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1
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0027053905
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Factors regulating the magnitude of long-term potentiation induced by theta pattern stimulation
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NIH to study Cortex's Ampalex in Alzheimers patients
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225777; November 14
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225777 NIH to study Cortex's Ampalex in Alzheimers patients. Cortex Pharm Inc Press Release 1996 November 14
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(1996)
Cortex Pharm Inc Press Release
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-
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3
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0029991210
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Psychological effects of a drug that facilitates brain AMPA receptors
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225928; note
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225928 Psychological effects of a drug that facilitates brain AMPA receptors. Lynch G, Kessler M, Rogers G, Ambros-Ingerson J, Granger R, Schehr RS Int Clin Psychopharmacol 1996 11 1 13-19 Report that CX-516 has a positive effect on the recall of nonsense syllables.
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Int Clin Psychopharmacol
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Lynch, G.1
Kessler, M.2
Rogers, G.3
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Granger, R.5
Schehr, R.S.6
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4
-
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0013361530
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Enrollment begins in phase I/II trial of Cortex's AMPALEX in Alzheimers disease patients
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234221; February 17
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234221 Enrollment begins in phase I/II trial of Cortex's AMPALEX in Alzheimers disease patients. Cortex Pharmaceuticals Inc Press Release 1997 February 17
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(1997)
Cortex Pharmaceuticals Inc Press Release
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5
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0001102050
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Reduction of methamphetamine hyperactivity by AMPA receptor facilitation: Positive interaction with typical and atypical antipsychotics
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240054
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240054 Reduction of methamphetamine hyperactivity by AMPA receptor facilitation: Positive interaction with typical and atypical antipsychotics. Johnson SA, Larson J, Luu NT, Herbst TA, Rogers G, Lynch G Pharmacologist 1997 39 1 120
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Pharmacologist
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Johnson, S.A.1
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6
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0028088995
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Facilitation of glutamate receptors enhances memory
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248440
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248440 Facilitation of glutamate receptors enhances memory. Staubli U, Rogers G, Lynch G Proc Natl Acad Sci USA 1994 91 2 777-781
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Proc Natl Acad Sci USA
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Staubli, U.1
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0030436860
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Effects of a memory-enhancing drug on DL-α-amino-3-hydroxy-5-methyl-4-isoxazolepropioninc acid receptor currents and synaptic transmission in hippocampus
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Effects of a memory-enhancing drug on DL-α-amino-3-hydroxy-5-methyl-4-isoxazolepropioninc acid receptor currents and synaptic transmission in hippocampus. Arai A, Kessler M, Rogers G, Lynch G J Pharmacol Exp Ther 1996 278 2 627-638
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J Pharmacol Exp Ther
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Arai, A.1
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0029587573
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Facilitation of olfactory learning by a modulator of AMPA receptors
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260653; note
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260653 Facilitation of olfactory learning by a modulator of AMPA receptors. Larson J, Lieu T, Petchpradub V, LeDuc B, Ngo H, Rogers GA, Lynch G J Neurosci 1995 15 12 8023-8030 CX-516 improves the formation of long-term memory in rats in odor discrimination.
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J Neurosci
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Larson, J.1
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Rogers, G.A.6
Lynch, G.7
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10
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0030604259
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Chronic treatment with typical and atypical antipsychotics increases the AMPA-preferring form of AMPA receptor in rat brain
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260654
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260654 Chronic treatment with typical and atypical antipsychotics increases the AMPA-preferring form of AMPA receptor in rat brain. McCoy L, Cox C, Richfield EK Eur J Pharmacol 1996 318 1 41-45
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0030601751
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Effects of a centrally active benzoylpyrrolidine drug on AMPA receptor kinetics
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260655; note
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260655 Effects of a centrally active benzoylpyrrolidine drug on AMPA receptor kinetics. Arai A, Kessler M, Ambros Ingerson J, Quan A, Yigiter E, Rogers G, Lynch G Neuroscience 1996 75 2 573-585 Effects of CX-516 on the kinetic properties of AMPA receptors were studied.
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Neuroscience
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Arai, A.1
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12
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0031214027
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Enhancement by an ampakine of memory encoding in humans
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266240; note
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266240 Enhancement by an ampakine of memory encoding in humans. Ingvar M, Ambros-Ingerson J, Davis M, Granger R, Kessler M, Rogers GA, Schehr RS, Lynch G Exp Neurol 1997 146 2 553-559 CX-516 was tested for its positive effect on visual association, recognition of odors and acquisition of a visuospatial maze.
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Exp Neurol
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Ingvar, M.1
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Schehr, R.S.7
Lynch, G.8
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13
-
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0013364988
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Effects of the AMPA receptor modulator CX614 synaptic responses and AMPA receptor kinetics
-
269819; Abs 478.9
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269819 Effects of the AMPA receptor modulator CX614 synaptic responses and AMPA receptor kinetics. Arai A, Ly J, Kessler M, Hennegriff M, Rogers G, Lynch G Abstr Soc Neurosci 1997 23 Pt 2 Abs 478.9
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Abstr Soc Neurosci
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Arai, A.1
Ly, J.2
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Lynch, G.6
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14
-
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0003361398
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Attenuation of excitotoxic damage by nanomolar levels of AMPAkines in long-term hippocampal slices
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272227; Abs 900.9
-
272227 Attenuation of excitotoxic damage by nanomolar levels of AMPAkines in long-term hippocampal slices. Bahr BA, Kawasaki BT, Quach C, Marrs C, Rogers G Abstr Soc Neurosci 1997 23 Pt 2 Abs 900.9
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Abstr Soc Neurosci
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Bahr, B.A.1
Kawasaki, B.T.2
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15
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25044446294
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Memory enhancing effects and pharmacokinetics of the new AMPA receptor modulator CX 516 in aged healthy male subjects
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280526
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280526 Memory enhancing effects and pharmacokinetics of the new AMPA receptor modulator CX 516 in aged healthy male subjects. Rost KL, Stephan K, Koeman MAC, Rogers G, Schehr R, Fuder H, Herrmann WM Naunyn Schmiedebergs Arch Pharmacol 1997 356 4 Suppl 1 R55
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Rost, K.L.1
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16
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33749697895
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Ampakine antidepressant activity in two animal models of depression
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298828 Ampakine antidepressant activity in two animal models of depression. Malatynska E, Rogers GA, Goldenberg R, Shuck C, Crites G, Lynch G, Marrs C, Knapp RJ Int Congr Pharmacol 1998 P 35.132
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Malatynska, E.1
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Marrs, C.7
Knapp, R.J.8
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17
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0030613550
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A profile of the behavioral changes produced by facilitation of AMPA-type glutamate receptors
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301247
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301247 A profile of the behavioral changes produced by facilitation of AMPA-type glutamate receptors. Davis CM, Moskovitz B, Nguyen MA, Tran BB, Arai A, Lynch G, Granger R Psychopharmacology 1997 133 2 161-167
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Davis, C.M.1
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Tran, B.B.4
Arai, A.5
Lynch, G.6
Granger, R.7
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18
-
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0342601397
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AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired
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301248
-
301248 AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired. Rogan MT, Staubli UV, Ledoux JE J Neurosci 1997 17 15 5928-5935
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Rogan, M.T.1
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Ledoux, J.E.3
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19
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0032551573
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AMPA receptor desensitization modulates synaptic responses induced by repetitive afferent stimulation in hippocampal slices
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309232
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309232 AMPA receptor desensitization modulates synaptic responses induced by repetitive afferent stimulation in hippocampal slices. Arai A, Lynch G Brain Res 1998 799 2 235-242
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Arai, A.1
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20
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0032551699
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The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization
-
309235
-
309235 The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization. Arai A, Lynch G Brain Res 1998 799 2 230-234
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Brain Res
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Arai, A.1
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21
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0031017606
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GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: A reverse transcriptase-polymerase chain reaction (RT-PCR) study
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309242
-
309242 GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: A reverse transcriptase-polymerase chain reaction (RT-PCR) study. Eastwood SL, Burnet PWJ, Harrison PJ Brain Res Mol Brain Res 1997 44 1 92-98
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Eastwood, S.L.1
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22
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0029916627
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Facilitation of glutamate receptors reverses an age-associated memory impairment in rats
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309246
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309246 Facilitation of glutamate receptors reverses an age-associated memory impairment in rats. Granger R, Deadwyler S, Davis M, Moskovitz B, Kessler M, Rogers G, Lynch G Synapse 1996 22 4 332-337
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Lynch, G.7
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23
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0027143781
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A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning-dependent task
-
A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning-dependent task. Granger R, Staubli U, Davies M, Perez Y, Nilsson L, Rogers GA, Lynch G Synapse 1993 15 4 326-329
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Synapse
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Granger, R.1
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Lynch, G.7
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24
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0032053403
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Facilitative effects of the ampakine CX516 on short-term memory in rats: Enhacement of delayed-nonmatch-to-sample performance
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309260
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309260 Facilitative effets of the ampakine CX516 on short-term memory in rats: Enhacement of delayed-nonmatch-to-sample performance. Hampson RE, Rogers G, Lynch G, Deadwyler SA J Neurosci 1998 18 7 2740-2747
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Hampson, R.E.1
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25
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0031723421
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AMPA receptor binding and subunit mRNA expression in prefrontal cortex an striatum of elderly schizophrenics
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309261
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309261 AMPA receptor binding and subunit mRNA expression in prefrontal cortex an striatum of elderly schizophrenics. Healy DJ, Haroutunian V, Powchik P, Davidson M, Davis KL, Watson SJ, Meador-Woodruff JH Neuropsychopharmacology 1998 19 4 278-286
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Healy, D.J.1
Haroutunian, V.2
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26
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0030998308
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Stable expression of recombinant AMPA receptor subunits: Binding affinities and effects of allosteric modulators
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309264
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309264 Stable expression of recombinant AMPA receptor subunits: Binding affinities and effects of allosteric modulators. Hennegriff M, Arai A, Kessler M, Vanderklish P, Mutneja MS, Rogers G, Neve RL, Lynch G J Neurochem 1997 68 6 2424-2434
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J Neurochem
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Hennegriff, M.1
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Mutneja, M.S.5
Rogers, G.6
Neve, R.L.7
Lynch, G.8
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27
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0031912842
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Regional preferences of AMPA receptor modulators determined through agonist binding autoradiography
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309267 Regional preferences of AMPA receptor modulators determined through agonist binding autoradiography. Kessler M, Mutneja MS, Rogers G, Lynch G Brain Res 1998 783 1 121-126
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Brain Res
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28
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0031148706
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Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans
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309278
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309278 Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans. Lynch G, Granger R, Ambros-Ingerson J, Davis CM, Kessler M, Schehr R Exp Neurol 1997 145 1 89-92
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Exp Neurol
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Lynch, G.1
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29
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0028928732
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Enhanced glutamatergic neurotransmission facilitates classical conditioning in the freely moving rat
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309286
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309286 Enhanced glutamatergic neurotransmission facilitates classical conditioning in the freely moving rat. Shors TJ, Servatius RJ, Thompson RF, Rogers G, Lynch G Neurosci Lett 1995 186 2-3 153-156
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(1995)
Neurosci Lett
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Shors, T.J.1
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30
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0030272391
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Effects of pharmacologically facilitating glutamatergic transmission in the trisynaptic intrahippocampal circuit
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309289 Effects of pharmacologically facilitating glutamatergic transmission in the trisynaptic intrahippocampal circuit. Sirvio J, Larson J, Quach CN, Rogers GA, Lynch G Neuroscience 1996 74 4 1025-1035
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Neuroscience
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Sirvio, J.1
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Rogers, G.A.4
Lynch, G.5
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31
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0028100048
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Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo
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309316
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309316 Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo. Staubli U, Perez Y, Xu FB, Rogers G, Ingvar M, Stoneelander S, Lynch G Proc Natl Acad Sci USA 1994 91 23 11158-11162
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(1994)
Proc Natl Acad Sci USA
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Staubli, U.1
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0030857778
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Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion
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309338 Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion. Vanover KE J Pharmacol 1997 332 2 115-119
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AMPA receptor activation potentiated by the AMPA modulator 1-BCP is toxic to cultured rat hippocampal neurons
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309354
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309354 AMPA receptor activation potentiated by the AMPA modulator 1-BCP is toxic to cultured rat hippocampal neurons. Yamada KA Neurosci Lett 1998 249 2-3 119-122
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(1998)
Neurosci Lett
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34
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0031690684
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Modulating excitatory synaptic neurotransmission: Potential treatment for neurological disease?
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309355; note
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309355 Modulating excitatory synaptic neurotransmission: Potential treatment for neurological disease? Yamada KA Neurobiol Dis 1998 5 2 67-80 Review discussing the concept of positive modulation of AMPA receptors in relation to cognitive and neurotoxic effects.
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Yamada, K.A.1
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0347914422
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Excitatory Amino Acids 'Ten Years Later' (Part II) Selected Presentations Relevant for Drug Development, Manaus, Brazil
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310943
-
310943 Excitatory Amino Acids 'Ten Years Later' (Part II) Selected Presentations Relevant for Drug Development, Manaus, Brazil. IDDB Meeting Report 1998 November 18-22
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IDDB Meeting Report 1998 November 18-22
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Danysz, W.1
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36
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0013368506
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Cortex receives National Institutes of Health small business grant; AMPAkines investigated as a potential new therapy for stroke
-
325719; May 24
-
325719 Cortex receives National Institutes of Health small business grant; AMPAkines investigated as a potential new therapy for stroke. Cortex Pharmaceuticals Inc Press Release 1999 May 24
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(1999)
Cortex Pharmaceuticals Inc Press Release
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-
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37
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0013450565
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Cortex Pharmaceuticals' AMPAKINESs increase neurotrophin expression - Increased neurotrophic factors may slow or possibly stop the normal brain ageing process
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352775; January 18
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352775 Cortex Pharmaceuticals' AMPAKINESs increase neurotrophin expression - Increased neurotrophic factors may slow or possibly stop the normal brain ageing process. Cortex Pharmaceuticals Inc Press Release 2000 January 18
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(2000)
Cortex Pharmaceuticals Inc Press Release
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-
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38
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0013407356
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Shire and Cortex announce agreement to evaluate AMPAKINE CX516 for the treatment of attention deficit hyperactivity disorder (ADHD)
-
363618; April 19; note
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363618 Shire and Cortex announce agreement to evaluate AMPAKINE CX516 for the treatment of attention deficit hyperactivity disorder (ADHD). Shire Pharmaceuticals Group Plc Press Release 2000 April 19 CX-516, licensed to Shire, appears to be covered by the PCT application WO-09638414, which has been filed in 81 countries and granted in the US. The compound is stated to be useful in the treatment of a range of neurological disorders, including schizophrenia and depression.
-
(2000)
Shire Pharmaceuticals Group Plc Press Release
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-
-
39
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0344178117
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Synergistic interactions between AMPAkines and antipsychotic drugs
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371936
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371936 Synergistic interactions between AMPAkines and antipsychotic drugs. Johnson SA, Luu NT, Herbst TA, Knapp R, Lutz D, Arai A, Rogers GA, Lynch G J Pharmacol Exp Ther 1999 289 1 392-397
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J Pharmacol Exp Ther
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Knapp, R.4
Lutz, D.5
Arai, A.6
Rogers, G.A.7
Lynch, G.8
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40
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0013413107
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Cortex announces collaborative research, joint clinical research and licensing agreements
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385846; October 16
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385846 Cortex announces collaborative research, joint clinical research and licensing agreements. Cortex Pharmaceuticals Inc Press Release 2000 October 16
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(2000)
Cortex Pharmaceuticals Inc Press Release
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-
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41
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0004337776
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Society for Neuroscience 30th Annual Meeting (Part IV) - Overnight Report - New Orleans, LA, USA
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388709
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388709 Society for Neuroscience 30th Annual Meeting (Part IV) - Overnight Report - New Orleans, LA, USA. Nicholls R IDDB Meeting Report 2000 November 4-9
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IDDB Meeting Report 2000 November 4-9
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Nicholls, R.1
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42
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0013364989
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Organon exercises option to license Cortex AMPAKINE technology for depression
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397366
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397366 Organon exercises option to license Cortex AMPAKINE technology for depression. Cortex Pharmaceuticals Inc Press Release 2001
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(2001)
Cortex Pharmaceuticals Inc Press Release
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-
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43
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0013361948
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Shire Pharmaceuticals to initiate trial of AMPAKINE CX516 in patients with attention deficit hyperactivity disorder (ADHD)
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412513; June 13
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412513 Shire Pharmaceuticals to initiate trial of AMPAKINE CX516 in patients with attention deficit hyperactivity disorder (ADHD). Shire Pharmaceuticals Group Plc Press Release 2001 June 13
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(2001)
Shire Pharmaceuticals Group Plc Press Release
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44
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Novel AMPA receptor potentiators LY392098 and LY404187: Effects on recombinant human AMPA receptors in vitro
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417935 Novel AMPA receptor potentiators LY392098 and LY404187: Effects on recombinant human AMPA receptors in vitro. Miu P, Jarvie KR, Radhakrishnan V, Gates MR, Ogden A, Ornstein PL, Zarrinmayeh H, Ho K, Peters D, Grabell J, Gupta A, Zimmerman DM, Bleakman D Neuropharmacology 2001 40 8 976-983
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Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo
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426041 A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia. Goff DC, Leahy L, Berman I, Posever T, Herz L, Leon AC, Johnson SA, Lynch G J Clin Psychopharmacol 2001 21 5 484-487
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Goff, D.C.1
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