The GnRH promoter: Target of transcription factors, hormones, and signaling pathways

Molecular and Cellular Endocrinology

Volumn 140, Issue 1-2, 1998, Pages 151-155

  B Nelson, Shelley ^a   A Eraly, Satish ^a   L Mellon, Pamela ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gene expression; Gonadotropin releasing hormone; POU homeodomain

Indexed keywords

GONADORELIN; TRANSCRIPTION FACTOR;

CONFERENCE PAPER; HORMONAL REGULATION; HYPOTHALAMUS; PRIORITY JOURNAL;

ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GONADOTROPIN-RELEASING HORMONE; HORMONES; HUMANS; OCTAMER TRANSCRIPTION FACTOR-6; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0032565741     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(98)00043-4     Document Type: Conference Paper

References (22)

1. Bruder J.M., Spaulding A.J., Wierman M.E. Phorbol ester inhibition of rat gonadotropin-releasing hormone promoter activity: role of fos and jun in the repression of transcription. Mol. Endocrinol. 10:1996;35-44.
2. Chandran U.R., Attardi B., Friedman R., Zheng Z., Roberts J.L., DeFranco D.B. Glucocorticoid repression of the mouse gonadotropin-releasing hormone gene is mediated by promoter elements that are recognized by heteromeric complexes containing glucocorticoid receptor. J. Biol. Chem. 271:1996;20412-20420.
3. Clark M.E., Mellon P.L. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol. Cell. Biol. 15:1995;6169-6177.
4. Dong K.-W., Yu K.-L., Roberts J.L. Identification of a major up-stream transcription start site for the human progonadotropin-releasing hormone gene used in reproductive tissues and cell lines. Mol. Endocrinol. 7:1993;1654-1666.
5. Dong K.W., Duval P., Zeng Z., Gordon K., Williams R.F., Hodgen G.D., Jones G., Kerdelhue B., Roberts J.L. Multiple transcription start sites for the GnRH gene in rhesus and cynomolgus monkeys: a non-human primate model for studying GnRH gene regulation. Mol. Cell. Endocrinol. 117:1996;121-130.
6. Dong K.-W., Yu K.-L., Chen Z.-G., Chen Y.-D., Roberts J.-L. Characterization of multiple promoters directing tissue-specific expression of the human gonadotropin-releasing hormone gene. Endocrinology. 138:1997;2754-2762.
7. Eraly S.A., Mellon P.L. Regulation of GnRH transcription by protein kinase C is mediated by evolutionarily conserved, promoter-proximal elements. Mol. Endocrinol. 9:1995;848-859.
8. Eraly S.A., Nelson S.B., Huang K.M., Mellon P.L. Oct-1 binds promoter elements required for transcription of the gonadotrophin-releasing hormone gene. Mol. Endocrinol. 12:1998;469-481.
9. Kepa J.K., Neeley C.I., Jacobsen B.M., Bruder J.M., McDonnell D.P., Leslie K.K., Wierman M.E. Estrogen receptor mediated repression of rat gonadotropin releasing hormone (GnRH) promoter activity in hypothalamic cells. Endocrine. 2:1994;947-956.
10. Kepa J.K., Jacobsen B.M., Boen E.A., Prendergast P., Edwards D.P., Takimoto G., Wierman M.E. Direct binding of progesterone receptor to nonconsensus DNA sequences represses rat GnRH. Mol. Cell. Endocrinol. 117:1996;27-39.
11. Lawson M.A., Whyte D.B., Mellon P.L. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol. Cell. Biol. 16:1996;3596-3605.
12. Lei Z.M., Rao C.V. Novel presence of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and the down-regulating action of hCG on gonadotropin-releasing hormone gene expression in immortalized hypothalamic GT1-7 neurons. Mol. Endocrinol. 8:1994;111-1121.
13. Lei Z., Rao C.V. cis-acting elements and trans-acting proteins in the transcriptional inhibition of gonadotropin-releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons. J. Biol. Chem. 272:1997;14365-14371.
14. Liposits Z., Merchenthaler I., Wetsel W.C., Reid J.J., Mellon P.L., Weiner R.I., Negro-Vilar A. Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone. Endocrinology. 129:1991;1575-1583.
15. Mellon P.L., Windle J.J., Goldsmith P., Pedula C., Roberts J., Weiner R.I. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 5:1990;1-10.
16. Radovick, S., Wray, S., Lee, E., Nicols, D.K., Nakayama, Y., Weintraub, B.D., Westphal, H., Cutler, J., G. B., Wondisford, F.E., 1991. Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 3402-3406.
17. Wetsel W.C., Valença M.M., Merchenthaler I., Liposits Z., López F.J., Weiner R.I., Mellon P.L., Negro-Vilar A. Intrinsic pulsatile secretory activity of immortalized LHRH secreting neurons. Proc. Natl. Acad. Sci. USA. 89:1992;4149-4153.
18. Whyte D.B., Lawson M.A., Belsham D.D., Eraly S.A., Bond C.T., Adelman J.P., Mellon P.L. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol. Endocrinol. 9:1995;467-477.
19. Wierman M.E., Xiong X., Kepa J.K., Spaulding A.J., Jacobsen B.M., Fang Z., Nilaver G., Ojeda S.R. Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP/Oct-6/Tst-1: a regulatory mechanism of phenotype expression? Mol. Cell. Biol. 17:1997;1652-1665.
20. Wray S., Grant P., Gainer H. Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode. Proc. Natl. Acad. Sci. USA. 86:1989;8132-8136.
21. Zakaria M., Dunn I.C., Zhen S., Su E., Smith E., Patriquin E., Radovick S. Phorbol ester regulation of the gonadotropin-releasing hormone (GnRH) gene in GnRH-secreting cell lines: a molecular basis for species differences. Mol. Endocrinol. 10:1996;1282-1291.
22. Zhen S., Zakaria M., Wolfe A., Radovick S. Regulation of gonadotropin-releasing hormone (GnRH) gene expression by insulin-like growth factor 1 in a cultured GnRH-expressing neuronal cell line. Mol. Endocrinol. 11:1997;1145-1155.