Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 11, 2000, Pages 6079-6084

  Habib, Kamal E ^a,c   Weld, Katherine P ^e   Rice, Kenner C ^b   Pushkas, Judy ^e   Champoux, Maribeth ^f   Listwak, Samuel ^a   Webster, Elizabeth L ^a   Atkinson, Arthur J ^c   Schulkin, Jay ^a   Contoreggi, Carlo ^g   Chrousos, George P ^d   McCann J, Samuel M ^h   Suomi, Stephen J ^f   Higley, J Dee ^e   Gold, Philip W ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^f NIH Animal Center   (United States)

^g NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^h PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTALARMIN; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; PLACEBO;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; EXPLORATORY BEHAVIOR; GAS CHROMATOGRAPHY; HYPOPHYSIS ADRENAL SYSTEM; MALE; MASS SPECTROMETRY; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RHESUS MONKEY; SEXUAL BEHAVIOR; STRESS;

ADMINISTRATION, ORAL; ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; ARGININE VASOPRESSIN; CORTICOTROPIN-RELEASING HORMONE; DOUBLE-BLIND METHOD; DRUG EVALUATION, PRECLINICAL; EPINEPHRINE; EXPLORATORY BEHAVIOR; FEAR; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MACACA MULATTA; MALE; NOREPINEPHRINE; PITUITARY-ADRENAL SYSTEM; PYRIMIDINES; PYRROLES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEXUAL BEHAVIOR, ANIMAL; SOCIAL DOMINANCE; STRESS, PSYCHOLOGICAL;

EID: 12944262399     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.11.6079     Document Type: Article

References (49)

1. Chrousos, G. P. & Gold, P. W. (1992) J. Am. Med. Assoc. 267, 1244-1252.
2. Behan, D. P., Grigoriadis, D. E., Lovenberg, T., Chalmers, D., Heinrichs, S., Liaw, C. & De Souza, E. B. (1996) Mol. Psychiatry 1, 265-277.
3. Gold, P. W., Kling, M. A., Khan, I., Calabrese, J. R., Kalogeras, K., Post, R. M., Avgerinos, P. C., Loriaux, D. L. & Chrousos, G. P. (1987) Adv. Biochem. Psychopharmacol. 43, 183-200.
4. Ghizzoni, L., Vottero, A., Street, M. E. & Bernasconi, S. (1996) J. Clin. Endocrinol. Metab. 81, 1397-1400.
5. Barbarino, A., Corsello, S. M., Delia Casa, S., Tofani, A., Sciuto, R., Rota, C. A., Bollanti, L. & Barini, A. (1990) J. Clin. Endocrinol. Metab. 71, 1368-1374.
6. Chrousos, G. P. (1999) Am. J. Obstet. Gynecol. 180, S249-S250.
7. Charney, D. S. & Bremner, J. D. (1999) in The Neurobiology of Mental Illness, eds. Charney, D. S., Nestler, E. J. & Bunney, B. S. (Oxford Univ. Press, New York), pp. 494-517.
8. Higley, J. D., Suomi, S. J. & Linnoila, M. (1992) Biol. Psychiatry 32, 127-145.
9. Chen, Y. L. (1994) International Patent WO 9413676-A1.
10. Chen, Y. L., Mansbach, R. S., Winter, S. M., Brooks, E., Collins, J., Corman, M. L., Dunaiskis, A. R., Faraci, W. S., Gallaschun, R. J., Schmidt, A. & Schulz, D. W. (1997) J. Med. Chem. 40, 1749-1754.
11. Webster, E. L., Lewis, D. B., Torpy, D. J., Zachman, E. K., Rice, K. C. & Chrousos, G. P. (1996) Endocrinology 137, 5747-5750.
12. Bernstein, I. S., Gordon, T. P. & Rose, R. M. (1974) in Primate Aggression, Territoriality, and Xenophobia, ed. Holloway, R. L. (Academic, London), pp. 211-240.
13. Kaplan, J. R. (1986) in Behavior, Conservation and Ecology, eds. Mitchell, G. & Erwin, J. (Liss, New York), Vol. 2, Part A, pp. 455-492.
14. McKinney, W. T. (1988) in Models of Mental Disorders: A New Comparative Psychiatry, ed. McKinney, W. T. (Plenum, New York), pp. 97-124.
15. Fleishaker, J. C. & Smith, R. B. (1987) J. Clin. Pharmacol. 27, 922-926.
16. Atkinson, A. J., Jr. & Kushner, W. (1979) Annu. Rev. Pharmacol. Toxicol. 19, 105-127.
17. Vellucci, S. V. (1990) Pharmacol. Ther. 47, 167-180.
18. Higley, J. D., Hopkins, W. D., Thompson, W. W., Byrne, E. A., Hirsch, R. M. & Suomi, S. J. (1992) Dev. Psychol. 28, 1163-1171.
19. De Bellis, M. D., Gold, P. W., Geracioti, T. D., Jr., Listwak, S. J. & Kling, M. A. (1993) Am. J. Psychiatry. 150, 656-657.
20. Chrousos, G. P., Schulte, H. M., Oldfield, E. H., Gold, P. W., Cutler, G. B., Jr. & Loriaux, D. L. (1984) N. Engl. J. Med. 310, 622-626.
21. de Goeij, D. C., Kvetnansky, R., Whitnall, M. H., Jezova, D., Berkenbosch, F. & Tilders, F. J. (1991) Neuroendocrinology 53, 150-159.
22. Smith, M. A., Kling, M. A., Whitfield, H. J., Brandt, H. A., Demitrack, M. A., Geracioti, T. D., Chrousos, G. P. & Gold, P. W. (1989) Horm. Res. 31, 66-71.
23. Eisenhofer, G., Goldstein, D. S., Stull, R., Keiser, H. R., Sunderland, T., Murphy, D. L. & Kopin, I. J. (1986) Clin. Chem. 32, 2030-2033.
24. Baldwin, J. D. (1986) in Behavior, Conservation and Ecology, eds. Mitchell, G. & Erwin, J. (Liss, New York), Vol. 2, Part A, pp. 295-326.
25. Glowa, J. R. & Gold, P. W. (1991) Neuropeptides 18, 55-61.
26. Kalin, N. H. (1985) Fed. Proc. 44, 249-253.
27. Coplan, J. D., Andrews, M. W., Rosenblum, L. A., Owens, M. J., Friedman, S., Gorman, J. M. & Nemeroff, C. B. (1996) Proc. Natl. Acad. Sci. USA 93, 1619-1623.
28. Lundkvist, J., Chai, Z., Teheranian, R., Hasanvan, H., Bartfai, T., Jenck, F., Widmer, U. & Moreau, J. L. (1996) Eur. J. Pharmacol. 309, 195-200.
29. Holsboer, F. (1999) J. Psychiatr. Res. 33, 181-214.
30. Deak, T., Nguyen, K. T., Ehrlich, A. L., Watkins, L. R., Spencer, R. L., Maier, S. F., Licinio, J., Wong, M. L., Chrousos, G. P., Webster, E. & Gold, P. W. (1999) Endocrinology 140, 79-86.
31. Sanchez, M. M., Young, L. J., Plotsky, P. M. & Insel, T. R. (1999) J. Comp. Neurol. 408, 365-377.
32. Wong, M. L., Webster, E. L., Spokes, H., Phu, P., Ehrhart-Bornstein, M., Bornstein, S., Park, C. S., Rice, K. C., Chrousos, G. P., Licinio, J. & Gold, P. W. (1999) Life Sci. 65, L53-L58.
33. Bornstein, S. R., Webster, E. L., Torpy, D. J., Richman, S. J., Mitsiades, N., Igel, M., Lewis, D. B., Rice, K. C., Joost, H. G., Tsokos, M. & Chrousos, G. P. (1998) Endocrinology 139, 1546-1555.
34. Chrousos, G. P. (1995) N. Engl. J. Med. 332, 1351-1362.
35. Karanth, S., Lyson, K. & McCann, S. M. (1993) Proc. Natl. Acad. Sci. USA 90, 3383-3387.
36. Webster, E. L., Torpy, D. J., Elenkov, I. J. & Chrousos, G. P. (1998) Ann. N.Y. Acad. Sci. 840, 21-32.
37. Krause, B., Moller, S., Goretzlehner, G., Ulrich, U., Matuszewski, F., Wodrig, W. & Weber, A. (1992) Exp. Clin. Endocrinol. 99, 113-115.
38. Laatikainen, T. J. (1991) Ann. Med. 23, 489-496.
39. Theoharides, T. C., Singh, L. K., Boucher, W., Pang, X., Letourneau, R., Webster, E. & Chrousos, G. (1998) Endocrinology 139, 403-413.
40. Tache, Y., Martinez, V., Million, M. & Rivier, J. (1999) Can. J. Gastroenterol. 13, Suppl. A, 18A-25A.
41. Swiatkowski, M. & Rybakowski, J. K. (1993) J. Affective Disord. 28, 199-202.
42. Fukudo, S., Nomura, T. & Hongo, M. (1998) Gut 42, 845-849.
43. Gutkowska, J., Jankowski, M., Mukaddam-Daher, S. & McCann, S. M. (2000) Proc. Natl. Acad. Sci. USA 97, 483-488.
44. Ferry, B., Roozendaal, B. & McGaugh, J. L. (1999) Biol. Psychiatry 46, 1140-1152.
45. Liang, K. C., Chen, L. L. & Huang, T. E. (1995) Chin. J. Physiol. 38, 81-91.
46. Quirarte, G. L., Roozendaal, B. & McGaugh, J. L. (1997) Proc. Natl. Acad. Sci. USA 94, 14048-14053.
47. Gold, P. W., Goodwin, F. K. & Chrousos, G. P. (1988) N. Engl. J. Med. 319, 348-353.
48. Wong, M. L., Kling, M. A., Munson, P. J., Listwak, S., Licinio, J., Prolo, P., Karp, B., McCutcheon, I. E., Geracioti, T. D., Jr., DeBellis, M. D., et al. (2000) Proc. Natl. Acad. Sci. USA 97, 325-330.
49. Ellison, J. M. (1998) Harvard Rev. Psychiatry 6, 177-189.