Generation of targeted C2-symmetrical compound libraries by solution-phase combinatorial chemistry

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 14, 1997, Pages 1903-1908

  Boger, Dale L ^a   Ozer, Rachel S ^a   Andersson, Carl Magnus ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DIMERIZATION; DRUG DESIGN; DRUG RECEPTOR BINDING; PEPTIDE SYNTHESIS; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION; TECHNIQUE;

EID: 0030744021     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00330-2     Document Type: Article

References (24)

1. Heldin, C.-H. Cell 1995, 80, 213. Wells, J. A. Curr. Opin. Cell Biol. 1994, 6, 163.
2. Heldin, C.-H. Cell 1995, 80, 213. Wells, J. A. Curr. Opin. Cell Biol. 1994, 6, 163.
3. Ullrich, A.; Schlessinger, J. Cell 1990, 61, 203.
4. Stahl, N.; Yancopoulos, G. D. Cell 1993, 74, 587.
5. Wells, J. A. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 1. Wells, J. A. Science 1996, 273, 449. Erythropoietin: Basic and Clinical Aspects; Spivak, J. L., Ed.; W. B. Saunders: Philadelphia, 1994; Vol 8.
6. Wells, J. A. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 1. Wells, J. A. Science 1996, 273, 449. Erythropoietin: Basic and Clinical Aspects; Spivak, J. L., Ed.; W. B. Saunders: Philadelphia, 1994; Vol 8.
7. Wells, J. A. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 1. Wells, J. A. Science 1996, 273, 449. Erythropoietin: Basic and Clinical Aspects; Spivak, J. L., Ed.; W. B. Saunders: Philadelphia, 1994; Vol 8.
8. Somers, W.; Ultsch, M.; De Vos, A. M.; Kossiakoff, A. A. Nature 1994, 372, 478.
9. Krantz, S. B. Blood 1991, 77, 419. Philo, J. S.; Aoki, K. H.; Arakawa, T.; Narhi, L. O.; Wen, J. Biochemistry 1996, 35, 1681.
10. Krantz, S. B. Blood 1991, 77, 419. Philo, J. S.; Aoki, K. H.; Arakawa, T.; Narhi, L. O.; Wen, J. Biochemistry 1996, 35, 1681.
11. Massagué, J.; Attisano, L.; Wrana, J. L. Trends Cell Biol. 1994, 4, 172.
12. Smith, C. A.; Farrah, T.; Goodwin, R. G. Cell 1994, 76, 959.
13. Spencer, D. M.; Wandless, T. J.; Schreiber, S. L.; Crabtree, G. R. Science 1993, 262, 1019. Austin, D. J.; Crabtree, G. R.; Schreiber, S. L. Chem. Biol. 1994, 1, 131. Belshaw, P. J.; Ho, S. N.; Crabtree, G. R.; Schreiber, S. L. Proc. Natl. Acad. Sci., U.S.A. 1996, 93, 4604.
14. Spencer, D. M.; Wandless, T. J.; Schreiber, S. L.; Crabtree, G. R. Science 1993, 262, 1019. Austin, D. J.; Crabtree, G. R.; Schreiber, S. L. Chem. Biol. 1994, 1, 131. Belshaw, P. J.; Ho, S. N.; Crabtree, G. R.; Schreiber, S. L. Proc. Natl. Acad. Sci., U.S.A. 1996, 93, 4604.
15. Spencer, D. M.; Wandless, T. J.; Schreiber, S. L.; Crabtree, G. R. Science 1993, 262, 1019. Austin, D. J.; Crabtree, G. R.; Schreiber, S. L. Chem. Biol. 1994, 1, 131. Belshaw, P. J.; Ho, S. N.; Crabtree, G. R.; Schreiber, S. L. Proc. Natl. Acad. Sci., U.S.A. 1996, 93, 4604.
16. Seed, B. Chem. Biol. 1994, 1, 125.
17. Boger, D. L.; Tarby, C. M.; Myers, P. L.; Caporale, L. H. J. Am. Chem. Soc. 1996, 118, 2109. Cheng, S.; Tarby, C. M.; Corner, D. D.; Williams, J. P.; Caporale, L. H.; Myers, P. L.; Boger, D. L. Bioorg. Med. Chem. 1996, 4, 727. Tarby, C. M.; Cheng, S.; Boger, D. L. In Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery; Chaiken, I. M.; Janda, K. D., Eds.; ACS: Washington, 1996; p 81.
18. Boger, D. L.; Tarby, C. M.; Myers, P. L.; Caporale, L. H. J. Am. Chem. Soc. 1996, 118, 2109. Cheng, S.; Tarby, C. M.; Corner, D. D.; Williams, J. P.; Caporale, L. H.; Myers, P. L.; Boger, D. L. Bioorg. Med. Chem. 1996, 4, 727. Tarby, C. M.; Cheng, S.; Boger, D. L. In Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery; Chaiken, I. M.; Janda, K. D., Eds.; ACS: Washington, 1996; p 81.
19. Boger, D. L.; Tarby, C. M.; Myers, P. L.; Caporale, L. H. J. Am. Chem. Soc. 1996, 118, 2109. Cheng, S.; Tarby, C. M.; Corner, D. D.; Williams, J. P.; Caporale, L. H.; Myers, P. L.; Boger, D. L. Bioorg. Med. Chem. 1996, 4, 727. Tarby, C. M.; Cheng, S.; Boger, D. L. In Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery; Chaiken, I. M.; Janda, K. D., Eds.; ACS: Washington, 1996; p 81.
20. Boger, D. L.; Chai, W.; Ozer, R.; Andersson, C.-M. Bioorg. Med. Chem. Lett. 1997, 7, 463.
21. Terrett, N. K.; Bojanic, D.; Brown, D.; Bungay, P. J.; Gardner, M.; Gordon, D. W.; Mayers, C. J.; Steele, J. Bioorg. Med. Chem. Lett. 1995, 5, 917.
22. Lyttle, M. H. Drug Dev. Res. 1995, 35, 230.
23. The application of water-soluble coupling reagents in solution-phase peptide synthesis was introduced by Sheehan and coworkers: Sheehan, J. C.; Hlavka, J. J. J. Org. Chem. 1956, 21, 439.
24. Freshly activated and methanol-washed Dowex 50WX8-400 strongly acidic resin was used.