Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3- ylmethylamine

Journal of Medicinal Chemistry

Volumn 46, Issue 15, 2003, Pages 3189-3192

  Johnson, Michael P ^a   Baez, Melvyn ^a   Jagdmann Jr , G Erik ^a   Britton, Thomas C ^a   Large, Thomas H ^a   Callagaro, David O ^a   Tizzano, Joseph P ^a   Monn, James A ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANXIOLYTIC AGENT; LY 181837; LY 487379; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; N (4 PHENOXYPHENYL) N (3 PYRIDINYLMETHYL)ETHANESULFONAMIDE; N [4 (2 METHOXYPHENOXY)PHENYL] N (2,2,2 TRIFLUOROETHYLSULFONYL)PYRID 3 YLMETHYLAMINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ALLOSTERIC REGULATION; ANIMALS; ANTI-ANXIETY AGENTS; CALCIUM; CELLS, CULTURED; DRUG SYNERGISM; EXCITATORY AMINO ACID AGONISTS; HUMANS; KINETICS; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STARTLE REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0038155299     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034015u     Document Type: Article

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