메뉴 건너뛰기




Volumn 303, Issue 3, 2002, Pages 919-927

The group II metabotropic glutamate receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; CLOZAPINE; DECAHYDRO 6 [2 (1H TETRAZOL 5 YL)ETHYL] 3 ISOQUINOLINECARBOXYLIC ACID; DOPAMINE; HALOPERIDOL; KETANSERIN; METABOTROPIC RECEPTOR AGONIST; METIROSINE METHYL ESTER; NEUROLEPTIC AGENT; NORADRENALIN; PHENCYCLIDINE;

EID: 0036894693     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.038422     Document Type: Article
Times cited : (56)

References (45)
  • 1
    • 0034055690 scopus 로고    scopus 로고
    • Serotonin model of schizophrenia: Emerging role of glutamate mechanisms
    • Aghajanian GK and Marek GJ (2000) Serotonin model of schizophrenia: Emerging role of glutamate mechanisms. Brain Res Rev 31:302-312.
    • (2000) Brain Res Rev , vol.31 , pp. 302-312
    • Aghajanian, G.K.1    Marek, G.J.2
  • 3
    • 0032907608 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity
    • Anwyl R (1999) Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity. Br Res Rev 29:83-120.
    • (1999) Br Res Rev , vol.29 , pp. 83-120
    • Anwyl, R.1
  • 4
    • 0020629581 scopus 로고
    • The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate
    • Anis NA, Berry SC, Burton NR, and Lodge D (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br J Pharmacol 79:565-575.
    • (1983) Br J Pharmacol , vol.79 , pp. 565-575
    • Anis, N.A.1    Berry, S.C.2    Burton, N.R.3    Lodge, D.4
  • 5
    • 0028785179 scopus 로고
    • New insights into the biology of schizophrenia through the mechanism of action of clozapine
    • Brunello N, Masotto C, Staeardo L, Markstein R, and Racagni G (1995) New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacology 13:177-213.
    • (1995) Neuropsychopharmacology , vol.13 , pp. 177-213
    • Brunello, N.1    Masotto, C.2    Staeardo, L.3    Markstein, R.4    Racagni, G.5
  • 6
    • 0003158171 scopus 로고
    • The dopamine theory revisited
    • Bloom FE and Kupfer DJ eds, Raven Press, New York
    • Carlsson A (1995) The dopamine theory revisited, in Psychopharmacology: The Fourth Generation of Progress (Bloom FE and Kupfer DJ eds) pp 379-400, Raven Press, New York.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 379-400
    • Carlsson, A.1
  • 7
    • 0024501249 scopus 로고
    • The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice
    • Carlsson M and Carlsson A (1989) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm 75:221-226.
    • (1989) J Neural Transm , vol.75 , pp. 221-226
    • Carlsson, M.1    Carlsson, A.2
  • 8
    • 0032848507 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus damphetamine motor behaviors in rats
    • Cartmell J, Monn JA, and Schoepp DD (1999) The metabotropic glutamate receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus damphetamine motor behaviors in rats. J Pharmacol Exp Ther 291:161-170.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 161-170
    • Cartmell, J.1    Monn, J.A.2    Schoepp, D.D.3
  • 9
    • 0033968293 scopus 로고    scopus 로고
    • Tolerance to the motor impairment, but not the reversal of PCP-induced motor activities by oral administration of the mGlu 2/3 receptor agonist, LY379263
    • Cartmell J, Monn JA, and Schoepp DD (2000) Tolerance to the motor impairment, but not the reversal of PCP-induced motor activities by oral administration of the mGlu 2/3 receptor agonist, LY379263. Naunyn-Schmiedeberg's Arch Pharmacol 361:39-46.
    • (2000) Naunyn-Schmiedeberg's Arch Pharmacol , vol.361 , pp. 39-46
    • Cartmell, J.1    Monn, J.A.2    Schoepp, D.D.3
  • 10
    • 0034992871 scopus 로고    scopus 로고
    • Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated and can be elicited in the presence of uptake blockade
    • Cartmell J, Perry KW, Salhoff CR, Monn JA, and Schoepp DD (2001) Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated and can be elicited in the presence of uptake blockade. Neuropharmacology 40:847-855.
    • (2001) Neuropharmacology , vol.40 , pp. 847-855
    • Cartmell, J.1    Perry, K.W.2    Salhoff, C.R.3    Monn, J.A.4    Schoepp, D.D.5
  • 11
    • 0034731587 scopus 로고    scopus 로고
    • Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum
    • Cartmell J, Salhoff CR, Perry KW, Monn JA, and Schoepp DD (2000) Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum. Brain Res 887:378-384.
    • (2000) Brain Res , vol.887 , pp. 378-384
    • Cartmell, J.1    Salhoff, C.R.2    Perry, K.W.3    Monn, J.A.4    Schoepp, D.D.5
  • 12
    • 0033844601 scopus 로고    scopus 로고
    • Regulation of neurotransmitter release by metabotropic glutamate receptors
    • Cartmell J and Schoepp DD (2000) Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem 75:889-907.
    • (2000) J Neurochem , vol.75 , pp. 889-907
    • Cartmell, J.1    Schoepp, D.D.2
  • 13
    • 0001050065 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: Potential drug targets for the treatment of schizophrenia
    • Chavez-Noriega LE, Scaffhauser H, and Campbell UC (2002) Metabotropic glutamate receptors: Potential drug targets for the treatment of schizophrenia. Curr Drug Targets 1:261-281.
    • (2002) Curr Drug Targets , vol.1 , pp. 261-281
    • Chavez-Noriega, L.E.1    Scaffhauser, H.2    Campbell, U.C.3
  • 14
    • 0035996492 scopus 로고    scopus 로고
    • Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats
    • Clark M, Johnson BG, Wright RA, Monn JA, and Schoepp DD (2002) Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats. Pharmacol Biochem Behav 73:339-346.
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 339-346
    • Clark, M.1    Johnson, B.G.2    Wright, R.A.3    Monn, J.A.4    Schoepp, D.D.5
  • 15
    • 0017255979 scopus 로고
    • Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
    • Creese I, Burt DR, and Snyder SH (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science (Wash DC) 192:481-483.
    • (1976) Science (Wash DC) , vol.192 , pp. 481-483
    • Creese, I.1    Burt, D.R.2    Snyder, S.H.3
  • 16
    • 0031172242 scopus 로고    scopus 로고
    • Synaptic transmission: Well placed modulators
    • Forsythe ID and Barnes-Davies M (1997) Synaptic transmission: Well placed modulators. Curr Biol 7:R362-R365.
    • (1997) Curr Biol , vol.7
    • Forsythe, I.D.1    Barnes-Davies, M.2
  • 17
    • 0029051676 scopus 로고
    • The phencyclidine-glutamate model of schizophrenia
    • Halberstadt AL (1995) The phencyclidine-glutamate model of schizophrenia. Clin Neuropharmacol 18:237-249.
    • (1995) Clin Neuropharmacol , vol.18 , pp. 237-249
    • Halberstadt, A.L.1
  • 18
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt JD and Zukin SR (1991) Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148:1301-1308.
    • (1991) Am J Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, J.D.1    Zukin, S.R.2
  • 19
    • 0344835242 scopus 로고    scopus 로고
    • Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin
    • Krebs-Thomson K, Lehmann-Masten V, Naiem S, Paulus MP, and Geyer MA (1998) Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin. Eur J Pharmacol 343:135-143.
    • (1998) Eur J Pharmacol , vol.343 , pp. 135-143
    • Krebs-Thomson, K.1    Lehmann-Masten, V.2    Naiem, S.3    Paulus, M.P.4    Geyer, M.A.5
  • 20
    • 0032517108 scopus 로고    scopus 로고
    • Systemic PCP treatment elevates brain extracellular 5-HT: A microdialysis study in awake rats
    • Martin P, Carlsson ML, and Hjorth S (1998) Systemic PCP treatment elevates brain extracellular 5-HT: A microdialysis study in awake rats. Neuroreport 9:2985-2988.
    • (1998) Neuroreport , vol.9 , pp. 2985-2988
    • Martin, P.1    Carlsson, M.L.2    Hjorth, S.3
  • 24
    • 0032575715 scopus 로고    scopus 로고
    • Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
    • Moghaddam B and Adams BW (1998) Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science (Wash DC) 281:1349-1352.
    • (1998) Science (Wash DC) , vol.281 , pp. 1349-1352
    • Moghaddam, B.1    Adams, B.W.2
  • 25
    • 15644369847 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties
    • Monn JA, Valli MJ, Massey SM, Wright RA, Salhoff CR, Johnson BG, Howe T, Alt CA, Rhodes GA, Robey RL, et al. (1997) Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J Med Chem 40:528-537.
    • (1997) J Med Chem , vol.40 , pp. 528-537
    • Monn, J.A.1    Valli, M.J.2    Massey, S.M.3    Wright, R.A.4    Salhoff, C.R.5    Johnson, B.G.6    Howe, T.7    Alt, C.A.8    Rhodes, G.A.9    Robey, R.L.10
  • 26
    • 0018703025 scopus 로고
    • Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics
    • Murray TF and Horita A (1979) Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics. Life Sci 24:2217-2225.
    • (1979) Life Sci , vol.24 , pp. 2217-2225
    • Murray, T.F.1    Horita, A.2
  • 27
    • 0026437728 scopus 로고
    • Molecular diversity of glutamate receptors and implications for brain function
    • Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science (Wash DC) 258:597-603.
    • (1992) Science (Wash DC) , vol.258 , pp. 597-603
    • Nakanishi, S.1
  • 28
    • 0027190384 scopus 로고
    • Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat
    • Ohishi H, Shigemoto R, Kaneko T, Nakanishi S, and Mizuno N (1993a) Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience 53:1009-1018.
    • (1993) Neuroscience , vol.53 , pp. 1009-1018
    • Ohishi, H.1    Shigemoto, R.2    Kaneko, T.3    Nakanishi, S.4    Mizuno, N.5
  • 29
    • 0027168754 scopus 로고
    • Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study
    • Ohishi H, Shigemoto R, Kaneko T, Nakanishi S, and Mizuno N (1993b) Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study. J Comp Neurol 335:252-266.
    • (1993) J Comp Neurol , vol.335 , pp. 252-266
    • Ohishi, H.1    Shigemoto, R.2    Kaneko, T.3    Nakanishi, S.4    Mizuno, N.5
  • 30
    • 0028088017 scopus 로고
    • Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex
    • Ohishi H, Ogawa-Meguro R, Shigemoto R, Kaneko T, Nakanishi S, and Mizuno N (1994) Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron 13:55-66.
    • (1994) Neuron , vol.13 , pp. 55-66
    • Ohishi, H.1    Ogawa-Meguro, R.2    Shigemoto, R.3    Kaneko, T.4    Nakanishi, S.5    Mizuno, N.6
  • 31
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney JW, and Farber NB (1995) Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52:998-1007.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 32
    • 0027296719 scopus 로고
    • 3SR,4aRS,6RS,8aRS-6-(2-(1H-tetrazol-5-yl)ethyl)-decahydroisoquinoline-3- carboxylic acid: A structurally novel, systemically active, competitive AMPA receptor antagonist
    • Ornstein PL, Arnold MB, Augenstein NK, Lodge D, Leander JD, and Schoepp DD (1993) 3SR,4aRS,6RS,8aRS-6-(2-(1H-tetrazol-5-yl)ethyl)-decahydroisoquinoline- 3-carboxylic acid: A structurally novel, systemically active, competitive AMPA receptor antagonist. J Med Chem 36:2046-2048.
    • (1993) J Med Chem , vol.36 , pp. 2046-2048
    • Ornstein, P.L.1    Arnold, M.B.2    Augenstein, N.K.3    Lodge, D.4    Leander, J.D.5    Schoepp, D.D.6
  • 33
    • 0031466662 scopus 로고    scopus 로고
    • Organization of glutamate receptors at the synapse
    • Ottersen OP and Landsend AS (1997) Organization of glutamate receptors at the synapse. Eur J Neurosci 9:2219-2224.
    • (1997) Eur J Neurosci , vol.9 , pp. 2219-2224
    • Ottersen, O.P.1    Landsend, A.S.2
  • 34
    • 0035119996 scopus 로고    scopus 로고
    • Pharmacology characterization of locomotor sensitization induced by chronic phencyclidine administration
    • Phillips M, Wang C, and Johnson K (2001) Pharmacology characterization of locomotor sensitization induced by chronic phencyclidine administration. J Pharmacol Exp Ther 296:905-913.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 905-913
    • Phillips, M.1    Wang, C.2    Johnson, K.3
  • 35
    • 0029187946 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin J-P and Duvoisin R (1995) The metabotropic glutamate receptors: Structure and functions. Neuropharmacology 34:1-26.
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.-P.1    Duvoisin, R.2
  • 36
    • 0034811597 scopus 로고    scopus 로고
    • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system
    • Schoepp DD (2001) Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299:1-9.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 1-9
    • Schoepp, D.D.1
  • 39
    • 0011900802 scopus 로고    scopus 로고
    • Preclinical pharmacology of mGlu2/3 receptor agonists: Novel agents for schizphrenia?
    • Schoepp DD and Marek GJ (2002) Preclinical pharmacology of mGlu2/3 receptor agonists: Novel agents for schizphrenia? Curr Drug Targets 1:215-225.
    • (2002) Curr Drug Targets , vol.1 , pp. 215-225
    • Schoepp, D.D.1    Marek, G.J.2
  • 40
    • 0033959387 scopus 로고    scopus 로고
    • LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine
    • Schreiber R, Lowe D, Voerste A, and De Vry J (2000) LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine. Eur J Pharmacol 388:R3-R4.
    • (2000) Eur J Pharmacol , vol.388
    • Schreiber, R.1    Lowe, D.2    Voerste, A.3    De Vry, J.4
  • 41
    • 0000514829 scopus 로고
    • Dopamine receptors: Clinical correlates
    • Bloom FE and Kupfer DJ eds, Raven Press, New York
    • Seeman P (1995) Dopamine receptors: clinical correlates, in Psychopharmacology: The Fourth Generation of Progress (Bloom FE and Kupfer DJ eds) pp 295-302, Raven Press, New York.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 295-302
    • Seeman, P.1
  • 42
    • 0017068246 scopus 로고
    • Antipsychotic drug doses and neuroleptic/dopamine receptors
    • Seeman P, Lee T, Chau-Wong M, and Wong K (1976) Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature (Lond) 261:717-719.
    • (1976) Nature (Lond) , vol.261 , pp. 717-719
    • Seeman, P.1    Lee, T.2    Chau-Wong, M.3    Wong, K.4
  • 43
    • 0030057542 scopus 로고    scopus 로고
    • The behavioral and neurochemical effects of phencyclidine in humans and animals: Some implications for modeling psychosis
    • Steinpreis RE (1996) The behavioral and neurochemical effects of phencyclidine in humans and animals: Some implications for modeling psychosis. Behav Brain Res 74:45-55.
    • (1996) Behav Brain Res , vol.74 , pp. 45-55
    • Steinpreis, R.E.1
  • 44
    • 0018638978 scopus 로고
    • Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats
    • Sturgeon RD, Fessler RG, and Meltzer HY (1979) Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats. Eur J Pharmacol 59:169-179.
    • (1979) Eur J Pharmacol , vol.59 , pp. 169-179
    • Sturgeon, R.D.1    Fessler, R.G.2    Meltzer, H.Y.3
  • 45
    • 0011897596 scopus 로고    scopus 로고
    • In vivo receptor neurochemical studies with olanzapine
    • Tran PV, Bymaster FP, Tye N, Herrera JM, Breier A, and Tollefson GD eds, Lippincott Williams & Wilkins, Philadelphia
    • Zhang W and Bymaster FP (2000) In vivo receptor neurochemical studies with olanzapine, in Olanzapine (Zyprexa): A Novel Antipsychotic (Tran PV, Bymaster FP, Tye N, Herrera JM, Breier A, and Tollefson GD eds) pp 146-159, Lippincott Williams & Wilkins, Philadelphia.
    • (2000) Olanzapine (Zyprexa): A Novel Antipsychotic , pp. 146-159
    • Zhang, W.1    Bymaster, F.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.