메뉴 건너뛰기




Volumn 9, Issue 11, 2004, Pages 984-997

Glutamate as a therapeutic target in psychiatric disorders

Author keywords

Amino acid transporters; D serine; Glycine; NMDA receptors; Schizophrenia

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; AMINO ACID TRANSPORTER; AMPA RECEPTOR; CLOZAPINE; CYCLOSERINE; DEXTRO SERINE; DIZOCILPINE; EGLUMETAD; GLUTAMIC ACID; GLYCINE; IONOTROPIC RECEPTOR; KETAMINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; NEUROTRANSMITTER; PHENCYCLIDINE; SEROTONIN UPTAKE INHIBITOR; SMALL NEUTRAL AMINO ACID TRANSPORTER; UNCLASSIFIED DRUG;

EID: 8744278883     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001551     Document Type: Review
Times cited : (470)

References (189)
  • 1
    • 0027994421 scopus 로고
    • The neocortex. An overview of its evolutionary development, structural organization and synaptology
    • Nieuwenhuys R. The neocortex. An overview of its evolutionary development, structural organization and synaptology. Anat Embryol (Berlin) 1994; 190: 307-337.
    • (1994) Anat Embryol (Berlin) , vol.190 , pp. 307-337
    • Nieuwenhuys, R.1
  • 2
    • 0035993231 scopus 로고    scopus 로고
    • Excitatory amino acid transporters: Keeping up with glutamate
    • Amara SG, Fontana AC. Excitatory amino acid transporters: keeping up with glutamate. Neurochem Int 2002; 41: 313-318.
    • (2002) Neurochem Int , vol.41 , pp. 313-318
    • Amara, S.G.1    Fontana, A.C.2
  • 3
    • 0036706164 scopus 로고    scopus 로고
    • Biophysical basis of brain activity: Implications for neuroimaging
    • Shulman RG, Hyder F, Rothman DL. Biophysical basis of brain activity: implications for neuroimaging. Q Rev Biophys 2002; 35: 287-325.
    • (2002) Q Rev Biophys , vol.35 , pp. 287-325
    • Shulman, R.G.1    Hyder, F.2    Rothman, D.L.3
  • 5
    • 1242317638 scopus 로고    scopus 로고
    • Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
    • Mackenzie B, Erickson JD. Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch 2003; 447: 784-795.
    • (2003) Pflugers Arch , vol.447 , pp. 784-795
    • Mackenzie, B.1    Erickson, J.D.2
  • 6
    • 0034471963 scopus 로고    scopus 로고
    • Neuron-astrocyte interactions: Implications for cellular energetics and antioxidant levels
    • Aschner M. Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels. Neurotoxicology 2000; 21: 1101-1107.
    • (2000) Neurotoxicology , vol.21 , pp. 1101-1107
    • Aschner, M.1
  • 8
    • 0001838392 scopus 로고    scopus 로고
    • High dose glycine nutrition affects glial cell morphology in rat hippocampus and cerebellum
    • Shoham S, Javitt DC, Heresco-Levy U. High dose glycine nutrition affects glial cell morphology in rat hippocampus and cerebellum. Int J Neuropsychopharmacol 1999; 2: 35-40.
    • (1999) Int J Neuropsychopharmacol , vol.2 , pp. 35-40
    • Shoham, S.1    Javitt, D.C.2    Heresco-Levy, U.3
  • 9
    • 0035873734 scopus 로고    scopus 로고
    • Chronic high-dose glycine nutrition: Effects on rat brain cell morphology
    • Shoham S, Javitt DC, Heresco-Levy U. Chronic high-dose glycine nutrition: effects on rat brain cell morphology. Biol Psychiatry 2001; 49: 876-885.
    • (2001) Biol Psychiatry , vol.49 , pp. 876-885
    • Shoham, S.1    Javitt, D.C.2    Heresco-Levy, U.3
  • 10
    • 0032790229 scopus 로고    scopus 로고
    • Subunit- and site-specific pharmacology of the NMDA receptor channel
    • Yamakura T, Shimoji K. Subunit- and site-specific pharmacology of the NMDA receptor channel. Prog Neurobiol 1999; 59: 279-298.
    • (1999) Prog Neurobiol , vol.59 , pp. 279-298
    • Yamakura, T.1    Shimoji, K.2
  • 11
    • 0038561177 scopus 로고    scopus 로고
    • Expression mechanisms underlying long-term potentiation: A postsynaptic view
    • Nicoll RA. Expression mechanisms underlying long-term potentiation: a postsynaptic view. Philos Trans Roy Soc London B Biol Sci 2003; 358: 721-726.
    • (2003) Philos Trans Roy Soc London B Biol Sci , vol.358 , pp. 721-726
    • Nicoll, R.A.1
  • 12
    • 0025823190 scopus 로고
    • NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus
    • Kwon YH, Esguerra M, Sur M. NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus. J Neurophysiol 1991; 66: 414-428.
    • (1991) J Neurophysiol , vol.66 , pp. 414-428
    • Kwon, Y.H.1    Esguerra, M.2    Sur, M.3
  • 13
    • 0035369543 scopus 로고    scopus 로고
    • NMDA receptor-mediated dendritic spikes and coincident signal amplification
    • Schiller J, Schiller Y. NMDA receptor-mediated dendritic spikes and coincident signal amplification. Curr Opin Neurobiol 2001; 11: 343-348.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 343-348
    • Schiller, J.1    Schiller, Y.2
  • 14
    • 0035283068 scopus 로고    scopus 로고
    • Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortex
    • Rivadulla C, Sharma J, Sur M. Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortex. J Neurosci 2001; 21: 1710-1719.
    • (2001) J Neurosci , vol.21 , pp. 1710-1719
    • Rivadulla, C.1    Sharma, J.2    Sur, M.3
  • 15
    • 0025313016 scopus 로고
    • Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. I. Lagged cells
    • Heggelund P, Hartveit E. Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. I. Lagged cells. J Neurophysiol 1990; 63: 1347-1360.
    • (1990) J Neurophysiol , vol.63 , pp. 1347-1360
    • Heggelund, P.1    Hartveit, E.2
  • 16
    • 0035132867 scopus 로고    scopus 로고
    • Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex
    • Philpot BD, Sekhar AK, Shouval HZ, Bear MF. Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex. Neuron 2001; 29: 157-169.
    • (2001) Neuron , vol.29 , pp. 157-169
    • Philpot, B.D.1    Sekhar, A.K.2    Shouval, H.Z.3    Bear, M.F.4
  • 17
    • 0036678999 scopus 로고    scopus 로고
    • A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
    • Shouval HZ, Bear MF, Cooper LN. A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proc Natl Acad Sci USA 2002; 99: 10831-10836.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10831-10836
    • Shouval, H.Z.1    Bear, M.F.2    Cooper, L.N.3
  • 18
    • 0035058882 scopus 로고    scopus 로고
    • Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines
    • Shirao T, Sekino Y. Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines. Neurosci Res 2001; 40: 1-7.
    • (2001) Neurosci Res , vol.40 , pp. 1-7
    • Shirao, T.1    Sekino, Y.2
  • 19
    • 0032102070 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate receptor clustering at excitatory synapses
    • O'Brien RJ, Lau LF, Huganir RL. Molecular mechanisms of glutamate receptor clustering at excitatory synapses. Curr Opin Neurobiol 1998; 8: 364-369.
    • (1998) Curr Opin Neurobiol , vol.8 , pp. 364-369
    • O'Brien, R.J.1    Lau, L.F.2    Huganir, R.L.3
  • 20
    • 0036618260 scopus 로고    scopus 로고
    • Activity-dependent recruitment of extrasynaptic NMDA receptor activation at an AMPA receptor-only synapse
    • Clark BA, Cull-Candy SG. Activity-dependent recruitment of extrasynaptic NMDA receptor activation at an AMPA receptor-only synapse. J Neurosci 2002; 22: 4428-4436.
    • (2002) J Neurosci , vol.22 , pp. 4428-4436
    • Clark, B.A.1    Cull-Candy, S.G.2
  • 21
    • 0037061686 scopus 로고    scopus 로고
    • Mobile NMDA receptors at hippocampal synapses
    • Tovar KR, Westbrook GL. Mobile NMDA receptors at hippocampal synapses. Neuron 2002; 34: 255-264.
    • (2002) Neuron , vol.34 , pp. 255-264
    • Tovar, K.R.1    Westbrook, G.L.2
  • 22
    • 0023091647 scopus 로고
    • Glycine potentiates the NMDA responses in cultured mouse brain neurons
    • Johnson JW, Asher P. Glycine potentiates the NMDA responses in cultured mouse brain neurons. Nature 1987; 325: 529-531.
    • (1987) Nature , vol.325 , pp. 529-531
    • Johnson, J.W.1    Asher, P.2
  • 23
    • 0027473657 scopus 로고
    • Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging
    • Hashimoto A, Nishikawa T, Oka T, Takahashi K. Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. J Neurochem 1993; 60: 783-786.
    • (1993) J Neurochem , vol.60 , pp. 783-786
    • Hashimoto, A.1    Nishikawa, T.2    Oka, T.3    Takahashi, K.4
  • 25
    • 0024502818 scopus 로고
    • D-cycloserine: A ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics
    • Hood WF, Compton RP, Monahan JB. D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neurosci Lett 1989; 98: 91-95.
    • (1989) Neurosci Lett , vol.98 , pp. 91-95
    • Hood, W.F.1    Compton, R.P.2    Monahan, J.B.3
  • 26
    • 0030919910 scopus 로고    scopus 로고
    • Control of NMDA receptor activation by a glycine transporter co-expressed in Xenopus oocytes
    • Supplisson S, Bergman C. Control of NMDA receptor activation by a glycine transporter co-expressed in Xenopus oocytes. J Neurosci 1997; 17: 4580-4590.
    • (1997) J Neurosci , vol.17 , pp. 4580-4590
    • Supplisson, S.1    Bergman, C.2
  • 27
    • 0029020761 scopus 로고
    • Functional comparison of D-serine and glycine in rodents: The effect on cloned NMDA receptors and the extracellular concentration
    • Matsui T, Sekiguchi M, Hashimoto A, Tomita U, Nishikawa T, Wada K. Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem 1995; 65: 454-458.
    • (1995) J Neurochem , vol.65 , pp. 454-458
    • Matsui, T.1    Sekiguchi, M.2    Hashimoto, A.3    Tomita, U.4    Nishikawa, T.5    Wada, K.6
  • 28
    • 0023215742 scopus 로고
    • High-affinity transport of gamma-aminobutyric acid, glycine, taurine, L-aspartic acid, and L-glutamatic acid in synaptosomal (P2) tissue: A kinetic and substrate specificity analysis
    • Debler EA, Lajtha A. High-affinity transport of gamma-aminobutyric acid, glycine, taurine, L-aspartic acid, and L-glutamatic acid in synaptosomal (P2) tissue: a kinetic and substrate specificity analysis. J Neurochemistry 1987; 48: 1851-1856.
    • (1987) J Neurochemistry , vol.48 , pp. 1851-1856
    • Debler, E.A.1    Lajtha, A.2
  • 29
    • 15944428993 scopus 로고    scopus 로고
    • System A mediated glycine transport in cortical synaptosomes is inhibited by therapeutic concentrations of clozapine: Implications for mechanims of action
    • submitted
    • Javitt DC, Duncan L, McGrath E, Balla A, Sershen H. System A mediated glycine transport in cortical synaptosomes is inhibited by therapeutic concentrations of clozapine: implications for mechanims of action. Mol Psychiatry, submitted.
    • Mol Psychiatry
    • Javitt, D.C.1    Duncan, L.2    McGrath, E.3    Balla, A.4    Sershen, H.5
  • 30
    • 0142059881 scopus 로고    scopus 로고
    • Glycine transporter isoforms in the mammalian central nervous system: Structures, functions and therapeutic promises
    • Gomeza J, Ohno K, Betz H. Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises. Curr Opin Drug Discov Devel 2003; 6: 675-682.
    • (2003) Curr Opin Drug Discov Devel , vol.6 , pp. 675-682
    • Gomeza, J.1    Ohno, K.2    Betz, H.3
  • 31
    • 0033757857 scopus 로고    scopus 로고
    • Neuronal and glial glycine transporters have different stoichiometries
    • Roux MJ, Supplisson S. Neuronal and glial glycine transporters have different stoichiometries. Neuron 2000; 25: 373-383.
    • (2000) Neuron , vol.25 , pp. 373-383
    • Roux, M.J.1    Supplisson, S.2
  • 32
    • 0036262643 scopus 로고    scopus 로고
    • ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline
    • Takanaga H, Tokuda N, Ohtsuki S, Hosoya K, Terasaki T. ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline. Mol Pharmacol 2002; 61: 1289-1296.
    • (2002) Mol Pharmacol , vol.61 , pp. 1289-1296
    • Takanaga, H.1    Tokuda, N.2    Ohtsuki, S.3    Hosoya, K.4    Terasaki, T.5
  • 33
    • 0031560917 scopus 로고    scopus 로고
    • The origin and turnover of D-serine in brain
    • Dunlop DS, Neidle A. The origin and turnover of D-serine in brain. Biochem Biophys Res Commun 1997; 235: 26-30.
    • (1997) Biochem Biophys Res Commun , vol.235 , pp. 26-30
    • Dunlop, D.S.1    Neidle, A.2
  • 35
    • 0033539510 scopus 로고    scopus 로고
    • Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
    • Wolosker H, Blackshaw S, Snyder SH. Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Notl Acad Sci USA 1999; 96: 13409-13414.
    • (1999) Proc Notl Acad Sci USA , vol.96 , pp. 13409-13414
    • Wolosker, H.1    Blackshaw, S.2    Snyder, S.H.3
  • 36
    • 0037108758 scopus 로고    scopus 로고
    • Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia
    • Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 2002; 99: 13675-13680.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13675-13680
    • Chumakov, I.1    Blumenfeld, M.2    Guerassimenko, O.3    Cavarec, L.4    Palicio, M.5    Abderrahim, H.6
  • 37
    • 0037150760 scopus 로고    scopus 로고
    • A novel alanine-insensitive D-serine transporter in rat brain synaptosomal membranes
    • Javitt DC, Balla A, Sershen H. A novel alanine-insensitive D-serine transporter in rat brain synaptosomal membranes. Brain Res 2002; 941: 146-149.
    • (2002) Brain Res , vol.941 , pp. 146-149
    • Javitt, D.C.1    Balla, A.2    Sershen, H.3
  • 38
    • 8744312190 scopus 로고    scopus 로고
    • Uptake and release of [3H]D-serine in the synaptosomal P2 fraction prepared from the rat cerebral cortex
    • Yamamoto N, Tomita U, Umino A, Kaneda K, Kawaguchi N, Iwama H et al. Uptake and release of [3H]D-serine in the synaptosomal P2 fraction prepared from the rat cerebral cortex. Neurochem Res 2001; 26: 285.
    • (2001) Neurochem Res , vol.26 , pp. 285
    • Yamamoto, N.1    Tomita, U.2    Umino, A.3    Kaneda, K.4    Kawaguchi, N.5    Iwama, H.6
  • 39
    • 0034672306 scopus 로고    scopus 로고
    • The AMPAR subunit GluR2: Still front and center-stage
    • Tanaka H, Grooms SY, Bennett MV, Zukin RS. The AMPAR subunit GluR2: still front and center-stage. Brain Res 2000; 886: 190-207.
    • (2000) Brain Res , vol.886 , pp. 190-207
    • Tanaka, H.1    Grooms, S.Y.2    Bennett, M.V.3    Zukin, R.S.4
  • 41
    • 0032606035 scopus 로고    scopus 로고
    • AMPA receptors in epilepsy and as targets for antiepileptic drugs
    • Rogawski MA, Donevan SD. AMPA receptors in epilepsy and as targets for antiepileptic drugs. Adv Neurol 1999; 79: 947-963.
    • (1999) Adv Neurol , vol.79 , pp. 947-963
    • Rogawski, M.A.1    Donevan, S.D.2
  • 42
    • 0035077550 scopus 로고    scopus 로고
    • Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors
    • Suppiramaniam V, Bahr BA, Sinnarajah S, Owens K, Rogers G, Yilma S et al. Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors. Synapse 2001; 40: 154-158.
    • (2001) Synapse , vol.40 , pp. 154-158
    • Suppiramaniam, V.1    Bahr, B.A.2    Sinnarajah, S.3    Owens, K.4    Rogers, G.5    Yilma, S.6
  • 43
    • 0042868860 scopus 로고    scopus 로고
    • Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: Behavioural characterization and implications for the treatment of CNS disorders
    • Spooren W, Ballard T, Gasparini F, Amalric M, Mutel V, Schreiber R. Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders. Behav Pharmacol 2003; 14: 257-277.
    • (2003) Behav Pharmacol , vol.14 , pp. 257-277
    • Spooren, W.1    Ballard, T.2    Gasparini, F.3    Amalric, M.4    Mutel, V.5    Schreiber, R.6
  • 47
    • 0032694066 scopus 로고    scopus 로고
    • NMDA receptor hypofunction model of schizophrenia
    • Olney JW, Newcomer JW, Farber NB. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 1999; 33: 523-533.
    • (1999) J Psychiatr Res , vol.33 , pp. 523-533
    • Olney, J.W.1    Newcomer, J.W.2    Farber, N.B.3
  • 49
    • 0031875396 scopus 로고    scopus 로고
    • The NMDA antagonist model for schizophrenia: Promise and pitfalls
    • Abi-Saab WM, D'Souza DC, Moghaddam B, Krystal JH. The NMDA antagonist model for schizophrenia: promise and pitfalls. Pharmacopsychiatry 1998; 31(Suppl 2): 104-109.
    • (1998) Pharmacopsychiatry , vol.31 , Issue.SUPPL. 2 , pp. 104-109
    • Abi-Saab, W.M.1    D'Souza, D.C.2    Moghaddam, B.3    Krystal, J.H.4
  • 50
    • 0030044715 scopus 로고    scopus 로고
    • The glutamatergic dysfunction hypothesis for schizophrenia
    • Coyle JT. The glutamatergic dysfunction hypothesis for schizophrenia. Harv Rev Psychiatry 1996; 3: 241-253.
    • (1996) Harv Rev Psychiatry , vol.3 , pp. 241-253
    • Coyle, J.T.1
  • 52
    • 0036384325 scopus 로고    scopus 로고
    • NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia
    • Kapur S, Seeman P. NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia. Mol Psychiatry 2002; 7: 837-844.
    • (2002) Mol Psychiatry , vol.7 , pp. 837-844
    • Kapur, S.1    Seeman, P.2
  • 53
    • 0002556294 scopus 로고
    • Abnormal mental states induced by phencyclidine as a model of schizophrenia
    • Domino E (ed). NPP Books: Ann Arbor, MI
    • Domino E, Luby E. Abnormal mental states induced by phencyclidine as a model of schizophrenia. In: Domino E (ed). PCP (Phencyclidine): Historical and Current Perspectives. NPP Books: Ann Arbor, MI, 1981 pp 401-418.
    • (1981) PCP (Phencyclidine): Historical and Current Perspectives , pp. 401-418
    • Domino, E.1    Luby, E.2
  • 54
    • 77952810889 scopus 로고
    • Pharmacological effects of CI-581, a new dissociative anesthetic, in man
    • Domino EF, Chodoff P, Corssen G. Pharmacological effects of CI-581, a new dissociative anesthetic, in man. Clin Pharmacol Ther 1965; 6: 279-291.
    • (1965) Clin Pharmacol Ther , vol.6 , pp. 279-291
    • Domino, E.F.1    Chodoff, P.2    Corssen, G.3
  • 55
    • 0023082787 scopus 로고
    • Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia
    • Javitt DC. Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia. Hillside J Clin Psychiatry 1987; 9: 12-35.
    • (1987) Hillside J Clin Psychiatry , vol.9 , pp. 12-35
    • Javitt, D.C.1
  • 56
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991; 148: 1301-1308.
    • (1991) Am J Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.C.1    Zukin, S.R.2
  • 58
    • 7544251500 scopus 로고    scopus 로고
    • Neuropsychology of first-episode schizophrenia: Initial characterization and clinical correlates
    • Bilder RM, Goldman RS, Robinson D, Reiter G, Bell L, Bates JA et al. Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. Am J Psychiatry 2000; 157: 549-559.
    • (2000) Am J Psychiatry , vol.157 , pp. 549-559
    • Bilder, R.M.1    Goldman, R.S.2    Robinson, D.3    Reiter, G.4    Bell, L.5    Bates, J.A.6
  • 59
    • 0024455878 scopus 로고
    • Synaptic plasticity and learning: Selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5
    • Morris RGM. Synaptic plasticity and learning: selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J Neurosci 1989; 9: 3040-3057.
    • (1989) J Neurosci , vol.9 , pp. 3040-3057
    • Morris, R.G.M.1
  • 61
    • 0032859516 scopus 로고    scopus 로고
    • Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia
    • Adler CM, Malhotra AK, Elman I, Goldberg T, Egan M, Pickar D et al. Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am J Psychiatry 1999; 156: 1646-1649.
    • (1999) Am J Psychiatry , vol.156 , pp. 1646-1649
    • Adler, C.M.1    Malhotra, A.K.2    Elman, I.3    Goldberg, T.4    Egan, M.5    Pickar, D.6
  • 62
    • 0033663587 scopus 로고    scopus 로고
    • Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: Implications for models of cognitive deficits in schizophrenia
    • Umbricht D, Schmid L, Koller R, Vollenweider FX, Hell D, Javitt DC. Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia. Arch Gen Psychiatry 2000; 57: 1139-1147.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 1139-1147
    • Umbricht, D.1    Schmid, L.2    Koller, R.3    Vollenweider, F.X.4    Hell, D.5    Javitt, D.C.6
  • 63
    • 0019307569 scopus 로고
    • The PCP psychosis: Prolonged intoxication or drug-precipitated functional illness?
    • Erard R, Luisada PV, Peele R. The PCP psychosis: prolonged intoxication or drug-precipitated functional illness? J Psychedelic Drugs 1980; 12: 235-245.
    • (1980) J Psychedelic Drugs , vol.12 , pp. 235-245
    • Erard, R.1    Luisada, P.V.2    Peele, R.3
  • 66
    • 0030749913 scopus 로고    scopus 로고
    • Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics
    • Malhotra AK, Pinals DA, Adler CM, Elman I, Clifton A, Pickar D et al. Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics. Neuropsychopharmacology 1997; 17: 141-150.
    • (1997) Neuropsychopharmacology , vol.17 , pp. 141-150
    • Malhotra, A.K.1    Pinals, D.A.2    Adler, C.M.3    Elman, I.4    Clifton, A.5    Pickar, D.6
  • 67
    • 0036501435 scopus 로고    scopus 로고
    • Mismatch negativity predicts psychotic experiences induced by NMDA receptor antagonist in healthy volunteers
    • Umbricht D, Koller R, Vollenweider FX, Schmid L. Mismatch negativity predicts psychotic experiences induced by NMDA receptor antagonist in healthy volunteers. Biol Psychiatry 2002; 51: 400-406.
    • (2002) Biol Psychiatry , vol.51 , pp. 400-406
    • Umbricht, D.1    Koller, R.2    Vollenweider, F.X.3    Schmid, L.4
  • 68
    • 0021355583 scopus 로고
    • Phencyclidine in combination with d-amphetamine: Differential effects on acquisition and performance of response chains in monkeys
    • Thompson DM, Moerschbaecher JM. Phencyclidine in combination with d-amphetamine: differential effects on acquisition and performance of response chains in monkeys. Pharmacol Biochem Behav 1984; 20: 619-627.
    • (1984) Pharmacol Biochem Behav , vol.20 , pp. 619-627
    • Thompson, D.M.1    Moerschbaecher, J.M.2
  • 69
    • 0023100444 scopus 로고
    • Effects of phencyclidine, ketamine and MDMA on complex operant behavior in monkeys
    • Thompson DM, Winsauer PJ, Mastropaolo J. Effects of phencyclidine, ketamine and MDMA on complex operant behavior in monkeys. Pharmacol Biochem Behav 1987; 26: 401-405.
    • (1987) Pharmacol Biochem Behav , vol.26 , pp. 401-405
    • Thompson, D.M.1    Winsauer, P.J.2    Mastropaolo, J.3
  • 70
    • 0035931337 scopus 로고    scopus 로고
    • Phencyclidine (PCP)-induced deficits of prepulse inhibition in monkeys
    • Linn GS, Javitt DC. Phencyclidine (PCP)-induced deficits of prepulse inhibition in monkeys. Neuroreport 2001; 12: 117-120.
    • (2001) Neuroreport , vol.12 , pp. 117-120
    • Linn, G.S.1    Javitt, D.C.2
  • 71
    • 0141889804 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys
    • Linn GS, Negi SS, Gerum SV, Javitt DC. Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys. Psychopharmacology (Berlin) 2003; 169: 234-239.
    • (2003) Psychopharmacology (Berlin) , vol.169 , pp. 234-239
    • Linn, G.S.1    Negi, S.S.2    Gerum, S.V.3    Javitt, D.C.4
  • 72
    • 0034915264 scopus 로고    scopus 로고
    • Effects of phencyclidine on prepulse inhibition of acoustic startle response in the Macaque
    • Javitt DC, Lindsley RW. Effects of phencyclidine on prepulse inhibition of acoustic startle response in the Macaque. Psychophysiology 2001; 156: 165-168.
    • (2001) Psychophysiology , vol.156 , pp. 165-168
    • Javitt, D.C.1    Lindsley, R.W.2
  • 73
    • 0028323167 scopus 로고
    • Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994; 51: 199-214.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3    Freeman, G.K.4    Delaney, R.5    Bremner, J.D.6
  • 75
    • 0034988360 scopus 로고    scopus 로고
    • Continuous phencyclidine treatment induces schizophrenia-like hyperreactivity of striatal dopamine release
    • Balla A, Koneru R, Smiley J, Sershen H, Javitt DC. Continuous phencyclidine treatment induces schizophrenia-like hyperreactivity of striatal dopamine release. Neuropsychopharmacology 2001; 25: 157-164.
    • (2001) Neuropsychopharmacology , vol.25 , pp. 157-164
    • Balla, A.1    Koneru, R.2    Smiley, J.3    Sershen, H.4    Javitt, D.C.5
  • 76
    • 0037209259 scopus 로고    scopus 로고
    • Subchronic; continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release
    • Balla A, Sershen H, Serra M, Koneru R, Javitt DC. Subchronic; continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release. Neuropsychopharmacology 2003; 28: 34-44.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 34-44
    • Balla, A.1    Sershen, H.2    Serra, M.3    Koneru, R.4    Javitt, D.C.5
  • 78
    • 0032946806 scopus 로고    scopus 로고
    • Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: Involvement in frontostriatal cognitive deficits
    • Jentsch JD, Taylor JR, Elsworth JD, Redmond Jr DE, Roth RH. Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits. Neuroscience 1999; 90: 823-832.
    • (1999) Neuroscience , vol.90 , pp. 823-832
    • Jentsch, J.D.1    Taylor, J.R.2    Elsworth, J.D.3    Redmond Jr., D.E.4    Roth, R.H.5
  • 79
    • 0033588176 scopus 로고    scopus 로고
    • Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
    • Mohn AR, Gainetdinov RR, Caron MG, Koller BH. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 1999; 98: 427-436.
    • (1999) Cell , vol.98 , pp. 427-436
    • Mohn, A.R.1    Gainetdinov, R.R.2    Caron, M.G.3    Koller, B.H.4
  • 80
    • 0035862965 scopus 로고    scopus 로고
    • Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit
    • Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M, Nabeshima T. Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit. J Neurosci 2001; 21: 750-757.
    • (2001) J Neurosci , vol.21 , pp. 750-757
    • Miyamoto, Y.1    Yamada, K.2    Noda, Y.3    Mori, H.4    Mishina, M.5    Nabeshima, T.6
  • 81
    • 0036703884 scopus 로고    scopus 로고
    • Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity
    • Ballard TM, Pauly-Evers M, Higgins GA, Ouagazzal AM, Mutel V, Borroni E et al. Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity. J Neurosci 2002; 22: 6713-6723.
    • (2002) J Neurosci , vol.22 , pp. 6713-6723
    • Ballard, T.M.1    Pauly-Evers, M.2    Higgins, G.A.3    Ouagazzal, A.M.4    Mutel, V.5    Borroni, E.6
  • 82
    • 0034793826 scopus 로고    scopus 로고
    • Differential effects of enrichment on learning and memory function in NR2B transgenic mice
    • Tang YP, Wang H, Feng R, Kyin M, Tsien JZ. Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology 2001; 41: 779-790.
    • (2001) Neuropharmacology , vol.41 , pp. 779-790
    • Tang, Y.P.1    Wang, H.2    Feng, R.3    Kyin, M.4    Tsien, J.Z.5
  • 84
    • 0030862672 scopus 로고    scopus 로고
    • Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine
    • Jentsch JD, Redmond Jr DE, Elsworth JD, Taylor JR, Youngren KD, Roth RH. Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science 1997; 277: 953-955.
    • (1997) Science , vol.277 , pp. 953-955
    • Jentsch, J.D.1    Redmond Jr., D.E.2    Elsworth, J.D.3    Taylor, J.R.4    Youngren, K.D.5    Roth, R.H.6
  • 85
    • 0034282999 scopus 로고    scopus 로고
    • Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: Evidence for cognitive impulsivity
    • Jentsch JD, Roth RH, Taylor JR. Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity. Biol Psychiatry 2000; 48: 415-424.
    • (2000) Biol Psychiatry , vol.48 , pp. 415-424
    • Jentsch, J.D.1    Roth, R.H.2    Taylor, J.R.3
  • 86
    • 0035007671 scopus 로고    scopus 로고
    • In and out of the K-hole: A comparison of the acute and residual effects of ketamine in frequent and infrequent ketamine users
    • Curran HV, Monaghan L. In and out of the K-hole: a comparison of the acute and residual effects of ketamine in frequent and infrequent ketamine users. Addiction 2001; 96: 749-760.
    • (2001) Addiction , vol.96 , pp. 749-760
    • Curran, H.V.1    Monaghan, L.2
  • 87
    • 84907120911 scopus 로고
    • Ketamine-can chronic use impair memory?
    • Jansen KL. Ketamine-can chronic use impair memory? Int J Addict 1990; 25: 133-139.
    • (1990) Int J Addict , vol.25 , pp. 133-139
    • Jansen, K.L.1
  • 88
    • 0032906809 scopus 로고    scopus 로고
    • Long-term changes in brain following continuous phencyclidine administration: An autoradiographic study using flunitrazepam, ketanserin, mazindol, quinuclidinyl benzilate, piperidyl-3,4-3H(N)-TCP, and AMPA receptor ligands
    • Ellison G, Keys A, Noguchi K. Long-term changes in brain following continuous phencyclidine administration: an autoradiographic study using flunitrazepam, ketanserin, mazindol, quinuclidinyl benzilate, piperidyl-3,4-3H(N)-TCP, and AMPA receptor ligands [In Process Citation]. Pharmacol Toxicol 1999; 84: 9-17.
    • (1999) Pharmacol Toxicol , vol.84 , pp. 9-17
    • Ellison, G.1    Keys, A.2    Noguchi, K.3
  • 89
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam B, Adams B, Verma A, Daly D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 1997; 17: 2921-2927.
    • (1997) J Neurosci , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 90
    • 0037475156 scopus 로고    scopus 로고
    • Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: Modulation by a group II selective metabotropic glutamate receptor agonist LY379268
    • Lorrain DS, Baccei CS, Bristow LJ, Anderson JJ, Varney MA. Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268. Neuroscience 2003; 117: 697-706.
    • (2003) Neuroscience , vol.117 , pp. 697-706
    • Lorrain, D.S.1    Baccei, C.S.2    Bristow, L.J.3    Anderson, J.J.4    Varney, M.A.5
  • 91
    • 0032575715 scopus 로고    scopus 로고
    • Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
    • Moghaddam B, Adams BW. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 1998; 281: 1349-1352.
    • (1998) Science , vol.281 , pp. 1349-1352
    • Moghaddam, B.1    Adams, B.W.2
  • 92
    • 0034054949 scopus 로고    scopus 로고
    • Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: Support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists
    • Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A et al. Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists. Arch Gen Psychiatry 2000; 57: 270-276.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 270-276
    • Anand, A.1    Charney, D.S.2    Oren, D.A.3    Berman, R.M.4    Hu, X.S.5    Cappiello, A.6
  • 93
    • 0027231058 scopus 로고
    • Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: Comparison to hippocampus and basal ganglia
    • Moghaddam B. Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia. J Neurochem 1993; 60: 1650-1657.
    • (1993) J Neurochem , vol.60 , pp. 1650-1657
    • Moghaddam, B.1
  • 94
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction in schizophrenia
    • Olney JW, Farber NB. Glutamate receptor dysfunction in schizophrenia. Arch Gen Psychiatry 1995; 52: 998-1007.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 96
    • 0032974130 scopus 로고    scopus 로고
    • D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: A double-blind, parallel, placebo-controlled study
    • van Berckel BN, Evenblij CN, van Loon BJ, Maas MF, van der Geld MA, Wynne HJ et al. D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: a double-blind, parallel, placebo-controlled study. Neuropsychopharmacology 1999; 21: 203-210.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 203-210
    • Van Berckel, B.N.1    Evenblij, C.N.2    Van Loon, B.J.3    Maas, M.F.4    Van Der Geld, M.A.5    Wynne, H.J.6
  • 100
    • 0030665569 scopus 로고    scopus 로고
    • Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics
    • Evins AE, Amico ET, Shih V, Goff DC. Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics. J Neural Transm 1997; 104: 761-766.
    • (1997) J Neural Transm , vol.104 , pp. 761-766
    • Evins, A.E.1    Amico, E.T.2    Shih, V.3    Goff, D.C.4
  • 101
    • 0037272236 scopus 로고    scopus 로고
    • Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1
    • Melone M, Bragina L, Conti F. Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1. Mol Psychiatry 2003; 8: 12-13.
    • (2003) Mol Psychiatry , vol.8 , pp. 12-13
    • Melone, M.1    Bragina, L.2    Conti, F.3
  • 102
    • 0036032336 scopus 로고    scopus 로고
    • Differential effects of chronic haloperidol and clozapine administration on glutamatergic transmission in the frontoparietal cortex in rats: Microdialysis and electrophysiological studies
    • Pietraszek M, Golembiowska K, Bijak M, Ossowska K, Wolfarth S. Differential effects of chronic haloperidol and clozapine administration on glutamatergic transmission in the frontoparietal cortex in rats: microdialysis and electrophysiological studies. Naunyn Schmiedebergs Arch Pharmacol 2002; 366: 417-424.
    • (2002) Naunyn Schmiedebergs Arch Pharmacol , vol.366 , pp. 417-424
    • Pietraszek, M.1    Golembiowska, K.2    Bijak, M.3    Ossowska, K.4    Wolfarth, S.5
  • 103
    • 0031024622 scopus 로고    scopus 로고
    • Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: Implications for schizophrenia and substance abuse
    • Javitt DC, Frusciante M. Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse. Psychopharmacology (Berlin) 1997; 129: 96-98.
    • (1997) Psychopharmacology (Berlin) , vol.129 , pp. 96-98
    • Javitt, D.C.1    Frusciante, M.2
  • 104
    • 0034757197 scopus 로고    scopus 로고
    • The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain
    • Harsing Jr LG, Solyom S, Salamon C. The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain. Neurochem Res 2001; 26: 915-923.
    • (2001) Neurochem Res , vol.26 , pp. 915-923
    • Harsing Jr., L.G.1    Solyom, S.2    Salamon, C.3
  • 105
    • 0034015991 scopus 로고    scopus 로고
    • Inhibition of striatal dopamine release by glycine and glycyldodecylamide
    • Javitt DC, Sershen H, Hashim A, Lajtha A. Inhibition of striatal dopamine release by glycine and glycyldodecylamide. Brain Res Bull 2000; 52: 213-216.
    • (2000) Brain Res Bull , vol.52 , pp. 213-216
    • Javitt, D.C.1    Sershen, H.2    Hashim, A.3    Lajtha, A.4
  • 106
    • 0030811293 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide
    • Javitt DC, Sershen H, Hashim A, Lajtha A. Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide. Neuropsychopharmacology 1997; 17: 202-204.
    • (1997) Neuropsychopharmacology , vol.17 , pp. 202-204
    • Javitt, D.C.1    Sershen, H.2    Hashim, A.3    Lajtha, A.4
  • 107
    • 0022472786 scopus 로고
    • Effect of glycine derivatives on behavioral changes induced by 3-mercaptopropionic acid or phencyclidine in mice
    • Toth E, Weiss B, Banay-Schwartz M, Laitha A. Effect of glycine derivatives on behavioral changes induced by 3-mercaptopropionic acid or phencyclidine in mice. Res Comm Psychol Psychiat Behav 1986; 11: 1-9.
    • (1986) Res Comm Psychol Psychiat Behav , vol.11 , pp. 1-9
    • Toth, E.1    Weiss, B.2    Banay-Schwartz, M.3    Laitha, A.4
  • 108
    • 0033558578 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors
    • Javitt DC, Balla A, Sershen H, Lajtha A, A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors. Biol Psychiatry 1999; 45: 668-679.
    • (1999) Biol Psychiatry , vol.45 , pp. 668-679
    • Javitt, D.C.1    Balla, A.2    Sershen, H.3    Lajtha, A.4
  • 109
    • 0035206590 scopus 로고    scopus 로고
    • N[3-(4′-fluorophenyl]-3-(4′-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport
    • Aubrey KR, Vandenberg RJ. N[3-(4′-fluorophenyl]-3-(4′- phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. Br J Pharmacol 2001; 134: 1429-1436.
    • (2001) Br J Pharmacol , vol.134 , pp. 1429-1436
    • Aubrey, K.R.1    Vandenberg, R.J.2
  • 112
    • 0842286593 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists
    • Javitt DC, Balla A, Burch S, Suckow R, Xie S, Sershen H. Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists. Neuropsychopharmacalogy 2003; 29: 300-307.
    • (2003) Neuropsychopharmacalogy , vol.29 , pp. 300-307
    • Javitt, D.C.1    Balla, A.2    Burch, S.3    Suckow, R.4    Xie, S.5    Sershen, H.6
  • 113
    • 0041920952 scopus 로고    scopus 로고
    • The glycine transporter type I inhibitor N-[3-(4′-fluorophenyl)-3- (4′-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior
    • Kinney GG, Sur C, Burno M, Mallorga PJ, Williams JB, Figueroa DJ et al. The glycine transporter type I inhibitor N-[3-(4′-fluorophenyl)-3- (4′-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci 2003; 23: 7586-7591.
    • (2003) J Neurosci , vol.23 , pp. 7586-7591
    • Kinney, G.G.1    Sur, C.2    Burno, M.3    Mallorga, P.J.4    Williams, J.B.5    Figueroa, D.J.6
  • 114
    • 0037320805 scopus 로고    scopus 로고
    • Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo
    • Chen L, Muhlhauser M, Yang CR. Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo. J Neurophysiol 2003; 89: 691-703.
    • (2003) J Neurophysiol , vol.89 , pp. 691-703
    • Chen, L.1    Muhlhauser, M.2    Yang, C.R.3
  • 115
    • 0344430085 scopus 로고    scopus 로고
    • Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: Reversal by glycine and a glycine transporter inhibitor
    • Le Pen G, Kew J, Alberati D, Borroni E, Heitz MP, Moreau JL. Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and a glycine transporter inhibitor. Biol Psychiatry 2003; 54: 1162-1170.
    • (2003) Biol Psychiatry , vol.54 , pp. 1162-1170
    • Le Pen, G.1    Kew, J.2    Alberati, D.3    Borroni, E.4    Heitz, M.P.5    Moreau, J.L.6
  • 116
    • 1542617755 scopus 로고    scopus 로고
    • Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia
    • Tsai G, Lane HY, Yang P, Chong MY, Lange N. Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 2004; 55: 452-456.
    • (2004) Biol Psychiatry , vol.55 , pp. 452-456
    • Tsai, G.1    Lane, H.Y.2    Yang, P.3    Chong, M.Y.4    Lange, N.5
  • 118
    • 0034796599 scopus 로고    scopus 로고
    • A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia
    • Goff DC, Leahy L, Berman I, Posever T, Herz L, Leon AC et al. A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia. J Clin Psychopharmacol 2001; 21: 484-487.
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 484-487
    • Goff, D.C.1    Leahy, L.2    Berman, I.3    Posever, T.4    Herz, L.5    Leon, A.C.6
  • 119
    • 0036773660 scopus 로고    scopus 로고
    • Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: A case series
    • Marenco S, Egan MF, Goldberg TE, Knable MB, McClure RK, Winterer G et al. Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series. Schizophr Res 2002; 57: 221-226.
    • (2002) Schizophr Res , vol.57 , pp. 221-226
    • Marenco, S.1    Egan, M.F.2    Goldberg, T.E.3    Knable, M.B.4    McClure, R.K.5    Winterer, G.6
  • 121
    • 0034054949 scopus 로고    scopus 로고
    • Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: Support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists
    • Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A et al. Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists. Arch Gen Psychiatry 2000; 57: 270-276.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 270-276
    • Anand, A.1    Charney, D.S.2    Oren, D.A.3    Berman, R.M.4    Hu, X.S.5    Cappiello, A.6
  • 122
    • 0344979751 scopus 로고    scopus 로고
    • Clozapine plus lamotrigine in treatment-resistant schizophrenia
    • Dursun SM, McIntosh D, Milliken H. Clozapine plus lamotrigine in treatment-resistant schizophrenia. Arch Gen Psychiatry 1999; 56: 950.
    • (1999) Arch Gen Psychiatry , vol.56 , pp. 950
    • Dursun, S.M.1    McIntosh, D.2    Milliken, H.3
  • 123
    • 0035663840 scopus 로고    scopus 로고
    • Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: A naturalistic case-series outcome study
    • Dursun SM, Deakin JF. Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: a naturalistic case-series outcome study. J Psychopharmacol 2001; 15: 297-301.
    • (2001) J Psychopharmacol , vol.15 , pp. 297-301
    • Dursun, S.M.1    Deakin, J.F.2
  • 125
    • 0037112011 scopus 로고    scopus 로고
    • Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes
    • Benquet P, Gee CE, Gerber U. Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. J Neurosci 2002; 22: 9679-9686.
    • (2002) J Neurosci , vol.22 , pp. 9679-9686
    • Benquet, P.1    Gee, C.E.2    Gerber, U.3
  • 126
    • 0036662898 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: Mediation through the Pyk2/Src-family kinase pathway in cortical neurons
    • Heidinger V, Manzerra P, Wang XQ, Strasser U, Yu SP, Choi DW et al. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci 2002; 22: 5452-5461.
    • (2002) J Neurosci , vol.22 , pp. 5452-5461
    • Heidinger, V.1    Manzerra, P.2    Wang, X.Q.3    Strasser, U.4    Yu, S.P.5    Choi, D.W.6
  • 127
    • 0036945935 scopus 로고    scopus 로고
    • The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    • Henry SA, Lehmann-Masten V, Gasparini F, Geyer MA, Markou A. The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology 2002; 43: 1199-1209.
    • (2002) Neuropharmacology , vol.43 , pp. 1199-1209
    • Henry, S.A.1    Lehmann-Masten, V.2    Gasparini, F.3    Geyer, M.A.4    Markou, A.5
  • 129
    • 0037448394 scopus 로고    scopus 로고
    • 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity
    • Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J et al. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 2003; 46: 204-206.
    • (2003) J Med Chem , vol.46 , pp. 204-206
    • Cosford, N.D.1    Tehrani, L.2    Roppe, J.3    Schweiger, E.4    Smith, N.D.5    Anderson, J.6
  • 130
    • 0036669731 scopus 로고    scopus 로고
    • Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats
    • Pilc A, Klodzinska A, Branski P, Nowak G, Palucha A, Szewczyk B et al. Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats. Neuropharmacology 2002; 43: 181-187.
    • (2002) Neuropharmacology , vol.43 , pp. 181-187
    • Pilc, A.1    Klodzinska, A.2    Branski, P.3    Nowak, G.4    Palucha, A.5    Szewczyk, B.6
  • 132
    • 1642328941 scopus 로고    scopus 로고
    • Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice
    • Brody SA, Conquet F, Geyer MA. Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice. Psychopharmacology (Berl) 2003; 172: 187-195.
    • (2003) Psychopharmacology (Berl) , vol.172 , pp. 187-195
    • Brody, S.A.1    Conquet, F.2    Geyer, M.A.3
  • 134
    • 0037461581 scopus 로고    scopus 로고
    • Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex
    • Maeda J, Suhara T, Okauchi T, Semba J. Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex. Neurosci Lett 2003; 336: 171-174.
    • (2003) Neurosci Lett , vol.336 , pp. 171-174
    • Maeda, J.1    Suhara, T.2    Okauchi, T.3    Semba, J.4
  • 135
    • 0001050066 scopus 로고    scopus 로고
    • The metabotropic glutamate receptors: Structure, activation mechanism and pharmacology
    • Pin JP, Acher F. The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Target CNS Neurol Disord 2002; 1: 297-317.
    • (2002) Curr Drug Target CNS Neurol Disord , vol.1 , pp. 297-317
    • Pin, J.P.1    Acher, F.2
  • 136
    • 0345016983 scopus 로고    scopus 로고
    • Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex
    • Muly EC, Maddox M, Smith Y. Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex. J Comp Neurol 2003; 467: 521-535.
    • (2003) J Comp Neurol , vol.467 , pp. 521-535
    • Muly, E.C.1    Maddox, M.2    Smith, Y.3
  • 137
    • 0042422052 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptors in the monkey striatum: Subsynaptic association with glutamatergic and dopaminergic afferents
    • Paquet M, Smith Y. Group I metabotropic glutamate receptors in the monkey striatum: subsynaptic association with glutamatergic and dopaminergic afferents. J Neurosci 2003; 23: 7659-7669.
    • (2003) J Neurosci , vol.23 , pp. 7659-7669
    • Paquet, M.1    Smith, Y.2
  • 138
    • 0011900802 scopus 로고    scopus 로고
    • Preclinical pharmacology of mGlu2/3 receptor agonists: Novel agents for schizophrenia?
    • Schoepp DD, Marek GJ. Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia? Curr Drug Target CNS Neurol Disord 2002; 1: 215-225.
    • (2002) Curr Drug Target CNS Neurol Disord , vol.1 , pp. 215-225
    • Schoepp, D.D.1    Marek, G.J.2
  • 139
    • 0035996492 scopus 로고    scopus 로고
    • Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats
    • Clark M, Johnson BG, Wright RA, Monn JA, Schoepp DD. Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats. Pharmacol Biochem Behav 2002; 73: 339-346.
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 339-346
    • Clark, M.1    Johnson, B.G.2    Wright, R.A.3    Monn, J.A.4    Schoepp, D.D.5
  • 140
    • 0042178301 scopus 로고    scopus 로고
    • Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: Linkage disequilibrium mapping using SNPs evenly distributed across the gene region
    • Makino C, Fujii Y, Kikuta R, Hirata N, Tani A, Shibata A et al. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. Am J Med Genet 2003; 116B: 17-22.
    • (2003) Am J Med Genet , vol.116 B , pp. 17-22
    • Makino, C.1    Fujii, Y.2    Kikuta, R.3    Hirata, N.4    Tani, A.5    Shibata, A.6
  • 141
    • 0034068655 scopus 로고    scopus 로고
    • Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine
    • Cartmell J, Monn JA, Schoepp DD. Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine. Psychopharmacology (Berlin) 2000; 148: 423-429.
    • (2000) Psychopharmacology (Berlin) , vol.148 , pp. 423-429
    • Cartmell, J.1    Monn, J.A.2    Schoepp, D.D.3
  • 142
    • 0036894693 scopus 로고    scopus 로고
    • The group II metabotropic glutamate receptor agonist (-)-2-oxa-4- aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats
    • Swanson CJ, Schoepp DD. The group II metabotropic glutamate receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats. J Pharmacol Exp Ther 2002; 303: 919-927.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 919-927
    • Swanson, C.J.1    Schoepp, D.D.2
  • 143
    • 0141446177 scopus 로고    scopus 로고
    • Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge
    • Lorrain DS, Schaffhauser H, Campbell UC, Baccei CS, Correa LD, Rowe B et al. Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge. Neuropsychopharmacology 2003; 28: 1622-1632.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1622-1632
    • Lorrain, D.S.1    Schaffhauser, H.2    Campbell, U.C.3    Baccei, C.S.4    Correa, L.D.5    Rowe, B.6
  • 145
    • 0038155299 scopus 로고    scopus 로고
    • Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N- (2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine
    • Johnson MP, Baez M, Jagdmann Jr GE, Britton TC, Large TH, Callagaro DO et al. Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N- (2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine. J Med Chem 2003; 46: 3189-3192.
    • (2003) J Med Chem , vol.46 , pp. 3189-3192
    • Johnson, M.P.1    Baez, M.2    Jagdmann Jr., G.E.3    Britton, T.C.4    Large, T.H.5    Callagaro, D.O.6
  • 146
    • 0036971043 scopus 로고    scopus 로고
    • Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats
    • Tatarczynska E, Palucha A, Szewczyk B, Chojnacka-Wojcik E, Wieronska J, Pilc A. Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats. Pol J Pharmacol 2002; 54: 707-710.
    • (2002) Pol J Pharmacol , vol.54 , pp. 707-710
    • Tatarczynska, E.1    Palucha, A.2    Szewczyk, B.3    Chojnacka-Wojcik, E.4    Wieronska, J.5    Pilc, A.6
  • 148
    • 0141954291 scopus 로고    scopus 로고
    • The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease
    • Rogawski MA, Wenk GL. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev 2003; 9: 275-308.
    • (2003) CNS Drug Rev , vol.9 , pp. 275-308
    • Rogawski, M.A.1    Wenk, G.L.2
  • 149
    • 0141707078 scopus 로고    scopus 로고
    • The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: Preclinical evidence
    • Danysz W, Parsons CG. The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence. Int J Geriatr Psychiatry 2003; 18: S23-32.
    • (2003) Int J Geriatr Psychiatry , vol.18
    • Danysz, W.1    Parsons, C.G.2
  • 150
    • 0037146905 scopus 로고    scopus 로고
    • Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40)
    • Miguel-Hidalgo JJ, Alvarez XA, Cacabelos R, Quack G. Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40). Brain Res 2002; 958: 210-221.
    • (2002) Brain Res , vol.958 , pp. 210-221
    • Miguel-Hidalgo, J.J.1    Alvarez, X.A.2    Cacabelos, R.3    Quack, G.4
  • 151
    • 0037223547 scopus 로고    scopus 로고
    • Amyloid beta protein enhances the clearance of extracellular L-glutamate by cultured rat cortical astrocytes
    • Abe K, Misawa M. Amyloid beta protein enhances the clearance of extracellular L-glutamate by cultured rat cortical astrocytes. Neurosci Res 2003; 45: 25-31.
    • (2003) Neurosci Res , vol.45 , pp. 25-31
    • Abe, K.1    Misawa, M.2
  • 156
    • 0033015134 scopus 로고    scopus 로고
    • Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment
    • Tsai GE, Falk WE, Gunther J, Coyle JT. Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. Am J Psychiatry 1999; 156: 467-469.
    • (1999) Am J Psychiatry , vol.156 , pp. 467-469
    • Tsai, G.E.1    Falk, W.E.2    Gunther, J.3    Coyle, J.T.4
  • 157
    • 0024399735 scopus 로고
    • Loss of glycine-dependent radioligand binding to the N-methyl-D- aspartate-phencyclidine receptor complex in patients with Alzheimer's disease
    • Procter AW, Stirling JM, Stratmann GC, Cross AJ, Bowen DM. Loss of glycine-dependent radioligand binding to the N-methyl-D-aspartate-phencyclidine receptor complex in patients with Alzheimer's disease. Neurosci Lett 1989; 101: 62-66.
    • (1989) Neurosci Lett , vol.101 , pp. 62-66
    • Procter, A.W.1    Stirling, J.M.2    Stratmann, G.C.3    Cross, A.J.4    Bowen, D.M.5
  • 158
    • 0036667175 scopus 로고    scopus 로고
    • CX-516 cortex pharmaceuticals
    • Danysz W. CX-516 cortex pharmaceuticals. Curr Opin Invest Drugs 2002; 3: 1081-1088.
    • (2002) Curr Opin Invest Drugs , vol.3 , pp. 1081-1088
    • Danysz, W.1
  • 161
    • 0041488670 scopus 로고    scopus 로고
    • Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans
    • Grillon C, Cordova J, Levine LR, Morgan III CA. Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans. Psychopharmacology (Berlin) 2003; 168: 446-454.
    • (2003) Psychopharmacology (Berlin) , vol.168 , pp. 446-454
    • Grillon, C.1    Cordova, J.2    Levine, L.R.3    Morgan III, C.A.4
  • 162
    • 0141644133 scopus 로고    scopus 로고
    • LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress
    • Schoepp DD, Wright RA, Levine LR, Gaydos B, Potter WZ. LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress. Stress 2003; 6: 189-197.
    • (2003) Stress , vol.6 , pp. 189-197
    • Schoepp, D.D.1    Wright, R.A.2    Levine, L.R.3    Gaydos, B.4    Potter, W.Z.5
  • 163
    • 0042521068 scopus 로고    scopus 로고
    • LY-354740 (Eli Lilly)
    • Pilc A. LY-354740 (Eli Lilly). IDrugs 2003; 6: 66-71.
    • (2003) IDrugs , vol.6 , pp. 66-71
    • Pilc, A.1
  • 164
    • 0002805623 scopus 로고
    • The psychotropic effect of cycloserine: A new use of an antibiotic
    • Crane GE. The psychotropic effect of cycloserine: a new use of an antibiotic. Compr Psychiatry 1961; 2: 51-59.
    • (1961) Compr Psychiatry , vol.2 , pp. 51-59
    • Crane, G.E.1
  • 165
    • 0030571516 scopus 로고    scopus 로고
    • Antidepressant-like effects of 1-aminocyclopropanecarboxylic acid and D-cycloserine in an animal model of depression
    • Papp M, Moryl E. Antidepressant-like effects of 1- aminocyclopropanecarboxylic acid and D-cycloserine in an animal model of depression. Eur J Pharmacol 1996; 316: 145-151.
    • (1996) Eur J Pharmacol , vol.316 , pp. 145-151
    • Papp, M.1    Moryl, E.2
  • 167
    • 0036212738 scopus 로고    scopus 로고
    • Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
    • Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G et al. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Mol Psychiatry 2002; 7(Suppl 1): S71-S80.
    • (2002) Mol Psychiatry , vol.7 , Issue.SUPPL. 1
    • Krystal, J.H.1    Sanacora, G.2    Blumberg, H.3    Anand, A.4    Charney, D.S.5    Marek, G.6
  • 168
    • 0346461630 scopus 로고    scopus 로고
    • Glutamate and Depression: Clinical and Preclinical Studies
    • Paul IA, Skolnick P. Glutamate and Depression: Clinical and Preclinical Studies. Ann NY Acad Sci 2003; 1003: 250-272.
    • (2003) Ann NY Acad Sci , vol.1003 , pp. 250-272
    • Paul, I.A.1    Skolnick, P.2
  • 169
    • 0346219343 scopus 로고    scopus 로고
    • Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats
    • Palz S, Ucha A, Tatarczynska E, Branski P, Szewczyk B, Wieronska JM et al. Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats. Neuropharmacology 2004; 46:
    • (2004) Neuropharmacology , vol.46 , pp. 151-159
    • Palz, S.1    Ucha, A.2    Tatarczynska, E.3    Branski, P.4    Szewczyk, B.5    Wieronska, J.M.6
  • 170
    • 0036218088 scopus 로고    scopus 로고
    • Antidepressant mechanisms: Functional and molecular correlates of excitatory amino acid neurotransmission
    • Stewart CA, Reid IC. Antidepressant mechanisms: functional and molecular correlates of excitatory amino acid neurotransmission. Mol Psychiatry 2002; 7(Suppl 1): S15-S22.
    • (2002) Mol Psychiatry , vol.7 , Issue.SUPPL. 1
    • Stewart, C.A.1    Reid, I.C.2
  • 171
    • 0033853608 scopus 로고    scopus 로고
    • The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder. A critical review
    • Petrie RX, Reid IC, Stewart CA. The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder. A critical review. Pharmacol Ther 2000; 87: 11-25.
    • (2000) Pharmacol Ther , vol.87 , pp. 11-25
    • Petrie, R.X.1    Reid, I.C.2    Stewart, C.A.3
  • 172
    • 0034672410 scopus 로고    scopus 로고
    • The neurobiology of stress: From serendipity to clinical relevance
    • McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res 2000; 886: 172-189.
    • (2000) Brain Res , vol.886 , pp. 172-189
    • McEwen, B.S.1
  • 173
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000; 20: 9104-9110.
    • (2000) J Neurosci , vol.20 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 174
    • 0035134536 scopus 로고    scopus 로고
    • NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus
    • Nacher J, Rosell DR, Alonso-Llosa G, McEwen BS. NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus. Eur J Neurosci 2001; 13: 512-520.
    • (2001) Eur J Neurosci , vol.13 , pp. 512-520
    • Nacher, J.1    Rosell, D.R.2    Alonso-Llosa, G.3    McEwen, B.S.4
  • 178
    • 0041857957 scopus 로고    scopus 로고
    • NMDA receptors in the rat orbital prefrontal cortex are involved in guidance of instrumental behaviour under reversal conditions
    • Bohn I, Giertler C, Hauber W. NMDA receptors in the rat orbital prefrontal cortex are involved in guidance of instrumental behaviour under reversal conditions. Cereb Cortex 2003; 13: 968-976.
    • (2003) Cereb Cortex , vol.13 , pp. 968-976
    • Bohn, I.1    Giertler, C.2    Hauber, W.3
  • 179
    • 15644383835 scopus 로고    scopus 로고
    • D-cycloserine, a partial NMDA receptor-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine has no effect
    • Riekkinen Jr P, Ikonen S, Riekkinen M. D-cycloserine, a partial NMDA receptor-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine has no effect. Neuroreport 1998; 9: 3647-3651.
    • (1998) Neuroreport , vol.9 , pp. 3647-3651
    • Riekkinen Jr., P.1    Ikonen, S.2    Riekkinen, M.3
  • 180
    • 0026565077 scopus 로고
    • D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task
    • Schuster GM, Schmidt WJ. D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task. Eur J Pharmacol 1992; 224: 97-98.
    • (1992) Eur J Pharmacol , vol.224 , pp. 97-98
    • Schuster, G.M.1    Schmidt, W.J.2
  • 184
    • 1442333154 scopus 로고    scopus 로고
    • High dose glycine added to olanzapine and risperidone for the treatment of schizophrenia
    • Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC. High dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004; 55: 165-171.
    • (2004) Biol Psychiatry , vol.55 , pp. 165-171
    • Heresco-Levy, U.1    Ermilov, M.2    Lichtenberg, P.3    Bar, G.4    Javitt, D.C.5
  • 185
    • 0032403626 scopus 로고    scopus 로고
    • D-serine added to antipsychotics for the treatment of schizophrenia
    • Tsai G, Yang P, Chung LC, Lange N, Coyle JT. D-serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 1998; 44: 1081-1089.
    • (1998) Biol Psychiatry , vol.44 , pp. 1081-1089
    • Tsai, G.1    Yang, P.2    Chung, L.C.3    Lange, N.4    Coyle, J.T.5
  • 186
    • 8744279591 scopus 로고    scopus 로고
    • Clnical trials with glycine site agonists of the NMDA receptor used as adjuvants to conventional and atypical antipsychotics
    • Heresco-Levy U. Clnical trials with glycine site agonists of the NMDA receptor used as adjuvants to conventional and atypical antipsychotics. Int J Neuropsychopharmacol 2004; 7: S25.
    • (2004) Int J Neuropsychopharmacol , vol.7
    • Heresco-Levy, U.1
  • 187
    • 0032902238 scopus 로고    scopus 로고
    • A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia
    • Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA et al. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psychiatry 1999; 56: 21-27.
    • (1999) Arch Gen Psychiatry , vol.56 , pp. 21-27
    • Goff, D.C.1    Tsai, G.2    Levitt, J.3    Amico, E.4    Manoach, D.5    Schoenfeld, D.A.6
  • 188
    • 0036184549 scopus 로고    scopus 로고
    • Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia
    • Heresco-Levy U, Ermilov M, Shimoni J, Shapira B, Silipo G, Javitt DC. Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia. Am J Psychiatry 2002; 159: 480-482.
    • (2002) Am J Psychiatry , vol.159 , pp. 480-482
    • Heresco-Levy, U.1    Ermilov, M.2    Shimoni, J.3    Shapira, B.4    Silipo, G.5    Javitt, D.C.6
  • 189
    • 0033557737 scopus 로고    scopus 로고
    • A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia
    • Goff DC, Henderson DC, Evins AE, Amico E. A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia. Biol Psychiatry 1999; 45: 512-514.
    • (1999) Biol Psychiatry , vol.45 , pp. 512-514
    • Goff, D.C.1    Henderson, D.C.2    Evins, A.E.3    Amico, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.