N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport

British Journal of Pharmacology

Volumn 134, Issue 7, 2001, Pages 1429-1436

  Aubrey, K R ^a   Vandenberg, R J ^a  

^a University of Sydney   (Australia)

Author keywords

Drug lipid bilayer interactions; Glycine uptake; GLYT1; GLYT2; Long lasting inhibition; NFPS; N 3 (4 fluorophenyl) 3 (4 phenylphenoxy)propyl sarcosine; Schizophrenia

Indexed keywords

GLYCINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N [3 (4' FLUOROPHENYL) 3 (4' PHENYLPHENOXY)PROPYL]SARCOSINE; RECEPTOR SUBTYPE; SARCOSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL SURFACE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG STRUCTURE; ELECTROPHYSIOLOGY; LIPID BILAYER; MOLECULAR DYNAMICS; NEUROTRANSMISSION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; REGULATORY MECHANISM; SYNAPSE; VOLTAGE CLAMP; XENOPUS LAEVIS;

EID: 0035206590     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704381     Document Type: Article

References (26)

1. Neurotransmitter transporters : Recent progress
2. Why are long-acting beta-adrenoceptor agonists long-acting?
3. Stoichiometry of sodium- and chloride-coupled glycine transport in synaptic plasma membrane vesicles derived from rat brain
4. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
5. Nonvesicular release of neurotransmitter
6. Molecular basis for proton regulation of glycine transport by GLYT1b
7. Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses
8. Modulation of N-methyl-D-aspartate receptor function by glycine transport
9. Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor
10. On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor
11. Glycine and N-methyl-D-aspartate receptors: Physiological significance and possible therapeutic applications
12. Cloning, expression, and localization of a rat brain high-affinity glycine transporter
13. GABA Receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1
14. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia
15. Cloned glutamate receptors
16. Cloning of the human glycine transporter type 1: Molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes
17. Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features
18. Cloning and expression of a glycine transporter from mouse brain
19. N-methyl-D-aspartic acid receptor structure and function
20. Characterization of the 5′ region of the rat brain glycine transporter GLYT2 gene: Identification of a novel isoform
21. Equilibrium and kinetic studies of the interactions of salmeterol with membrane bilayers
22. Neuronal and glial glycine transporters have different stoichiometries
23. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters
24. Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors
25. Control of NMDA receptor activation by a glycine transporter co-expressed in Xenopus oocytes