Discovery and SAR of Org 24598 - A selective glycine uptake inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 15, 2001, Pages 2007-2009

  Brown, Angus ^a   Carlyle, Ian ^a   Clark, John ^a   Hamilton, William ^a   Gibson, Samuel ^a   McGarry, George ^a   McEachen, Sandra ^a   Rae, Duncan ^a   Thorn, Simon ^a   Walker, Glenn ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; GLYCINE RECEPTOR ANTAGONIST; ORG 24598; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; BRAIN; CARRIER PROTEINS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; ORGANIC ANION TRANSPORTERS; RADIOLIGAND ASSAY; RATS; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; SENSITIVITY AND SPECIFICITY; SPINE; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 0035817222     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00355-9     Document Type: Article

References (13)