The synthesis of 2-imidazolidones on solid support by tandem aminoacylation/Michael addition

Tetrahedron Letters

Volumn 39, Issue 12, 1998, Pages 1477-1480

  Goff, Dane ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; IMIDAZOLIDINE DERIVATIVE; ISOCYANIC ACID DERIVATIVE;

ACYLATION; ARTICLE; CHEMICAL REACTION; SYNTHESIS;

EID: 0032546192     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00009-4     Document Type: Article

References (14)

1. 1) To be submitted toTetrahedron Letters.
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7. 6) For some interesting recent examples: Forbes, I.T., Ham, P., Booth, D., Martin, R.T., Thompson, M., Baxter, G.S., Blackburn, T.P., Glen, A., Kennett, G.A., Wood, M.D., J. Med. Chem., 1995, 38, 2524-2530. Lewis, R.T., Macleod, A.M., Merchant, K.J., Kelleher, F., Sanderson, I., Herbert, R.H., Cascieri, M.A., Sadowski, S., Ball, R.G., Hoogsteen, K., J. Med. Chem., 1995, 38, 923-933.
8. 3N and heating were required to get clean reaction.
9. 2O containing 1 mL/L TFA in 40 min.
10. 9) The proton connectivities for 4a and 5a were completely assigned by DQ-COSY experiments.
11. 10) The Rink amide resin was obtained from Advanced ChemTech, Louisville, KY, while the HMPB-BHA resin was obtained from Novabiochem, San Diego, CA.
12. 11) For example: a) Arunachalam, T., Fan, H., Pillai, K.M.R., Ranganathan, R.S., J. Org. Chem., 1995, 60, 4428-4438
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