads and molecular modeling
    • Edited by E.C Hermann and R. Franke. Springer-Verlag, Berlin
    • Fauchère, J.L. 1995. Optimization of peptide leads and molecular modeling. In Computer-aided drug design in industrial research. Edited by E.C Hermann and R. Franke. Springer-Verlag, Berlin. pp. 129-161.
    • (1995) Computer-aided Drug Design in Industrial Research , pp. 129-161
    • Fauchère, J.L.1
  • 15
  • 17
    • 0026108692 scopus 로고
    • Light directed spatially addressable parallel chemical synthesis
    • Washington, D.C.
    • Fodor, S.P.A., Read, J.L., Pirrung, M.C., Stryer, L., Lu, A.T., and Solas, D. 1991. Light directed spatially addressable parallel chemical synthesis. Science (Washington, D.C.), 251: 767-773.
    • (1991) Science , vol.251 , pp. 767-773
    • Fodor, S.P.A.1    Read, J.L.2    Pirrung, M.C.3    Stryer, L.4    Lu, A.T.5    Solas, D.6
  • 18
    • 0029040208 scopus 로고
    • Deconvolution of combinatorial libraries for drug discovery: A model system
    • Freier, S.M., Konings, D.A., Wyatt, J.R., and Ecker, D.J. 1995. Deconvolution of combinatorial libraries for drug discovery: a model system. J. Med. Chem. 38: 344-352.
    • (1995) J. Med. Chem. , vol.38 , pp. 344-352
    • Freier, S.M.1    Konings, D.A.2    Wyatt, J.R.3    Ecker, D.J.4
  • 19
    • 0010394489 scopus 로고    scopus 로고
    • Molecular dynamic simulations as a tool to investigate the three-dimensional diversity of peptide and pseudopeptide libraries
    • Computer assisted lead finding and optimization. Edited by H. van de Waterbeemd, B. Testa, and G. Folkers
    • Grassy, G., Yasri, A., Calas, B., Armbruster, A.M., Lahana, R., and Fauchère, J.L. 1997. Molecular dynamic simulations as a tool to investigate the three-dimensional diversity of peptide and pseudopeptide libraries. In Computer assisted lead finding and optimization. Edited by H. van de Waterbeemd, B. Testa, and G. Folkers. Helv. Chim. Acta. pp. 211-221.
    • (1997) Helv. Chim. Acta , pp. 211-221
    • Grassy, G.1    Yasri, A.2    Calas, B.3    Armbruster, A.M.4    Lahana, R.5    Fauchère, J.L.6
  • 20
    • 0029930278 scopus 로고    scopus 로고
    • Solid-phase organic reactions: A review of the recent literature
    • Hermkens, P.H., Ottenheijm, H.C., and Rees, D. 1996. Solid-phase organic reactions: a review of the recent literature. Tetrahedron, 52: 4527-4554.
    • (1996) Tetrahedron , vol.52 , pp. 4527-4554
    • Hermkens, P.H.1    Ottenheijm, H.C.2    Rees, D.3
  • 21
    • 0000478940 scopus 로고
    • General method for the rapid solid phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids
    • Houghten, R.A. 1985. General method for the rapid solid phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. U.S.A. 82: 5131-5135.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 5131-5135
    • Houghten, R.A.1
  • 22
    • 0026419319 scopus 로고
    • Generation and use of synthetic combinatorial libraries for basic research and drug discovery
    • Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T., and Cuervo, J. 1991. Generation and use of synthetic combinatorial libraries for basic research and drug discovery. Nature (London), 354: 84-86.
    • (1991) Nature (London) , vol.354 , pp. 84-86
    • Houghten, R.A.1    Pinilla, C.2    Blondelle, S.E.3    Appel, J.R.4    Dooley, C.T.5    Cuervo, J.6
  • 24
    • 0029155961 scopus 로고
    • Development of highly potent and selective phosphinic peptide inhibitors of zinc endopeptidase 24-15 using combinatorial chemistry
    • Jiracek, J., Yotakis, A., Vincent, B., Lecoq, A., Nicolaou, A., Checler, F., and Dive, V. 1995. Development of highly potent and selective phosphinic peptide inhibitors of zinc endopeptidase 24-15 using combinatorial chemistry. J. Biol. Chem. 270: 21 701-21 706.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21701-21706
    • Jiracek, J.1    Yotakis, A.2    Vincent, B.3    Lecoq, A.4    Nicolaou, A.5    Checler, F.6    Dive, V.7
  • 26
    • 0028953765 scopus 로고
    • Measuring diversity: Experimental design of combinatorial libraries for drug discovery
    • Martin, E.J., Blaney, J.M., Siani, M.A., Spellmeyer, D.C., Wong, A.K., and Moos, W.H. 1995. Measuring diversity: experimental design of combinatorial libraries for drug discovery. J. Med. Chem. 38: 1431-1436.
    • (1995) J. Med. Chem. , vol.38 , pp. 1431-1436
    • Martin, E.J.1    Blaney, J.M.2    Siani, M.A.3    Spellmeyer, D.C.4    Wong, A.K.5    Moos, W.H.6
  • 27
    • 0028173391 scopus 로고
    • Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity
    • Ostresh, J.M., Husar, G.M., Blondelle, S.E., Dörner, B., Weber, P.A., and Houghten, R.A. 1994a. Libraries from libraries: chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity. Proc. Natl. Acad. Sci. U.S.A. 91: 11 138-11 142.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 11138-11142
    • Ostresh, J.M.1    Husar, G.M.2    Blondelle, S.E.3    Dörner, B.4    Weber, P.A.5    Houghten, R.A.6
  • 28
    • 0028172455 scopus 로고
    • Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings
    • Ostresh, J.M., Winkle, J.H., Hamashin, V.T., and Houghten, R.A. 1994b. Peptide libraries: determination of relative reaction rates of protected amino acids in competitive couplings. Biopolymers, 34: 1681-1689.
    • (1994) Biopolymers , vol.34 , pp. 1681-1689
    • Ostresh, J.M.1    Winkle, J.H.2    Hamashin, V.T.3    Houghten, R.A.4
  • 29
    • 9844222933 scopus 로고    scopus 로고
    • Oxford Molecular Ltd., Magdalen Center, Oxford Science Park, Standford-on-Thames, Oxford OX4 4GA, England
    • Oxford Molecular Ltd. 1996. Software MAD V2.21 and TSAR V2.31. Oxford Molecular Ltd., Magdalen Center, Oxford Science Park, Standford-on-Thames, Oxford OX4 4GA, England.
    • (1996) Software MAD V2.21 and TSAR V2.31
  • 30
    • 85008894386 scopus 로고
    • Diketopiperazine formation in solid phase peptide synthesis using p-alkoxybenzyl ester resins and Fmoc amino acids
    • Pedroso, E., Grandas, A., Heras, X.D.L., Eritja, R., and Giralt, E. 1986. Diketopiperazine formation in solid phase peptide synthesis using p-alkoxybenzyl ester resins and Fmoc amino acids. Tetrahedron Lett. 27: 743-746.
    • (1986) Tetrahedron Lett. , vol.27 , pp. 743-746
    • Pedroso, E.1    Grandas, A.2    Heras, X.D.L.3    Eritja, R.4    Giralt, E.5
  • 31
    • 0016403524 scopus 로고
    • Studies on the coupling step in solid phase peptide synthesis. Further competition experiments and attempts to assess formation of ion pairs
    • Ragnarsson, U., Karlsson, S.M., and Sandberg, B.E. 1974. Studies on the coupling step in solid phase peptide synthesis. Further competition experiments and attempts to assess formation of ion pairs. J. Org. Chem. 39:3837-3841.
    • (1974) J. Org. Chem. , vol.39 , pp. 3837-3841
    • Ragnarsson, U.1    Karlsson, S.M.2    Sandberg, B.E.3
  • 32
    • 0039524437 scopus 로고    scopus 로고
    • Ernst-Simon-Strasse 9, D-72072 Tübingen, Germany
    • Rapp, W. 1996. Rapp Polymere. Ernst-Simon-Strasse 9, D-72072 Tübingen, Germany.
    • (1996) Rapp Polymere
    • Rapp, W.1
  • 33
    • 0028587371 scopus 로고
    • Synthesis and biological evaluation of a library containing potentially 1600 amides/esters. A strategy for rapid compound generation and screening
    • Smith, P.W., Lai, J.Y., Whittington, A.R., Cox, B., Houston, J.G., Stylli, C.H., Banks, M.N., and Tiller, P.R. 1994. Synthesis and biological evaluation of a library containing potentially 1600 amides/esters. A strategy for rapid compound generation and screening. Bioorg. Med. Chem. Lett. 4: 2821-2824.
    • (1994) Bioorg. Med. Chem. Lett. , vol.4 , pp. 2821-2824
    • Smith, P.W.1    Lai, J.Y.2    Whittington, A.R.3    Cox, B.4    Houston, J.G.5    Stylli, C.H.6    Banks, M.N.7    Tiller, P.R.8
  • 35
    • 7044263277 scopus 로고    scopus 로고
    • Synthesis and applications of small molecules libraries
    • Thompson, L.A., and Ellman, J.A. 1996. Synthesis and applications of small molecules libraries. Chem. Rev. 96: 555-600.
    • (1996) Chem. Rev. , vol.96 , pp. 555-600
    • Thompson, L.A.1    Ellman, J.A.2
  • 36
    • 0028556408 scopus 로고
    • Identifying motifs of protein kinases by a random library approach
    • Wu, J., Ma, Q.N., and Lam, K.S. 1994. Identifying motifs of protein kinases by a random library approach. Biochemistry, 33: 14 825-14 833.
    • (1994) Biochemistry , vol.33 , pp. 14825-14833
    • Wu, J.1    Ma, Q.N.2    Lam, K.S.3
  • 37
    • 0030050672 scopus 로고    scopus 로고
    • Two new criteria for choosing sample size in combinatorial chemistry
    • Zhao, P.L., Nachbar, R.B., Bolognese, J.A., and Chapman, K. 1996. Two new criteria for choosing sample size in combinatorial chemistry. J. Med. Chem. 39: 350-352.
    • (1996) J. Med. Chem. , vol.39 , pp. 350-352
    • Zhao, P.L.1    Nachbar, R.B.2    Bolognese, J.A.3    Chapman, K.4


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