Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice

Psychopharmacology

Volumn 172, Issue 2, 2004, Pages 187-195

  Brody, S A ^a   Conquet, F ^b   Geyer, M A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Clozapine; Ketamine; Lamotrigine; M100907; Metabotrophic glutamate; mGluR5; Raclopride

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; CLOZAPINE; KETAMINE; LAMOTRIGINE; METABOTROPIC RECEPTOR 5; NEUROLEPTIC AGENT; RACLOPRIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; ELECTROMYOGRAPHY; MOTOR PERFORMANCE; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RECEPTOR BLOCKING; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION;

ANIMALS; ANTIPSYCHOTIC AGENTS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL INHIBITION; RECEPTORS, METABOTROPIC GLUTAMATE; STARTLE REACTION;

EID: 1642328941     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1635-3     Document Type: Article

References (50)

1. Allen RM, Young SJ (1978) Phencyclidine-induced psychosis. Am J Psychiatry 135:1081-1084
2. Bakshi VP, Geyer MA (1995) Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine. Psychopharmacology 122:198-201
3. Bakshi VP, Swerdlow NR, Geyer MA (1994) Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271:787-794
4. Bakshi VP, Swerdlow NR, Braff DL, Geyer MA (1998) Reversal of isolation rearing-induced deficits in prepulse inhibition by seroquel and olanzapine. Biol Psychiatry 43:436-445
5. Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia: human and animal model studies. Arch Gen Psychiatry 47:181-188
6. Braff DL, Geyer MA, Swerdlow NR (2001) Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology 156:234-258
7. Brody SA, Dulawa SC, Geyer MA, Conquet F (2003a) Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors. Mol Psychiatry (in press)
8. Brody SA, Geyer MA, Large CH (2003b) Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice. Psychopharmacology 169:240-246
9. Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. J Clin Psychiatry 60:79-88
10. Calabrese JR, Suppes T, Bowden CL, Sachs GS, Swann AC, McElroy SL, Kusumakar V, Ascher JA, Earl NL, Greene PL, Monaghan ET (2000) A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry 61:841-850
11. 2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist than dopamine agonist induced hyperactivity in mice. J Neural Transm 106:123-129
12. Castellanos FX, Fine EJ, Kaysen D, Marsh WL, Rappaport JL, Hallet M (1996) Sensorimotor gating in boys with Tourette's syndrome and ADHD: preliminary results. Biol Psychiatry 39:33-41
13. Curzon P, Decker MW (1998) Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry 22:129-146
14. Devon RS, Porteous DJ (1997) Physical mapping of a glutamate receptor gene in relation to a balanced translocation associated with schizophrenia in a large Scottish family. Psychiatr Genet 7:165-169
15. Dulawa SC, Geyer MA (1996) Psychopharmacology of prepulse inhibition in mice. Chin J Physiol 39:139-146
16. Duncan EJ, Madonick SH, Parwani A, Angrist B, Rajan R, Chakravorty S, Efferen TR, Szilagyi S, Stephanides M, Chappell PB, Gonzenbach S, Ko GN, Rotrosen JP (2001) Clinical and sensorimotor gating effects of ketamine in normals. Neuropsychopharmacology 25:72-83
17. Geyer MA, Swerdlow NR (1998) Measurement of the startle response, prepulse inhibition, and habituation. In: Crawley JN, Skolnick P (eds) Current protocols in neuroscience. Wiley, New York, pp 8.7.1-8.7.15
18. Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology 156:117-154
19. Graham FK, Putnam LE, Leavitt LA (1975) Lead-stimulation effects on human cardiac orienting and blink reflexes. J Exp Psychol Hum Percept Perform 104:161-169
20. Grauer SM, Marquis KL (1999) Intracerebral administration of metabotropic glutamate receptor agonists disrupts prepulse inhibition of acoustic startle in Sprague-Dawley rats. Psychopharmacology 141:405-412
21. Henry SA, Dulawa SC, Conquet F, Geyer MA (1999) Severe disruption of prepulse inhibition (PPI) in mice lacking mGluR5. Soc Neurosci Abstr 25:449
22. Henry SA, Lehmann-Masten V, Gasparini F, Geyer MA, Markou A (2002) The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology 43:1199-1209
23. Hoffman HS, Ison JR (1980) Reflex modification in the domain of startle. 1. Some empirical findings and their implications for how the nervous system processes sensory input. Psychol Rev 87:175-189
24. Karper LP, Grillon C, Abi-Saab D, Morgan CAI, Charney DS, Krystal J (1995) The effect of ketamine on pre-pulse inhibition and attention. Schizophr Res 15:180
25. 2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther 277:968-981
26. Kinney GG, Burno M, Campbell UC, Hernandez LM, Rodriguez D, Bristow LJ, Conn PJ (2003) Metabotropic glutamate subtype 5 receptors (mGluR5) modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther 306:116-123
27. Le Pen G, Moreau JL (2002) Disruption of prepulse inhibition of startle reflex in a neurodevelopmental model of schizophrenia: reversal by clozapine, olanzapine and risperidone but not by haloperidol. Neuropsychopharmacology 27:1-11
28. Linn GS, Javitt DC (2001) Phencyclidine (PCP)-induced deficits of prepulse inhibition in monkeys. NeuroReport 12:117-120
29. Linn GS, Negi SS, Gerum SV, Javitt DC (2003) Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys. Psychopharmacology 169:234-239
30. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, Roder JC (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17:5196-5205
31. Ludewig S, Ludewig K, Geyer MA, Hell D, Vollenweider FX (2002) Prepulse inhibition deficits in patients with panic disorder. Depress Anxiety 15:55-60
32. Mansbach RS, Geyer MA (1989) Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology 2:299-308
33. Martin P, Waters N, Waters S, Carlsson A, Carlsson ML (1997) MK-801-induced hyperlocomotion: differential effects of M100907, SDZ PSD 958 and raclopride. Eur J Pharmacol 335:107-116
34. Martinez ZA, Oostwegel J, Geyer MA, Ellison GD, Swerdlow NR (2000) "Early" and "late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits. Neuropsychopharmacology 23:517-527
35. McAlonan GM, Daly E, Kumari V, Critchley HD, van Amelsvoort T, Suckling J, Simmons A, Sigmundsson T, Greenwood K, Russell A, Schmitz N, Happe F, Howlin P, Murphy DGM (2002) Brain anatomy and sensorimotor gating in Asperger's syndrome. Brain 125:1594-1606
36. McGhie A, Chapman J (1961) Disorders of attention and perception in early schizophrenia. Br J Med Psychol 34:102-116
37. Ohnuma T, Augood SJ, Arai H, McKenna PJ, Emson PC (1998) Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia. Mol Brain Res 56:207-217
38. Oka A, Takashima S (1999) The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains. Acta Neuropathol 97:275-278
39. Perry W, Minassian A, Feifel D, Braff DL (2001) Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry 50:418-424
40. Pietraszek M, Ossowska K (1998) Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats. Naunyn Schmiedeberg's Arch Pharmacol 357:466-471
41. 2 receptor antagonists. J Neurosci 21:305-313
42. Schall U, Schon A, Zerbin D, Eggers C, Oades RD (1996) Event-related potentials during an auditory discrimination with prepulse inhibition in patients with schizophrenia, obsessive-compulsive disorder and healthy subjects. Int J Neurosci 84:15-33
43. Sorensen SM, Kehne JH, Fadayel GM, Humphreys TM, Ketteler HJ, Sullivan CK, Taylor VL, Schmidt CJ (1993) Characterization of the 5-HT(2) receptor antagonist MDL 100907 as a putative atypical antipsychotic - behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther 266:684-691
44. Swerdlow NR, Geyer MA (1993) Clozapine and haloperidol in an animal-model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44:741-744
45. Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994) Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51:139-154
46. Swerdlow NR, Paulsen J, Braff DL, Butters N, Geyer MA, Swenson MR (1995) Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease. J Neurol Neurosurg Psychiatry 58:192-200
47. Swerdlow NR, Geyer MA, Braff DL (2001) Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology 156:194-215
48. 2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats. Neuropsychopharmacology 20:311-321
49. Yatham LN, Kusumakar V, Calabrese JR, Rao R, Scarrow G, Kroeker G (2002) Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations. J Clin Psychiatry 63:275-283
50. Zhang WN, Pouzet B, Jongen-Relo AL, Weiner I, Feldon J (1999) Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: a possible model for the screening of atypical antipsychotics. NeuroReport 10:2533-2538