Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines

Tetrahedron Letters

Volumn 37, Issue 27, 1996, Pages 4643-4646

  Gordeev, Mikhail F ^a   Patel, Dinesh V ^a   Wu, Jie ^a   Gordon, Eric M ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDINE DERIVATIVE; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; TECHNIQUE;

EID: 0030200397     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00923-9     Document Type: Article

References (20)

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5. (e) Patel, D. V.; Gordon, E. M. Drug Discovery Today. 1996, in press.
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14. 4. Roth, H. J.; Kleemann, A. In: Pharmaceutical Chemistry. Volume 1: Drug Synthesis. N.Y.: John Wiley & Sons, 1988.
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17. 13C-4 ca. 147 ppm.
18. 8. Similar oxidative dealkylation of 1,4-dihydropyridines with nitric acid has been reported. See, Boecker, R. H.; Guengerich, F. P. J. Med. Chem. 1986, 29, 1596.
19. 1H NMR and ESI MS data.
20. 10. Kajino, M.; Meguro, K. Heterocycles. 1990, 31, 2153.