Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure

Brain Research

Volumn 744, Issue 1, 1997, Pages 166-170

  Maecker, Heather ^a   Desai, Aparna ^a   Dash, Rajesh ^a   Rivier, Jean ^b   Vale, Wylie ^b   Sapolsky, Robert ^a  

^a STANFORD UNIVERSITY   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

astressin; corticotropin releasing factor (CRF) antagonist; hippocampus; neuron loss; seizure

Indexed keywords

ASTRESSIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR DERIVATIVE; EXCITOTOXIN; KAINIC ACID; NEUROPROTECTIVE AGENT; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; HISTOLOGY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

ANALYSIS OF VARIANCE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORTICOTROPIN-RELEASING HORMONE; HIPPOCAMPUS; KAINIC ACID; MALE; MICROINJECTIONS; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 0031015756     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01207-3     Document Type: Article

References (30)

1. Aldenhoff, J., Groul, D., Rivier, J., Vale, W., Siggins, G., Groul, D., Rivier, J., Vale, W. and Siggins, G., CRF decreases postburst hyperpolarizations and excites hippocampal neurons, Science, 221 (1983) 875-877.
2. Baram, T., Hirsch, E., Snead, O. and Schultz, L., Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala, Ann. Neurol., 31 (1992) 488-494.
3. Ben-Ari, Y., Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy, Neuroscience, 14 (1985) 375-389.
4. Bishop, G. and King, J., Differential modulation of Purkinje cell activity by enkephalin and CRF, Neuropeptides, 22 (1992) 167-175.
5. Cummings, S., Young, W. and King, J., Early development of cerebellar afferent systems that contain CRF, J. Comp. Neurol., 350 (1994) 534-540.
6. Ehlers, C., Henrikson, S., Wang, M., Rivier, J., Vale, W. and Bloom, F., CRF produces increases in brain excitability and convulsive seizures in rats, Brain Res., 278 (1983) 332-337.
7. Feibel, J., Hardi, P., Campbell, M., Goldstein, N. and Joynt, R., Prognostic value of the stress response following stroke, J. Am. Med. Assoc., 238 (1977) 1374-1379.
8. Freund, T., Buzsáki, G., Leon, A., Baimbridge, K. and Somogyi, P., Relationship of neuronal vulnerability and calcium binding protein immunoreactivity in ischemia, Exp. Brain Res., 83 (1990) 55-61.
9. Gulyas, K., Rivier, C., Perrin, M., Koerber, S., Sutton, S., Corrigan, A., Lahrich, S., Craig, A., Vale, W. and Rivier, J., Potent, structually constrained agonists and competitive antagonists of corticotropin-releasing factor, Proc. Natl. Acad. Sci. USA, 92 (1995) 10575-10579.
10. Hoffman, W., Pellegrino, D., Werner, C., Kochs, E., Albrecht, R. and Schulte, J., Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats, Anesthesiology, 76 (1992) 755-762.
11. Koide, T., Wieloch, T. and Siesjö, B., Circulating catecholamines modulate ischemic brain damage, J. Cereb. Blood Flow Metab., 6 (1986) 559-565.
12. Lyons, M., Anderson, R. and Meyer, F., Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury, Brain Res., 545 (1991) 339-342.
13. Madtes, P. and King, J., Distribution of CRF binding sites in the opossum cerebellum, Neuropeptides, 28 (1995) 51-58.
14. Marrosu, F., Fratta, W., Carcangiu, P., Giaheddu, M. and Gessa, G., Localised epileptiform activity induced by murine CRF in rats, Epilepsia, 29 (1988) 369-375.
15. Michenfelder, J., Milde, J. and Sundt, T., Cerebral protection by barbiturate anesthesia, Arch. Neurol., 33 (1976) 345-352.
16. Ribak, C. and Baram, T., Selective death of hippocampal CA3 pyramidal cells with mossy fiber afferents after CRH-induced status epilepticus in infant rats, Dev. Brain Res., 91 (1996) 245-251.
17. Sapolsky, R., Glucocorticoids and damage to the central nervous system: the current state of confusion, Stress, (1996) in press.
18. Sapolsky, R. and Stein, B., Status epilepticus-induced hippocampal damage is modulated by glucose availability, Neurosci. Lett., 97 (1988) 157-164.
19. Shu, C., Hoffman, W., Thomas, C. and Albrecht, R., Sympathetic activity enhances glucose-related ischemic injury in the rat, Anesthesiology, 78 (1993) 1120-1125.
20. Siggins, G., Gruol, D., Aldenhoff, J. and Pittman, Q., Electrophysiological actions of CRF in the central nervous system, Fed. Proc., 44 (1985) 237-245.
21. Standefer, M. and Little, J., Improved neurological outcome in experimental focal cerebral ischemia treated with propranolol, Neurosurgery, 18 (1986) 136-140.
22. Stein-Behrens, B., Mattson, M., Chang, I., Yeh, M. and Sapolsky, R., Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus, J. Neurosci., 14 (1994) 5373-5380.
23. Strijbos, P., Relton, J. and Rothwell, N., Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain, Brain Res., 656 (1994) 405-408.
24. Thomas, H., Ling, N. and Wei, E., CRF and related peptides as anti-inflammatory agonists, Ann. NY Acad. Sci., 697 (1993) 219-228.
25. Vale, W., Speiss, J., Rivier, C. and Rivier, J., Characterization of a 41 residue ovine hypothalamic peptide that stimulates the secretion of corticotrophin and β-endorphin, Science, 813 (1981) 1394-1397.
26. Vale, W., Rivier, C., Brown, M., Spiess, J., Koob, G., Swanson, L., Bilezikjian, L., Bloom, F. and Rivier, J., Chemical and biological characterization of corticotropin releasing factor, Rec. Prog. Horm. Res., 39 (1983) 245-270.
27. Wei, E. and Gao, G., Corticotropin-releasing factor: an inhibitor of vascular leakage in rat skeletal muscle and brain cortex after injury, Regul. Peptides, 33 (1991) 93-104.
28. Wei, E. and Thomas, H., Correlation of neuroendocrine and antiedema activities of alanine-corticotropin-releasing factor analogs, Eur. J. Pharmacol., 263 (1994) 319-321.
29. Werner, C., Hoffman, W., Thomas, C., Miletich, D. and Albrecht, R., Ganglionic blockade improves neurologic outcome from incomplete ischemia in rats: partial reversal by exogenous catecholamines, Anesthesiology, 73 (1990) 923-929.
30. Wong, M., Loddick, S., Bongiorno, P., Gold, P., De Souza, E., Licinio, J. and Rothwell, N., Is CRH neurotoxic during focal cerebral ischemia? Soc. Neurosci. Abstr., 21 (1995) 94.12.