Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth

Journal of Clinical Investigation

Volumn 107, Issue 12, 2001, Pages 1571-1580

  Low, M J ^a   Otero Corchon, V ^a   Parlow, A F ^a   Ramirez, J L ^a   Kumar, U ^a   Patel, Y C ^a   Rubinstein, M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; MESSENGER RNA; SOMATOSTATIN; SOMATOSTATIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BODY GROWTH; BODY HEIGHT; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE RELEASE; HYPOPHYSIS; HYPOTHALAMUS; KNOCKOUT MOUSE; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0034968209     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11941     Document Type: Article

References (41)

1. Genesis of the ultradian rhythm of GH secretion: A new model unifying experimental observations in rats
2. A new orphan receptor involved in pulsatile growth hormone release
3. Patterns of growth hormone-releasing factor and somarostatin secretion into the hypophysial-portal circulation of the rat
4. Sexual dimorphism in the control of growth hormone secretion
5. Regulatory mechanisms of growth hormone secretion are sexually dimorphic
6. Sexual dimorphism and testosterone-dependent regulation of somatostatin gene expression in the periventricular nucleus of the rat brain
7. Correlation of hypothalamic somatostatin mRNA expression and peptide content with secretion: Sexual dimorphism and differential regulation by gonadal factors
8. Sex differentiation of growth hormone-releasing hormone and somatostatin neurons in the mouse hypothalamus: An immunohistochemical and morphological study
9. Ontogeny and sexual differentiation of somatostatin biosynthesis and secretion in the hypothalamic periventricular-median eminence pathway
10. Somatostatin and its receptor family
11. Sexually dimorphic expression of sst1 and sst2 somatostatin receptor subtypes in the arcuate nucleus and anterior pituitary of adult rats
12. Chronic treatment with estrogen up-regulates expression of sst2 messenger ribonucleic acid (mRNA) but down-regulates expression of sst5 mRNA in rat pituitaries
13. Gonadal regulation of somatostatin receptor 1, 2 and 3 mRNA levels in the rat anterior pituitary
14. Short-term adult exposure to estradiol feminizes the male pattern of spontaneous and growth hormone-releasing factor-stimulated growth hormone secretion in the rat
15. Single exposure to testosterone in adulthood rapidly induces regularity in the growth hormone release process
16. Differential expression in male and female mouse liver of very similar mRNAs specified by two group 1 major urinary protein genes
17. Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes
18. Interpulse interval in circulating growth hormone patterns regulates sexully dimorphic expression of hepatic cytochrome P450
19. Requirements of STAT5b for sexual dimorphism of body growth rates and liver gene expression
20. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
21. STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression
22. STAT5 signaling in sexually dimorphic gene expression and growth patterns
23. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption
24. Hormonal regulation of liver cytochrome P450 enzymes
25. Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons
26. Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs
27. Tissue-specific posttranslational processing of preprosomatostatin encoded by a metallothionein-somarostatin fusion gene in transgenic mice
28. Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker
29. Prosomatostatin-specific antigen in rat brain: Localization by immunocytochemical staining with an antiserum to a synthetic sequence of preprosomarostatin
30. Growth hormone-releasing hormone peptide and mRNA are overexpressed in GH-deficient Ames dwarf mice
31. Expression of the five somatostatin receptor (STR1-5) subtypes in rat pituitary somatotrophes: Quantitative analysis by double-layer immuno-fluorescence confocal microscopy
32. Differential regulation of somatostatin receptor types 1-5 in rat aorta after angioplasty
33. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse
34. Developmental action of estrogen receptor-alpha feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver
35. Sex differences in the ultradian pattern of plasma growth hormone concentrations in mice
36. Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver
37. Characterization and regulation of sex-specific mouse steroid hydroxylase genes
38. Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor 1 levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly
39. Extrahypothalamic growth-hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: Plasma GRF levels in 177 acromegalic patients
40. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice
41. Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice