Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

Nature Genetics

Volumn 24, Issue 4, 2000, Pages 403-409

  Coste, Sarah C ^a   Kesterson, Robert A ^c   Heldwein, Kurt A ^a   Stevens, Susan L ^a   Heard, Amanda D ^a   Hollis, Jacob H ^a   Murray, Susan E ^a   Hill, Jennifer K ^a   Pantely, George A ^b   Hohimer, Alan R ^b   Hatton, Daniel C ^b   Phillips, Tamara J ^b,d   Finn, Deborah A ^b   Low, Malcolm J ^b   Rittenberg, Marvin B ^a   Stenzel, Peter ^a,b   Stenzel Poore, Mary P ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR;

ADAPTATION; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN RELEASE; EMBRYO; FEMALE; HEMODYNAMICS; HORMONAL REGULATION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRESS;

ADAPTATION, PHYSIOLOGICAL; ADAPTATION, PSYCHOLOGICAL; ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANOREXIA; CARDIOVASCULAR SYSTEM; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; EATING; ECHOCARDIOGRAPHY; EXPLORATORY BEHAVIOR; FEMALE; GENE TARGETING; GROOMING; HEART RATE; HYPERTENSION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MICE; MICE, KNOCKOUT; PITUITARY-ADRENAL SYSTEM; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRESS; VENTRICULAR FUNCTION, LEFT;

ANIMALIA; RODENTIA;

EID: 0034087469     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/74255     Document Type: Article

References (29)

1. Vale, W., Speiss, J., Rivier, C. & Rivier, J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science 213, 1394-1397 (1981).
2. Sutton, R.E., Koob, G.F., Moal, M.L., Rivier, J. & Vale, W. Corticotropin-releasing factor produces fear-enhancing behavioral activation in rats. J. Neurosci. 10, 175-183 (1982).
3. Vaughan, J. et al Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378, 287-292 (1995).
4. Stenzel, P. et al. Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol. Endocrinol. 9, 637-645 (1995).
5. Chen, R., Lewis, K., Perrin, M. & Vale, W.W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc. Natl Acad. Sci. USA 90, 8967-8971 (1993).
6. Chalmers, D.T., Lovenberg, T.W. & DeSouza, E.B. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J. Neurosci. 15, 6340-6350 (1995).
7. Timpl, P. et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor. Nature Genet. 19, 162-166 (1998).
8. Smith, G.W. et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20, 1093-1102 (1998).
9. Heldwein, K.A., Redick, D.L., Rittenberg, M.B., Claycomb, W.C. & Stenzel-Poore, M.P. Corticotropin-releasing hormone receptor expression and functional coupling in neonatal cardiac myocytes and AT-1 cells. Endocrinology 137, 3631-3639 (1996).
10. Parkes, D., Rivest, S., Lee, S., Rivier, C. & Vale, W. Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus. Mol. Endo. 7, 1357-1367 (1993).
11. Ono, N., Bedran, D.E., Castro, J.C. & McCann, S.M. Ultrashort-loop positive feedback of corticotropin (ACTH)-releasing factor to enhance ACTH release in stress. Proc. Natl Acad. Sci. USA 82, 3528-3531 (1985).
12. Bale, T.L. et al. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nature Genet. 24, 410-414 (2000).
13. Liebsch, G., Landgraf, R., Engelmann, M., Lorscher, P. & Holsboer, F. Differential behavioral effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain. J. Psychiatr. Res. 33, 153-163 (1999).
14. Spruijt, B.M., van Hooff, J.A.R.A.M. & Gispen, W.H. Ethology and neurobiology of grooming behavior. Physiol. Rev. 72, 825-852 (1992).
15. McEwen, B.S. Stress, adaptation and disease: allostasis and allostatic load. Ann. NY Acad. Sci. 840, 33-44 (1998).
16. Spina, M. et al. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 173, 1561-1564 (1996).
17. Arase, K., York, D.A., Shimizu, H., Shargill, N. & Bray, G.A. Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am. J. Physiol. 255, E255-E259 (1988).
18. Woods, S.C., Seeley, R.J., Porte, D. Jr & Schwartz, M.W. Signals that regulate food intake and energy homeostasis. Science 280, 1378-1383 (1998).
19. Overton, J.M. & Fisher, L.A. Differentiated hemodynamic responses to central versus peripheral administration of corticotropin-releasing factor in conscious rats. J. Auton. Nerv. Syst. 35, 43-52 (1991).
20. Okosi, A. et al. Expression and protective effects of urocortin in cardiac myocytes. Neuropeptides 32, 167-171 (1998).
21. Grunt, M. et al. Dilatory and inotropic effects of corticotropin-releasing factor (CRF) on the isolated heart. Horm. Metab. Res. 24, 56-59 (1992).
22. Parkes, D.G., Vaughan, J., Rivier, J., Vale, W. & May, C.N. Cardiac inotropic actions of urocortin in conscious sheep. Am. J. Physiol. 272, H2115-H2122 (1997).
23. Fentzke, R.C. et al. Evaluation of ventricular and arterial hemodynamics in anesthetized closed-chest mice. J. Am. Soc. Echocardiogr. 10, 915-925 (1997).
24. Warltier, D.C. & Pagel, P.S. Cardiovascular and respiratory actions of desflurane: is desflurane different from isoflurane? Anesth. Analg. 75 (suppl.), S17-29 (1992).
25. Miyakoda, G., Yoshida, A., Takisawa, H. & Nakamura, T. β-Adrenergic regulation of contractility and protein phosphorylation in spontaneously beating isolated rat myocardial cells. J. Biochem. 102, 211-224 (1987).
26. Franklin, K. & Paxinos, G. The Mouse Brain in Stereotaxic Coordinates (Academic Press, San Diego, 1997).
27. Gu, G., Varoqueaux, F. & Simerly, R.B. Hormonal regulation of glutamate receptor gene expression in the anteroventral periventricular nucleus of the hypothalamus. J. Neurosci. 19, 3213-3222 (1999).
28. Wagoner, L.E. et al. Lysis of adult ventricular myocytes by cells infiltrating rejecting murine cardiac allografts. Circulation 93, 111-119 (1996).
29. Fukamizu, A. et al. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J. Biol. Chem. 268, 11617-11621 (1993).