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Volumn 2, Issue , 2017, Pages

NF-κB signaling in inflammation

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EID: 85064627519     PISSN: 20959907     EISSN: 20593635     Source Type: Journal    
DOI: 10.1038/sigtrans.2017.23     Document Type: Review
Times cited : (5819)

References (137)
  • 1
    • 77953496625 scopus 로고    scopus 로고
    • The NF-kappaB family of transcription factors and its regulation
    • Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009; 1: a000034.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Oeckinghaus, A.1    Ghosh, S.2
  • 2
    • 84878547634 scopus 로고    scopus 로고
    • Regulation of nuclear factor-kappaB in autoimmunity
    • Sun SC, Chang JH, Jin J. Regulation of nuclear factor-kappaB in autoimmunity. Trends Immunol 2013; 34: 282–289.
    • (2013) Trends Immunol , vol.34 , pp. 282-289
    • Sun, S.C.1    Chang, J.H.2    Jin, J.3
  • 3
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-kappaB signaling pathway
    • Sun SC. Non-canonical NF-kappaB signaling pathway. Cell Res 2011; 21: 71–85.
    • (2011) Cell Res , vol.21 , pp. 71-85
    • Sun, S.C.1
  • 4
    • 4544228457 scopus 로고    scopus 로고
    • Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology
    • Beinke S, Ley SC. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 2004; 382: 393–409.
    • (2004) Biochem J , vol.382 , pp. 393-409
    • Beinke, S.1    Ley, S.C.2
  • 5
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009; 27: 693–733.
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 6
    • 84960080303 scopus 로고    scopus 로고
    • NF-kappaB in inflammation and renal diseases
    • Zhang H, Sun SC. NF-kappaB in inflammation and renal diseases. Cell Biosci 2015; 5: 63.
    • (2015) Cell Biosci , vol.5 , pp. 63
    • Zhang, H.1    Sun, S.C.2
  • 7
    • 0033996762 scopus 로고    scopus 로고
    • The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
    • Karin M, Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 2000; 12: 85–98.
    • (2000) Semin Immunol , vol.12 , pp. 85-98
    • Karin, M.1    Delhase, M.2
  • 8
    • 52049095036 scopus 로고    scopus 로고
    • New insights into NF-kappaB regulation and function
    • Sun SC, Ley SC. New insights into NF-kappaB regulation and function. Trends Immunol 2008; 29: 469–478.
    • (2008) Trends Immunol , vol.29 , pp. 469-478
    • Sun, S.C.1    Ley, S.C.2
  • 9
    • 77957252647 scopus 로고    scopus 로고
    • The IKK complex, a central regulator of NF-kappaB activation
    • Israel A. The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol 2010; 2: a000158.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Israel, A.1
  • 10
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008; 132: 344–362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 11
    • 84858735072 scopus 로고    scopus 로고
    • The noncanonical NF-kappaB pathway
    • Sun SC. The noncanonical NF-kappaB pathway. Immunol Rev 2012; 246: 125–140.
    • (2012) Immunol Rev , vol.246 , pp. 125-140
    • Sun, S.C.1
  • 12
    • 78650892187 scopus 로고    scopus 로고
    • A special issue on NF-kappaB signaling and function
    • Sun SC, Liu ZG. A special issue on NF-kappaB signaling and function. Cell Res 2011; 21: 1–2.
    • (2011) Cell Res , vol.21 , pp. 1-2
    • Sun, S.C.1    Liu, Z.G.2
  • 13
    • 0034745420 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
    • Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 2001; 7: 401–409.
    • (2001) Mol Cell , vol.7 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.C.3
  • 14
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKK alpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    • Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G et al. Activation by IKK alpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001; 293: 1495–1499.
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3    Greten, F.R.4    Krahn, G.5    Bonizzi, G.6
  • 15
    • 77955906264 scopus 로고    scopus 로고
    • The nuclear factor NF-kappaB pathway in inflammation
    • Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 2009; 1: a001651.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Lawrence, T.1
  • 16
    • 0034746919 scopus 로고    scopus 로고
    • NF-kappaB: A key role in inflammatory diseases
    • Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001; 107: 7–11.
    • (2001) J Clin Invest , vol.107 , pp. 7-11
    • Tak, P.P.1    Firestein, G.S.2
  • 19
    • 66449088641 scopus 로고    scopus 로고
    • Pathogen recognition and inflammatory signaling in innate immune defenses
    • Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009; 22: 240–273.
    • (2009) Clin Microbiol Rev , vol.22 , pp. 240-273
    • Mogensen, T.H.1
  • 20
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140: 805–820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 21
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol 2011; 30: 16–34.
    • (2011) Int Rev Immunol , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 22
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109: S81–S96.
    • (2002) Cell , vol.109 , pp. S81-S96
    • Ghosh, S.1    Karin, M.2
  • 23
    • 79651473582 scopus 로고    scopus 로고
    • NF-kappaB in immunobiology
    • Hayden MS, Ghosh S. NF-kappaB in immunobiology. Cell Res 2011; 21: 223–244.
    • (2011) Cell Res , vol.21 , pp. 223-244
    • Hayden, M.S.1    Ghosh, S.2
  • 24
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 2008; 42: 145–151.
    • (2008) Cytokine , vol.42 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 25
    • 4344613405 scopus 로고    scopus 로고
    • Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
    • Gohda J, Matsumura T, Inoue J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J Immunol 2004; 173: 2913–2917.
    • (2004) J Immunol , vol.173 , pp. 2913-2917
    • Gohda, J.1    Matsumura, T.2    Inoue, J.3
  • 26
    • 84961683180 scopus 로고    scopus 로고
    • Ubiquitin signaling in immune responses
    • Hu H, Sun SC. Ubiquitin signaling in immune responses. Cell Res 2016; 26: 457–483.
    • (2016) Cell Res , vol.26 , pp. 457-483
    • Hu, H.1    Sun, S.C.2
  • 27
    • 27544434183 scopus 로고    scopus 로고
    • Essential function for the kinase TAK1 in innate and adaptive immune responses
    • Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 2005; 6: 1087–1095.
    • (2005) Nat Immunol , vol.6 , pp. 1087-1095
    • Sato, S.1    Sanjo, H.2    Takeda, K.3    Ninomiya-Tsuji, J.4    Yamamoto, M.5    Kawai, T.6
  • 29
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010; 327: 1098–1102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'shea, J.J.1    Paul, W.E.2
  • 30
    • 84919457872 scopus 로고    scopus 로고
    • Molecular mechanisms that influence the macrophage m1-m2 polarization balance
    • Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol 2014; 5: 614.
    • (2014) Front Immunol , vol.5 , pp. 614
    • Wang, N.1    Liang, H.2    Zen, K.3
  • 31
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012; 122: 787–795.
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 32
    • 0037310024 scopus 로고    scopus 로고
    • The many faces of macrophage activation
    • Mosser DM. The many faces of macrophage activation. J Leukoc Biol 2003; 73: 209–212.
    • (2003) J Leukoc Biol , vol.73 , pp. 209-212
    • Mosser, D.M.1
  • 33
    • 84899733210 scopus 로고    scopus 로고
    • MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases
    • Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D et al. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med 2014; 211: 887–907.
    • (2014) J Exp Med , vol.211 , pp. 887-907
    • Yu, M.1    Zhou, H.2    Zhao, J.3    Xiao, N.4    Roychowdhury, S.5    Schmitt, D.6
  • 34
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010; 11: 373–384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 35
    • 36049033394 scopus 로고    scopus 로고
    • Signaling to NF-kappaB by Toll-like receptors
    • Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 2007; 13: 460–469.
    • (2007) Trends Mol Med , vol.13 , pp. 460-469
    • Kawai, T.1    Akira, S.2
  • 36
    • 70349472923 scopus 로고    scopus 로고
    • Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
    • Chang M, Jin W, Sun SC. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 2009; 10: 1089–1095.
    • (2009) Nat Immunol , vol.10 , pp. 1089-1095
    • Chang, M.1    Jin, W.2    Sun, S.C.3
  • 37
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (*)
    • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 2010; 28: 445–489.
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 38
    • 84873695281 scopus 로고    scopus 로고
    • NF-kappaB: Roles and regulation in different CD4(+) T-cell subsets
    • Oh H, Ghosh S. NF-kappaB: roles and regulation in different CD4(+) T-cell subsets. Immunol Rev 2013; 252: 41–51.
    • (2013) Immunol Rev , vol.252 , pp. 41-51
    • Oh, H.1    Ghosh, S.2
  • 39
    • 80052971340 scopus 로고    scopus 로고
    • The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity
    • Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J et al. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol 2011; 12: 1002–1009.
    • (2011) Nat Immunol , vol.12 , pp. 1002-1009
    • Chang, M.1    Jin, W.2    Chang, J.H.3    Xiao, Y.4    Brittain, G.C.5    Yu, J.6
  • 40
    • 0032711223 scopus 로고    scopus 로고
    • Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo
    • Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR et al. Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immunol 1999; 163: 5116–5124.
    • (1999) J Immunol , vol.163 , pp. 5116-5124
    • Aronica, M.A.1    Mora, A.L.2    Mitchell, D.B.3    Finn, P.W.4    Johnson, J.E.5    Sheller, J.R.6
  • 42
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
    • Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2001; 2: 45–50.
    • (2001) Nat Immunol , vol.2 , pp. 45-50
    • Das, J.1    Chen, C.H.2    Yang, L.3    Cohn, L.4    Ray, P.5    Ray, A.6
  • 43
    • 64849107608 scopus 로고    scopus 로고
    • NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation
    • Chang M, Lee AJ, Fitzpatrick L, Zhang M, Sun SC. NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation. J Immunol 2009; 182: 3131–3138.
    • (2009) J Immunol , vol.182 , pp. 3131-3138
    • Chang, M.1    Lee, A.J.2    Fitzpatrick, L.3    Zhang, M.4    Sun, S.C.5
  • 44
    • 34250848216 scopus 로고    scopus 로고
    • IkappaB kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis
    • Greve B, Weissert R, Hamdi N, Bettelli E, Sobel RA, Coyle A et al. IkappaB kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. JImmunol2007; 179: 179–185.
    • Jimmunol , vol.2007 , pp. 179-185
    • Greve, B.1    Weissert, R.2    Hamdi, N.3    Bettelli, E.4    Sobel, R.A.5    Coyle, A.6
  • 45
    • 77956944349 scopus 로고    scopus 로고
    • Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel
    • Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon MF. Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel. J Immunol 2010; 185: 2350–2359.
    • (2010) J Immunol , vol.185 , pp. 2350-2359
    • Chen, G.1    Hardy, K.2    Bunting, K.3    Daley, S.4    Ma, L.5    Shannon, M.F.6
  • 46
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012; 30: 531–564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 47
    • 84949110031 scopus 로고    scopus 로고
    • TCR signaling to NF-kappaB and mTORC1: Expanding roles of the CARMA1 complex
    • Shi JH, Sun SC. TCR signaling to NF-kappaB and mTORC1: expanding roles of the CARMA1 complex. Mol Immunol 2015; 68: 546–557.
    • (2015) Mol Immunol , vol.68 , pp. 546-557
    • Shi, J.H.1    Sun, S.C.2
  • 48
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • Long M, Park SG, Strickland I, Hayden MS, Ghosh S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 2009; 31: 921–931.
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 49
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome
    • Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI et al. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity 2009; 31: 932–940.
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3    Li, L.4    Liou, H.C.5    Greene, M.I.6
  • 50
    • 84859900589 scopus 로고    scopus 로고
    • Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells
    • Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X et al. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol 2012; 13: 481–490.
    • (2012) Nat Immunol , vol.13 , pp. 481-490
    • Chang, J.H.1    Xiao, Y.2    Hu, H.3    Jin, J.4    Yu, J.5    Zhou, X.6
  • 51
    • 84055193888 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase plays an essential T cell-intrinsic role in graft-versus-host disease and lethal autoimmunity in mice
    • Murray SE, Polesso F, Rowe AM, Basak S, Koguchi Y, Toren KG et al. NF-kappaB-inducing kinase plays an essential T cell-intrinsic role in graft-versus-host disease and lethal autoimmunity in mice. J Clin Invest 2011; 121: 4775–4786.
    • (2011) J Clin Invest , vol.121 , pp. 4775-4786
    • Murray, S.E.1    Polesso, F.2    Rowe, A.M.3    Basak, S.4    Koguchi, Y.5    Toren, K.G.6
  • 52
    • 84959420371 scopus 로고    scopus 로고
    • Cell intrinsic role of NF-kappaB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
    • Li Y, Wang H, Zhou X, Xie X, Chen X, Jie Z et al. Cell intrinsic role of NF-kappaB-inducing kinase in regulating T cell-mediated immune and autoimmune responses. Sci Rep 2016; 6: 22115.
    • (2016) Sci Rep , vol.6
    • Li, Y.1    Wang, H.2    Zhou, X.3    Xie, X.4    Chen, X.5    Jie, Z.6
  • 53
    • 84907029151 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer
    • Yu J, Wang Y, Yan F, Zhang P, Li H, Zhao H et al. Noncanonical NF-kappaB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer. J Immunol 2014; 193: 2574–2586.
    • (2014) J Immunol , vol.193 , pp. 2574-2586
    • Yu, J.1    Wang, Y.2    Yan, F.3    Zhang, P.4    Li, H.5    Zhao, H.6
  • 54
    • 84884483844 scopus 로고    scopus 로고
    • A cell-intrinsic requirement for NF-kappaB-inducing kinase in CD4 and CD8 T cell memory
    • Rowe AM, Murray SE, Raue HP, Koguchi Y, Slifka MK, Parker DC. A cell-intrinsic requirement for NF-kappaB-inducing kinase in CD4 and CD8 T cell memory. J Immunol 2013; 191: 3663–3672.
    • (2013) J Immunol , vol.191 , pp. 3663-3672
    • Rowe, A.M.1    Murray, S.E.2    Raue, H.P.3    Koguchi, Y.4    Slifka, M.K.5    Parker, D.C.6
  • 55
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009; 9: 271–285.
    • (2009) Nat Rev Immunol , vol.9 , pp. 271-285
    • Croft, M.1
  • 56
    • 84976516826 scopus 로고    scopus 로고
    • Inflammasomes: Mechanism of assembly, regulation and signalling
    • Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 2016; 16: 407–420.
    • (2016) Nat Rev Immunol , vol.16 , pp. 407-420
    • Broz, P.1    Dixit, V.M.2
  • 57
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140: 821–832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 59
    • 84936891896 scopus 로고    scopus 로고
    • Inflammasomes: Mechanism of action, role in disease, and therapeutics
    • Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 2015; 21: 677–687.
    • (2015) Nat Med , vol.21 , pp. 677-687
    • Guo, H.1    Callaway, J.B.2    Ting, J.P.3
  • 60
    • 84927732725 scopus 로고    scopus 로고
    • Regulation of inflammasome activation
    • Man SM, Kanneganti TD. Regulation of inflammasome activation. Immunol Rev 2015; 265: 6–21.
    • (2015) Immunol Rev , vol.265 , pp. 6-21
    • Man, S.M.1    Kanneganti, T.D.2
  • 61
    • 84995751273 scopus 로고    scopus 로고
    • Mechanism and regulation of NLRP3 inflammasome activation
    • He Y, Hara H, Nunez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci 2016; 41: 1012–1021.
    • (2016) Trends Biochem Sci , vol.41 , pp. 1012-1021
    • He, Y.1    Hara, H.2    Nunez, G.3
  • 62
    • 84867770402 scopus 로고    scopus 로고
    • Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
    • Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F, Alnemri ES. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 2012; 287: 36617–36622.
    • (2012) J Biol Chem , vol.287 , pp. 36617-36622
    • Juliana, C.1    Fernandes-Alnemri, T.2    Kang, S.3    Farias, A.4    Qin, F.5    Alnemri, E.S.6
  • 63
    • 84872782298 scopus 로고    scopus 로고
    • Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
    • Py BF, Kim MS, Vakifahmetoglu-Norberg H, Yuan J. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell 2013; 49: 331–338.
    • (2013) Mol Cell , vol.49 , pp. 331-338
    • Py, B.F.1    Kim, M.S.2    Vakifahmetoglu-Norberg, H.3    Yuan, J.4
  • 64
    • 84928050252 scopus 로고    scopus 로고
    • Mechanisms of inflammasome activation: Recent advances and novel insights
    • Vanaja SK, Rathinam VA, Fitzgerald KA. Mechanisms of inflammasome activation: recent advances and novel insights. Trends Cell Biol 2015; 25: 308–315.
    • (2015) Trends Cell Biol , vol.25 , pp. 308-315
    • Vanaja, S.K.1    Rathinam, V.A.2    Fitzgerald, K.A.3
  • 65
    • 84862807232 scopus 로고    scopus 로고
    • TLR-induced NF-kappaB activation regulates NLRP3 expression in murine macrophages
    • Qiao Y, Wang P, Qi J, Zhang L, Gao C. TLR-induced NF-kappaB activation regulates NLRP3 expression in murine macrophages. FEBS Lett 2012; 586: 1022–1026.
    • (2012) FEBS Lett , vol.586 , pp. 1022-1026
    • Qiao, Y.1    Wang, P.2    Qi, J.3    Zhang, L.4    Gao, C.5
  • 66
    • 70249138036 scopus 로고    scopus 로고
    • Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    • Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 2009; 183: 787–791.
    • (2009) J Immunol , vol.183 , pp. 787-791
    • Bauernfeind, F.G.1    Horvath, G.2    Stutz, A.3    Alnemri, E.S.4    Macdonald, K.5    Speert, D.6
  • 67
    • 34548225362 scopus 로고    scopus 로고
    • NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKK beta
    • Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKK beta. Cell 2007; 130: 918–931.
    • (2007) Cell , vol.130 , pp. 918-931
    • Greten, F.R.1    Arkan, M.C.2    Bollrath, J.3    Hsu, L.C.4    Goode, J.5    Miething, C.6
  • 68
    • 84959420149 scopus 로고    scopus 로고
    • NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria
    • Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J et al. NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria. Cell 2016; 164: 896–910.
    • (2016) Cell , vol.164 , pp. 896-910
    • Zhong, Z.1    Umemura, A.2    Sanchez-Lopez, E.3    Liang, S.4    Shalapour, S.5    Wong, J.6
  • 70
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
    • Shi CS, Shenderov K, Huang NN, Kabat J, Abu-Asab M, Fitzgerald KA et al. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol 2012; 13: 255–263.
    • (2012) Nat Immunol , vol.13 , pp. 255-263
    • Shi, C.S.1    Shenderov, K.2    Huang, N.N.3    Kabat, J.4    Abu-Asab, M.5    Fitzgerald, K.A.6
  • 71
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221–225.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 72
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011; 12: 222–230.
    • (2011) Nat Immunol , vol.12 , pp. 222-230
    • Nakahira, K.1    Haspel, J.A.2    Rathinam, V.A.3    Lee, S.J.4    Dolinay, T.5    Lam, H.C.6
  • 73
    • 56649112944 scopus 로고    scopus 로고
    • Immune deficiency or hyperactivity-Nf-kappab illuminates autoimmunity
    • Pai S, Thomas R. Immune deficiency or hyperactivity-Nf-kappab illuminates autoimmunity. J Autoimmun 2008; 31: 245–251.
    • (2008) J Autoimmun , vol.31 , pp. 245-251
    • Pai, S.1    Thomas, R.2
  • 74
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205–2219.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 75
    • 0029552889 scopus 로고
    • High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis
    • Asahara H, Asanuma M, Ogawa N, Nishibayashi S, Inoue H. High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis. Biochem Mol Biol Int 1995; 37: 827–832.
    • (1995) Biochem Mol Biol Int , vol.37 , pp. 827-832
    • Asahara, H.1    Asanuma, M.2    Ogawa, N.3    Nishibayashi, S.4    Inoue, H.5
  • 76
    • 15844384253 scopus 로고    scopus 로고
    • Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue
    • Marok R, Winyard PG, Coumbe A, Kus ML, Gaffney K, Blades S et al. Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum 1996; 39: 583–591.
    • (1996) Arthritis Rheum , vol.39 , pp. 583-591
    • Marok, R.1    Winyard, P.G.2    Coumbe, A.3    Kus, M.L.4    Gaffney, K.5    Blades, S.6
  • 77
    • 0030773099 scopus 로고    scopus 로고
    • NF-kappa B activation in human knee-joint synovial tissue during the early stage of joint inflammation
    • Gilston V, Jones HW, Soo CC, Coumbe A, Blades S, Kaltschmidt C et al. NF-kappa B activation in human knee-joint synovial tissue during the early stage of joint inflammation. Biochem Soc Trans 1997; 25: 518S.
    • (1997) Biochem Soc Trans , vol.25 , pp. 518S
    • Gilston, V.1    Jones, H.W.2    Soo, C.C.3    Coumbe, A.4    Blades, S.5    Kaltschmidt, C.6
  • 78
    • 0031886794 scopus 로고    scopus 로고
    • Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: Spontaneous activation of NF-kappaB and CBF1
    • Miyazawa K, Mori A, Yamamoto K, Okudaira H. Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1. Am J Pathol 1998; 152: 793–803.
    • (1998) Am J Pathol , vol.152 , pp. 793-803
    • Miyazawa, K.1    Mori, A.2    Yamamoto, K.3    Okudaira, H.4
  • 79
    • 0032428729 scopus 로고    scopus 로고
    • AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis
    • Han Z, Boyle DL, Manning AM, Firestein GS. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998; 28: 197–208.
    • (1998) Autoimmunity , vol.28 , pp. 197-208
    • Han, Z.1    Boyle, D.L.2    Manning, A.M.3    Firestein, G.S.4
  • 83
    • 80052195163 scopus 로고    scopus 로고
    • A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
    • Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M et al. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 2011; 43: 908–912.
    • (2011) Nat Genet , vol.43 , pp. 908-912
    • Matmati, M.1    Jacques, P.2    Maelfait, J.3    Verheugen, E.4    Kool, M.5    Sze, M.6
  • 84
    • 42949171833 scopus 로고    scopus 로고
    • Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation
    • Simmonds RE, Foxwell BM. Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation. Rheumatology 2008; 47: 584–590.
    • (2008) Rheumatology , vol.47 , pp. 584-590
    • Simmonds, R.E.1    Foxwell, B.M.2
  • 85
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001; 19: 163–196.
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 87
    • 78650858041 scopus 로고    scopus 로고
    • Role of NF-kappaB in the skeleton
    • Novack DV. Role of NF-kappaB in the skeleton. Cell Res 2011; 21: 169–182.
    • (2011) Cell Res , vol.21 , pp. 169-182
    • Novack, D.V.1
  • 88
    • 70349705616 scopus 로고    scopus 로고
    • NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
    • Yao Z, Xing L, Boyce BF. NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism. J Clin Invest 2009; 119: 3024–3034.
    • (2009) J Clin Invest , vol.119 , pp. 3024-3034
    • Yao, Z.1    Xing, L.2    Boyce, B.F.3
  • 89
    • 84944691739 scopus 로고    scopus 로고
    • Bone as a target organ in rheumatic disease: Impact on osteoclasts and osteoblasts
    • Baum R, Gravallese EM. Bone as a target organ in rheumatic disease: impact on osteoclasts and osteoblasts. Clin Rev Allergy Immunol 2016; 51: 1–15.
    • (2016) Clin Rev Allergy Immunol , vol.51 , pp. 1-15
    • Baum, R.1    Gravallese, E.M.2
  • 91
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: An updated view of their molecular identity and genetic programming
    • Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 2008; 8: 337–348.
    • (2008) Nat Rev Immunol , vol.8 , pp. 337-348
    • Dong, C.1
  • 92
    • 84936891385 scopus 로고    scopus 로고
    • IL-12 and IL-23 cytokines: From discovery to targeted therapies for immune-mediated inflammatory diseases
    • Teng MW, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM et al. IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med 2015; 21: 719–729.
    • (2015) Nat Med , vol.21 , pp. 719-729
    • Teng, M.W.1    Bowman, E.P.2    McElwee, J.J.3    Smyth, M.J.4    Casanova, J.L.5    Cooper, A.M.6
  • 93
    • 84943815876 scopus 로고    scopus 로고
    • The role of BAFF in the progression of rheumatoid arthritis
    • Wei F, Chang Y, Wei W. The role of BAFF in the progression of rheumatoid arthritis. Cytokine 2015; 76: 537–544.
    • (2015) Cytokine , vol.76 , pp. 537-544
    • Wei, F.1    Chang, Y.2    Wei, W.3
  • 94
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361: 2066–2078.
    • (2009) N Engl J Med , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 96
    • 0031595210 scopus 로고    scopus 로고
    • Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa
    • Rogler G, Brand K, Vogl D, Page S, Hofmeister R, Andus T et al. Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 1998; 115: 357–369.
    • (1998) Gastroenterology , vol.115 , pp. 357-369
    • Rogler, G.1    Brand, K.2    Vogl, D.3    Page, S.4    Hofmeister, R.5    Andus, T.6
  • 97
    • 0031925362 scopus 로고    scopus 로고
    • Activation of nuclear factor kappa B inflammatory bowel disease
    • Schreiber S, Nikolaus S, Hampe J. Activation of nuclear factor kappa B inflammatory bowel disease. Gut 1998; 42: 477–484.
    • (1998) Gut , vol.42 , pp. 477-484
    • Schreiber, S.1    Nikolaus, S.2    Hampe, J.3
  • 99
    • 33745562220 scopus 로고    scopus 로고
    • Role of the NFKB1-94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes
    • Glas J, Torok HP, Tonenchi L, Muller-Myhsok B, Mussack T, Wetzke M et al. Role of the NFKB1-94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes. Inflamm Bowel Dis 2006; 12: 606–611.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 606-611
    • Glas, J.1    Torok, H.P.2    Tonenchi, L.3    Muller-Myhsok, B.4    Mussack, T.5    Wetzke, M.6
  • 100
    • 85013392319 scopus 로고    scopus 로고
    • Damaging heterozygous mutations in NFKB1 lead to diverse immunological phenotypes
    • e-pub ahead of print 21 January 2017; doi:10.1016/j. jaci.2016.10.054
    • Kaustio M, Haapaniemi E, Goos H, Hautala T, Park G, Syrjanen J et al. Damaging heterozygous mutations in NFKB1 lead to diverse immunological phenotypes. J Allergy Clin Immunol 2017, e-pub ahead of print 21 January 2017; doi:10.1016/j. jaci.2016.10.054.
    • (2017) J Allergy Clin Immunol
    • Kaustio, M.1    Haapaniemi, E.2    Goos, H.3    Hautala, T.4    Park, G.5    Syrjanen, J.6
  • 101
    • 33750598021 scopus 로고    scopus 로고
    • Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    • Zhang J, Stirling B, Temmerman ST, Ma CA, Fuss IJ, Derry JM et al. Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest 2006; 116: 3042–3049.
    • (2006) J Clin Invest , vol.116 , pp. 3042-3049
    • Zhang, J.1    Stirling, B.2    Temmerman, S.T.3    Ma, C.A.4    Fuss, I.J.5    Derry, J.M.6
  • 102
    • 34250368115 scopus 로고    scopus 로고
    • Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses
    • Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF et al. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 2007; 204: 1475–1485.
    • (2007) J Exp Med , vol.204 , pp. 1475-1485
    • Reiley, W.W.1    Jin, W.2    Lee, A.J.3    Wright, A.4    Wu, X.5    Tewalt, E.F.6
  • 104
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice
    • Neurath MF, Pettersson S, Meyer zum Buschenfelde KH, Strober W. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat Med 1996; 2: 998–1004.
    • (1996) Nat Med , vol.2 , pp. 998-1004
    • Neurath, M.F.1    Pettersson, S.2    Meyer Zum Buschenfelde, K.H.3    Strober, W.4
  • 105
    • 27644453163 scopus 로고    scopus 로고
    • Treatment of murine Th1-and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides
    • Fichtner-Feigl S, Fuss IJ, Preiss JC, Strober W, Kitani A. Treatment of murine Th1-and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides. J Clin Invest 2005; 115: 3057–3071.
    • (2005) J Clin Invest , vol.115 , pp. 3057-3071
    • Fichtner-Feigl, S.1    Fuss, I.J.2    Preiss, J.C.3    Strober, W.4    Kitani, A.5
  • 106
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004; 118: 285–296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.W.5    Egan, L.J.6
  • 107
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 2007; 446: 557–561.
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1    Becker, C.2    Wullaert, A.3    Gareus, R.4    van Loo, G.5    Danese, S.6
  • 108
    • 33947573767 scopus 로고    scopus 로고
    • Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    • Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 2007; 446: 552–556.
    • (2007) Nature , vol.446 , pp. 552-556
    • Zaph, C.1    Troy, A.E.2    Taylor, B.C.3    Berman-Booty, L.D.4    Guild, K.J.5    Du, Y.6
  • 109
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 2009; 9: 393–407.
    • (2009) Nat Rev Immunol , vol.9 , pp. 393-407
    • Goverman, J.1
  • 110
    • 84973325720 scopus 로고    scopus 로고
    • GWAS analysis implicates NF-kappaB-mediated induction of inflammatory T cells in multiple sclerosis
    • Hussman JP, Beecham AH, Schmidt M, Martin ER, McCauley JL, Vance JM et al. GWAS analysis implicates NF-kappaB-mediated induction of inflammatory T cells in multiple sclerosis. Genes Immun 2016; 17: 305–312.
    • (2016) Genes Immun , vol.17 , pp. 305-312
    • Hussman, J.P.1    Beecham, A.H.2    Schmidt, M.3    Martin, E.R.4    McCauley, J.L.5    Vance, J.M.6
  • 111
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • International Multiple Sclerosis Genetics, C Genetics, Consortium, Beecham AH, Patsopoulos NA, Xifara DK, Davis MF et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 2013; 45: 1353–1360.
    • (2013) Nat Genet , vol.45 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3    Davis, M.F.4
  • 112
    • 0036615454 scopus 로고    scopus 로고
    • Inhibitors in the NFkappaB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations
    • Miterski B, Bohringer S, Klein W, Sindern E, Haupts M, Schimrigk S et al. Inhibitors in the NFkappaB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations. Genes Immun 2002; 3: 211–219.
    • (2002) Genes Immun , vol.3 , pp. 211-219
    • Miterski, B.1    Bohringer, S.2    Klein, W.3    Sindern, E.4    Haupts, M.5    Schimrigk, S.6
  • 113
    • 84884753706 scopus 로고    scopus 로고
    • Nuclear factor kappa B (NF-kappaB) in multiple sclerosis pathology
    • Mc Guire C, Prinz M, Beyaert R, van Loo G. Nuclear factor kappa B (NF-kappaB) in multiple sclerosis pathology. Trends Mol Med 2013; 19: 604–613.
    • (2013) Trends Mol Med , vol.19 , pp. 604-613
    • Mc Guire, C.1    Prinz, M.2    Beyaert, R.3    van Loo, G.4
  • 115
    • 84868548958 scopus 로고    scopus 로고
    • T cell receptor/ CARMA1/NF-kappaB signaling controls T-helper (Th) 17 differentiation
    • Molinero LL, Cubre A, Mora-Solano C, Wang Y, Alegre ML. T cell receptor/ CARMA1/NF-kappaB signaling controls T-helper (Th) 17 differentiation. Proc Natl Acad Sci USA 2012; 109: 18529–18534.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 18529-18534
    • Molinero, L.L.1    Cubre, A.2    Mora-Solano, C.3    Wang, Y.4    Alegre, M.L.5
  • 116
    • 84874928867 scopus 로고    scopus 로고
    • Para-caspase MALT1 deficiency protects mice from autoimmune-mediated demyeli-nation
    • Mc Guire C, Wieghofer P, Elton L, Muylaert D, Prinz M, Beyaert R et al. Para-caspase MALT1 deficiency protects mice from autoimmune-mediated demyeli-nation. J Immunol 2013; 190: 2896–2903.
    • (2013) J Immunol , vol.190 , pp. 2896-2903
    • Mc Guire, C.1    Wieghofer, P.2    Elton, L.3    Muylaert, D.4    Prinz, M.5    Beyaert, R.6
  • 117
    • 80055116357 scopus 로고    scopus 로고
    • The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis
    • Ruan Q, Kameswaran V, Zhang Y, Zheng S, Sun J, Wang J et al. The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis. J Exp Med 2011; 208: 2321–2333.
    • (2011) J Exp Med , vol.208 , pp. 2321-2333
    • Ruan, Q.1    Kameswaran, V.2    Zhang, Y.3    Zheng, S.4    Sun, J.5    Wang, J.6
  • 118
    • 80555133361 scopus 로고    scopus 로고
    • The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis
    • Chen G, Hardy K, Pagler E, Ma L, Lee S, Gerondakis S et al. The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J Immunol 2011; 187: 4483–4491.
    • (2011) J Immunol , vol.187 , pp. 4483-4491
    • Chen, G.1    Hardy, K.2    Pagler, E.3    Ma, L.4    Lee, S.5    Gerondakis, S.6
  • 119
    • 80054837244 scopus 로고    scopus 로고
    • NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses
    • Hofmann J, Mair F, Greter M, Schmidt-Supprian M, Becher B. NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. J Exp Med 2011; 208: 1917–1929.
    • (2011) J Exp Med , vol.208 , pp. 1917-1929
    • Hofmann, J.1    Mair, F.2    Greter, M.3    Schmidt-Supprian, M.4    Becher, B.5
  • 120
    • 69249223474 scopus 로고    scopus 로고
    • Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK
    • Jin W, Zhou XF, Yu J, Cheng X, Sun SC. Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood 2009; 113: 6603–6610.
    • (2009) Blood , vol.113 , pp. 6603-6610
    • Jin, W.1    Zhou, X.F.2    Yu, J.3    Cheng, X.4    Sun, S.C.5
  • 121
    • 84855992548 scopus 로고    scopus 로고
    • Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation
    • Ellrichmann G, Thone J, Lee DH, Rupec RA, Gold R, Linker RA. Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation. J Neuroinflammation 2012; 9: 15.
    • (2012) J Neuroinflammation , vol.9 , pp. 15
    • Ellrichmann, G.1    Thone, J.2    Lee, D.H.3    Rupec, R.A.4    Gold, R.5    Linker, R.A.6
  • 122
    • 84979582926 scopus 로고    scopus 로고
    • IKKbeta-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier
    • Lee MJ, Bing SJ, Choi J, Jang M, Lee G, Lee H et al. IKKbeta-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier. Mol Neurodegener 2016; 11: 54.
    • (2016) Mol Neurodegener , vol.11 , pp. 54
    • Lee, M.J.1    Bing, S.J.2    Choi, J.3    Jang, M.4    Lee, G.5    Lee, H.6
  • 123
    • 33747609345 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
    • van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M et al. Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol 2006; 7: 954–961.
    • (2006) Nat Immunol , vol.7 , pp. 954-961
    • van Loo, G.1    de Lorenzi, R.2    Schmidt, H.3    Huth, M.4    Mildner, A.5    Schmidt-Supprian, M.6
  • 124
    • 84865852211 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-kappaB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis
    • Brambilla R, Dvoriantchikova G, Barakat D, Ivanov D, Bethea JR, Shestopalov VI. Transgenic inhibition of astroglial NF-kappaB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis. J Neuroinflammation 2012; 9: 213.
    • (2012) J Neuroinflammation , vol.9 , pp. 213
    • Brambilla, R.1    Dvoriantchikova, G.2    Barakat, D.3    Ivanov, D.4    Bethea, J.R.5    Shestopalov, V.I.6
  • 125
    • 64849094450 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation
    • Brambilla R, Persaud T, Hu X, Karmally S, Shestopalov VI, Dvoriantchikova G et al. Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J Immunol 2009; 182: 2628–2640.
    • (2009) J Immunol , vol.182 , pp. 2628-2640
    • Brambilla, R.1    Persaud, T.2    Hu, X.3    Karmally, S.4    Shestopalov, V.I.5    Dvoriantchikova, G.6
  • 126
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011; 473: 317–325.
    • (2011) Nature , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 127
    • 84952718180 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activation as a pathological mechanism of lipid metabolism and atherosclerosis
    • Yu XH, Zheng XL, Tang CK. Nuclear factor-kappaB activation as a pathological mechanism of lipid metabolism and atherosclerosis. Adv Clin Chem 2015; 70: 1–30.
    • (2015) Adv Clin Chem , vol.70 , pp. 1-30
    • Yu, X.H.1    Zheng, X.L.2    Tang, C.K.3
  • 128
    • 1842681951 scopus 로고    scopus 로고
    • Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis
    • Monaco C, Andreakos E, Kiriakidis S, Mauri C, Bicknell C, Foxwell B et al. Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci USA 2004; 101: 5634–5639.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5634-5639
    • Monaco, C.1    Andreakos, E.2    Kiriakidis, S.3    Mauri, C.4    Bicknell, C.5    Foxwell, B.6
  • 130
    • 24944473034 scopus 로고    scopus 로고
    • NF-kappaB controls the global proinflammatory response in endothelial cells: Evidence for the regulation of a pro-atherogenic program
    • Kempe S, Kestler H, Lasar A, Wirth T. NF-kappaB controls the global proinflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program. Nucleic Acids Res 2005; 33: 5308–5319.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5308-5319
    • Kempe, S.1    Kestler, H.2    Lasar, A.3    Wirth, T.4
  • 131
    • 1342345219 scopus 로고    scopus 로고
    • Nuclear factor kappaB: A potential therapeutic target in atherosclerosis and thrombosis
    • Monaco C, Paleolog E. Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc Res 2004; 61: 671–682.
    • (2004) Cardiovasc Res , vol.61 , pp. 671-682
    • Monaco, C.1    Paleolog, E.2
  • 133
  • 134
    • 84870061589 scopus 로고    scopus 로고
    • Myeloid-specific IkappaB kinase beta deficiency decreases atherosclerosis in low-density lipo-protein receptor-deficient mice
    • Park SH, Sui Y, Gizard F, Xu J, Rios-Pilier J, Helsley RN et al. Myeloid-specific IkappaB kinase beta deficiency decreases atherosclerosis in low-density lipo-protein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2012; 32: 2869–2876.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2869-2876
    • Park, S.H.1    Sui, Y.2    Gizard, F.3    Xu, J.4    Rios-Pilier, J.5    Helsley, R.N.6
  • 136
    • 72549111131 scopus 로고    scopus 로고
    • The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy
    • Lin Y, Bai L, Chen W, Xu S. The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets 2010; 14: 45–55.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 45-55
    • Lin, Y.1    Bai, L.2    Chen, W.3    Xu, S.4
  • 137
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(Kappa)B kinase-beta
    • Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 1998; 396: 77–80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3


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