Neuroendocrinology

Williams Textbook of Endocrinology, Twelfth Edition

Volumn , Issue , 2011, Pages 103-174

  Low, Malcolm J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85170159223     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4377-0324-5.00007-9     Document Type: Chapter

References (467)

1. A Fröhlich (1901) Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie. Wein Klin Rundsch 15 883.
2. S Crowe, H Cushing and J Homans (1910) Experimental hypophysectomy. Bull Johns Hopkins Hosp 21 128-169.
3. B Aschner (1912) Uber die Funktion der Hypophyse. Pflugers Arch Physiol 146 1.
4. AW Hetherington and SW Ranson (1940) Hypothalamic lesions and adiposity in the rat. Anat Rec 78 149-172.
5. G Popa and U Fielding (1930) A portal circulation from the pituitary to the hypothalamic region. J Anat 65 88.
6. GB Wislocki and LS King (1936) Permeability of the hypophysis and hypothalamus to vital dyes, with study of hypophyseal blood supply. Am J Anat 58 421-472.
7. G Harris (1948) Neural control of the pituitary. Physiol Rev 28 139-179.
8. AV Schally, TW Redding, CY Bowers, et al. (1969) Isolation and properties of porcine thyrotropin-releasing hormone. J Biol Chem 244 4077-4088.
9. R Burgus, TF Dunn, D Desiderio, et al. (1970) Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor. Nature 226 321-325.
10. AV Schally (1978) Aspects of hypothalamic regulation of the pituitary gland (Nobel lecture). Science 202 18-28.
11. R Guillemin (1978) Peptides in the brain: the new endocrinology of the neuron (Nobel lecture). Science 202 390-402.
12. Y Zhang, A Proenca, M Maffei, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-434.
13. M Kojima, H Hosoda, Y Date, et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-660.
14. DJ Spergel, U Kruth, DF Hanley, et al. (1999) GABA- and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice. J Neurosci 19 2037-2050.
15. MA Cowley, JL Smart, M Rubinstein, et al. (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 480-484.
16. B Scharrer (1987) Neurosecretion: beginnings and new directions in neuropeptide research. Annu Rev Neurosci 10 1-17.
17. CH Sawyer (1978) History of the neurovascular concept of hypothalamo-hypophysial control. Biol Reprod 18 325-328.
18. T Hokfelt, O Johansson, A Ljungdahl, et al. (1980) Peptidergic neurons. Nature 284 515-521.
19. GW Harris (1970) Structure and function of the median eminence. Am J Anat 129 245-246.
20. AD Loewy (1990) Anatomy of the autonomic nervous system: an overview. AD Loewy, KM Spyer,(Eds) Central Regulation of Autonomic Function New York: Oxford University Press 3-16.
21. T Hokfelt, J Lundberg, M Schultzberg, et al. (1980) Coexistence of peptides and putative transmitters in neurons. Adv Biochem Psychopharmacol 22 1-23.
22. AE Ryabinin, NO Tsivkovskaia and SA Ryabinin (2005) Urocortin 1-containing neurons in the human Edinger-Westphal nucleus. Neuroscience 134 1317-1323.
23. B Ahren (2000) Autonomic regulation of islet hormone secretion: implications for health and disease. Diabetologia 43 393-410.
24. HR Berthoud, EA Fox and TL Powley (1990) Localization of vagal preganglionics that stimulate insulin and glucagon secretion. Am J Physiol 258 R160-R168.
25. AR Saltiel (2001) New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104 517-529.
26. BE Levin, AA Dunn-Meynell and VH Routh (1999) Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. Am J Physiol 276 R1223-R1231.
27. X Zhu, AS Gleiberman and MG Rosenfeld (2007) Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol Rev 87 933-963.
28. Y Koutcherov, JK Mai and G Paxinos (2003) Hypothalamus of the human fetus. J Chem Neuroanat 26 253-270.
29. KM McClellan, KL Parker and S Tobet (2006) Development of the ventromedial nucleus of the hypothalamus. Front Neuroendocrinol 27 193-209.
30. KE Whitlock (2005) Origin and development of GnRH neurons. Trends Endocrinol Metab 16 145-151.
31. A Caqueret, C Yang, S Duplan, et al. (2005) Looking for trouble: a search for developmental defects of the hypothalamus. Horm Res 64 222-230.
32. DE McNay, M Pelling, S Claxton, et al. (2006) Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells. Mol Endocrinol 20 1623-1632.
33. NG Forger (2006) Cell death and sexual differentiation of the nervous system. Neuroscience 138 929-938.
34. RB Simerly (2005) Wired on hormones: endocrine regulation of hypothalamic development. Curr Opin Neurobiol 15 81-85.
35. I Fujisawa (2004) Magnetic resonance imaging of the hypothalamic-neurohypophyseal system. J Neuroendocrinol 16 297-302.
36. H Braak and E Braak (1992) Anatomy of the human hypothalamus (chiasmatic and tuberal region). Prog Brain Res 93 3-14. discussion 14-16
37. VR Evans, AB Manning, LH Bernard, et al. (1994) Alpha-melanocyte-stimulating hormone and N-acetyl-beta-endorphin immunoreactivities are localized in the human pituitary but are not restricted to the zona intermedia. Endocrinology 134 97-106.
38. DW Lincoln and AC Paisley (1982) Neuroendocrine control of milk ejection. J Reprod Fertil 65 571-586.
39. R Burstein, KD Cliffer and GJ Giesler Jr (1987) Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon. J Neurosci 7 4159-4164.
40. KM Knigge and DE Scott (1970) Structure and function of the median eminence. Am J Anat 129 223-243.
41. T Trandafir, C Dionisie and E Repciuc (1982) The development of the hypothalamo-hypophysial portal system in human fetus. Endocrinologie 20 127-134.
42. RB Page (1982) Pituitary blood flow. Am J Physiol 243 E427-E442.
43. EM Rodriguez, JL Blazquez, FE Pastor, et al. (2005) Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol 247 89-164.
44. I Clarke, D Jessop, R Millar, et al. (1993) Many peptides that are present in the external zone of the median eminence are not secreted into the hypophysial portal blood of sheep. Neuroendocrinology 57 765-775.
45. JC King and BS Rubin (1995) Dynamic alterations in luteinizing hormone-releasing hormone (LHRH) neuronal cell bodies and terminals of adult rats. Cell Mol Neurobiol 15 89-106.
46. Y Koutcherov, JK Mai, KW Ashwell, et al. (2000) Organization of the human paraventricular hypothalamic nucleus. J Comp Neurol 423 299-318.
47. AK Johnson and PM Gross (1993) Sensory circumventricular organs and brain homeostatic pathways. FASEB J 7 678-686.
48. WF Ganong (2000) Circumventricular organs: definition and role in the regulation of endocrine and autonomic function. Clin Exp Pharmacol Physiol 27 422-427.
49. AV Ferguson and JS Bains (1997) Actions of angiotensin in the subfornical organ and area postrema: implications for long term control of autonomic output. Clin Exp Pharmacol Physiol 24 96-101.
50. EM Rodriguez, S Rodriguez and S Hein (1998) The subcommissural organ. Microsc Res Tech 41 98-123.
51. WA Banks, AJ Kastin, W Huang, et al. (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17 305-311.
52. JB Tatro and ML Entwistle (1994) Identification of a specific mammalian melanocortin receptor antagonist. Ann N Y Acad Sci 739 315-319.
53. MW Schwartz, RJ Seeley, LA Campfield, et al. (1996) Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98 1101-1106.
54. CF Elias, C Aschkenasi, C Lee, et al. (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23 775-786.
55. CM Blatteis (1992) Role of the OVLT in the febrile response to circulating pyrogens. Prog Brain Res 91 409-412.
56. T Oka, K Oka, TE Scammell, et al. (2000) Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. J Comp Neurol 428 20-32.
57. BJ Oldfield, RJ Bicknell, RM McAllen, et al. (1991) Intravenous hypertonic saline induces Fos immunoreactivity in neurons throughout the lamina terminalis. Brain Res 561 151-156.
58. DG Standaert and CB Saper (1988) Origin of the atriopeptin-like immunoreactive innervation of the paraventricular nucleus of the hypothalamus. J Neurosci 8 1940-1950.
59. CB Saper and D Levisohn (1983) Afferent connections of the median preoptic nucleus in the rat: anatomical evidence for a cardiovascular integrative mechanism in the anteroventral third ventricular (AV3V) region. Brain Res 288 21-31.
60. JB Simpson and A Routtenberg (1978) Subfornical organ: a dipsogenic site of action of angiotensin II. Science 201 379-381.
61. AD Miller and RA Leslie (1994) The area postrema and vomiting. Front Neuroendocrinol 15 301-320.
62. I Merchenthaler, M Lane and P Shughrue (1999) Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 403 261-280.
63. TH Moran, PH Robinson, MS Goldrich, et al. (1986) Two brain cholecystokinin receptors: implications for behavioral actions. Brain Res 362 175-179.
64. JW Osborn, JP Collister and SH Carlson (2000) Angiotensin and osmoreceptor inputs to the area postrema: role in long-term control of fluid homeostasis and arterial pressure. Clin Exp Pharmacol Physiol 27 443-449.
65. SM Reppert (1997) Melatonin receptors: molecular biology of a new family of G protein-coupled receptors. J Biol Rhythms 12 528-531.
66. ML Dubocovich and M Markowska (2005) Functional MT1 and MT2 melatonin receptors in mammals. Endocrine 27 101-110.
67. RY Moore and NJ Lenn (1972) A retinohypothalamic projection in the rat. J Comp Neurol 146 1-14.
68. AG Watts and LW Swanson (1987) Efferent projections of the suprachiasmatic nucleus: II. Studies using retrograde transport of fluorescent dyes and simultaneous peptide immunohistochemistry in the rat. J Comp Neurol 258 230-252.
69. RK Leak and RY Moore (2001) Topographic organization of suprachiasmatic nucleus projection neurons. J Comp Neurol 433 312-334.
70. CB Saper, AD Loewy, LW Swanson, et al. (1976) Direct hypothalamo-autonomic connections. Brain Res 117 305-312.
71. TA Rando, CW Bowers and RE Zigmond (1981) Localization of neurons in the rat spinal cord which project to the superior cervical ganglion. J Comp Neurol 196 73-83.
72. J Borjigin, X Li and SH Snyder (1999) The pineal gland and melatonin: molecular and pharmacologic regulation. Annu Rev Pharmacol Toxicol 39 53-65.
73. JA Boutin, V Audinot, G Ferry, et al. (2005) Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci 26 412-419.
74. NS Foulkes, J Borjigin, SH Snyder, et al. (1997) Rhythmic transcription: the molecular basis of circadian melatonin synthesis. Trends Neurosci 20 487-492.
75. K Nakazawa, U Marubayashi and SM McCann (1991) Mediation of the short-loop negative feedback of luteinizing hormone (LH) on LH-releasing hormone release by melatonin-induced inhibition of LH release from the pars tuberalis. Proc Natl Acad Sci U S A 88 7576-7579.
76. RJ Reiter (1980) The pineal and its hormones in the control of reproduction in mammals. Endocr Rev 1 109-131.
77. RJ Reiter (1998) Melatonin and human reproduction. Ann Med 30 103-108.
78. MS Rea, MG Figueiro, JD Bullough, et al. (2005) A model of phototransduction by the human circadian system. Brain Res Brain Res Rev 50 213-228.
79. S Shibata, VM Cassone and RY Moore (1989) Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro. Neurosci Lett 97 140-144.
80. C Liu, DR Weaver, X Jin, et al. (1997) Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 19 91-102.
81. X Jin, C von Gall, RL Pieschl, et al. (2003) Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol 23 1054-1060.
82. J Arendt (2000) Melatonin, circadian rhythms, and sleep. N Engl J Med 343 1114-1116.
83. N Buscemi, B Vandermeer, N Hooton, et al. (2005) The efficacy and safety of exogenous melatonin for primary sleep disorders: a meta-analysis. J Gen Intern Med 20 1151-1158.
84. N Buscemi, B Vandermeer, N Hooton, et al. (2006) Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 332 385-393.
85. JC Houk (1988) Control strategies in physiological systems. FASEB J 2 97-107.
86. F Yates (1974) Modeling periodicities in reproductive, adrenocortical and metabolic systems. M Ferin, F Hakberg, RM Richart,(Eds) Biorhythms and Human Reproduction New York: John Wiley & Sons 133-142.
87. JI DiStefano, A Stubberud and I Williams (1967) Theory and Problems of Feedback and Control Systems. New York: Schaum Publishing
88. H Kitano (2002) Computational systems biology. Nature 420 206-210.
89. RY Moore (1992) The organization of the human circadian timing system: The fourth C.U. Ariens Kappers lecture. Prog Brain Res 93 99-115. discussion 115-117
90. CB Saper, J Lu, TC Chou, et al. (2005) The hypothalamic integrator for circadian rhythms. Trends Neurosci 28 152-157.
91. SM Reppert and DR Weaver (2002) Coordination of circadian timing in mammals. Nature 418 935-941.
92. CP Richter (1967) Sleep and activity: their relation to the 24-hour clock. Res Publ Assoc Res Nerv Ment Dis 45 8-29.
93. S Perreau-Lenz, P Pevet, RM Buijs, et al. (2004) The biological clock: the bodyguard of temporal homeostasis. Chronobiol Int 21 1-25.
94. F Gachon, E Nagoshi, SA Brown, et al. (2004) The mammalian circadian timing system: from gene expression to physiology. Chromosoma 113 103-112.
95. DK Welsh, DE Logothetis, M Meister, et al. (1995) Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 14 697-706.
96. SM Reppert (1992) Pre-natal development of a hypothalamic biological clock. Prog Brain Res 93 119-131. discussion 132
97. M Yamada, S Radovick, FE Wondisford, et al. (1990) Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone. Mol Endocrinol 4 551-556.
98. SL Lee, K Stewart and RH Goodman (1988) Structure of the gene encoding rat thyrotropin releasing hormone. J Biol Chem 263 16604-16609.
99. EA Nillni and KA Sevarino (1999) The biology of pro-thyrotropin-releasing hormone-derived peptides. Endocr Rev 20 599-648.
100. IM Jackson (1982) Thyrotropin-releasing hormone. N Engl J Med 306 145-155.
101. KM Gautvik, AH Tashjian Jr, IA Kourides, et al. (1974) Thyrotropin-releasing hormone is not the sole physiologic mediator of prolactin release during suckling. N Engl J Med 290 1162-1165.
102. M Yamada, T Satoh and M Mori (2003) Mice lacking the thyrotropin-releasing hormone gene: what do they tell us? Thyroid 13 1111-1121.
103. RE Straub, GC Frech, RH Joho, et al. (1990) Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci U S A 87 9514-9518.
104. Y Sun, X Lu and MC Gershengorn (2003) Thyrotropin-releasing hormone receptors: similarities and differences. J Mol Endocrinol 30 87-97.
105. KA Gary, KA Sevarino, GG Yarbrough, et al. (2003) The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics. J Pharmacol Exp Ther 305 410-416.
106. GG Yarbrough, J Kamath, A Winokur, et al. (2007) Thyrotropin-releasing hormone (TRH) in the neuroaxis: therapeutic effects reflect physiological functions and molecular actions. Med Hypotheses 69 1249-1256.
107. AM Callahan, MA Frye, LB Marangell, et al. (1997) Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: confounding effects of tolerance and implications for therapeutics. Biol Psychiatry 41 264-272.
108. Y Takeuchi, T Takano, J Abe, et al. (2001) Thyrotropin-releasing hormone: role in the treatment of West syndrome and related epileptic encephalopathies. Brain Dev 23 662-667.
109. JE Morley (1981) Neuroendocrine control of thyrotropin secretion. Endocr Rev 2 396-436.
110. P Snyder and R Utiger (1972) Inhibition of thyrotropin releasing hormone by small quantities of thyroid hormones. J Clin Invest 51 2077-2084.
111. A Vagenakis, B Rapoport, F Azizi, et al. (1974) Hyper-response to thyrotropin releasing hormone accompanying small decreases in serum thyroid hormone concentration. J Clin Invest 54 913-918.
112. EM Dyess, TP Segerson, Z Liposits, et al. (1988) Triiodothyronine exerts direct cell-specific regulation of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus. Endocrinology 123 2291-2297.
113. G Schreiber, BR Southwell and SJ Richardson (1995) Hormone delivery systems to the brain: transthyretin. Exp Clin Endocrinol Diabetes 103 75-80.
114. RM Lechan and I Kakucska (1992) Feedback regulation of thyrotropin-releasing hormone gene expression by thyroid hormone in the hypothalamic paraventricular nucleus. Ciba Found Symp 168 144-158. discussion 158-164
115. RM Lechan and C Fekete (2005) Role of thyroid hormone deiodination in the hypothalamus. Thyroid 15 883-897.
116. A Arimura and AV Schally (1976) Increase in basal and thyrotropin-releasing hormone (TRH)-stimulated secretion of thyrotropin (TSH) by passive immunization with antiserum to somatostatin in rats. Endocrinology 98 1069-1072.
117. G Brabant, K Prank, U Ranft, et al. (1990) Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman. J Clin Endocrinol Metab 70 403-409.
118. F Fares (2006) The role of O-linked and N-linked oligosaccharides on the structure-function of glycoprotein hormones: development of agonists and antagonists. Biochim Biophys Acta 1760 560-567.
119. S Arancibia, F Rage, H Astier, et al. (1996) Neuroendocrine and autonomous mechanisms underlying thermoregulation in cold environment. Neuroendocrinology 64 257-267.
120. S Shioda, Y Nakai, A Sato, et al. (1986) Electron-microscopic cytochemistry of the catecholaminergic innervation of TRH neurons in the rat hypothalamus. Cell Tissue Res 245 247-252.
121. R Toni, IM Jackson and RM Lechan (1990) Neuropeptide-Y-immunoreactive innervation of thyrotropin-releasing hormone-synthesizing neurons in the rat hypothalamic paraventricular nucleus. Endocrinology 126 2444-2453.
122. L Wartofsky and KD Burman (1982) Alterations in thyroid function in patients with systemic illness: the “euthyroid sick syndrome.”. Endocr Rev 3 164-217.
123. I Kakucska, Y Qi and RM Lechan (1995) Changes in adrenal status affect hypothalamic thyrotropin-releasing hormone gene expression in parallel with corticotropin-releasing hormone. Endocrinology 136 2795-2802.
124. A Cintra, K Fuxe, AC Wikstrom, et al. (1990) Evidence for thyrotropin-releasing hormone and glucocorticoid receptor-immunoreactive neurons in various preoptic and hypothalamic nuclei of the male rat. Brain Res 506 139-144.
125. ZX Shi, A Levy and SL Lightman (1993) Hippocampal input to the hypothalamus inhibits thyrotrophin and thyrotrophin-releasing hormone gene expression. Neuroendocrinology 57 576-580.
126. CA Spencer, SM Lum, JF Wilber, et al. (1983) Dynamics of serum thyrotropin and thyroid hormone changes in fasting. J Clin Endocrinol Metab 56 883-888.
127. NG Blake, DJ Eckland, OJ Foster, et al. (1991) Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation. Endocrinology 129 2714-2718.
128. RS Ahima, D Prabakaran, C Mantzoros, et al. (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382 250-252.
129. G Legradi, CH Emerson, RS Ahima, et al. (1997) Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 138 2569-2576.
130. RM Lechan and C Fekete (2004) Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome. J Endocrinol Invest 27 105-119.
131. RM Lechan and C Fekete (2006) Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Peptides 27 310-325.
132. M Harris, C Aschkenasi, CF Elias, et al. (2001) Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 107 111-120.
133. CT Montague, IS Farooqi, JP Whitehead, et al. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387 903-908.
134. IS Farooqi, GS Yeo, JM Keogh, et al. (2000) Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106 271-279.
135. JM Dubuis, JM Dayer, CA Siegrist-Kaiser, et al. (1988) Human recombinant interleukin-1 beta decreases plasma thyroid hormone and thyroid stimulating hormone levels in rats. Endocrinology 123 2175-2181.
136. DE Scarborough, SL Lee, CA Dinarello, et al. (1989) Interleukin-1 beta stimulates somatostatin biosynthesis in primary cultures of fetal rat brain. Endocrinology 124 549-551.
137. XP Pang, JM Hershman, CJ Mirell, et al. (1989) Impairment of hypothalamic-pituitary-thyroid function in rats treated with human recombinant tumor necrosis factor-alpha (cachectin). Endocrinology 125 76-84.
138. JI Koenig, K Snow, BD Clark, et al. (1990) Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide. Endocrinology 126 3053-3058.
139. E Spath-Schwalbe, H Schrezenmeier, S Bornstein, et al. (1996) Endocrine effects of recombinant interleukin 6 in man. Neuroendocrinology 63 237-243.
140. J Spiess, J Rivier, C Rivier and W Vale (1981) Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc Natl Acad Sci USA 78 6517-6521.
141. S Shibahara, Y Morimoto, Y Furutani, et al. (1983) Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. Embo J 2 775-779.
142. DA Lovejoy and RJ Balment (1999) Evolution and physiology of the corticotropin-releasing factor (CRF) family of neuropeptides in vertebrates. Gen Comp Endocrinol 115 1-22.
143. SY Hsu and AJ Hsueh (2001) Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med 7 605-611.
144. R Chen, KA Lewis, MH Perrin, et al. (1993) Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci U S A 90 8967-8971.
145. CP Chang, RV Pearse 2nd, S O’Connell, et al. (1993) Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 11 1187-1195.
146. P Stenzel, R Kesterson, W Yeung, et al. (1995) Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol Endocrinol 9 637-645.
147. O Valdenaire, T Giller, V Breu, et al. (1997) A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor. Biochim Biophys Acta 1352 129-132.
148. WA Kostich, A Chen, K Sperle, et al. (1998) Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor. Mol Endocrinol 12 1077-1085.
149. K Takahashi, K Totsune, M Sone, et al. (1998) Regional distribution of urocortin-like immunoreactivity and expression of urocortin mRNA in the human brain. Peptides 19 643-647.
150. A Chen, E Zorrilla, S Smith, et al. (2006) Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. J Neurosci 26 5500-5510.
151. C Li, P Chen, J Vaughan, et al. (2007) Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis. Proc Natl Acad Sci U S A 104 4206-4211.
152. DT Chalmers, TW Lovenberg and EB De Souza (1995) Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J Neurosci 15 6340-6350.
153. TW Lovenberg, DT Chalmers, C Liu, et al. (1995) CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology 136 4139-4142.
154. EA Linton, CD Wolfe, DP Behan, et al. (1990) Circulating corticotropin-releasing factor in pregnancy. Adv Exp Med Biol 274 147-164.
155. DP Behan, EA Linton and PJ Lowry (1989) Isolation of the human plasma corticotrophin-releasing factor-binding protein. J Endocrinol 122 23-31.
156. DN Orth and CD Mount (1987) Specific high-affinity binding protein for human corticotropin-releasing hormone in normal human plasma. Biochem Biophys Res Commun 143 411-417.
157. TL Bale and WW Vale (2004) CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 44 525-557.
158. J Rivier, C Rivier and W Vale (1984) Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science 224 889-891.
159. H Maecker, A Desai, R Dash, et al. (1997) Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res 744 166-170.
160. KE Habib, KP Weld, KC Rice, et al. (2000) Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc Natl Acad Sci U S A 97 6079-6084.
161. JH Broadbear, G Winger, JE Rivier, et al. (2004) Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys. Neuropsychopharmacology 29 1112-1121.
162. A Ruhmann, I Bonk, CR Lin, et al. (1998) Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2beta-selective antisauvagine-30. Proc Natl Acad Sci U S A 95 15264-15269.
163. SJ Claes (2004) Corticotropin-releasing hormone (CRH) in psychiatry: from stress to psychopathology. Ann Med 36 50-61.
164. ME Keck, F Holsboer and MB Muller (2004) Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders. Ann N Y Acad Sci 1018 445-457.
165. A Gravanis and AN Margioris (2005) The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications. Curr Med Chem 12 1503-1512.
166. GN Smagin, SC Heinrichs and AJ Dunn (2001) The role of CRH in behavioral responses to stress. Peptides 22 713-724.
167. S Modell, CJ Lauer, W Schreiber, et al. (1998) Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology 18 253-262.
168. CB Nemeroff and WW Vale (2005) The neurobiology of depression: inroads to treatment and new drug discovery. J Clin Psychiatry 66(suppl 7), 5-13.
169. DG Parkes, RS Weisinger and CN May (2001) Cardiovascular actions of CRH and urocortin: an update. Peptides 22 821-827.
170. SC Coste, RA Kesterson, KA Heldwein, et al. (2000) Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet 24 403-409.
171. TL Bale, A Contarino, GW Smith, et al. (2000) Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet 24 410-414.
172. DS Jessop, MS Harbuz and SL Lightman (2001) CRH in chronic inflammatory stress. Peptides 22 803-807.
173. PA Seymour, AW Schmidt and DW Schulz (2003) The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review. CNS Drug Rev 9 57-96.
174. F Holsboer and M Ising (2008) Central CRH system in depression and anxiety: evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol 583 350-357.
175. ME Keller-Wood and MF Dallman (1984) Corticosteroid inhibition of ACTH secretion. Endocr Rev 5 1-24.
176. JL Arriza, RB Simerly, LW Swanson, et al. (1988) The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Neuron 1 887-900.
177. ER de Kloet, MS Oitzl and M Joels (1993) Functional implications of brain corticosteroid receptor diversity. Cell Mol Neurobiol 13 433-455.
178. RM Sapolsky, LC Krey and BS McEwen (1986) The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 7 284-301.
179. AG Watts (2005) Glucocorticoid regulation of peptide genes in neuroendocrine CRH neurons: a complexity beyond negative feedback. Front Neuroendocrinol 26 109-130.
180. R Malcher-Lopes, S Di, VS Marcheselli, et al. (2006) Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci 26 6643-6650.
181. MF Dallman (2005) Fast glucocorticoid actions on brain: back to the future. Front Neuroendocrinol 26 103-108.
182. JP Herman, H Figueiredo, NK Mueller, et al. (2003) Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 24 151-180.
183. PE Sawchenko, HY Li and A Ericsson (2000) Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms. Prog Brain Res 122 61-78.
184. DR Ziegler, WE Cullinan and JP Herman (2005) Organization and regulation of paraventricular nucleus glutamate signaling systems: N-methyl-D-aspartate receptors. J Comp Neurol 484 43-56.
185. BL Roland and PE Sawchenko (1993) Local origins of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat. J Comp Neurol 332 123-143.
186. R Sapolsky, C Rivier, G Yamamoto, et al. (1987) Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238 522-524.
187. F Berkenbosch, J van Oers, A del Rey, et al. (1987) Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238 524-526.
188. H Besedovsky, A del Rey, E Sorkin, et al. (1986) Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233 652-654.
189. S Reichlin (1999) Neuroendocrinology of infection and the innate immune system. Recent Prog Horm Res 54 133-181. discussion 181-183
190. S Reichlin (1993) Neuroendocrine-immune interactions. N Engl J Med 329 1246-1253.
191. A Gudmundsson and M Carnes (1997) Pulsatile adrenocorticotropic hormone: an overview. Biol Psychiatry 41 342-365.
192. LJ Muglia, L Jacobson, SC Weninger, et al. (1997) Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice. J Clin Invest 99 2923-2929.
193. D Engler, E Redei and I Kola (1999) The corticotropin-release inhibitory factor hypothesis: a review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenocorticotropin secretion and biosynthesis. Endocr Rev 20 460-500.
194. S Reichlin (1960) Growth and the hypothalamus. Endocrinology 67 760-773.
195. K Mayo, W Vale, J Rivier, et al. (1983) Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor. Nature 306 86-88.
196. J Rivier, J Speiss, M Thorner, et al. (1982) Characterisation of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 300 276-278.
197. R Guillemin, P Barazeau, P Bohlen, et al. (1981) Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 218 585-587.
198. L Frohman, M Szabo, M Berelowitz, et al. (1980) Partial purification and characterization of a peptide with growth hormone-releasing activity from extrapituitary tumors in patients with acromegaly. J Clin Invest 65 43-54.
199. LA Frohman, TR Downs, P Chomczynski, et al. (1990) Growth hormone-releasing hormone: structure, gene expression and molecular heterogeneity. Acta Paediatr Scand Suppl 367 81-86.
200. KE Mayo, GM Cerelli, RV Lebo, et al. (1985) Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. Proc Natl Acad Sci U S A 82 63-67.
201. LA Frohman, TR Downs, EP Heimer, et al. (1989) Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma. J Clin Invest 83 1533-1540.
202. M Thorner, L Frohman, D Leong, et al. (1984) Extrahypothalamic growth hormone-releasing factor (GRF) is a rare cause of acromegaly: plasma GRF levels in 177 acromegalic patients. J Clin Endocrinol Metab 59 846-849.
203. Y Dayal, H Lin, K Tallberg, et al. (1986) Immunocytochemical demonstration of growth hormone-releasing factor in gastrointestinal and pancreatic endocrine tumors. Am J Clin Pathol 85 13-20.
204. O Khorram, M Garthwaite, E Grosen, et al. (2001) Human uterine and ovarian expression of growth hormone-releasing hormone messenger RNA in benign and malignant gynecologic conditions. Fertil Steril 75 174-179.
205. S Gonzalez-Crespo and A Boronat (1991) Expression of the rat growth hormone-releasing hormone gene in placenta is directed by an alternative promoter. Proc Natl Acad Sci U S A 88 8749-8753.
206. EE Muller, V Locatelli and D Cocchi (1999) Neuroendocrine control of growth hormone secretion. Physiol Rev 79 511-607.
207. BD Gaylinn, JK Harrison, JR Zysk, et al. (1993) Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Mol Endocrinol 7 77-84.
208. KE Mayo, PA Godfrey, ST Suhr, et al. (1995) Growth hormone-releasing hormone: synthesis and signaling. Recent Prog Horm Res 50 35-73.
209. G Baumann and H Maheshwari (1997) The dwarfs of Sindh: severe growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene. Acta Paediatr Suppl 423 33-38.
210. MP Wajnrajch, JM Gertner, MD Harbison, et al. (1996) Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nat Genet 12 88-90.
211. A Giustina and JD Veldhuis (1998) Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19 717-797.
212. L Stefaneanu, K Kovacs, E Horvath, et al. (1989) Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation. Endocrinology 125 2710-2718.
213. KE Mayo, RE Hammer, LW Swanson, et al. (1988) Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. Mol Endocrinol 2 606-612.
214. L Vallar, A Spada and G Giannattasio (1987) Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330 566-568.
215. A Steiger, J Guldner, U Hemmeter, et al. (1992) Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology 56 566-573.
216. E Van Cauter, R Leproult and L Plat (2000) Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA 284 861-868.
217. FJ Vaccarino, SH Kennedy, E Ralevski, et al. (1994) The effects of growth hormone-releasing factor on food consumption in anorexia nervosa patients and normals. Biol Psychiatry 35 446-451.
218. RG Smith, S Feighner, K Prendergast, et al. (1999) A new orphan receptor involved in pulsatile growth hormone release. Trends Endocrinol Metab 10 128-135.
219. AD Howard, SD Feighner, DF Cully, et al. (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273 974-977.
220. M Maghnie, V Spica-Russotto, M Cappa, et al. (1998) The growth hormone response to hexarelin in patients with different hypothalamic-pituitary abnormalities. J Clin Endocrinol Metab 83 3886-3889.
221. E Arvat, M Maccario, L Di Vito, et al. (2001) Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 86 1169-1174.
222. R Baldelli, XL Otero, JP Camina, et al. (2001) Growth hormone secretagogues as diagnostic tools in disease states. Endocrine 14 95-99.
223. M Gasperi, G Aimaretti, G Scarcello, et al. (1999) Low dose hexarelin and growth hormone (GH)-releasing hormone as a diagnostic tool for the diagnosis of GH deficiency in adults: comparison with insulin-induced hypoglycemia test. J Clin Endocrinol Metab 84 2633-2637.
224. JD Veldhuis, SM Anderson, N Shah, et al. (2001) Neurophysiological regulation and target-tissue impact of the pulsatile mode of growth hormone secretion in the human. Growth Horm IGF Res 11(Suppl A), S25-S37.
225. RJ Ross, S Tsagarakis, A Grossman, et al. (1987) GH feedback occurs through modulation of hypothalamic somatostatin under cholinergic control: studies with pyridostigmine and GHRH. Clin Endocrinol (Oxf) 27 727-733.
226. H Zheng, A Bailey, MH Jiang, et al. (1997) Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol 11 1709-1717.
227. AT Soliman, MM El Zalabany, M Salama, et al. (2000) Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. Metabolism 49 819-825.
228. B Bloch, RC Gaillard, P Brazeau, et al. (1984) Topographical and ontogenetic study of the neurons producing growth hormone-releasing factor in human hypothalamus. Regul Pept 8 21-31.
229. A Mota, A Bento, A Penalva, et al. (1995) Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion. J Clin Endocrinol Metab 80 1973-1977.
230. EE Muller (1997) Cholinergic function and neural control of GH secretion: a critical re-appraisal. Eur J Endocrinol 137 338-342.
231. J Atiea, F Creagh, M Page, et al. (1989) Early morning hyperglycemia in insulin-dependent diabetes: acute and sustained effects of cholinergic blockage. J Clin Endocrinol Metab 69 390-395.
232. A Giustina, M Licini, M Schettino, et al. (1994) Physiological role of galanin in the regulation of anterior pituitary function in humans. Am J Physiol 266 E57-E61.
233. SG Cella, V Locatelli, V De Gennaro, et al. (1988) Epinephrine mediates the growth hormone-releasing effect of galanin in infant rats. Endocrinology 122 855-859.
234. E Van Cauter, M Kerkhofs, A Caufriez, et al. (1992) A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrinol Metab 74 1441-1450.
235. CA Jaffe, B Ocampo-Lim, W Guo, et al. (1998) Regulatory mechanisms of growth hormone secretion are sexually dimorphic. J Clin Invest 102 153-164.
236. SM Pincus, EF Gevers, IC Robinson, et al. (1996) Females secrete growth hormone with more process irregularity than males in both humans and rats. Am J Physiol 270 E107-E115.
237. MJ Low, V Otero-Corchon, AF Parlow, et al. (2001) Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest 107 1571-1580.
238. C Wagner, SR Caplan and GS Tannenbaum (1998) Genesis of the ultradian rhythm of GH secretion: a new model unifying experimental observations in rats. Am J Physiol 275 E1046-E1054.
239. L Krulich, A Dhariwal and S McCann (1968) Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 83 783-790.
240. P Brazeau, W Vale, R Burgus, et al. (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179 77-79.
241. AS Galanopoulou, G Kent, SN Rabbani, et al. (1993) Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways: putative role of the endoproteases furin, PC1, and PC2. J Biol Chem 268 6041-6049.
242. LP Shen and WJ Rutter (1984) Sequence of the human somatostatin I gene. Science 224 168-171.
243. JM Conlon, H Tostivint and H Vaudry (1997) Somatostatin- and urotensin II-related peptides: molecular diversity and evolutionary perspectives. Regul Pept 69 95-103.
244. L de Lecea, JR Criado, O Prospero-Garcia, et al. (1996) A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 381 242-245.
245. AD Spier and L de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev 33 228-241.
246. S Fukusumi, C Kitada, S Takekawa, et al. (1997) Identification and characterization of a novel human cortistatin-like peptide. Biochem Biophys Res Commun 232 157-163.
247. FG Andersen, J Jensen, RS Heller, et al. (1999) Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer. FEBS Lett 445 315-320.
248. G Goudet, S Delhalle, F Biemar, et al. (1999) Functional and cooperative interactions between the homeodomain PDX1, Pbx, and Prep1 factors on the somatostatin promoter. J Biol Chem 274 4067-4073.
249. PT Schwartz and M Vallejo (1998) Differential regulation of basal and cyclic adenosine 3′,5′- monophosphate-induced somatostatin gene transcription in neural cells by DNA control elements that bind homeodomain proteins. Mol Endocrinol 12 1280-1293.
250. G Capone, C Choi and J Vertifuille (1998) Regulation of the preprosomatostatin gene by cyclic-AMP in cerebrocortical neurons. Brain Res Mol Brain Res 60 247-258.
251. M Montminy, P Brindle, J Arias, et al. (1996) Regulation of somatostatin gene transcription by cyclic adenosine monophosphate. Metabolism 45 4-7.
252. PT Schwartz, B Perez-Villamil, A Rivera, et al. (2000) Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells. J Biol Chem 275 19106-19114.
253. YC Patel (1999) Somatostatin and its receptor family. Front Neuroendocrinol 20 157-198.
254. VS Thoss, J Perez, A Probst, et al. (1996) Expression of five somatostatin receptor mRNAs in the human brain and pituitary. Naunyn Schmiedebergs Arch Pharmacol 354 411-419.
255. MZ Strowski, RM Parmar, AD Blake, et al. (2000) Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 141 111-117.
256. AD Blake, AC Badway and MZ Strowski (2004) Delineating somatostatin's neuronal actions. Curr Drug Targets CNS Neurol Disord 3 153-160.
257. GW Mathern, TL Babb, JK Pretorius, et al. (1995) Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. J Neurosci 15 3990-4004.
258. C Kluge, C Stoppel, C Szinyei, et al. (2008) Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity. Learn Mem 15 252-260.
259. L Yang, SC Berk, SP Rohrer, et al. (1998) Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci U S A 95 10836-10841.
260. SP Rohrer, ET Birzin, RT Mosley, et al. (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 737-740.
261. GD Slooter, A Mearadji, WA Breeman, et al. (2001) Somatostatin receptor imaging, therapy and new strategies in patients with neuroendocrine tumours. Br J Surg 88 31-40.
262. SW Lamberts, AJ van der Lely, WW de Herder, et al. (1996) Octreotide. N Engl J Med 334 246-254.
263. WJ Schirmer, TM O'Dorisio, TP Schirmer, et al. (1993) Intraoperative localization of neuroendocrine tumors with 125I-TYR(3)-octreotide and a hand-held gamma-detecting probe. Surgery 114 745-751. discussion 751-752
264. M Henze, J Schuhmacher, P Hipp, et al. (2001) PET imaging of somatostatin receptors using [ 68Ga]DOTATOC. J Nucl Med 42 1053-1056.
265. P Rochaix, N Delesque, JP Esteve, et al. (1999) Gene therapy for pancreatic carcinoma: local and distant antitumor effects after somatostatin receptor sst2 gene transfer. Hum Gene Ther 10 995-1008.
266. ME Freeman, B Kanyicska, A Lerant, et al. (2000) Prolactin: structure, function, and regulation of secretion. Physiol Rev 80 1523-1631.
267. N Ben-Jonathan and R Hnasko (2001) Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 22 724-763.
268. N Ben-Jonathan (1985) Dopamine: a prolactin-inhibiting hormone. Endocr Rev 6 564-589.
269. RM MacLeod, EH Fontham and JE Lehmeyer (1970) Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Neuroendocrinology 6 283-294.
270. MG Caron, M Beaulieu, V Raymond, et al. (1978) Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release. J Biol Chem 253 2244-2253.
271. PC Goldsmith, MJ Cronin and RI Weiner (1979) Dopamine receptor sites in the anterior pituitary. J Histochem Cytochem 27 1205-1207.
272. SL Asa, MA Kelly, DK Grandy, et al. (1999) Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice. Endocrinology 140 5348-5355.
273. A Lerant, ME Herman and ME Freeman (1996) Dopaminergic neurons of periventricular and arcuate nuclei of pseudopregnant rats: semicircadian rhythm in Fos-related antigen immunoreactivities and in dopamine concentration. Endocrinology 137 3621-3628.
274. LL Peters, MT Hoefer and N Ben-Jonathan (1981) The posterior pituitary: regulation of anterior pituitary prolactin secretion. Science 213 659-661.
275. RA Durham, JD Johnson, MJ Eaton, et al. (1998) Opposing roles for dopamine D1 and D2 receptors in the regulation of hypothalamic tuberoinfundibular dopamine neurons. Eur J Pharmacol 355 141-147.
276. L Vallar and J Meldolesi (1989) Mechanisms of signal transduction at the dopamine D2 receptor. Trends Pharmacol Sci 10 74-77.
277. YH Wang and RA Maurer (1999) A role for the mitogen-activated protein kinase in mediating the ability of thyrotropin-releasing hormone to stimulate the prolactin promoter. Mol Endocrinol 13 1094-1104.
278. T Yonehara, H Kanasaki, H Yamamoto, et al. (2001) Involvement of mitogen-activated protein kinase in cyclic adenosine 3′,5′-monophosphate-induced hormone gene expression in rat pituitary GH(3) cells. Endocrinology 142 2811-2819.
279. KK Jacob, E Wininger, K DiMinni, et al. (1999) The EGF response element in the prolactin promoter. Mol Cell Endocrinol 152 137-145.
280. RN Day, J Liu, V Sundmark, et al. (1998) Selective inhibition of prolactin gene transcription by the ETS-2 repressor factor. J Biol Chem 273 31909-31915.
281. S Suzuki, I Yamamoto and J Arita (1999) Mitogen-activated protein kinase-dependent stimulation of proliferation of rat lactotrophs in culture by 3′,5′-cyclic adenosine monophosphate. Endocrinology 140 2850-2858.
282. SE Senogles (2007) D2 dopamine receptor-mediated antiproliferation in a small cell lung cancer cell line, NCI-H69. Anticancer Drugs 18 801-807.
283. SE Lindley, JW Gunnet, KJ Lookingland, et al. (1988) Effects of alterations in the activity of tuberohypophysial dopaminergic neurons on the secretion of alpha-melanocyte stimulating hormone. Proc Soc Exp Biol Med 188 282-286.
284. BM Chronwall, WR Millington, WS Griffin, et al. (1987) Histological evaluation of the dopaminergic regulation of proopiomelanocortin gene expression in the intermediate lobe of the rat pituitary, involving in situ hybridization and [3H]thymidine uptake measurement. Endocrinology 120 1201-1211.
285. BM Chronwall, TD Davis, MW Severidt, et al. (2001) Constitutive expression of functional GABA(B) receptors in mIL-tsA58 cells requires both GABA(B(1)) and GABA(B(2)) genes. J Neurochem 77 1237-1247.
286. MH Samuels, J Veldhuis and EC Ridgway (1995) Copulsatile release of thyrotropin and prolactin in normal and hypothyroid subjects. Thyroid 5 369-372.
287. GM Nagy, TJ Gorcs and B Halasz (1991) Attenuation of the suckling-induced prolactin release and the high afternoon oscillations of plasma prolactin secretion of lactating rats by antiserum to vasopressin. Neuroendocrinology 54 566-570.
288. BJ Arey and ME Freeman (1990) Oxytocin, vasoactive-intestinal peptide, and serotonin regulate the mating-induced surges of prolactin secretion in the rat. Endocrinology 126 279-284.
289. WK Samson, MD Lumpkin and SM McCann (1986) Evidence for a physiological role for oxytocin in the control of prolactin secretion. Endocrinology 119 554-560.
290. A Shimatsu, Y Kato, H Ohta, et al. (1984) Involvement of hypothalamic vasoactive intestinal polypeptide (VIP) in prolactin secretion induced by serotonin in rats. Proc Soc Exp Biol Med 175 414-416.
291. A Kjaer (1993) Vasopressin as a neuroendocrine regulator of anterior pituitary hormone secretion. Acta Endocrinol (Copenh) 129 489-496.
292. N Itoh, K Obata, N Yanaihara, et al. (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547-549.
293. T Hokfelt, J Fahrenkrug, K Tatemoto, et al. (1983) The PHI (PHI-27)/corticotropin-releasing factor/enkephalin immunoreactive hypothalamic neuron: possible morphological basis for integrated control of prolactin, corticotropin, and growth hormone secretion. Proc Natl Acad Sci U S A 80 895-898.
294. C Denef, D Manet and R Dewals (1980) Dopaminergic stimulation of prolactin release. Nature 285 243-246.
295. BJ Arey, TP Burris, P Basco, et al. (1993) Infusion of dopamine at low concentrations stimulates the release of prolactin from alpha-methyl-p-tyrosine-treated rats. Proc Soc Exp Biol Med 203 60-63.
296. S Hinuma, Y Habata, R Fujii, et al. (1998) A prolactin-releasing peptide in the brain. Nature 393 272-276.
297. S Fukusumi, R Fujii and S Hinuma (2006) Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. Peptides 27 1073-1086.
298. Y Takayanagi, H Matsumoto, M Nakata, et al. (2008) Endogenous prolactin-releasing peptide regulates food intake in rodents. J Clin Invest 118 4014-4024.
299. J Schwartz, S Van de Pavert, I Clarke, et al. (1998) Paracrine interactions within the pituitary gland. Ann N Y Acad Sci 839 239-243.
300. I Murai and N Ben-Jonathan (1987) Posterior pituitary lobectomy abolishes the suckling-induced rise in prolactin (PRL): evidence for a PRL-releasing factor in the posterior pituitary. Endocrinology 121 205-211.
301. DL Allen, MJ Low, RG Allen, et al. (1995) Identification of two classes of prolactin-releasing factors in intermediate lobe tumors from transgenic mice. Endocrinology 136 3093-3099.
302. E Ellerkmann, TE Porter, GM Nagy, et al. (1992) N-acetylation is required for the lactotrope recruitment activity of alpha-melanocyte-stimulating hormone and beta-endorphin. Endocrinology 131 566-570.
303. JL Voogt, Y Lee, S Yang, et al. (2001) Regulation of prolactin secretion during pregnancy and lactation. Prog Brain Res 133 173-185.
304. JE DeMaria, JD Livingstone and ME Freeman (2000) Ovarian steroids influence the activity of neuroendocrine dopaminergic neurons. Brain Res 879 139-147.
305. L Milenkovic, AF Parlow and SM McCann (1990) Physiological significance of the negative short-loop feedback of prolactin. Neuroendocrinology 52 389-392.
306. LA Arbogast and JL Voogt (1997) Prolactin (PRL) receptors are colocalized in dopaminergic neurons in fetal hypothalamic cell cultures: effect of PRL on tyrosine hydroxylase activity. Endocrinology 138 3016-3023.
307. CJ Phelps and DL Hurley (1999) Pituitary hormones as neurotrophic signals: update on hypothalamic differentiation in genetic models of altered feedback. Proc Soc Exp Biol Med 222 39-58.
308. CJ Phelps and ND Horseman (2000) Prolactin gene disruption does not compromise differentiation of tuberoinfundibular dopaminergic neurons. Neuroendocrinology 72 2-10.
309. P Callahan, S Klosterman, D Prunty, et al. (2000) Immunoneutralization of endogenous opioid peptides prevents the suckling-induced prolactin increase and the inhibition of tuberoinfundibular dopaminergic neurons. Neuroendocrinology 71 268-276.
310. LD Van de Kar and CL Bethea (1982) Pharmacological evidence that serotonergic stimulation of prolactin secretion is mediated via the dorsal raphe nucleus. Neuroendocrinology 35 225-230.
311. I Creese, DR Burt and SH Snyder (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192 481-483.
312. K Melkersson and AL Hulting (2000) Prolactin-secreting pituitary adenoma in neuroleptic treated patients with psychotic disorder. Eur Arch Psychiatry Clin Neurosci 250 6-10.
313. RG Veldman, M Frolich, SM Pincus, et al. (2001) Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia. J Clin Endocrinol Metab 86 1562-1567.
314. J Waldstreicher, JF Duffy, EN Brown, et al. (1996) Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels—a clinical research center study. J Clin Endocrinol Metab 81 1483-1487.
315. S Diaz, M Seron-Ferre, H Cardenas, et al. (1989) Circadian variation of basal plasma prolactin, prolactin response to suckling, and length of amenorrhea in nursing women. J Clin Endocrinol Metab 68 946-955.
316. WB Malarkey, JC Hall, DK Pearl, et al. (1991) The influence of academic stress and season on 24-hour concentrations of growth hormone and prolactin. J Clin Endocrinol Metab 73 1089-1092.
317. PH Seeburg and JP Adelman (1984) Characterization of cDNA for precursor of human luteinizing hormone releasing hormone. Nature 311 666-668.
318. HF Urbanski, RB White, RD Fernald, et al. (1999) Regional expression of mRNA encoding a second form of gonadotropin-releasing hormone in the macaque brain. Endocrinology 140 1945-1948.
319. NM Sherwood, DA Lovejoy and IR Coe (1993) Origin of mammalian gonadotropin-releasing hormones. Endocr Rev 14 241-254.
320. RD Fernald and RB White (1999) Gonadotropin-releasing hormone genes: phylogeny, structure, and functions. Front Neuroendocrinol 20 224-240.
321. AJ Pawson, K Morgan, SR Maudsley, et al. (2003) Type II gonadotrophin-releasing hormone (GnRH-II) in reproductive biology. Reproduction 126 271-278.
322. SB Nelson, SA Eraly and PL Mellon (1998) The GnRH promoter: target of transcription factors, hormones, and signaling pathways. Mol Cell Endocrinol 140 151-155.
323. JP Hapgood, H Sadie, W van Biljon, et al. (2005) Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. J Neuroendocrinol 17 619-638.
324. CK Cheng and PC Leung (2005) Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans. Endocr Rev 26 283-306.
325. ML Givens, R Kurotani, N Rave-Harel, et al. (2004) Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol 18 2950-2966.
326. ML Givens, N Rave-Harel, VD Goonewardena, et al. (2005) Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem 280 19156-19165.
327. CH Phoenix and KC Chambers (1990) Sexual performance of old and young male rhesus macaques following treatment with GnRH. Physiol Behav 47 513-517.
328. S Wray (2001) Development of luteinizing hormone releasing hormone neurones. J Neuroendocrinol 13 3-11.
329. G MacColl, R Quinton and PM Bouloux (2002) GnRH neuronal development: insights into hypogonadotrophic hypogonadism. Trends Endocrinol Metab 13 112-118.
330. JP Hardelin and C Dode (2008) The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2, et al. Sex Dev 2 181-193.
331. RN Clayton (1988) Mechanism of GnRH action in gonadotrophs. Hum Reprod 3 479-483.
332. PM Conn and WF Crowley Jr (1994) Gonadotropin-releasing hormone and its analogs. Annu Rev Med 45 391-405.
333. LA Rispoli and TM Nett (2005) Pituitary gonadotropin-releasing hormone (GnRH) receptor: structure, distribution and regulation of expression. Anim Reprod Sci 88 57-74.
334. N Lahlou, JC Carel, JL Chaussain, et al. (2000) Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics. J Pediatr Endocrinol Metab 13(suppl 1), 723-737.
335. T Reissmann, AV Schally, P Bouchard, et al. (2000) The LHRH antagonist cetrorelix: a review. Hum Reprod Update 6 322-331.
336. PW Carmel, S Araki and M Ferin (1976) Pituitary stalk portal blood collection in rhesus monkeys: evidence for pulsatile release of gonadotropin-releasing hormone (GnRH). Endocrinology 99 243-248.
337. IJ Clarke and JT Cummins (1982) The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111 1737-1739.
338. Y Mori, M Nishihara, T Tanaka, et al. (1991) Chronic recording of electrophysiological manifestation of the hypothalamic gonadotropin-releasing hormone pulse generator activity in the goat. Neuroendocrinology 53 392-395.
339. G Martinez de la Escalera, AL Choi and RI Weiner (1992) Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci U S A 89 1852-1855.
340. SC Chappel, A Ulloa-Aguirre and C Coutifaris (1983) Biosynthesis and secretion of follicle-stimulating hormone. Endocr Rev 4 179-211.
341. RB Simerly, C Chang, M Muramatsu, et al. (1990) Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 294 76-95.
342. GG Kuiper, PJ Shughrue, I Merchenthaler, et al. (1998) The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems. Front Neuroendocrinol 19 253-286.
343. PJ Shughrue, MV Lane and I Merchenthaler (1997) Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol 388 507-525.
344. CL Bethea, NA Brown and SG Kohama (1996) Steroid regulation of estrogen and progestin receptor messenger ribonucleic acid in monkey hypothalamus and pituitary. Endocrinology 137 4372-4383.
345. TM Plant (1986) Gonadal regulation of hypothalamic gonadotropin-releasing hormone release in primates. Endocr Rev 7 75-88.
346. Y Nakai, TM Plant, DL Hess, et al. (1978) On the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion in the rhesus monkey. Endocrinology 102 1008-1014.
347. TR Kumar and MJ Low (1995) Hormonal regulation of human follicle-stimulating hormone-beta subunit gene expression: GnRH stimulation and GnRH-independent androgen inhibition. Neuroendocrinology 61 628-637.
348. W Bishop, PS Kalra, CP Fawcett, et al. (1972) The effects of hypothalamic lesions on the release of gonadotropins and prolactin in response to estrogen and progesterone treatment in female rats. Endocrinology 91 1404-1410.
349. JE Levine, PE Chappell, JS Schneider, et al. (2001) Progesterone receptors as neuroendocrine integrators. Front Neuroendocrinol 22 69-106.
350. SB Seminara (2005) Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion. Front Neuroendocrinol 26 131-138.
351. HM Dungan, DK Clifton and RA Steiner (2006) Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 147 1154-1158.
352. SM Popa, DK Clifton and RA Steiner (2008) The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annu Rev Physiol 70 213-238.
353. SL Kaplan, MM Grumbach and ML Aubert (1976) The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function. Recent Prog Horm Res 32 161-243.
354. JS Winter, C Faiman, WC Hobson, et al. (1975) Pituitary-gonadal relations in infancy: I. Patterns of serum gonadotropin concentrations from birth to four years of age in man and chimpanzee. J Clin Endocrinol Metab 40 545-551.
355. TM Plant (2001) Neurobiological bases underlying the control of the onset of puberty in the rhesus monkey: a representative higher primate. Front Neuroendocrinol 22 107-139.
356. RM Boyar, RS Rosenfeld, S Kapen, et al. (1974) Human puberty: simultaneous augmented secretion of luteinizing hormone and testosterone during sleep. J Clin Invest 54 609-618.
357. VL Gay and TM Plant (1988) Sustained intermittent release of gonadotropin-releasing hormone in the prepubertal male rhesus monkey induced by N-methyl-DL-aspartic acid. Neuroendocrinology 48 147-152.
358. SR Ojeda, YJ Ma, BJ Lee, et al. (2000) Glia-to-neuron signaling and the neuroendocrine control of female puberty. Recent Prog Horm Res 55 197-223. discussion 223-224
359. FJ Ebling (2005) The neuroendocrine timing of puberty. Reproduction 129 675-683.
360. AG Stoyanovitch, MA Johnson, DK Clifton, et al. (2005) Galanin-like peptide rescues reproductive function in the diabetic rat. Diabetes 54 2471-2476.
361. JL Cameron (1997) Stress and behaviorally induced reproductive dysfunction in primates. Semin Reprod Endocrinol 15 37-45.
362. C Rivier, J Rivier and W Vale (1986) Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor. Science 231 607-609.
363. YJ Feng, E Shalts, LN Xia, et al. (1991) An inhibitory effect of interleukin-1a on basal gonadotropin release in the ovariectomized rhesus monkey: reversal by a corticotropin-releasing factor antagonist. Endocrinology 128 2077-2082.
364. MD Chen, KT O’Byrne, SE Chiappini, et al. (1992) Hypoglycemic “stress” and gonadotropin-releasing hormone pulse generator activity in the rhesus monkey: role of the ovary. Neuroendocrinology 56 666-673.
365. RL Norman and CJ Smith (1992) Restraint inhibits luteinizing hormone and testosterone secretion in intact male rhesus macaques: effects of concurrent naloxone administration. Neuroendocrinology 55 405-415.
366. FF Chehab, ME Lim and R Lu (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12 318-320.
367. JE Schneider, D Zhou and RM Blum (2000) Leptin and metabolic control of reproduction. Horm Behav 37 306-326.
368. J Honegger, M Buchfelder and R Fahlbusch (1999) Surgical treatment of craniopharyngiomas: endocrinological results. J Neurosurg 90 251-257.
369. XQ Yuan and CE Wade (1991) Neuroendocrine abnormalities in patients with traumatic brain injury. Front Neuroendocrinol 12 209-230.
370. S Benvenga, A Campenni, RM Ruggeri, et al. (2000) Clinical review 113: hypopituitarism secondary to head trauma. J Clin Endocrinol Metab 85 1353-1361.
371. J Daaboul and P Steinbok (1998) Abnormalities of water metabolism after surgery for optic/chiasmatic astrocytomas in children. Pediatr Neurosurg 28 181-185.
372. M Maghnie, G Cosi, E Genovese, et al. (2000) Central diabetes insipidus in children and young adults. N Engl J Med 343 998-1007.
373. WA Scherbaum, JA Wass, GM Besser, et al. (1986) Autoimmune cranial diabetes insipidus: its association with other endocrine diseases and with histiocytosis X. Clin Endocrinol (Oxf) 25 411-420.
374. AE Al-Agha, MJ Thomsett, JF Ratcliffe, et al. (2001) Acquired central diabetes insipidus in children: a 12-year Brisbane experience. J Paediatr Child Health 37 172-175.
375. SL Mootha, AJ Barkovich, MM Grumbach, et al. (1997) Idiopathic hypothalamic diabetes insipidus, pituitary stalk thickening, and the occult intracranial germinoma in children and adolescents. J Clin Endocrinol Metab 82 1362-1367.
376. H Nagasaki, M Ito, H Yuasa, et al. (1995) Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus. J Clin Endocrinol Metab 80 1352-1356.
377. JP Morello and DG Bichet (2001) Nephrogenic diabetes insipidus. Annu Rev Physiol 63 607-630.
378. M Birnbaumer (2001) The V2 vasopressin receptor mutations and fluid homeostasis. Cardiovasc Res 51 409-415.
379. S Nielsen, J Frokiaer, D Marples, et al. (2002) Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82 205-244.
380. SA Lieberman, AL Oberoi, CR Gilkison, et al. (2001) Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab 86 2752-2756.
381. MV Smith and ER Laws Jr (1994) Magnetic resonance imaging measurements of pituitary stalk compression and deviation in patients with nonprolactin-secreting intrasellar and parasellar tumors: lack of correlation with serum prolactin levels. Neurosurgery 34 834-839. discussion 839
382. JL Voelker, RL Campbell and J Muller (1991) Clinical, radiographic, and pathological features of symptomatic Rathke's cleft cysts. J Neurosurg 74 535-544.
383. S Zucchini, P Ambrosetto, G Carla, et al. (1995) Primary empty sella: differences and similarities between children and adults. Acta Paediatr 84 1382-1385.
384. P Bjerre (1990) The empty sella: a reappraisal of etiology and pathogenesis. Acta Neurol Scand Suppl 130 1-25.
385. D Klingmuller, W Dewes, T Krahe, et al. (1987) Magnetic resonance imaging of the brain in patients with anosmia and hypothalamic hypogonadism (Kallmann's syndrome). J Clin Endocrinol Metab 65 581-584.
386. VR Nanduri and R Stanhope (1999) Why is the retention of gonadotrophin secretion common in children with panhypopituitarism due to septo-optic dysplasia? Eur J Endocrinol 140 48-50.
387. B Bhagavath, RH Podolsky, M Ozata, et al. (2006) Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism. Fertil Steril 85 706-713.
388. A Chryssikopoulos, O Gregoriou, N Vitoratos, et al. (1998) The predictive value of double Gn-RH provocation test in unprimed Gn-RH-primed and steroid-primed female patients with Kallmann's syndrome. Int J Fertil Womens Med 43 291-299.
389. FJ Hayes, SB Seminara and WF Crowley Jr (1998) Hypogonadotropic hypogonadism. Endocrinol Metab Clin North Am 27 739-763. vii
390. MH Samuels and EC Ridgway (1992) Central hypothyroidism. Endocrinol Metab Clin North Am 21 903-919.
391. WE Winter and MR Signorino (2001) Review: molecular thyroidology. Ann Clin Lab Sci 31 221-244.
392. JO Jorgensen, SA Pedersen, P Laurberg, et al. (1989) Effects of growth hormone therapy on thyroid function of growth hormone-deficient adults with and without concomitant thyroxine-substituted central hypothyroidism. J Clin Endocrinol Metab 69 1127-1132.
393. SR Rose (2001) Cranial irradiation and central hypothyroidism. Trends Endocrinol Metab 12 97-104.
394. J Argente, SA Abusrewil, G Bona, et al. (2001) Isolated growth hormone deficiency in children and adolescents. J Pediatr Endocrinol Metab 14(suppl 2), 1003-1008.
395. M Maghnie, S Ghirardello and E Genovese (2004) Magnetic resonance imaging of the hypothalamus-pituitary unit in children suspected of hypopituitarism: who, how and when to investigate. J Endocrinol Invest 27 496-509.
396. E Nishihara, H Kimura, T Ishimaru, et al. (1997) A case of adrenal insufficiency due to acquired hypothalamic CRH deficiency. Endocr J 44 121-126.
397. JH Kyllo, MM Collins, KL Vetter, et al. (1996) Linkage of congenital isolated adrenocorticotropic hormone deficiency to the corticotropin releasing hormone locus using simple sequence repeat polymorphisms. Am J Med Genet 62 262-267.
398. S Vallette-Kasic, T Brue, AM Pulichino, et al. (2005) Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations. J Clin Endocrinol Metab 90 1323-1331.
399. J Fukata, N Shimizu, H Imura, et al. (1993) Human corticotropin-releasing hormone test in patients with hypothalamopituitary-adrenocortical disorders. Endocr J 40 597-606.
400. HK Gleeson and SM Shalet (2001) Endocrine complications of neoplastic diseases in children and adolescents. Curr Opin Pediatr 13 346-351.
401. W Arlt, U Hove, B Muller, et al. (1997) Frequent and frequently overlooked: treatment-induced endocrine dysfunction in adult long-term survivors of primary brain tumors. Neurology 49 498-506.
402. VC Prabhu and HG Brown (2005) The pathogenesis of craniopharyngiomas. Childs Nerv Syst 21 622-627.
403. I Halac and D Zimmerman (2005) Endocrine manifestations of craniopharyngioma. Childs Nerv Syst 21 640-648.
404. JG Curran and E O’Connor (2005) Imaging of craniopharyngioma. Childs Nerv Syst 21 635-639.
405. HI Hochman, DM Judge and S Reichlin (1981) Precocious puberty and hypothalamic hamartoma. Pediatrics 67 236-244.
406. SL Asa, K Kovacs, GT Tindall, et al. (1984) Cushing's disease associated with an intrasellar gangliocytoma producing corticotrophin-releasing factor. Ann Intern Med 101 789-793.
407. SL Asa, BW Scheithauer, JM Bilbao, et al. (1984) A case for hypothalamic acromegaly: a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor. J Clin Endocrinol Metab 58 796-803.
408. PA Lee (1999) Central precocious puberty: an overview of diagnosis, treatment, and outcome. Endocrinol Metab Clin North Am 28 901-918. xi
409. V De Sanctis, A Corrias, V Rizzo, et al. (2000) Etiology of central precocious puberty in males: the results of the Italian Study Group for Physiopathology of Puberty. J Pediatr Endocrinol Metab 13(suppl 1), 687-693.
410. M Cisternino, T Arrigo, AM Pasquino, et al. (2000) Etiology and age incidence of precocious puberty in girls: a multicentric study. J Pediatr Endocrinol Metab 13(suppl 1), 695-701.
411. SR Ojeda and S Heger (2001) New thoughts on female precocious puberty. J Pediatr Endocrinol Metab 14 245-256.
412. R Virdis, M Sigorini, A Laiolo, et al. (2000) Neurofibromatosis type 1 and precocious puberty. J Pediatr Endocrinol Metab 13(suppl 1), 841-844.
413. MA Rivarola, A Belgorosky, H Mendilaharzu, et al. (2001) Precocious puberty in children with tumours of the suprasellar and pineal areas: organic central precocious puberty. Acta Paediatr 90 751-756.
414. K Arita, F Ikawa, K Kurisu, et al. (1999) The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg 91 212-220.
415. C Debeneix, M Bourgeois, C Trivin, et al. (2001) Hypothalamic hamartoma: comparison of clinical presentation and magnetic resonance images. Horm Res 56 12-18.
416. SF Berkovic, F Andermann, D Melanson, et al. (1988) Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging. Ann Neurol 23 429-439.
417. JN Anasti, MR Flack, J Froehlich, et al. (1995) A potential novel mechanism for precocious puberty in juvenile hypothyroidism. J Clin Endocrinol Metab 80 276-279.
418. F Fauchon, A Jouvet, P Paquis, et al. (2000) Parenchymal pineal tumors: a clinicopathological study of 76 cases. Int J Radiat Oncol Biol Phys 46 959-968.
419. A Jouvet, G Saint-Pierre, F Fauchon, et al. (2000) Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol 10 49-60.
420. JE Baumgartner and MS Edwards (1992) Pineal tumors. Neurosurg Clin North Am 3 853-862.
421. EA Popovic and PJ Kelly (1993) Stereotactic procedures for lesions of the pineal region. Mayo Clin Proc 68 965-970.
422. SA Dahlborg, A Petrillo, JR Crossen, et al. (1998) The potential for complete and durable response in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery. Cancer J Sci Am 4 110-124.
423. M Chalumeau, W Chemaitilly, C Trivin, et al. (2002) Central precocious puberty in girls: an evidence-based diagnosis tree to predict central nervous system abnormalities. Pediatrics 109 61-67.
424. L Iughetti, B Predieri, M Ferrari, et al. (2000) Diagnosis of central precocious puberty: endocrine assessment. J Pediatr Endocrinol Metab 13(suppl 1), 709-715.
425. MI Argyropoulou and DN Kiortsis (2005) MRI of the hypothalamic-pituitary axis in children. Pediatr Radiol 35 1045-1055.
426. KO Klein, KM Barnes, JV Jones, et al. (2001) Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience. J Clin Endocrinol Metab 86 4711-4716.
427. L Tato, MO Savage, F Antoniazzi, et al. (2001) Optimal therapy of pubertal disorders in precocious/early puberty. J Pediatr Endocrinol Metab 14(suppl 2), 985-995.
428. Z Laron and R Kauli (2000) Experience with cyproterone acetate in the treatment of precocious puberty. J Pediatr Endocrinol Metab 13(suppl 1), 805-810.
429. P Feuillan, D Merke, EW Leschek, et al. (1999) Use of aromatase inhibitors in precocious puberty. Endocr Relat Cancer 6 303-306.
430. MP Warren and JL Fried (2001) Hypothalamic amenorrhea: the effects of environmental stresses on the reproductive system—a central effect of the central nervous system. Endocrinol Metab Clin North Am 30 611-629.
431. SS Yen (1993) Female hypogonadotropic hypogonadism: hypothalamic amenorrhea syndrome. Endocrinol Metab Clin North Am 22 29-58.
432. S Cannavo, L Curto and F Trimarchi (2001) Exercise-related female reproductive dysfunction. J Endocrinol Invest 24 823-832.
433. S Moschos, JL Chan and CS Mantzoros (2002) Leptin and reproduction: a review. Fertil Steril 77 433-444.
434. NI Williams, DL Helmreich, DB Parfitt, et al. (2001) Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training. J Clin Endocrinol Metab 86 5184-5193.
435. JA Hobart and DR Smucker (2000) The female athlete triad. Am Fam Physician 61 3357-3364. 3367
436. AP Goldstone (2004) Prader-Willi syndrome: advances in genetics, pathophysiology and treatment. Trends Endocrinol Metab 15 12-20.
437. AC Hackney (2001) Endurance exercise training and reproductive endocrine dysfunction in men: alterations in the hypothalamic-pituitary-testicular axis. Curr Pharm Des 7 261-273.
438. K Opstad (1994) Circadian rhythm of hormones is extinguished during prolonged physical stress, sleep and energy deficiency in young men. Eur J Endocrinol 131 56-66.
439. R Abs, J Verhelst, J Maeyaert, et al. (2000) Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab 85 2215-2222.
440. I Vanhorebeek and G Van den Berghe (2006) The neuroendocrine response to critical illness is a dynamic process. Crit Care Clin 22 1-15. v
441. BM Biller, A Luciano, PG Crosignani, et al. (1999) Guidelines for the diagnosis and treatment of hyperprolactinemia. J Reprod Med 44 1075-1084.
442. H Meierkord, S Shorvon, S Lightman, et al. (1992) Comparison of the effects of frontal and temporal lobe partial seizures on prolactin levels. Arch Neurol 49 225-230.
443. ME Molitch (1999) Diagnosis and treatment of prolactinomas. Adv Intern Med 44 117-153.
444. P Burman, EM Ritzen and AC Lindgren (2001) Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH. Endocr Rev 22 787-799.
445. BC Gohlke, VV Khadilkar, D Skuse, et al. (1998) Recognition of children with psychosocial short stature: a spectrum of presentation. J Pediatr Endocrinol Metab 11 509-517.
446. J Gilmour and D Skuse (1999) A case-comparison study of the characteristics of children with a short stature syndrome induced by stress (hyperphagic short stature) and a consecutive series of unaffected “stressed” children. J Child Psychol Psychiatry 40 969-978.
447. A Albanese, G Hamill, J Jones, et al. (1994) Reversibility of physiological growth hormone secretion in children with psychosocial dwarfism. Clin Endocrinol (Oxf) 40 687-692.
448. BB Bercu and FB Diamond Jr (1986) Growth hormone neurosecretory dysfunction. Clin Endocrinol Metab 15 537-590.
449. TH Lin, RT Kirkland, BM Sherman, et al. (1989) Growth hormone testing in short children and their response to growth hormone therapy. J Pediatr 115 57-63.
450. KM Attie (2000) Genetic studies in idiopathic short stature. Curr Opin Pediatr 12 400-404.
451. LD Voss (2001) Short normal stature and psychosocial disadvantage: a critical review of the evidence. J Pediatr Endocrinol Metab 14 701-711.
452. A Mehta and PC Hindmarsh (2002) The use of somatropin (recombinant growth hormone) in children of short stature. Paediatr Drugs 4 37-47.
453. TY Poussaint, PD Barnes, K Nichols, et al. (1997) Diencephalic syndrome: clinical features and imaging findings. AJNR Am J Neuroradiol 18 1499-1505.
454. AL Gropman, RJ Packer, HS Nicholson, et al. (1998) Treatment of diencephalic syndrome with chemotherapy: growth, tumor response, and long term control. Cancer 83 166-172.
455. KY Ho, JD Veldhuis, ML Johnson, et al. (1988) Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 81 968-975.
456. W Saeger, MJ Puchner and DK Ludecke (1994) Combined sellar gangliocytoma and pituitary adenoma in acromegaly or Cushing's disease: a report of 3 cases. Virchows Arch 425 93-99.
457. JA Posener, C DeBattista, GH Williams, et al. (2000) 24-Hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depression. Arch Gen Psychiatry 57 755-760.
458. GP Chrousos (2000) The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int J Obes Relat Metab Disord 24(Suppl 2), S50-S55.
459. P Bjorntorp and R Rosmond (2000) The metabolic syndrome: a neuroendocrine disorder? Br J Nutr 83(suppl 1), S49-S57.
460. S Wolff, R Adler, E Buskirk, et al. (1964) A syndrome of periodic hypothalamic discharge. Am J Med 36 956-967.
461. AL Albright, CG Hadjipanayis, LD Lunsford, et al. (2005) Individualized treatment of pediatric craniopharyngiomas. Childs Nerv Syst 21 649-654.
462. L Lin, J Faraco, R Li, et al. (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 365-376.
463. RM Chemelli, JT Willie, CM Sinton, et al. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 437-451.
464. KS Eriksson, O Sergeeva, RE Brown, et al. (2001) Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci 21 9273-9279.
465. C Anaclet, R Parmentier, K Ouk, et al. (2009) Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci 29 14423-14438.
466. D Gerashchenko, MD Kohls, M Greco, et al. (2001) Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat. J Neurosci 21 7273-7283.
467. TC Thannickal, RY Moore, R Nienhuis, et al. (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron 27 469-474.