Solution phase synthesis of chemical libraries for lead discovery

Journal of Biomolecular Screening

Volumn 1, Issue 4, 1996, Pages 179-186

  Garr, Cheryl D ^a   Peterson, John R ^a   Schultz, Lauri ^a   Oliver, Amy R ^a,b   Underiner, Ted L ^a,c   Cramer, Richard D ^d   Ferguson, Allan M ^d   Lawless, Michael S ^d   Patterson, David E ^d  

^a MDS Inc   (Canada)

^b ELI LILLY AND COMPANY   (United States)

^c CEPHALON INC   (United States)

^d TRIPOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001334659     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/108705719600100404     Document Type: Article

References (8)

1. Ferguson, A. M., Patterson, D. E., Garr, C. D., Underiner, T. L. (1996). Designing chemical libraries for lead discovery. J. Biomolec. Screening 1:65.
2. Patterson, D. E., Cramer, R. D., Ferguson, A. M., Clarke, R. D., Weinberger, L. E. (1996). Neighborhood behavior: A useful concept for validation of "Molecular Diversity" descriptors. J. Med. Chem. 39:3049.
3. Hansch, C., Leo, A. (1979). Substituent Constants for Correlation Analysis in Chemistry and Biology. Wiley-Interscience, New York.
4. Chini, M., Crotti, P., Macchia, F. (1991). Metal salts as new catalysts for mild and efficient aminolysis of oxiranes. Tetrahedron Lett. 31:4661.
5. Borch, R. F., Bernstein, M. D., Durst, H. D. (1971). The cyanohydridoborate anion as a selective reducing agent. J. Am. Chem. Soc. 93:2897.
6. Lane, C. F. (1975). Sodium cynaoborohydride - A highly selective reducing agent for organic functional groups. Synthesis 135.
7. Meurer, L. C., Tolman, R. L., Chapin, E. W., Saperstein, R., Vicario, P. P., Zrada, M. M., MacCoss, M. (1992). Synthesis and hypoglycemic activity of substituted (8-(1-piperazinyl)imidazo[1,2-alpyrazines. J. Med. Chem. 35:3845.
8. Selected Optiverse products were compared with compounds registered in the MDL Drug Data Report (MDDR) database.