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0029126779
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Inhibitors of human heart chyinase based on a peptiile library
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Bastos, M., Maeji, N.J. and Abeles, R.H., Inhibitors of human heart chyinase based on a peptiile library, Proc. Natl. Acad. Sci. USA, 92 (1995) 6738-6742.
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0029076548
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A transition state analogue inhibitor combinatorial library
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Campbell, D.A., Bermak, J.C., Burkoth, T.S. and Patel, D.V, A transition state analogue inhibitor combinatorial library, J. Am. Chem. Soc., 117 (1995) 5381-5382.
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Campbell, D.A.1
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3
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0029257836
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New promise in combinatorial chemistry: Synthesis, characterisation, and screening of small-molecule libraries in solution
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Carell, T., Wintrier, E.A., Sutherland, A.J., Rebek Jr., 1, Dunayevskiy, Y.M. and Vouros, P., New promise in combinatorial chemistry: Synthesis, characterisation, and screening of small-molecule libraries in solution, Chem. Biol., 2 (1995) 171-183.
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Carell, T.1
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0029896175
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One bead-one compound combinatorial peptide library: Different types of screening
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0029000767
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The construction and use of peptide and non-peptidic combinatorial libraries to discover enzyme inhibitors
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b. Seligmann, B., Abdul-Latif, F., Al-Obeidi, F., Flegelova, Z., Issakova, O., Kocis, P., Krchiïâk, V., Lam, K.S., Lcbl, M., Ostrem, J., Safar, P., Sepctov, N., Stierandova, A., Strop, P. and Wildgoose, P., The construction and use of peptide and non-peptidic combinatorial libraries to discover enzyme inhibitors, Eur. J. Med. Chem., 30 (Suppl.) (1995) 319s-335s.
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6
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0028935967
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Kinetic characterization of a peptide inhibitor of trypsin isolated from a synthetic peptide combinatorial library
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Dolle, R.E., Design, synthesis and evaluation of aspartyl protease libraries using a molecular encoding strategy, , First Japanese Conference on Combinatorial Chemistry and High Throughput Screening, Cambridge Healthtech Institute, Osaka, Japan, November 7-9, 1996.
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Dolle, R.E.1
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0027454521
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0028535335
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Eichler, J.1
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10
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0030594987
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Rapid synthesis of novel dipeptide inhibitors of human collagenase
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Foley, M.A., Hassman, A.S., Drewry, D.H., Gréer, D.G., Wagner, CD., Feldman, P.L., Herman, J., Bickett, D.M., McGeeham, G.M., Lambert, M.H. and Green, M., Rapid synthesis of novel dipeptide inhibitors of human collagenase, Bioorg. Med. Chem. Lett., 6 (1996) 1905-1910.
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Foley, M.A.1
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11
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33751304412
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Structure-based design and solid phase synthesis of cysteine protease inhibitors for parasitic diseases
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Orlando, FL, U.S.A., MEDI-039
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For a preliminary account see: Gong, B., Chen, X., Cheng, M., Li, R., Kenyon, G.L. and Cohen, F.E., Structure-based design and solid phase synthesis of cysteine protease inhibitors for parasitic diseases, 212th American Chemical Society Meeting, Orlando, FL, U.S.A., 1996, MEDI-039.
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Gong, B.1
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12
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0029741201
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Development of the first potent and selective inhibitor of the zinc endopeptidase neurolysin using a systematic approach based on combinatorial chemistry ofphosphinic peptidcs
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Jiracek, J., Yiotakis, A., Vincent, B., Checler, F. and Dive, V., Development of the first potent and selective inhibitor of the zinc endopeptidase neurolysin using a systematic approach based on combinatorial chemistry ofphosphinic peptidcs, }. Biol. Chem., 271 (1996) 19606-19611.
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13
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0029155961
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Development of highly potent and selective phosphinic peptide inhibitors of zinc endopeptidase 24-15 using combinatorial chemistry
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Jiracek, J., Yiotakis, A., Vincent, B., Lecoq, A., Nicolaou, A., Checler, F. and Dive, V, Development of highly potent and selective phosphinic peptide inhibitors of zinc endopeptidase 24-15 using combinatorial chemistry, J. Biol. Chem., 270 (1995) 21701-21706.
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14
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0028968619
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Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries
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0030005512
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Lloyd, J., Schmidt, J.B., Hunt, J.T., Barrish, J.C., Little, O.K. and Tymiak, A.A., Solid phase synthesis ofphosphinic acid endothelin convening enzyme inhibitors, Bioorg. Med. Chem. Lett., 6 (1996) 1323-1326.
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16
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0029042575
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Combinatorial organic synthesis of highly functionali:ed pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mereaptoacyl praline library
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Murphy, M.M., Schullek, J.R., Gordon, E.M. and Gallop, M.A., Combinatorial organic synthesis of highly functionali:ed pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mereaptoacyl praline library, J. Am. Chem. Soc., 117(1995)7029-7030.
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0026345157
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The rapid identification of IIIV prolease inhibitors through the synthesis and screening of defined peptide mixtures
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18
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0029092629
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Synthetic chemical diversity: Solid phase synthesis of libraries of C(2) symmetric inhibitors of IIIV protease containing diamino dial anddiamino alcohol cores
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Wang, G.T., Li, S., Wideburg, N., Krafft, O.A. and Kempf, D.J., Synthetic chemical diversity: Solid phase synthesis of libraries of C(2) symmetric inhibitors of IIIV protease containing diamino dial anddiamino alcohol cores, J. Med. Chem., 38 (1995) 2995-3002.
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19
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0029855561
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Complementarity of combinatorial chemistry and structure-based ligand design: Application to the discovery of novel inhibitors of matrix metalloproteinases
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Rockwell, A., Melden, M., Copeland, R.A., Hardman, K., Decicco, C.P. and DeGrado, W.F., Complementarity of combinatorial chemistry and structure-based ligand design: Application to the discovery of novel inhibitors of matrix metalloproteinases, J. Am. Chem. Soc., 118 (1996) 10337-10338.
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34249769282
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a. Chabala, J.C., Baldwin, J.J., Burbaum, J.J., Chelsky, D., Dillard, L.W., Henderson, I., Li, G, Ohlmeyer, M.H.J., Rändle, T.L., Reader, J.C., Rokosz, L. and Sigal, N.H., Binary encoded small-molecular libraries in drug discovery and optimization, Perspect. Drug Discov. Design, 2 (1994) 305-318.
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21
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0029013332
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22
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0029036168
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A paradigm-for drug discovery employing encoded combinatorial libraries
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Burbaum, J.J., Ohlmeyer, M.H.J., Reader, J.C., Henderson, I., Dillard, L.W., Li, G., Rändle, T.L-4, Sigal, N.H., Chelsky, D. and Baldwin, J.J., A paradigm-for drug discovery employing encoded combinatorial libraries, Proc. Natl. Acad. Sci. USA, 92 (1995)6027-6031.
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23
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15844410706
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Screening dériva ti-ed peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ioni:ation-mass spectrometry
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Gao, J., Cheng, R.C., Sigal, G.B., Bruce, J.E., Schwartz, B.L., Hofstadlcr, S.A., Andersen, G.A., Smith, R.D, and Whitesides, G.M., Screening dériva ti-ed peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ioni:ation-mass spectrometry, J. Med. Chem., 39 (1996) 1949-1955.
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24
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8944242226
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Deconvolution of combinatorial libraries for drug discovery: Experimental comparison of pooling strategies
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Lingardo, L.W., Davis, P.W., Ecker, D.J., Herbert, N., Acevedo, O., Sprankle, K., Brennan, T., Schwarcz, L., Freier, S.M. and Wyatt, J.R., Deconvolution of combinatorial libraries for drug discovery: Experimental comparison of pooling strategies, J. Med. Chem., 39 (1996) 2720-2726.
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Lingardo, L.W.1
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25
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0029981645
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The identification of cycloo.xygenase- inhibitors from 4-thia:oIidinone combinatorial libraries
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Look, G.C., Schullek, J.R., Holmes, C.P., Chinn, J.P., Gordon, E.M. and Gallop, M.A., The identification of cycloo.xygenase-] inhibitors from 4-thia:oIidinone combinatorial libraries, Bioorg. Med. Chem. Lett., 6 (1996) 707-712.
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Look, G.C.1
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Gallop, M.A.6
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26
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0029557124
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Identification of a hexapeptide inhibitor of the human immunodeficiency virus integraseprotein by using a combinatorial chemical library
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Lutzke, R.A.P., Eppens, N.A., Weber, P.A., Houghten, R.A. and Plasterk, R.H.A., Identification of a hexapeptide inhibitor of the human immunodeficiency virus integraseprotein by using a combinatorial chemical library, Proc. Natl. Acad. Sci. USA, 92 (1995) 11456-11460.
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27
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0028815228
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Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-subslituted cinnamic acid inhibitors of the protein tyrosine phosphatase PTP1B
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Moran, E.J., Sarshar, S., Cargill. J.F., Shahbaz, M.M., Lio, A., Mjalli, A.M.M. and Armstrong, R.W., Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-subslituted cinnamic acid inhibitors of the protein tyrosine phosphatase PTP1B, J. Am. Chem. Soc., 117 (1995) 1078710788.
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28
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0029740469
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A structure-based library approach to kinase inhibitors
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0029361890
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For a general review on combinatorial methods and solid-phase chemistries see: Ellman, J.A., Synthesis and application of small molecule libraries, Chem. Rev., 96 (1996) 555-600.
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