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Volumn 8, Issue 3, 1998, Pages 364-369

Molecular mechanisms of glutamate receptor clustering at excitatory synapses

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0032102070     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80062-7     Document Type: Article
Times cited : (243)

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    • Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL. GRIP, a synaptic PDZ domain-containing protein that interacts with AMPA receptors [see comments]. of outstanding interest Nature. 386:1997;279-284 Using the yeast two-hybrid system, these investigators isolated a PDZ domain containing protein that interacted specifically with the carboxy-terminal tail of GluR2 and GluR3. Co-immunoprecipitation and immunohistochemistry suggested that GRIP and AMPA receptors directly interact in neurons. As a second and related observation, the investigators also found that overexpression of the GLUR2 carboxyl terminus disrupted AMPA receptor synaptic targeting.
    • (1997) Nature , vol.386 , pp. 279-284
    • Dong, H.1    O'Brien, R.J.2    Fung, E.T.3    Lanahan, A.A.4    Worley, P.F.5    Huganir, R.L.6
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    • Cellular localization and laminar distribution of AMPA receptor subunit mRNAs and proteins in the rat cerebral cortex
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    • Glutamate receptors are selectively targeted as postsynaptic sites in neurons
    • of outstanding interest. This paper reported that glutamate receptors could be sorted within a given neuron based on their subunit composition. The authors found that in neurons with two different types of dendrites, GluR4 containing AMPA receptors were sorted into one type of dendrite, whereas those without GluR4 were sorted into another. This morphologic observation explained already known physiological differences between the synapses on these dendrites.
    • of outstanding interest Rubio M, Wenthold RJ. Glutamate receptors are selectively targeted as postsynaptic sites in neurons. Neuron. 18:1997;939-950 This paper reported that glutamate receptors could be sorted within a given neuron based on their subunit composition. The authors found that in neurons with two different types of dendrites, GluR4 containing AMPA receptors were sorted into one type of dendrite, whereas those without GluR4 were sorted into another. This morphologic observation explained already known physiological differences between the synapses on these dendrites.
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    • Rubio, M.1    Wenthold, R.J.2
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    • Homer: A protein that selectively binds metabotropic glutamate receptors
    • of outstanding interest. This paper shows that Homer, a PDZ-like domain containing protein, interacts with the cytoplasmic tails of the phospholipiase-C-linked metabotropic glutamate receptors, mGluR1a and mGluR5. Synaptic activity induces the expression of Homer and may thus regulate the targeting of the metabotropic glutamate receptor.
    • Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF. Homer: a protein that selectively binds metabotropic glutamate receptors. of outstanding interest Nature. 386:1997;284-288 This paper shows that Homer, a PDZ-like domain containing protein, interacts with the cytoplasmic tails of the phospholipiase-C-linked metabotropic glutamate receptors, mGluR1a and mGluR5. Synaptic activity induces the expression of Homer and may thus regulate the targeting of the metabotropic glutamate receptor.
    • (1997) Nature , vol.386 , pp. 284-288
    • Brakeman, P.R.1    Lanahan, A.A.2    O'Brien, R.3    Roche, K.4    Barnes, C.A.5    Huganir, R.L.6    Worley, P.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.