Long-term changes in brain following continuous phencyclidine administration: An autoradiographic study using flunitrazepam, ketanserin, mazindol, quinuclidinyl benzilate, piperidyl-3,4-3H(N)-TCP, and AMPA receptor ligands

Pharmacology and Toxicology

Volumn 84, Issue 1, 1999, Pages 9-17

  Ellison, Gaylord ^a   Keys, Alan ^a   Noguchi, Kevin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; FLUNITRAZEPAM; KETANSERIN; MAZINDOL; PHENCYCLIDINE; QUINUCLIDINYL BENZILATE;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; FEMALE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PSYCHOSIS; RAT; SCHIZOPHRENIA;

ANIMALIA;

EID: 0032906809     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1999.tb02104.x     Document Type: Article

References (35)

1. Andreasen, N., S. Arndt, V Swayze H, T. Cizadlo, M. Flaum, D. O'Leary, J. Ehrhardt & W. Yuh: Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 1994, 266, 294-298.
2. Allen, R. & S. Young: Phencyclidine induced psychosis. Amer J. Psychiat. 1978, 135, 1081-1084.
3. Aniline, O. & F. Pitts: Phencyclidine (PCP): a review and perspectives. CRC Crit. Rev. Toxicol. 1982, 10, 145-177.
4. Benes, F, I. Sorensen, S. Vincent & E. Bird: Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain. Cerebral Cortex 1992, 2, 503-512.
5. Benes, F.: Altered glutamatergic and GABAergic mechanisms in the cingulale cortex of the schizophrenic brain. Arch. Gen. Psychiat. 1995, 52, 1015-1018.
6. 3H-MK-801 binding to wellwashed rat brain membranes following cessation of chronic phencyclidine treatment. Pharm. Biochem. and Behav. 1995, 51, 435-438.
7. Ellison, G.: Continuous amphetamine and cocaine have similar neurotoxic effects in lateral habenular nucleus and fasciculus retroflexus. Brain Res. 1992, 598, 353-356.
8. Ellison, G.: The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain Res. Reviews 1995, 20, 250-267.
9. Ellison, G.: Competitive and non-competitive NMDA antagonists induce similar limbic degeneration. NeuroReport 1994, 5, 2688 2692.
10. Ellison, G. & A. Keys: Persisting changes in brain glucose uptake following neurotoxic doses of phencyclidine which mirror the acute effects of the drug. Psychopharmacol. 1996, 126, 271-274.
11. Ellison G. & W. Morris: Opposed stages of continuous amphetamine administration: parallel alterations in motor stereotypies and in vivo spiroperidol accumulation. Eur. J. Pharmacol. 1981, 74, 207-214.
12. Ellison, G. & R. Switzer III: Dissimilar patterns of degeneration in brain following four different addictive stimulants. Neuro Report 1993, 5, 17-20.
13. Fishette, C., B. Nock & K. Renner: Effects of 5,7-dihydroxytryptamine on serotonin-1 and serotonin-2 receptors throughout the rat central nervous system using quantitative autoradiography. Brain Res. 1987, 421, 263-279.
14. 3H kainate binding in hippocampus 24 hours after PCP. Neurosci. Letters 1994, 174, 149-153.
15. Gao, X. & C. Tamminga: MK801 induces late regional increases in NMDA and kainate receptor binding in rat brain. J. Neural Trans. 1995, 101, 105-113.
16. Gao, X., F. Shirakawa & C. Tamminga: Delayed regional metabolic actions of phencyclidine. Eur. J. Pharmacol. 1993, 241, 7-15.
17. Javitt, D. & S. Zukin: Recent advances in the phencyclidine model of schizophrenia. Amer J. Psychiatry 1991, 148, 1301-1308.
18. Keys, A. & G. Ellison: Enduring alterations in varied receptor systems and the dopamine transporter following continuous cocaine. Soc. Neurosc. Abstracts 1996, 22, 528.
19. Krystal, J., L. Karper, J. Seibyl, G. Freeman, D. Delancy, J. Bremner, G. Heninger, M. Bowers Jr. & D. Charney: Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Arch. Gen. Psychiat. 1994, 51, 199-214.
20. Lerner, S. & R. Burns: Phencyclidine use among youth: history, epidemiology, and acute and chronic intoxication. In: Phencyclidine, PCP abuse: An appraisal. Eds.: R. Petersen & R. Stillman. National Institute on Drug Abuse Monographs, Superintendent of Documents, U S Government Printing Office, Washington, D C 1978, 21, 66-118.
21. Maragos, W., J. Greenamyre, D. Chu, J. Penney & A. Young: A study of cortical and hippocampal NMDA and PCP receptors following selective cortical and subcortical lesions. Brain Res. 1991, 538, 36-45.
22. Maren, S., G. Tocco, S. Standley, M. Baudry & R. Thompson: Post-synaptic factors in the expression of long-term potentiation, LTP): increased glutamate receptor binding following LTP induction in vivo. Proc. Nat. Acad. Sciences 1993, 90, 9654-9658.
23. Meltzer, H., P. Holtzman, S. Hassan & A. Guschwan: Effects of phencyclidine and stress on plasma CPK and aldolase activity in man. Psychopharmacol. 1972, 26, 44-53.
24. Nielsen, E. B., M. Nielsen, G. Ellison & C. Bræstrup: Decreased spiroperidol and LSD binding in rat brain after continuous amphetamine. Eur. J. Pharmacol. 1980 66, 149-154.
25. Olney, J, J. Labruyere & M. Price: Pathological changes induced in cerebrocortical neurons by phencylidine and related drugs. Science 1989, 244, 1360-1362.
26. Olney, J, J. Labruyere, G. Wang, D. Wozniak, M. Price & M. Sesma: NMDA antagonist neurotoxicity: mechanisms and prevention. Science 1991, 254, 1515-1518.
27. Olney, J. & N. Farber: Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiat. 1995, 52, 998-1007.
28. Patel, T. & J. McCulloch: AMPA receptor antagonism attenuates MK-801-induced hypermetabolism in the posterior cingulate cortex. Brain Res. 1995, 686, 254-258.
29. Saransaari, P, S. Lillrank & S. Oja: Phencyclidine treatment in mice: effects on phencyclidine binding sites and glutamate uptake in cerebral cortex preparations. J. Neur. Transmission, Gen. Section 1993 93, 47-59.
30. Serfozo, P. & D. Cash: Glutamate receptor (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate subtype) activity enhanced by dizocilpine (MK801) in rat hippocampus. Eur. J. Biochem. 1995, 228, 498-505.
31. 3H]mazindol-label-ing of dopamine transporter in rat nucleus accumbens. Eur. J.Pharmacol. 1991 203, 141-144.
32. Sharp, J., D. Petersen & M. Langford: DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res. 1995, 687, 114-124.
33. Unnerstall, J., M. Kuhar, D. Niehoff & J. Palacios: Benzodiazepine receptors are coupled to a subpopulation of gamma-aminobulyric acid (GABA) receptors: evidence from a quantitative autoradiographic study. J. Pharmacol. Exp. Therap. 1981, 218, 797-804.
34. Wamsley, J., M. Lewis, M. Young & M. Kuhar: Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem. J. Neurosci. 1981, 1, 176-191.
35. Zeigler, S., J. Lipton, A. Toga & G. Ellison: Continuous cocaine produces persistent changes in brain neurochemistry and behavior different from amphetamine. Brain Res. 1991, 552, 27-35.