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Volumn 43, Issue 2, 2002, Pages 181-187

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

Author keywords

2 Methyl 6 (phenylethynyl) pyridine; Animal models of depression; Anxiety; Conflict drinking test; Convulsions; Depression; mGlu5 receptors; N methyl D aspartic acid; Olfactory bulbectomy

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; DESIPRAMINE; DIAZEPAM; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0036669731     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00082-5     Document Type: Article
Times cited : (153)

References (50)
  • 1
    • 0034042024 scopus 로고    scopus 로고
    • Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment
    • Andrews G., Sanderson K., Slade T., Issakidis C. Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment. Bulletin of World Health Organisation. 78:2000;446-454.
    • (2000) Bulletin of World Health Organisation , vol.78 , pp. 446-454
    • Andrews, G.1    Sanderson, K.2    Slade, T.3    Issakidis, C.4
  • 2
    • 0035124349 scopus 로고    scopus 로고
    • Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges
    • Attucci S., Carla V., Mannaioni G., Moroni F. Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. British Journal of Pharmacology. 132:2001;799-806.
    • (2001) British Journal of Pharmacology , vol.132 , pp. 799-806
    • Attucci, S.1    Carla, V.2    Mannaioni, G.3    Moroni, F.4
  • 3
    • 0034332480 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus
    • Awad H., Hubert G.W., Smith Y., Levey A.I., Conn P.J. Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. Journal of Neuroscience. 20:2000;7871-7879.
    • (2000) Journal of Neuroscience , vol.20 , pp. 7871-7879
    • Awad, H.1    Hubert, G.W.2    Smith, Y.3    Levey, A.I.4    Conn, P.J.5
  • 4
    • 0343851555 scopus 로고    scopus 로고
    • Effect of chronic antidepressant or electroconvulsive shock treatment on mGLuR1a immunoreactivity expression in the rat hippocampus
    • Bajkowska M., Brański P., Śmiałowska M., Pilc A. Effect of chronic antidepressant or electroconvulsive shock treatment on mGLuR1a immunoreactivity expression in the rat hippocampus. Polish Journal of Pharmacology. 51:1999;539-541.
    • (1999) Polish Journal of Pharmacology , vol.51 , pp. 539-541
    • Bajkowska, M.1    Brański, P.2    Śmiałowska, M.3    Pilc, A.4
  • 9
    • 2542507973 scopus 로고    scopus 로고
    • The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats
    • Chojnacka-Wójcik E., Tatarczyńska E., Pilc A. The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats. European Journal of Pharmacology. 319:1997;153-156.
    • (1997) European Journal of Pharmacology , vol.319 , pp. 153-156
    • Chojnacka-Wójcik, E.1    Tatarczyńska, E.2    Pilc, A.3
  • 12
    • 0030894148 scopus 로고    scopus 로고
    • (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu(5), but not mGlu(1), receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
    • Doherty A.J., Palmer M.J., Henley J.M., Collingridge G.L., Jane D.E. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu(5), but not mGlu(1), receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 36:1997;265-267.
    • (1997) Neuropharmacology , vol.36 , pp. 265-267
    • Doherty, A.J.1    Palmer, M.J.2    Henley, J.M.3    Collingridge, G.L.4    Jane, D.E.5
  • 15
    • 0027408298 scopus 로고
    • Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat
    • Glaum S.R., Miller R.J. Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat. Journal of Neuroscience. 13:1993;1636-1641.
    • (1993) Journal of Neuroscience , vol.13 , pp. 1636-1641
    • Glaum, S.R.1    Miller, R.J.2
  • 16
    • 0002801502 scopus 로고
    • Acute regulation of synaptic transmission by metabotropic glutamate receptors
    • P.J. Conn, & J. Patel. Totowa, NJ: Humana Press
    • Glaum S.R., Miller R.J. Acute regulation of synaptic transmission by metabotropic glutamate receptors. Conn P.J., Patel J., The Metabotropic Glutamate Receptors. 1994;147-172 Humana Press, Totowa, NJ.
    • (1994) The Metabotropic Glutamate Receptors , pp. 147-172
    • Glaum, S.R.1    Miller, R.J.2
  • 18
  • 19
    • 0031933951 scopus 로고    scopus 로고
    • Anxiolytic and side-effect profile of LY354740: A potent highly selective, orally active agonist for group II metabotropic glutamate receptors
    • Helton D.R., Tizzano J.P., Monn J.A., Schoepp D.D., Kallman M.J. Anxiolytic and side-effect profile of LY354740: a potent highly selective, orally active agonist for group II metabotropic glutamate receptors. Journal of Pharmacology and Experimental Therapeutics. 284:1998;651-660.
    • (1998) Journal of Pharmacology and Experimental Therapeutics , vol.284 , pp. 651-660
    • Helton, D.R.1    Tizzano, J.P.2    Monn, J.A.3    Schoepp, D.D.4    Kallman, M.J.5
  • 21
    • 0022200681 scopus 로고
    • Animal models of depression: Parallels and correlates to severe depression in humans
    • Jesberger J.A., Richardson J.S. Animal models of depression: parallels and correlates to severe depression in humans. Biological Psychiatry. 20:1985;764-784.
    • (1985) Biological Psychiatry , vol.20 , pp. 764-784
    • Jesberger, J.A.1    Richardson, J.S.2
  • 22
    • 0344980107 scopus 로고    scopus 로고
    • Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models
    • Kłodzińska A., Chojnacka-Wójcik E., Pałucha A., Brański P., Popik P., Pilc A. Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. Neuropharmacology. 38:1999;1831-1839.
    • (1999) Neuropharmacology , vol.38 , pp. 1831-1839
    • Kłodzińska, A.1    Chojnacka-Wójcik, E.2    Pałucha, A.3    Brański, P.4    Popik, P.5    Pilc, A.6
  • 23
    • 0034502492 scopus 로고    scopus 로고
    • Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats
    • Kłodzińska A., Tatarczyńska E., Chojnacka-Wójcik E., Pilc A. Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Polish Journal of Pharmacology. 52:2000;463-466.
    • (2000) Polish Journal of Pharmacology , vol.52 , pp. 463-466
    • Kłodzińska, A.1    Tatarczyńska, E.2    Chojnacka-Wójcik, E.3    Pilc, A.4
  • 24
    • 0019345893 scopus 로고
    • Anatomical physiological, and behavioral aspects of olfactory bulbectomy in the rat
    • Leonard B.E., Tuite M. Anatomical physiological, and behavioral aspects of olfactory bulbectomy in the rat. International Review of Neurobiology. 22:1981;251-286.
    • (1981) International Review of Neurobiology , vol.22 , pp. 251-286
    • Leonard, B.E.1    Tuite, M.2
  • 27
    • 0024596865 scopus 로고
    • The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
    • Monaghan D.T., Bridges R.J., Cotman C.W. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annual Review of Pharmacology and Toxicology. 29:1989;365-402.
    • (1989) Annual Review of Pharmacology and Toxicology , vol.29 , pp. 365-402
    • Monaghan, D.T.1    Bridges, R.J.2    Cotman, C.W.3
  • 28
    • 0033638723 scopus 로고    scopus 로고
    • Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
    • Oleary D.M., Movsesyan V., Vicini S., Faden A.I. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. British Journal of Pharmacology. 131:2000;1429-1437.
    • (2000) British Journal of Pharmacology , vol.131 , pp. 1429-1437
    • Oleary, D.M.1    Movsesyan, V.2    Vicini, S.3    Faden, A.I.4
  • 29
    • 0032524219 scopus 로고    scopus 로고
    • Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region
    • Pilc A., Brański P., Pałucha A., Tokarski K., Bijak M. Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region. European Journal of Pharmacology. 349:1998;83-87.
    • (1998) European Journal of Pharmacology , vol.349 , pp. 83-87
    • Pilc, A.1    Brański, P.2    Pałucha, A.3    Tokarski, K.4    Bijak, M.5
  • 30
    • 0005207845 scopus 로고    scopus 로고
    • A role of glutamate in the treatment of anxiety and depression, focus on group I metabotropic glutamate (mGlu) receptors
    • Pilc, A., Kłodzińska A., Nowak, G., 2002. A role of glutamate in the treatment of anxiety and depression, focus on group I metabotropic glutamate (mGlu) receptors. Drugs of the Future 3, 2002.
    • (2002) Drugs of the Future , vol.3 , pp. 2002
    • Pilc, A.1    Kłodzińska, A.2    Nowak, G.3
  • 31
    • 0029187946 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin J.P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 32
    • 0035959976 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    • Pisani A., Gubellini P., Bonsi P., Conquet F., Picconi B., Centonze D., Bernardi G., Calabresi P. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience. 106:2001;579-587.
    • (2001) Neuroscience , vol.106 , pp. 579-587
    • Pisani, A.1    Gubellini, P.2    Bonsi, P.3    Conquet, F.4    Picconi, B.5    Centonze, D.6    Bernardi, G.7    Calabresi, P.8
  • 34
    • 0017646652 scopus 로고
    • Olfactory bulb ablation in the rat: Behavioural changes and their reversal by antidepressant drugs
    • van Riezen H., Schnieden H., Wren A.F. Olfactory bulb ablation in the rat: behavioural changes and their reversal by antidepressant drugs. British Journal of Pharmacology. 60:1977;521-528.
    • (1977) British Journal of Pharmacology , vol.60 , pp. 521-528
    • Van Riezen, H.1    Schnieden, H.2    Wren, A.F.3
  • 35
    • 0034811597 scopus 로고    scopus 로고
    • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system
    • Schoepp D.D. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. Journal of Pharmacology and Experimental Therapeutics. 299:2001;12-20.
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.299 , pp. 12-20
    • Schoepp, D.D.1
  • 36
    • 0032983086 scopus 로고    scopus 로고
    • Antidepressants for the new millennium
    • Skolnick P. Antidepressants for the new millennium. European Journal of Pharmacology. 375:1999;31-40.
    • (1999) European Journal of Pharmacology , vol.375 , pp. 31-40
    • Skolnick, P.1
  • 37
    • 0030032399 scopus 로고    scopus 로고
    • Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: Implications for the pharmacotherapy of depression
    • Skolnick P., Layer R.T., Popik P., Nowak G., Paul I.A., Trullas R. Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Pharmacopsychiatry. 29:1996;23-26.
    • (1996) Pharmacopsychiatry , vol.29 , pp. 23-26
    • Skolnick, P.1    Layer, R.T.2    Popik, P.3    Nowak, G.4    Paul, I.A.5    Trullas, R.6
  • 38
    • 0034949246 scopus 로고    scopus 로고
    • Current perspectives on the development of non-biogenic amine-based antidepressants
    • Skolnick P., Legutko B., Li X., Bymaster F.P. Current perspectives on the development of non-biogenic amine-based antidepressants. Pharmacological Research. 43:2001;411-422.
    • (2001) Pharmacological Research , vol.43 , pp. 411-422
    • Skolnick, P.1    Legutko, B.2    Li, X.3    Bymaster, F.P.4
  • 42
    • 0034861333 scopus 로고    scopus 로고
    • Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): Complementary in vitro and in vivo evidence
    • Thomas L.S., Jane D.E., Gasparini F., Croucher M.J. Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence. Neuropharmacology. 41:2001;523-527.
    • (2001) Neuropharmacology , vol.41 , pp. 523-527
    • Thomas, L.S.1    Jane, D.E.2    Gasparini, F.3    Croucher, M.J.4
  • 43
    • 0034067960 scopus 로고    scopus 로고
    • Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro
    • Thomas L.S., Jane D.E., Harris J.R., Croucher M.J. Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro. Neuropharmacology. 39:2000;1554-1566.
    • (2000) Neuropharmacology , vol.39 , pp. 1554-1566
    • Thomas, L.S.1    Jane, D.E.2    Harris, J.R.3    Croucher, M.J.4
  • 44
    • 0032874391 scopus 로고    scopus 로고
    • Potentiation of NMDA and AMPA responses by the specific mGluR(5) agonist CHPG in spinal cord motoneurons
    • Ugolini A., Corsi M., Bordi F. Potentiation of NMDA and AMPA responses by the specific mGluR(5) agonist CHPG in spinal cord motoneurons. Neuropharmacology. 38:1999;1569-1576.
    • (1999) Neuropharmacology , vol.38 , pp. 1569-1576
    • Ugolini, A.1    Corsi, M.2    Bordi, F.3
  • 45
    • 0015004136 scopus 로고
    • A simple and reliable conflict procedure for testing anti-anxiety agents
    • Vogel J.R., Beer B., Clody D.E. A simple and reliable conflict procedure for testing anti-anxiety agents. Psychopharmacologia. 21:1971;1-7.
    • (1971) Psychopharmacologia , vol.21 , pp. 1-7
    • Vogel, J.R.1    Beer, B.2    Clody, D.E.3
  • 46
    • 0034041240 scopus 로고    scopus 로고
    • The burden of mental disorders: A comparison of methods between the Australian burden of disease studies and the global burden of disease study
    • Vos T., Mathers C.D. The burden of mental disorders: a comparison of methods between the Australian burden of disease studies and the global burden of disease study. Bulletin of World Health Organisation. 78:2000;427-438.
    • (2000) Bulletin of World Health Organisation , vol.78 , pp. 427-438
    • Vos, T.1    Mathers, C.D.2
  • 47
    • 0029617604 scopus 로고
    • Effects of site-selective NMDA receptor antagonists in an elevated plus-maze model of anxiety in mice
    • Wiley J.L., Cristello A.F., Balster R.L. Effects of site-selective NMDA receptor antagonists in an elevated plus-maze model of anxiety in mice. European Journal of Pharmacology. 294:1995;101-107.
    • (1995) European Journal of Pharmacology , vol.294 , pp. 101-107
    • Wiley, J.L.1    Cristello, A.F.2    Balster, R.L.3
  • 48
    • 0024517812 scopus 로고
    • Modulation of glutamate receptors: Molecular mechanisms and functional implications
    • Wróblewski J.T., Danysz W. Modulation of glutamate receptors: molecular mechanisms and functional implications. Annual Review of Pharmacology and Toxicology. 29:1989;441-474.
    • (1989) Annual Review of Pharmacology and Toxicology , vol.29 , pp. 441-474
    • Wróblewski, J.T.1    Danysz, W.2
  • 49
    • 0033372411 scopus 로고    scopus 로고
    • An antidepressant-induced decrease in the responsiveness of hippocampal neurons to group I metabotropic glutamate receptor activation
    • Zahorodna A., Bijak M. An antidepressant-induced decrease in the responsiveness of hippocampal neurons to group I metabotropic glutamate receptor activation. European Journal of Pharmacology. 386:1999;173-179.
    • (1999) European Journal of Pharmacology , vol.386 , pp. 173-179
    • Zahorodna, A.1    Bijak, M.2
  • 50
    • 0033847079 scopus 로고    scopus 로고
    • Frequency of anxiety disorders in psychiatric outpatients with major depressive disorder
    • Zimmerman M., McDermut W., Mattia J.I. Frequency of anxiety disorders in psychiatric outpatients with major depressive disorder. American Journal of Psychiatry. 157:2000;1337-1340.
    • (2000) American Journal of Psychiatry , vol.157 , pp. 1337-1340
    • Zimmerman, M.1    McDermut, W.2    Mattia, J.I.3


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