Hypogonadotropic hypogonadism

Endocrinology and Metabolism Clinics of North America

Volumn 27, Issue 4, 1998, Pages 739-763

  Hayes, F J ^a   Seminara, S B ^a   Crowley W F , Jr ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CONJUGATED ESTROGEN; DISULFIDE; DNA; ETHINYLESTRADIOL; FIBRONECTIN; FOLLITROPIN; GESTAGEN; GONADORELIN; GONADOTROPIN; HUMAN MENOPAUSAL GONADOTROPIN; LUTEINIZING HORMONE; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; NEUROPHYSIN; RECOMBINANT FOLLITROPIN; SEX HORMONE; STERYL SULFATASE; TESTOSTERONE; TESTOSTERONE CIPIONATE; TESTOSTERONE ENANTATE; TESTOSTERONE ESTER; TRIAMCINOLONE;

CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; FEMALE; GENE; GONADOTROPIN RELEASE; HORMONE DEFICIENCY; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KALLMANN SYNDROME; MALE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN IRRITATION; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0031647685     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8529(05)70039-6     Document Type: Article

References (94)

1. J.M. Adams A.E. Taylor D.A. Schoenfeld The midcycle gonadotropin surge in normal women occurs in the face of an unchanging gonadotropin-releasing hormone pulse frequency J Clin Endocrinol Metab 79 1994 858
2. M. Alen M. Reinila R. Vihko Response of serum hormones to androgen administration in power athletes Med Sci Sports 17 1985 354
3. D. Apter B. Cacciatore H. Alfthan Serum luteinizing hormone concentrations increase 100-fold in females from 7 years to adulthood, as measured by time-resolved immunofluorometric assay J Clin Endocrinol Metab 68 1989 53
4. A. Arimura A.A.J. Kastin D. Gonzales-Barcena Disappearance of LHRH in man as determined by radioimmunoassay Clin Endocrinol 3 1974 421
5. C.J. Bagatell W.J. Bremner Sperm counts and reproductive hormones in male marathoners and lean controls Fertil Steril 53 1990 688
6. A. Ballabio B. Bardoni R. Carrozzo Contiguous gene syndromes due to deletions in the distal short arm of the human X chromosome Proc Natl Acad Sci USA 86 1989 10001
7. J.A. Bartley D.K. Miller J.T. Hayford Concordance of X-linked glycerol kinase deficiency with X-linked congenital adrenal hypoplasia Lancet 2 1982 733
8. A. Bauman Markedly delayed puberty or Kallmann's syndrome variant J Androl 7 1986 224
9. I.Z. Beitins M.L. Dufau K. O'Loughlin Analysis of biological and immunological activities in the two pools of LH released during constant infusion of luteinizing hormone-releasing hormone (LHRH) in men J Clin Endocrinol Metab 45 1977 605
10. M. Berezin R. Weissenberg O. Rabinovitch Successful GnRH treatment in a patient with Kallmann's syndrome, who previously failed hMG/hCG therapy Andrologia 20 1988 285
11. S.L. Berga L.G. Girton The psychoneuroendocrinology of functional hypothalamic amenorrhea Psychiatr Clin North Am 12 1989 105
12. D. Bick B. Franco R.J. Sherins Intragenic deletion of the KALIG-1 gene in Kallmann's syndrome N Engl J Med 326 1992 1752
13. R. Birnbacher K. Wandl-Vergesslich H. Frisch Diagnosis of X-recessive Kallmann syndrome in early infancy: Evidence of hypoplastic rhinencephalon Eur J Pediatr 153 1994 245
14. R.M. Boyar R.S. Rosenfeld S. Kapen Human puberty: Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep J Clin Invest 54 1974 609
15. R.M. Boyar R.H.K. Wu S. Kapen Clinical and laboratory heterogeneity in idiopathic hypogonadotropic hypogonadism J Clin Endocrinol Metab 43 1976 1268
16. A.S. Burris H.W. Rodbard S.J. Winters Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size J Clin Endocrinol Metab 66 1988 1144
17. R.H. Castillo R.L. Matteri D.A. Dumesic Luteinizing hormone synthesis in cultured fetal human pituitary cells exposed to gonadotropin-releasing hormone J Clin Endocrinol Metab 75 1992 318
18. I.J. Clark J.T. Cummins The temporal relationship between gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes Endocrinology 111 1982 1737
19. S.J. Clark B.P. Hauffa K.P. Rodens Hormone ontogeny in the ovine fetus. XIX. The effect of a potent luteinizing hormone-releasing factor agonist on gonadotropin and testosterone release in the fetus and neonate Pediatr Res 25 1989 347
20. M. Cohen-Salmon F. Tronche del Castillo I. Characterization of the promoter of the human KAL gene, responsible for the X-chromosome-linked Kallmann syndrome Gene 164 1995 235
21. L.S. Constine P.D. Woolf D. Cann Hypothalamic-pituitary dysfunction after radiation for brain tumors N Engl J Med 328 1993 87
22. Crowley W.F. Jr M. Filicori D. Spratt The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women Recent Prog Horm Res 41 1985 473
23. de Morsier G. Etudes sur les dysraphies cranio-encephaliques. 1. Agenesie des lobes olfactifs (telencephaloschizis lateral) et des comissures calleuse et anterieure (telencephaloschizis median). La dysplasie olfacto-genitale Schweiz Arch Neurol Neurochir Psychiatr 74 1954 309
24. de Roux N. J. Young M. Misrahi A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor N Engl J Med 337 1997 1597
25. J. Drenth B.W. Low J.S. Richardson The toxin-agglutinin fold: A new group of small protein structures organized around a four-disulfide core J Biol Chem 255 1980 2652
26. G.M. Edelman K.L. Crossin Cell adhesion molecules: Implications for a molecular histology Annu Rev Biochem 60 1991 155
27. M. Filicori J.P. Butler Crowley W.F. Jr Neuroendocrine regulation of the corpus luteum in the human: Evidence for pulsatile progesterone secretion J Clin Invest 73 1984 1638
28. G. Filippi Klinefelter's syndrome in Sardinia: Clinical report of 265 hypogonadic males detected at the time of military check-up Clin Genet 30 1986 276
29. J.S. Finkelstein D.I. Spratt L. O'Dea Pulsatile gonadotropin secretion after discontinuation of long term gonadotropin-releasing hormone (GnRH) administration in a subset of GnRH-deficient men J Clin Endocrinol Metab 69 1989 377
30. B. Franco S. Guioli A. Pragliola A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules Nature 353 1991 529
31. M. Fromantin J. Gineste A. Didier Les impuberismes et les hypogonadismes a l'incorporation Probl Actuels Endocrinol Nutr 16 1972 179
32. N.A. Georgopoulos F.P. Pralong C.E. Seidman Genetic heterogeneity evidenced by low incidence of KAL-1 gene mutations in sporadic cases of gonadotropin-releasing hormone deficiency J Clin Endocrinol Metab 82 1997 213
33. M.M. Grumbach S.L. Kaplan The neuroendocrinology of human puberty: An ontogenetic perspective Grumbach M.M. Sizonenko P.C. Aubert M.L. Control of the Onset of Puberty 1990 Williams & Wilkins Baltimore 1
34. R.L. Habiby P. Boepple L. Nachtigall Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: Evidence that DAX-1 mutations lead to combined hypothalamic and pituitary defects in gonadotropin production J Clin Invest 98 1996 1055
35. J.E. Hall R.W. Whitcomb J.E. Rivier Differential regulation of luteinizing hormone, follicle-stimulating hormone, and free α-subunit from the gonadotrope by gonadotropin-releasing hormone (GnRH): Evidence from the use of two GnRH antagonists J Clin Endocrinol Metab 70 1990 328
36. J.E. Hall D.A. Schoenfeld K.A. Martin Hypothalamic gonadotropin-releasing hormone secretion and follicle-stimulating hormone dynamics during the luteal-follicular transition J Clin Endocrinol Metab 74 1992 600
37. D.J. Handelsman M.A. Mackey C. Howe An analysis of testosterone implants for androgen replacement therapy Clin Endocrinol 47 1997 311
38. J.P. Hardelin J. Levilliers J. Young Xp22.3 deletions in isolated familial Kallmann's syndrome J Clin Endocrinol Metab 76 1993 827
39. J.P. Hardelin J. Levilliers S. Blanchard Heterogeneity in the mutations responsible for X chromosome–linked Kallmann syndrome Hum Mol Genet 2 1993 373
40. Hoffman A.R. Crowley W.F. Jr Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone N Engl J Med 307 1982 1237
41. R.I. Jakacki R.P. Kelch S.E. Sauder Pulsatile secretion of luteinizing hormone in children J Clin Endocrinol Metab 55 1982 453
42. F.J. Kallmann W.A. Schoenfeld The genetic aspects of primary eunuchoidism Am J Ment Retard 158 1944 203
43. S.L. Kaplan M.M. Grumbach The ontogenesis of human foetal hormones. II. Luteinizing hormone (LH) and follicle stimulating hormone Acta Endocrinol 81 1976 808
44. A. Klibanski I.Z. Beitins T. Badger Reproductive function during fasting in men J Clin Endocrinol Metab 53 1981 258
45. S. Kliesch H.M. Behre E. Nieschlag Recombinant human follicle-stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadotropic male Fertil Steril 63 1995 1326
46. E. Lalli B. Bardoni E. Zazopoulos A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita Mol Endocrinol 11 1997 1950
47. K.S.L. Lam V.K.C. Tse C. Wang Effects of cranial irradiation on hypothalamic-pituitary function—a 5 year longitudinal study in patients with nasopharyngeal carcinoma Q J Med 78 1991 165
48. G.A. Laughlin C.E. Dominguez S.S.C. Yen Nutritional and endocrine-metabolic aberrations in women with functional hypothalamic amenorrhea J Clin Endocrinol Metab 83 1998 25
49. L.C. Layman K.D. Lanclos J.T. Wilson Gonadotropin-releasing hormone, follicle-stimulating hormone beta, luteinizing hormone beta gene structure in idiopathic hypogonadotropic hypogonadism Fertil Steril 57 1992 42
50. L.C. Layman D.P. Cohen M. Jin Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism Nat Genet 18 1998 14
51. R. Legouis J. Hardelin J. Levilliers The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules Cell 67 1991 423
52. R. Legouis C. Ayer-LeLievre M. Leibovici Expression of the KAL gene in multiple neuronal sites during chicken development Proc Natl Acad Sci USA 90 1993 2461
53. J.N. Levine K.Y.F. Pau V.D. Ramirez Simultaneous measurement of luteinizing hormone releasing hormone and luteinizing hormone release in unanaesthetized, ovariectomized sheep Endocrinology 111 1982 1449
54. B. Mannaerts B. Fauser N. Lahlou Serum hormone concentrations during treatment with multiple rising doses of recombinant follicle stimulating hormone (Puregon) in men with hypogonadotropic hypogonadism Fertil Steril 65 1996 406
55. K. Martin N. Santoro J. Hall Management of ovulatory disorders with pulsatile gonadotropin-releasing hormone J Clin Endocrinol Metab 71 1990 1081A
56. K.A. Martin J.E. Hall J.M. Adams Comparison of exogenous gonadotropins and pulsatile gonadotropin-releasing hormone for induction of ovulation in hypogonadotropic amenorrhea J Clin Endocrinol Metab 77 1993 125
57. A. Mason S.L. Pitts K. Nikolics The hypogonadal mouse: Reproductive functions restored by gene therapy Science 234 1986 1372
58. E.M. McColl G.D. Wheeler P. Gomes The effects of acute exercise on pulsatile LH release in high-mileage male runners Clin Endocrinol (Oxf) 31 1989 617
59. W.A. Meikle S. Arver A.S. Dobs Pharmacokinetics and metabolism of a permeation enhanced testosterone transdermal system in hypogonadal men: Influence of application site—a clinical research study J Clin Endocrinol Metab 81 1996 1832
60. T. Meitinger B. Heye C.J. Petit Definitive localization of X-linked Kallmann syndrome (hypogonadotropic hypogonadism and anosmia) to Xp22.3: Close linkage to the hypervariable repeat sequence CRI-S232 Am J Hum Genet 47 1990 664
61. L.B. Nachtigall P.A. Boepple F.P. Pralong Adult-onset idiopathic hypogonadotropic hypogonadism—a treatable form of male infertility N Engl J Med 336 1997 410
62. Y. Nakayama F.E. Wondisford R.W. Lash Analysis of gonadotropin-releasing hormone gene structure in families with familial central precocious puberty and idiopathic hypogonadotropic hypogonadism J Clin Endocrinol Metab 70 1990 1233
63. G. Parenti M.G. Rizzolo M. Ghezzi Variable penetrance of hypogonadism in a sibship with Kallmann syndrome due to a deletion of the KAL gene Am J Med Genet 57 1995 476
64. B. Pimstone S. Epstein S.M. Hamilton Metabolic clearance and plasma half-disappearance time of exogenous gonadotropin-releasing hormone in normal subjects and in patients with liver disease and chronic renal failure J Clin Endocrinol Metab 44 1977 356
65. R. Quinton V.M. Duke de Zoysa P.A. The neuroradiology of Kallmann's syndrome: A genotypic and phenotypic analysis J Clin Endocrinol Metab 81 1996 3010
66. A.D. Rogol K.K. Mittal B.J. White HLA-compatible paternity in two “fertile eunuchs” with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome) J Clin Endocrinol Metab 51 1980 275
67. E.I. Rugarli B. Lutz S.C. Kuratani Expression pattern of the Kallmann syndrome gene in the olfactory system suggests a role in neuronal targeting Nat Genet 4 1993 19
68. A. Ruokonen M. Alen N. Bolton Response of serum testosterone and its precursor steroids, SHBG and CBG to anabolic steroid and testosterone self-administration in man J Steroid Biochem 23 1985 33
69. W. Saal J. Happ U. Cordes Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism Fertil Steril 56 1991 319
70. R.J. Santen C.A. Paulsen Hypogonadotropic eunuchoidism. I. Clinical study of the mode of inheritance J Clin Endocrinol Metab 36 1973 47
71. N. Santoro M. Filicori Crowley W.F. Jr Hypogonadotropic disorders in men and women: Diagnosis and therapy with pulsatile gonadotropin-releasing hormone Endocr Rev 7 1986 11
72. J. Schopohl T. Eversmann G. Mehltretter Comparison of gonadotropin-releasing hormone and gonadotropin therapy in male patients with idiopathic hypothalamic hypogonadism Fertil Steril 56 1991 1143
73. J.D. Schwankhaus J. Currie M.J. Jaffe Neurologic findings in men with isolated hypogonadotropic hypogonadism Neurology 39 1989 223
74. M. Schwanzel-Fakuda D. Bick D.W. Pfaff Luteinizing hormone-releasing hormone (LHRH)–expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome Mol Brain Res 6 1989 311
75. A.G.H. Smals P.W.C. Kloppenborg van Haelst U.J.G. Fertile eunuch syndrome versus classic hypogonadotropic hypogonadism Acta Endocrinol 87 1978 389
76. V. Snegovskaya A. Viru Steroid and pituitary hormone responses to rowing: Relative significance of exercise intensity and duration and performance level Eur J Appl Physiol 67 1993 59
77. Spratt D.I. Crowley W.F. Jr J.P. Butler Pituitary luteinizing hormone responses to intravenous and subcutaneous administration of gonadotropin-releasing hormone in men J Clin Endocrinol Metab 61 1985 890
78. D.I. Spratt D.B. Carr G.R. Merriam The spectrum of abnormal patterns of gonadotropin-releasing hormone secretion in men with idiopathic hypogonadotropic hypogonadism: Clinical and laboratory correlations J Clin Endocrinol Metab 64 1987 283
79. D.I. Spratt L.S.L. O'Dea D. Schoenfeld Neuroendocrine-gonadal axis in men: Frequent sampling of LH, FSH, and testosterone Am J Physiol 254 1988 E658
80. G. Stetler M.T. Brewer R.C. Thompson Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases Nucleic Acids Res 14 1986 7883
81. D.M. Styne Puberty and its disorders in boys Endocrinol Metab Clin North Am 20 1991 43
82. C.L. Truwit A.J. Barkovich M.M. Grumbach MR imaging of Kallmann syndrome, a genetic disorder of neuronal migration affecting the olfactory and genital systems Am J Neuroradiol 14 1993 827
83. Van Dop C. S. Burstein F. Conte Isolated gonadotropin deficiency in boys: Clinical characteristics and growth J Pediatr 111 1987 684
84. J.D. Veldhuis A. Iranmanesh W.S. Evans Amplitude suppression of the pulsatile mode of immunoradiometric luteinizing hormone release in fasting-induced hypoandrogenemia in normal men J Clin Endocrinol Metab 76 1993 587
85. F. Waldhauser G. Weissenbacher H. Frisch Pulsatile secretion of gonadotropins in early infancy Eur J Pediatr 137 1981 71
86. J. Waldstreicher S.B. Seminara J.L. Jameson The genetic and clinical heterogeneity of gonadotropin-releasing hormone deficiency in the human J Clin Endocrinol Metab 81 1996 4388
87. M.P. Warren The effects of exercise on pubertal progression and reproductive function in girls J Clin Endocrinol Metab 51 1980 1150
88. Weiss J. Crowley W.F. Jr J.L. Jameson Normal structure of the gonadotropin-releasing hormone (GnRH) gene in patients with GnRH deficiency and idiopathic hypogonadotropic hypogonadism J Clin Endocrinol Metab 69 1989 299
89. G.D. Wheeler S.R. Wall A.N. Belcastro Reduced serum testosterone and prolactin levels in male distance runners JAMA 252 1984 514
90. Whitcomb R.W. Crowley W.F. Jr Diagnosis and treatment of isolated gonadotropin-releasing hormone deficiency in men J Clin Endocrinol Metab 70 1990 3
91. R.W. Whitcomb L.S. O'Dea J.S. Finkelstein Utility of free alpha-subunit as an alternative neuroendocrine marker of gonadotropin-releasing hormone (GnRH) stimulation of the gonadotroph in the human: Evidence from normal and GnRH-deficient men J Clin Endocrinol Metab 70 1990 1654
92. J.N. Wiemann D.K. Clifton R.A. Steiner Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat Endocrinology 124 1989 1760
93. S. Wray P. Grant H. Gainer Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode Proc Natl Acad Sci USA 86 1989 8132
94. F.C.W. Wu G.E. Butler C.J.H. Kelnar Ontogeny of pulsatile gonadotropin releasing hormone secretion from midchildhood, through puberty, to adulthood in the human male: A study using deconvolution analysis and an ultrasensitive immunofluorometric assay J Clin Endocrinol Metab 81 1996 1798